ATE503761T1 - Von aminosäuren abgeleitete, zyklische phosphonamide und verfahren zu deren synthese - Google Patents
Von aminosäuren abgeleitete, zyklische phosphonamide und verfahren zu deren syntheseInfo
- Publication number
- ATE503761T1 ATE503761T1 AT07008428T AT07008428T ATE503761T1 AT E503761 T1 ATE503761 T1 AT E503761T1 AT 07008428 T AT07008428 T AT 07008428T AT 07008428 T AT07008428 T AT 07008428T AT E503761 T1 ATE503761 T1 AT E503761T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphonamide
- ring
- template
- synthesis
- derived
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 125000005541 phosphonamide group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000011984 grubbs catalyst Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2462—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of unsaturated acyclic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/639,051 US6420586B1 (en) | 2000-08-15 | 2000-08-15 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE503761T1 true ATE503761T1 (de) | 2011-04-15 |
Family
ID=24562532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07008428T ATE503761T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete, zyklische phosphonamide und verfahren zu deren synthese |
| AT01964579T ATE463500T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01964579T ATE463500T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420586B1 (de) |
| EP (2) | EP1806351B1 (de) |
| JP (1) | JP5249486B2 (de) |
| AT (2) | ATE503761T1 (de) |
| AU (1) | AU2001285418A1 (de) |
| CA (1) | CA2419775C (de) |
| DE (2) | DE60144349D1 (de) |
| DK (2) | DK1806351T3 (de) |
| WO (1) | WO2002014344A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20030018053A (ko) * | 2000-07-18 | 2003-03-04 | 레오 파마 에이/에스 | 매트릭스 메탈로프로티나제 억제제 |
| CN1714096A (zh) * | 2002-01-18 | 2005-12-28 | 利奥制药有限公司 | Mmp抑制剂 |
| MXPA04010527A (es) * | 2002-04-26 | 2004-12-13 | Gilead Sciences Inc | Acumulacion celular de analogos de fosfonato de los compuestos inhibidores de la proteasa del virus de inmunodeficiencia humana (vih). |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| US7417055B2 (en) | 2003-04-25 | 2008-08-26 | Gilead Sciences, Inc. | Kinase inhibitory phosphonate analogs |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7427636B2 (en) | 2003-04-25 | 2008-09-23 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| EP1628685B1 (de) | 2003-04-25 | 2010-12-08 | Gilead Sciences, Inc. | Antivirale phosphonate analoge |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| CA2543144A1 (en) | 2003-10-24 | 2005-05-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US20080287471A1 (en) | 2003-12-22 | 2008-11-20 | Maria Fardis | 4'-Substituted Carbovir And Abacavir-Derivatives As Well As Related Compounds With Hiv And Hcv Antiviral Activity |
| PL216369B1 (pl) | 2004-07-27 | 2014-03-31 | Gilead Sciences | Pochodne fosfonianowe, kompozycje farmaceutyczne zawierające te pochodne oraz zastosowanie tych pochodnych do wytwarzania leku do hamowania wirusa HIV |
| US8592336B2 (en) | 2006-04-11 | 2013-11-26 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| US8648003B2 (en) | 2006-04-11 | 2014-02-11 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| PE20110219A1 (es) | 2008-07-08 | 2011-03-31 | Gilead Sciences Inc | Sales del compuesto n-[(s)({[(2r,5r)-5-(6-amino-9h-purin-9-il)-4-fluoro-2,5-dihidrofuran-2-il]oxi}metil)fenoxifosfinoil]-l-alaninato de etilo como inhibidores de vih |
| JP2013023454A (ja) * | 2011-07-19 | 2013-02-04 | Katayama Kagaku Kogyo Kk | ハロゲン化有機リン化合物の製造方法 |
| EP3960740B1 (de) | 2017-08-01 | 2023-11-15 | Gilead Sciences, Inc. | Kristalline formen von ethyl((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluor-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninat (gs-9131) vanillate zur behandlung von virusinfektionen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329687A (en) | 1964-01-16 | 1967-07-04 | Sandoz Ag | Thiadiazepinedioxides and their preparation |
| US5610294A (en) | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5710298A (en) | 1992-04-03 | 1998-01-20 | California Institute Of Technology | Method of preparing ruthenium and osmium carbene complexes |
| US5312940A (en) | 1992-04-03 | 1994-05-17 | California Institute Of Technology | Ruthenium and osmium metal carbene complexes for olefin metathesis polymerization |
| EP1251135A3 (de) | 1992-04-03 | 2004-01-02 | California Institute Of Technology | Hochwirksame Ruthenium- und Osmium- Metall-Carbenkomplexe für die Olefinmetathesereaktionen, und deren Herstellung |
| AU703962B2 (en) * | 1993-02-26 | 1999-04-01 | Du Pont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives |
| US5543517A (en) * | 1994-01-13 | 1996-08-06 | The Dupont Merck Pharmaceutical Company | Substituted bicyclic phosphoramides and derivatives thereof |
| US6083711A (en) | 1996-05-15 | 2000-07-04 | Smithkline Beecham Corporation | Proteases compositions capable of binding to said site, and methods of use thereof |
| US5917071A (en) | 1996-11-15 | 1999-06-29 | California Institute Of Technology | Synthesis of ruthenium or osmium metathesis catalysts |
| WO1999037643A1 (fr) | 1998-01-26 | 1999-07-29 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci |
-
2000
- 2000-08-15 US US09/639,051 patent/US6420586B1/en not_active Expired - Lifetime
-
2001
- 2001-08-06 AT AT07008428T patent/ATE503761T1/de not_active IP Right Cessation
- 2001-08-06 JP JP2002519481A patent/JP5249486B2/ja not_active Expired - Lifetime
- 2001-08-06 EP EP07008428A patent/EP1806351B1/de not_active Expired - Lifetime
- 2001-08-06 DK DK07008428.0T patent/DK1806351T3/da active
- 2001-08-06 EP EP01964579A patent/EP1311515B1/de not_active Expired - Lifetime
- 2001-08-06 CA CA2419775A patent/CA2419775C/en not_active Expired - Fee Related
- 2001-08-06 WO PCT/US2001/041606 patent/WO2002014344A2/en active Application Filing
- 2001-08-06 DE DE60144349T patent/DE60144349D1/de not_active Expired - Lifetime
- 2001-08-06 AT AT01964579T patent/ATE463500T1/de not_active IP Right Cessation
- 2001-08-06 DK DK01964579.5T patent/DK1311515T3/da active
- 2001-08-06 AU AU2001285418A patent/AU2001285418A1/en not_active Abandoned
- 2001-08-06 DE DE60141757T patent/DE60141757D1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1311515B1 (de) | 2010-04-07 |
| WO2002014344A3 (en) | 2002-09-06 |
| JP5249486B2 (ja) | 2013-07-31 |
| CA2419775A1 (en) | 2002-02-21 |
| DE60141757D1 (de) | 2010-05-20 |
| JP2004506646A (ja) | 2004-03-04 |
| DE60144349D1 (de) | 2011-05-12 |
| DK1806351T3 (da) | 2011-07-18 |
| EP1806351A3 (de) | 2007-09-26 |
| ATE463500T1 (de) | 2010-04-15 |
| US6420586B1 (en) | 2002-07-16 |
| EP1806351B1 (de) | 2011-03-30 |
| EP1806351A2 (de) | 2007-07-11 |
| EP1311515A2 (de) | 2003-05-21 |
| EP1311515A4 (de) | 2003-12-03 |
| AU2001285418A1 (en) | 2002-02-25 |
| CA2419775C (en) | 2014-12-02 |
| DK1311515T3 (da) | 2010-07-19 |
| WO2002014344A2 (en) | 2002-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |