ATE504291T1 - Dosierform mit einem innenkern und mindestens zwei bezugsschichten - Google Patents

Dosierform mit einem innenkern und mindestens zwei bezugsschichten

Info

Publication number
ATE504291T1
ATE504291T1 AT03799331T AT03799331T ATE504291T1 AT E504291 T1 ATE504291 T1 AT E504291T1 AT 03799331 T AT03799331 T AT 03799331T AT 03799331 T AT03799331 T AT 03799331T AT E504291 T1 ATE504291 T1 AT E504291T1
Authority
AT
Austria
Prior art keywords
inner core
dosage form
cover layers
compositions
layer
Prior art date
Application number
AT03799331T
Other languages
German (de)
English (en)
Inventor
Graham John Myatt
Original Assignee
Procter & Gamble
Alimentary Health Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Procter & Gamble, Alimentary Health Ltd filed Critical Procter & Gamble
Application granted granted Critical
Publication of ATE504291T1 publication Critical patent/ATE504291T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846—Poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/288—Compounds of unknown constitution, e.g. material from plants or animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2886—Dragees; Coated pills or tablets, e.g. with film or compression coating having two or more different drug-free coatings; Tablets of the type inert core-drug layer-inactive layer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Medicinal Preparation (AREA)
  • Laminated Bodies (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT03799331T 2002-10-03 2003-09-30 Dosierform mit einem innenkern und mindestens zwei bezugsschichten ATE504291T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/263,516 US8168170B2 (en) 2002-10-03 2002-10-03 Compositions having an inner core and at least three surrounding layers
PCT/US2003/030817 WO2004030652A2 (en) 2002-10-03 2003-09-30 Dosage form having an inner core and at least two coating layers

Publications (1)

Publication Number Publication Date
ATE504291T1 true ATE504291T1 (de) 2011-04-15

Family

ID=32068280

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03799331T ATE504291T1 (de) 2002-10-03 2003-09-30 Dosierform mit einem innenkern und mindestens zwei bezugsschichten

Country Status (12)

