DE60141757D1 - Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung - Google Patents
Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellungInfo
- Publication number
- DE60141757D1 DE60141757D1 DE60141757T DE60141757T DE60141757D1 DE 60141757 D1 DE60141757 D1 DE 60141757D1 DE 60141757 T DE60141757 T DE 60141757T DE 60141757 T DE60141757 T DE 60141757T DE 60141757 D1 DE60141757 D1 DE 60141757D1
- Authority
- DE
- Germany
- Prior art keywords
- phosphonamide
- ring
- template
- derived
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 title 1
- 125000005541 phosphonamide group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000011984 grubbs catalyst Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2462—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of unsaturated acyclic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/639,051 US6420586B1 (en) | 2000-08-15 | 2000-08-15 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
| PCT/US2001/041606 WO2002014344A2 (en) | 2000-08-15 | 2001-08-06 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60141757D1 true DE60141757D1 (de) | 2010-05-20 |
Family
ID=24562532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60144349T Expired - Lifetime DE60144349D1 (de) | 2000-08-15 | 2001-08-06 | Von Aminosäuren abgeleitete, zyklische Phosphonamide und Verfahren zu deren Synthese |
| DE60141757T Expired - Lifetime DE60141757D1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60144349T Expired - Lifetime DE60144349D1 (de) | 2000-08-15 | 2001-08-06 | Von Aminosäuren abgeleitete, zyklische Phosphonamide und Verfahren zu deren Synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420586B1 (de) |
| EP (2) | EP1311515B1 (de) |
| JP (1) | JP5249486B2 (de) |
| AT (2) | ATE463500T1 (de) |
| AU (1) | AU2001285418A1 (de) |
| CA (1) | CA2419775C (de) |
| DE (2) | DE60144349D1 (de) |
| DK (2) | DK1311515T3 (de) |
| WO (1) | WO2002014344A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU7047901A (en) * | 2000-07-18 | 2002-01-30 | Leo Pharm Prod Ltd | Matrix metalloproteinase inhibitors |
| CN1714096A (zh) * | 2002-01-18 | 2005-12-28 | 利奥制药有限公司 | Mmp抑制剂 |
| AU2003231766A1 (en) | 2002-04-26 | 2003-11-10 | Gilead Sciences, Inc. | Non nucleoside reverse transcriptase inhibitors |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| CA2522845A1 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Kinase inhibitor phosphonate conjugates |
| EP1628685B1 (de) | 2003-04-25 | 2010-12-08 | Gilead Sciences, Inc. | Antivirale phosphonate analoge |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| WO2004096287A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| US7432273B2 (en) | 2003-10-24 | 2008-10-07 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| AU2004290298A1 (en) | 2003-10-24 | 2005-05-26 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
| WO2005044279A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Purine nucleoside phosphonate conjugates |
| BRPI0417988A (pt) | 2003-12-22 | 2007-04-27 | Gilead Sciences Inc | análogos de fosfonato antivirais |
| ME03423B (de) | 2004-07-27 | 2020-01-20 | Gilead Sciences Inc | Phosphonat Analoga von HIV Inhibitor Verbindungen |
| US8592336B2 (en) | 2006-04-11 | 2013-11-26 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| US8648003B2 (en) | 2006-04-11 | 2014-02-11 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| BRPI0915878A2 (pt) | 2008-07-08 | 2015-11-03 | Gilead Sciences Inc | sais ou hidratos de compostos inibidores de hiv, seu uso e composição farmacêutica que os compreende |
| JP2013023454A (ja) * | 2011-07-19 | 2013-02-04 | Katayama Kagaku Kogyo Kk | ハロゲン化有機リン化合物の製造方法 |
| EP3661937B1 (de) | 2017-08-01 | 2021-07-28 | Gilead Sciences, Inc. | Kristalline formen von ethyl ((s)-((((2r,5r)-5-(6-amino-9h-purin-9-yl)-4-fluoro-2,5-dihydrofuran-2-yl)oxy)methyl)(phenoxy)phosphoryl)-l-alaninat (gs-9131) zur behandlung von viralen infektionen |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329687A (en) | 1964-01-16 | 1967-07-04 | Sandoz Ag | Thiadiazepinedioxides and their preparation |
| US5610294A (en) * | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| US5710298A (en) | 1992-04-03 | 1998-01-20 | California Institute Of Technology | Method of preparing ruthenium and osmium carbene complexes |
| US5312940A (en) | 1992-04-03 | 1994-05-17 | California Institute Of Technology | Ruthenium and osmium metal carbene complexes for olefin metathesis polymerization |
| EP0773948A4 (de) | 1992-04-03 | 1998-09-02 | California Inst Of Techn | Hochaktive ruthenium- oder osmium-metall-carben-komplexe für olefinmetathese-reaktionen und ihre synthese |
| AU703962B2 (en) * | 1993-02-26 | 1999-04-01 | Du Pont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives |
| US5543517A (en) * | 1994-01-13 | 1996-08-06 | The Dupont Merck Pharmaceutical Company | Substituted bicyclic phosphoramides and derivatives thereof |
| US6083711A (en) | 1996-05-15 | 2000-07-04 | Smithkline Beecham Corporation | Proteases compositions capable of binding to said site, and methods of use thereof |
| US5917071A (en) | 1996-11-15 | 1999-06-29 | California Institute Of Technology | Synthesis of ruthenium or osmium metathesis catalysts |
| WO1999037643A1 (fr) | 1998-01-26 | 1999-07-29 | Yamanouchi Pharmaceutical Co., Ltd. | Nouveaux derives heterocycliques a fusion benzenique ou sels de ceux-ci |
-
2000
- 2000-08-15 US US09/639,051 patent/US6420586B1/en not_active Expired - Lifetime
-
2001
- 2001-08-06 AT AT01964579T patent/ATE463500T1/de not_active IP Right Cessation
- 2001-08-06 WO PCT/US2001/041606 patent/WO2002014344A2/en active Application Filing
- 2001-08-06 AT AT07008428T patent/ATE503761T1/de not_active IP Right Cessation
- 2001-08-06 DE DE60144349T patent/DE60144349D1/de not_active Expired - Lifetime
- 2001-08-06 DE DE60141757T patent/DE60141757D1/de not_active Expired - Lifetime
- 2001-08-06 DK DK01964579.5T patent/DK1311515T3/da active
- 2001-08-06 CA CA2419775A patent/CA2419775C/en not_active Expired - Fee Related
- 2001-08-06 JP JP2002519481A patent/JP5249486B2/ja not_active Expired - Lifetime
- 2001-08-06 EP EP01964579A patent/EP1311515B1/de not_active Expired - Lifetime
- 2001-08-06 EP EP07008428A patent/EP1806351B1/de not_active Expired - Lifetime
- 2001-08-06 DK DK07008428.0T patent/DK1806351T3/da active
- 2001-08-06 AU AU2001285418A patent/AU2001285418A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CA2419775C (en) | 2014-12-02 |
| CA2419775A1 (en) | 2002-02-21 |
| ATE503761T1 (de) | 2011-04-15 |
| DK1311515T3 (da) | 2010-07-19 |
| DK1806351T3 (da) | 2011-07-18 |
| US6420586B1 (en) | 2002-07-16 |
| AU2001285418A1 (en) | 2002-02-25 |
| EP1806351B1 (de) | 2011-03-30 |
| EP1311515A4 (de) | 2003-12-03 |
| EP1311515A2 (de) | 2003-05-21 |
| ATE463500T1 (de) | 2010-04-15 |
| DE60144349D1 (de) | 2011-05-12 |
| EP1806351A3 (de) | 2007-09-26 |
| WO2002014344A3 (en) | 2002-09-06 |
| JP2004506646A (ja) | 2004-03-04 |
| EP1806351A2 (de) | 2007-07-11 |
| EP1311515B1 (de) | 2010-04-07 |
| JP5249486B2 (ja) | 2013-07-31 |
| WO2002014344A2 (en) | 2002-02-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |