ATE509092T1 - Rekombinante bcg-stämme mit verbesserter fähigkeit zum entweichen aus dem endosom - Google Patents

Rekombinante bcg-stämme mit verbesserter fähigkeit zum entweichen aus dem endosom

Info

Publication number
ATE509092T1
ATE509092T1 AT05858631T AT05858631T ATE509092T1 AT E509092 T1 ATE509092 T1 AT E509092T1 AT 05858631 T AT05858631 T AT 05858631T AT 05858631 T AT05858631 T AT 05858631T AT E509092 T1 ATE509092 T1 AT E509092T1
Authority
AT
Austria
Prior art keywords
endosome
escape
improved ability
recombinant bcg
bcg strains
Prior art date
Application number
AT05858631T
Other languages
English (en)
Inventor
Ronggai Sun
David Hone
Jerald Sadoff
Original Assignee
Aeras Global Tb Vaccine Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aeras Global Tb Vaccine Foundation filed Critical Aeras Global Tb Vaccine Foundation
Application granted granted Critical
Publication of ATE509092T1 publication Critical patent/ATE509092T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/33—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Clostridium (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Pulmonology (AREA)
  • Microbiology (AREA)
  • Wood Science & Technology (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biotechnology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT05858631T 2004-12-01 2005-11-23 Rekombinante bcg-stämme mit verbesserter fähigkeit zum entweichen aus dem endosom ATE509092T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63197304P 2004-12-01 2004-12-01
PCT/US2005/042602 WO2007058663A2 (en) 2004-12-01 2005-11-23 Recombinant bcg strains with enhanced ability to escape the endosome

Publications (1)

Publication Number Publication Date
ATE509092T1 true ATE509092T1 (de) 2011-05-15

Family

ID=38049094

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05858631T ATE509092T1 (de) 2004-12-01 2005-11-23 Rekombinante bcg-stämme mit verbesserter fähigkeit zum entweichen aus dem endosom

Country Status (17)

Country Link
US (3) US20100047286A1 (de)
EP (1) EP1827504B1 (de)
JP (1) JP5713523B2 (de)
KR (1) KR101329323B1 (de)
CN (1) CN101198358B (de)
AP (1) AP2007004033A0 (de)
AT (1) ATE509092T1 (de)
AU (1) AU2005338353B2 (de)
BR (1) BRPI0518091A2 (de)
CA (1) CA2589204C (de)
DK (1) DK1827504T3 (de)
EA (1) EA012434B1 (de)
ES (1) ES2366622T3 (de)
PE (1) PE20061168A1 (de)
TW (1) TWI456057B (de)
WO (1) WO2007058663A2 (de)
ZA (1) ZA200704765B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9809654B2 (en) 2002-09-27 2017-11-07 Vaccinex, Inc. Targeted CD1d molecules
SG159554A1 (en) * 2004-11-16 2010-03-30 Crucell Holland Bv Multivalent vaccines comprising recombinant viral vectors
WO2009025888A2 (en) 2007-05-10 2009-02-26 The Arizona Board Of Regents For And On Behalf Of Arizona State University Regulated synthesis of antigen and/or regulated attentuation to enhance vaccine immunogenics and/or safety
EP2162150A4 (de) * 2007-06-22 2011-10-12 Univ Guelph Impfstoff gegen clostridium perfringens
US20100015171A1 (en) 2008-07-15 2010-01-21 Statens Serum Institute Vaccines comprising tb 10.4
NZ593794A (en) * 2009-01-08 2013-04-26 Einstein Coll Med Bacterial vaccines with cell wall-associated ceramide-like glycolipids and uses thereof
CN103687959B (zh) * 2011-04-08 2016-10-12 贝斯泰医学中心公司 用于测定线粒体功能的方法、组合物和试剂盒
US20130115240A1 (en) * 2011-11-09 2013-05-09 National Health Research Institutes Recombinant bcg strains with enhanced ability to inhibit intracellular mycobacterial growth
EP2834356A4 (de) * 2012-04-02 2015-09-02 Univ Arizona Rekombinantes bakterium zur induktion einer zellulären immunantwort
WO2013158061A1 (en) 2012-04-16 2013-10-24 Aeras Global Tb Vaccine Foundation Recombinant mycobacterium encoding a heparin-binding hemagglutinin (hbha) fusion protein and uses thereof
US20150240201A1 (en) * 2012-09-27 2015-08-27 Chengdu Yongan Pharmaceutical Co., Ltd. Modified bcg strains with reduced or eliminated activity of lsr2 and pharmaceutical composition comprising same
US9371352B2 (en) 2013-02-08 2016-06-21 Vaccinex, Inc. Modified glycolipids and methods of making and using the same
ES2925950T3 (es) 2013-06-25 2022-10-20 Int Aids Vaccine Initiative Inc Composiciones para la tuberculosis y procedimientos de uso de las mismas
CN109890411A (zh) * 2016-06-16 2019-06-14 国际艾滋病疫苗行动组织公司 结核病组合物和治疗或预防结核病的方法
WO2017223146A1 (en) * 2016-06-22 2017-12-28 Aeras Recombinant cytomegalovirus vectors as vaccines for tuberculosis
EP3697806A4 (de) 2017-10-17 2021-10-27 International AIDS Vaccine Initiative, Inc. Tuberkulose-antigen-kassetten
KR102260116B1 (ko) 2018-11-19 2021-06-04 중앙대학교 산학협력단 항균 펩타이드 회피 유전자를 포함하는 재조합 바실러스 칼메트-게렝균의 방광암 항암 치료용 약학적 조성물
KR20200058319A (ko) 2018-11-19 2020-05-27 중앙대학교 산학협력단 항균 펩타이드 회피 유전자를 포함하는 재조합 바실러스 칼메트-게렝균의 방광암 항암 치료용 약학적 조성물
KR102135328B1 (ko) * 2018-12-19 2020-07-17 대한민국 결핵 2가 항원을 발현하는 약독화된 재조합 백시니아 바이러스 및 이를 포함하는 결핵 예방용 조성물
US10973908B1 (en) 2020-05-14 2021-04-13 David Gordon Bermudes Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine
CN114438106B (zh) * 2022-02-14 2024-01-19 首都医科大学附属北京胸科医院 Rv2779c基因及其表达产物作为抗结核分枝杆菌靶点的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994028137A1 (en) 1993-05-24 1994-12-08 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Regulator of contact-mediated hemolysin
EP0902086A1 (de) 1997-08-22 1999-03-17 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Tuberkolose Impfstoff
US6423545B1 (en) * 1999-07-08 2002-07-23 Albert Einstein College Of Medicine Of Yeshiva University Unmarked deletion mutants of mycobacteria and methods of using same
US6776993B2 (en) * 2000-02-22 2004-08-17 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Tuberculosis vaccine
US6924118B2 (en) * 2000-04-17 2005-08-02 The Regents Of The University Of California Recombinant intracellular pathogen immunogenic compositions and methods for use
US6471967B1 (en) * 2000-04-17 2002-10-29 The Regents Of The University Of California Recombinant intracellular pathogen vaccines and methods for use
CA2523084C (en) 2003-04-23 2012-09-04 Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V. Tuberculosis vaccine with improved efficacy
EP1649869A1 (de) 2004-10-21 2006-04-26 Vakzine Projekt Management GmbH Kombination von rekombinanten Mycobakterien und einem biologisch aktiven Agent als Vakzine
ES2370885T3 (es) * 2004-12-01 2011-12-23 Aeras Global Tuberculosis Vaccine Foundation Electroporación de mycobacterium y sobreexpresión de antígenos en micobacterias.

Also Published As

Publication number Publication date
US20100047286A1 (en) 2010-02-25
CA2589204A1 (en) 2007-05-24
US7666656B2 (en) 2010-02-23
TW200637910A (en) 2006-11-01
ZA200704765B (en) 2008-09-25
EA012434B1 (ru) 2009-10-30
EP1827504B1 (de) 2011-05-11
PE20061168A1 (es) 2006-10-27
CN101198358A (zh) 2008-06-11
AP2007004033A0 (en) 2007-06-30
BRPI0518091A2 (pt) 2008-11-25
KR101329323B1 (ko) 2013-11-14
DK1827504T3 (da) 2011-08-29
CA2589204C (en) 2013-10-29
JP2008521449A (ja) 2008-06-26
EA200701128A1 (ru) 2008-02-28
EP1827504A2 (de) 2007-09-05
CN101198358B (zh) 2013-06-26
US8043857B2 (en) 2011-10-25
AU2005338353B2 (en) 2011-04-14
EP1827504A4 (de) 2008-11-12
KR20070101855A (ko) 2007-10-17
US20080095794A1 (en) 2008-04-24
JP5713523B2 (ja) 2015-05-07
AU2005338353A1 (en) 2007-05-24
TWI456057B (zh) 2014-10-11
ES2366622T3 (es) 2011-10-24
WO2007058663A3 (en) 2007-07-12
US20100233213A1 (en) 2010-09-16
WO2007058663A2 (en) 2007-05-24

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