Country Link
US (1) US8168170B2 (zh)
EP (1) EP1558223B1 (zh)
JP (1) JP2006507259A (zh)
KR (2) KR20050083711A (zh)
CN (1) CN1684672B (zh)
AT (1) ATE504291T1 (zh)
AU (1) AU2003277102B2 (zh)
CA (1) CA2500390C (zh)
DE (1) DE60336671D1 (zh)
ES (1) ES2364458T3 (zh)
MX (1) MXPA05003586A (zh)
WO (1) WO2004030652A2 (zh)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100233312A9 (en) * 2005-04-11 2010-09-16 The Procter & Gamble Company Compositions comprising probiotic and sweetener components
WO2006122965A1 (en) 2005-05-18 2006-11-23 Dsm Ip Assets B.V. Compositions for enteral application of microorganisms
US8324192B2 (en) 2005-11-12 2012-12-04 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
US8679545B2 (en) 2005-11-12 2014-03-25 The Regents Of The University Of California Topical corticosteroids for the treatment of inflammatory diseases of the gastrointestinal tract
US8497258B2 (en) 2005-11-12 2013-07-30 The Regents Of The University Of California Viscous budesonide for the treatment of inflammatory diseases of the gastrointestinal tract
WO2008035332A1 (en) * 2006-09-19 2008-03-27 Technion Research And Development Foundation Ltd. Probiotic compositions and methods of making same
EP2073698B1 (en) 2006-09-29 2015-09-09 Medimetrics Personalized Drug Delivery B.V. Miniaturized threshold sensor
KR101503829B1 (ko) 2007-09-07 2015-03-18 삼성전자주식회사 데이터 압축 장치 및 방법
US8865692B2 (en) 2007-11-13 2014-10-21 Meritage Pharma, Inc Compositions for the treatment of gastrointestinal inflammation
EP3354276B1 (en) 2007-11-13 2020-01-01 Meritage Pharma, Inc. Compositions for the treatment of gastrointestinal inflammation
IL199781A0 (en) * 2009-07-09 2010-05-17 Yohai Zorea Heat resistant probiotic compositions and healthy food comprising them
US9771199B2 (en) 2008-07-07 2017-09-26 Mars, Incorporated Probiotic supplement, process for making, and packaging
JP5646158B2 (ja) * 2008-11-07 2014-12-24 ツキオカフィルム製薬株式会社 乳酸菌含有フィルム及び乳酸菌含有フィルムの製造方法
KR101689688B1 (ko) * 2008-11-18 2016-12-26 유씨비 파마, 에스.에이. ２­옥소­１­피롤리딘 유도체를 포함하는 지연 방출형 제형
US20110091606A1 (en) * 2009-09-23 2011-04-21 Todd Ehrlich Dietary Supplements in Beverages or Other Forms, and Methods of Use and Production
KR101143997B1 (ko) * 2010-03-04 2012-05-09 한미사이언스 주식회사 유산균 제제 및 5-ｈｔ4 수용체 효능제를 함유하는 경구 투여용 복합 제제 및 이의 제조방법
EP2603240B1 (en) * 2010-08-09 2019-11-20 Degama Smart Ltd. Probiotic liquid food products
CN102416170B (zh) * 2011-11-07 2013-08-07 重庆申高生化制药有限公司 多酶片的生产工艺
AU2013240289B2 (en) 2012-03-29 2018-01-25 Therabiome, Llc Gastrointestinal site-specific oral vaccination formulations active on the ileum and appendix
NZ711298A (en) * 2013-03-14 2021-07-30 Therabiome Llc Targeted gastrointestinal tract delivery of probiotic organisms and/or therapeutic agents
EP2946774B1 (en) 2014-05-19 2020-04-22 Tillotts Pharma AG Modified release coated capsules
EP2946773A1 (en) * 2014-05-19 2015-11-25 Tillotts Pharma AG Modified release coated capsules
CA2951739C (en) 2014-07-01 2023-09-19 Tntgamble, Inc. Bi-layer dual release probiotic tablets
CN105296433B (zh) 2014-08-01 2018-02-09 中山康方生物医药有限公司 一种ctla4抗体、其药物组合物及其用途
US10137164B2 (en) 2015-01-02 2018-11-27 Melaleuca, Inc. Dietary supplement compositions
TWI829098B (zh) 2015-01-02 2024-01-11 美商梅拉洛伊卡公司 細菌組成物
TWI788111B (zh) 2015-01-02 2022-12-21 美商梅拉洛伊卡公司 多元補充品組成物
WO2017035426A1 (en) 2015-08-27 2017-03-02 The Procter & Gamble Company Bifidobacterium longum
WO2018035710A1 (en) 2016-08-23 2018-03-01 Akeso Biopharma, Inc. Anti-ctla4 antibodies
KR102370803B1 (ko) * 2016-09-30 2022-03-07 (주)아모레퍼시픽 색소를 포함하는 캡슐, 및 이의 제조 방법
US12042519B2 (en) 2017-07-14 2024-07-23 The University Of Chicago Freeze-dried formulations including nanoparticles and methods of freeze-drying
KR102458445B1 (ko) * 2020-01-29 2022-10-24 박기원 반려동물용 다기능 미세 영양캡슐 제조방법 및 그 방법에 의해 제조된 반려동물용 미세 영양캡슐
US11426353B2 (en) * 2020-06-24 2022-08-30 13400719 Canada Inc. Composite coating for an active agent

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2540979A (en) 1948-04-24 1951-02-06 Smith Kline French Lab Enteric coating
DE1204363B (de) 1963-09-10 1965-11-04 Hoffmann La Roche Verfahren zur Herstellung einer oralen Arzneizubereitung, die ihren Wirkstoff erst im Ileum abgibt
GB1190387A (en) 1966-05-24 1970-05-06 Green Cross Corp Enteric Coated Medicaments
US3738952A (en) * 1969-05-09 1973-06-12 Colorcon Stabilized shellac sealing coating for tablets
US4248857A (en) 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
US4927763A (en) * 1984-03-21 1990-05-22 Chr. Hansen's Laboratory, Inc. Stabilization of dried bacteria extended in particulate carriers
DE3678643D1 (de) 1985-08-16 1991-05-16 Procter & Gamble Partikel mit konstanter wirkstofffreisetzung.
EP0212747B1 (en) 1985-08-16 1991-04-10 The Procter & Gamble Company Drug particles having constant release and immediate release
JPS62201823A (ja) 1986-02-28 1987-09-05 Freunt Ind Co Ltd 腸内有用細菌含有物およびその製造方法
US4816259A (en) 1987-02-12 1989-03-28 Chase Chemical Company, L.P. Process for coating gelatin capsules
FI77573C (fi) 1987-05-08 1989-04-10 Orion Yhtymae Oy Ny konsistens.
JPH01278781A (ja) 1988-05-02 1989-11-09 Nec Corp 不揮発性半導体記憶装置
IT1230576B (it) 1988-10-20 1991-10-28 Angeli Inst Spa Formulazioni farmaceutiche per via orale a liberazione selettiva nel colon
US5540945A (en) 1989-05-11 1996-07-30 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical preparations for oral administration that are adapted to release the drug at appropriate sites in the intestines
JPH06101994B2 (ja) 1989-08-16 1994-12-14 ユニコロイド株式会社 耐消化性腸内有用細菌及びその製法
PH27186A (en) 1989-09-07 1993-04-16 Ciba Geigy Ag Double-coated granules of disodium pamidronate
US5198227A (en) 1990-01-22 1993-03-30 Mcneil-Ppc, Inc. Dual subcoated simulated capsule medicament
IE61651B1 (en) 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
JP3472317B2 (ja) 1993-02-26 2003-12-02 味の素ファルマ株式会社 被覆製剤
GB2290965A (en) 1994-07-11 1996-01-17 Therapicon Srl Multiple layer capsules for drugs
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
JPH08242763A (ja) 1995-03-10 1996-09-24 Morishita Jintan Kk カプセル化された腸内有用細菌を含有するヨーグルト
CR5278A (es) 1995-03-24 1996-07-04 Lilly Co Eli Formulacion oral de 2-metil-tieno-benzodiacepina
SG80553A1 (en) 1995-07-20 2001-05-22 Tanabe Seiyaku Co Pharmaceutical preparation in form of coated capsule releasable at lower part of digestive tract
AU5179898A (en) 1996-11-06 1998-05-29 Sharmatek, Inc. Delayed delivery system for acid-sensitive drugs
WO1998027967A1 (en) 1996-12-20 1998-07-02 Dumex-Alpharma A/S Release-controlled coated tablets
ES2360341T3 (es) 1997-02-11 2011-06-03 Enterprise Ireland (Trading As Bioresearch Ireland) Cepas probióticas de lactobacillus salivarius y agentes antimicrobianos obtenidos a partir de las mismas.
US6030641A (en) * 1997-06-03 2000-02-29 Uni Colloid Kabushiki Kaisha Sustained release capsule and method for preparing the same
NZ503086A (en) 1997-08-29 2002-03-01 Upjohn Co An orally administrable pharmaceutical composition comprising an inner core and two outer layers, which render it substantially free of unpleasant tastes
KR100387245B1 (ko) * 1997-10-17 2003-08-19 일양약품주식회사 유산균의안정화를위한미세장용성코팅과립
SE9803871D0 (sv) 1998-11-11 1998-11-11 Pharmacia & Upjohn Ab Therapeutic method and formulation
JP2000191519A (ja) 1998-12-25 2000-07-11 Nippon Kayaku Co Ltd 薬効成分の不快な官能的性質が隠蔽された速放性粒状物
ID29150A (id) 1999-01-15 2001-08-02 Entpr Ireland Cs Penggunaan lactobacillus salivarius
DE19937361A1 (de) 1999-08-12 2001-02-22 Merck Patent Gmbh Orale Darreichungsform
CA2409286C (en) 2000-05-25 2012-05-15 Societe Des Produits Nestle S.A. Dog & cat food compositions having a probiotic lactobacillus strain
CA2359812C (en) 2000-11-20 2004-02-10 The Procter & Gamble Company Pharmaceutical dosage form with multiple coatings for reduced impact of coating fractures
NZ527930A (en) 2001-03-16 2005-11-25 Andrx Pharmaceuticals Llc Controlled release sulfonylurea formulation
EP1453487B2 (en) 2001-11-23 2021-03-31 Allergan Pharmaceuticals International Limited Pharmaceutical dosage form with multiple coatings

Also Published As

Publication number Publication date
DE60336671D1 (de) 2011-05-19
EP1558223A2 (en) 2005-08-03
ES2364458T3 (es) 2011-09-02
KR20050083711A (ko) 2005-08-26
EP1558223B1 (en) 2011-04-06
WO2004030652A2 (en) 2004-04-15
AU2003277102A1 (en) 2004-04-23
AU2003277102B2 (en) 2007-12-13
US20040120931A1 (en) 2004-06-24
JP2006507259A (ja) 2006-03-02
CN1684672A (zh) 2005-10-19
CA2500390C (en) 2012-07-10
CA2500390A1 (en) 2004-04-15
CN1684672B (zh) 2010-10-27
MXPA05003586A (es) 2007-08-22
WO2004030652A3 (en) 2004-05-06
US8168170B2 (en) 2012-05-01
KR20070091048A (ko) 2007-09-06

Similar Documents

Publication Publication Date Title
ATE504291T1 (de) Dosierform mit einem innenkern und mindestens zwei bezugsschichten
WO2004037310A3 (en) Surface coating comprising bioactive compound
WO2004006355A3 (en) Charge transport compositions which are quinazoline derivatives and electronic devices made with such compositions
AU2002352496A1 (en) Coated article with improved barrier layer structure and method of making the same
DE69712076D1 (de) Pulver beschichtungszusammensetzungen und beschichtete oberfläche mit multischicht-auflage
HUP0402591A2 (hu) Polimer bevonat orvosi eszközök számára
ATE394519T1 (de) Spritzpulver und lagerteil einer lagervorrichtung beschichtet mit dem spritzpulver
PT1007009E (pt) Composicao farmaceutica que possui duas camadas de revestimento
DE60200607D1 (de) Kontrolle der Dicke einer aufgedampften oder aufsublimierten organischen Schicht während der Herstellung eines organischen licht-emittierenden Bauteils
DE69735483D1 (de) Organisches lichtemittierendes bauelement und dessen herstellung
WO2004024989A3 (en) Layer by layer assembled nanocomposite barrier coatings
GB2353717A (en) Improved golf ball utilizing silicone materials
SG91948A1 (en) Manufacturing method of multilayer substrate and multilayer substrate produced by the manufacturing method
TW200609002A (en) Coated tablet formulation and method
MXPA02003152A (es) Composicion curable por luz uv, para producir revestimientos electroluminiscentes.
CA2447842A1 (en) Method for forming coating film on plastic substrate
ATE356854T1 (de) Überzugsmittelzusammensetzung
ATE300423T1 (de) Pla-folie mit guten antistatischen eigenschaften
AU2307402A (en) Microgranules based on active principle and method for making same
ZA949800B (en) Phosphate conversion coating and compositions and concentrates therefor with stable internal accelerator.
NO995224D0 (no) Polymerblandinger til forbedring av smöreeffekter til mellomdestillater
AU2003287849A8 (en) Lock arrangement for a substrate coating installation
EP1304705A4 (en) INSULATED POWER CABLE
DK1240010T3 (da) Kompositelementer
ATE325712T1 (de) Mehrschichtstrukturen

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties