ATE463500T1 - Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung - Google Patents
Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellungInfo
- Publication number
- ATE463500T1 ATE463500T1 AT01964579T AT01964579T ATE463500T1 AT E463500 T1 ATE463500 T1 AT E463500T1 AT 01964579 T AT01964579 T AT 01964579T AT 01964579 T AT01964579 T AT 01964579T AT E463500 T1 ATE463500 T1 AT E463500T1
- Authority
- AT
- Austria
- Prior art keywords
- phosphonamide
- ring
- template
- derived
- production
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 150000001413 amino acids Chemical class 0.000 title 1
- 125000005541 phosphonamide group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- PNPBGYBHLCEVMK-UHFFFAOYSA-N benzylidene(dichloro)ruthenium;tricyclohexylphosphanium Chemical compound Cl[Ru](Cl)=CC1=CC=CC=C1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1.C1CCCCC1[PH+](C1CCCCC1)C1CCCCC1 PNPBGYBHLCEVMK-UHFFFAOYSA-N 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 239000011984 grubbs catalyst Substances 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 238000006798 ring closing metathesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2454—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2462—Esteramides the amide moiety containing a substituent or a structure which is considered as characteristic of unsaturated acyclic amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/26—Amides of acids of phosphorus containing P-halide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65842—Cyclic amide derivatives of acids of phosphorus, in which one nitrogen atom belongs to the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
- C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
- C07F9/6584—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms having one phosphorus atom as ring hetero atom
- C07F9/65848—Cyclic amide derivatives of acids of phosphorus, in which two nitrogen atoms belong to the ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/639,051 US6420586B1 (en) | 2000-08-15 | 2000-08-15 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
| PCT/US2001/041606 WO2002014344A2 (en) | 2000-08-15 | 2001-08-06 | Amino acid-derived cyclic phosphonamides and methods of synthesizing the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE463500T1 true ATE463500T1 (de) | 2010-04-15 |
Family
ID=24562532
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07008428T ATE503761T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete, zyklische phosphonamide und verfahren zu deren synthese |
| AT01964579T ATE463500T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete zyklische phosphonamide und verfahren zu deren herstellung |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07008428T ATE503761T1 (de) | 2000-08-15 | 2001-08-06 | Von aminosäuren abgeleitete, zyklische phosphonamide und verfahren zu deren synthese |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6420586B1 (de) |
| EP (2) | EP1806351B1 (de) |
| JP (1) | JP5249486B2 (de) |
| AT (2) | ATE503761T1 (de) |
| AU (1) | AU2001285418A1 (de) |
| CA (1) | CA2419775C (de) |
| DE (2) | DE60141757D1 (de) |
| DK (2) | DK1311515T3 (de) |
| WO (1) | WO2002014344A2 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002006293A1 (en) * | 2000-07-18 | 2002-01-24 | Leo Pharma A/S | Matrix metalloproteinase inhibitors |
| CA2470649A1 (en) * | 2002-01-18 | 2003-07-24 | Leo Pharma A/S | Mmp inhibitors |
| MXPA04010527A (es) | 2002-04-26 | 2004-12-13 | Gilead Sciences Inc | Acumulacion celular de analogos de fosfonato de los compuestos inhibidores de la proteasa del virus de inmunodeficiencia humana (vih). |
| US7429565B2 (en) | 2003-04-25 | 2008-09-30 | Gilead Sciences, Inc. | Antiviral phosphonate analogs |
| US7407965B2 (en) | 2003-04-25 | 2008-08-05 | Gilead Sciences, Inc. | Phosphonate analogs for treating metabolic diseases |
| US7452901B2 (en) | 2003-04-25 | 2008-11-18 | Gilead Sciences, Inc. | Anti-cancer phosphonate analogs |
| WO2004096287A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Inosine monophosphate dehydrogenase inhibitory phosphonate compounds |
| WO2005002626A2 (en) | 2003-04-25 | 2005-01-13 | Gilead Sciences, Inc. | Therapeutic phosphonate compounds |
| KR20060022647A (ko) | 2003-04-25 | 2006-03-10 | 길리애드 사이언시즈, 인코포레이티드 | 키나아제 억제 포스포네이트 유사체 |
| US7470724B2 (en) | 2003-04-25 | 2008-12-30 | Gilead Sciences, Inc. | Phosphonate compounds having immuno-modulatory activity |
| WO2004096285A2 (en) | 2003-04-25 | 2004-11-11 | Gilead Sciences, Inc. | Anti-infective phosphonate conjugates |
| US7432261B2 (en) | 2003-04-25 | 2008-10-07 | Gilead Sciences, Inc. | Anti-inflammatory phosphonate compounds |
| WO2005044308A1 (en) | 2003-10-24 | 2005-05-19 | Gilead Sciences, Inc. | Phosphonate analogs of antimetabolites |
| US7427624B2 (en) | 2003-10-24 | 2008-09-23 | Gilead Sciences, Inc. | Purine nucleoside phosphorylase inhibitory phosphonate compounds |
| EP1678322A2 (de) | 2003-10-24 | 2006-07-12 | Gilead Sciences, Inc. | Verfahren und zusammensetzungen zur identifizierung therapeutischer verbindungen |
| NZ547907A (en) | 2003-12-22 | 2010-07-30 | Gilead Sciences Inc | 4'-Substituted carbovir-and abacavir-derivatives as well as related compounds with HIV and HCV antiviral activity |
| ES2720618T3 (es) | 2004-07-27 | 2019-07-23 | Gilead Sciences Inc | Análogos de fosfonato de compuestos de inhibidores de VIH |
| US8592336B2 (en) | 2006-04-11 | 2013-11-26 | Agency For Science, Technology And Research | Catalysts for ring-closing metathesis |
| EP2010318B1 (de) * | 2006-04-11 | 2014-04-02 | Agency for Science, Technology and Research | Katalysatoren für ringschlussmetathese |
| KR101642527B1 (ko) | 2008-07-08 | 2016-07-25 | 길리애드 사이언시즈, 인코포레이티드 | Ｈｉｖ 억제제 화합물의 염 |
| JP2013023454A (ja) * | 2011-07-19 | 2013-02-04 | Katayama Kagaku Kogyo Kk | ハロゲン化有機リン化合物の製造方法 |
| WO2019027920A1 (en) | 2017-08-01 | 2019-02-07 | Gilead Sciences, Inc. | CRYSTALLINE FORMS OF ETHYL ((S) - (((((2R, 5R) -5- (6-AMINO-9H-PURIN-9-YL) -4-FLUORO-2,5-DIHYDROFURAN-2-YL) OXY ) METHYL) (PHENOXY) PHOSPHORYL) -L-ALANINATE (GS-9131) FOR THE TREATMENT OF VIRAL INFECTIONS |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3329687A (en) | 1964-01-16 | 1967-07-04 | Sandoz Ag | Thiadiazepinedioxides and their preparation |
| US5610294A (en) | 1991-10-11 | 1997-03-11 | The Du Pont Merck Pharmaceutical Company | Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors |
| EP1251135A3 (de) | 1992-04-03 | 2004-01-02 | California Institute Of Technology | Hochwirksame Ruthenium- und Osmium- Metall-Carbenkomplexe für die Olefinmetathesereaktionen, und deren Herstellung |
| US5312940A (en) | 1992-04-03 | 1994-05-17 | California Institute Of Technology | Ruthenium and osmium metal carbene complexes for olefin metathesis polymerization |
| US5710298A (en) | 1992-04-03 | 1998-01-20 | California Institute Of Technology | Method of preparing ruthenium and osmium carbene complexes |
| AU703962B2 (en) * | 1993-02-26 | 1999-04-01 | Du Pont Pharmaceuticals Company | Substituted cyclic carbonyls and derivatives |
| US5543517A (en) * | 1994-01-13 | 1996-08-06 | The Dupont Merck Pharmaceutical Company | Substituted bicyclic phosphoramides and derivatives thereof |
| US6083711A (en) | 1996-05-15 | 2000-07-04 | Smithkline Beecham Corporation | Proteases compositions capable of binding to said site, and methods of use thereof |
| US5917071A (en) | 1996-11-15 | 1999-06-29 | California Institute Of Technology | Synthesis of ruthenium or osmium metathesis catalysts |
| AU2074699A (en) | 1998-01-26 | 1999-08-09 | Yamanouchi Pharmaceutical Co., Ltd. | Novel benzene-fused heterocyclic derivatives or salts thereof |
-
2000
- 2000-08-15 US US09/639,051 patent/US6420586B1/en not_active Expired - Lifetime
-
2001
- 2001-08-06 AU AU2001285418A patent/AU2001285418A1/en not_active Abandoned
- 2001-08-06 DK DK01964579.5T patent/DK1311515T3/da active
- 2001-08-06 EP EP07008428A patent/EP1806351B1/de not_active Expired - Lifetime
- 2001-08-06 AT AT07008428T patent/ATE503761T1/de not_active IP Right Cessation
- 2001-08-06 EP EP01964579A patent/EP1311515B1/de not_active Expired - Lifetime
- 2001-08-06 DE DE60141757T patent/DE60141757D1/de not_active Expired - Lifetime
- 2001-08-06 JP JP2002519481A patent/JP5249486B2/ja not_active Expired - Lifetime
- 2001-08-06 DK DK07008428.0T patent/DK1806351T3/da active
- 2001-08-06 WO PCT/US2001/041606 patent/WO2002014344A2/en not_active Ceased
- 2001-08-06 AT AT01964579T patent/ATE463500T1/de not_active IP Right Cessation
- 2001-08-06 DE DE60144349T patent/DE60144349D1/de not_active Expired - Lifetime
- 2001-08-06 CA CA2419775A patent/CA2419775C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DE60144349D1 (de) | 2011-05-12 |
| CA2419775A1 (en) | 2002-02-21 |
| CA2419775C (en) | 2014-12-02 |
| WO2002014344A2 (en) | 2002-02-21 |
| EP1806351B1 (de) | 2011-03-30 |
| EP1806351A2 (de) | 2007-07-11 |
| EP1311515A2 (de) | 2003-05-21 |
| US6420586B1 (en) | 2002-07-16 |
| WO2002014344A3 (en) | 2002-09-06 |
| AU2001285418A1 (en) | 2002-02-25 |
| EP1806351A3 (de) | 2007-09-26 |
| DE60141757D1 (de) | 2010-05-20 |
| JP2004506646A (ja) | 2004-03-04 |
| DK1806351T3 (da) | 2011-07-18 |
| EP1311515A4 (de) | 2003-12-03 |
| ATE503761T1 (de) | 2011-04-15 |
| JP5249486B2 (ja) | 2013-07-31 |
| DK1311515T3 (da) | 2010-07-19 |
| EP1311515B1 (de) | 2010-04-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |