ATE499832T1 - Transgenes tiermodel für neurodegenerative krankheiten - Google Patents

Transgenes tiermodel für neurodegenerative krankheiten

Info

Publication number
ATE499832T1
ATE499832T1 AT06007794T AT06007794T ATE499832T1 AT E499832 T1 ATE499832 T1 AT E499832T1 AT 06007794 T AT06007794 T AT 06007794T AT 06007794 T AT06007794 T AT 06007794T AT E499832 T1 ATE499832 T1 AT E499832T1
Authority
AT
Austria
Prior art keywords
transgenic animal
animal model
neurodegenerative diseases
well
disease
Prior art date
Application number
AT06007794T
Other languages
German (de)
English (en)
Inventor
George-Hyslop Peter H St
Paul E Fraser
David Westaway
Original Assignee
Univ Toronto
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Toronto filed Critical Univ Toronto
Application granted granted Critical
Publication of ATE499832T1 publication Critical patent/ATE499832T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0312—Animal model for Alzheimer's disease
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0306—Animal model for genetic diseases
    • A01K2267/0318—Animal model for neurodegenerative disease, e.g. non- Alzheimer's

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Environmental Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Animal Husbandry (AREA)
  • Psychiatry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Eye Examination Apparatus (AREA)
AT06007794T 2000-06-20 2001-06-19 Transgenes tiermodel für neurodegenerative krankheiten ATE499832T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US21253400P 2000-06-20 2000-06-20

Publications (1)

Publication Number Publication Date
ATE499832T1 true ATE499832T1 (de) 2011-03-15

Family

ID=22791418

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06007794T ATE499832T1 (de) 2000-06-20 2001-06-19 Transgenes tiermodel für neurodegenerative krankheiten
AT01949132T ATE323408T1 (de) 2000-06-20 2001-06-19 Transgenes tiermodell für neurodegenerative erkrankungen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT01949132T ATE323408T1 (de) 2000-06-20 2001-06-19 Transgenes tiermodell für neurodegenerative erkrankungen

Country Status (13)

Country Link
EP (3) EP1292187B1 (OSRAM)
JP (3) JP4938956B2 (OSRAM)
AT (2) ATE499832T1 (OSRAM)
AU (1) AU2001270377A1 (OSRAM)
CA (1) CA2407847C (OSRAM)
CY (1) CY1105122T1 (OSRAM)
DE (2) DE60144164D1 (OSRAM)
DK (1) DK1292187T3 (OSRAM)
ES (1) ES2262662T3 (OSRAM)
MX (1) MXPA02011516A (OSRAM)
PT (1) PT1292187E (OSRAM)
SI (1) SI1292187T1 (OSRAM)
WO (1) WO2001097607A2 (OSRAM)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4662719B2 (ja) 2002-04-19 2011-03-30 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント アルツハイマー病の処置のための免疫学的方法および組成物
US7544855B2 (en) * 2004-04-23 2009-06-09 Buck Institute Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664
JP4590638B2 (ja) * 2006-03-20 2010-12-01 国立大学法人鳥取大学 家族性筋萎縮性側索硬化症（ｆａｌｓ）発症するトランスジェニックマウス
CL2007002908A1 (es) 2007-10-09 2008-05-30 Univ Concepcion Procedimiento electroquimico in vitro para evaluar capacidad neurotoxica de estructuras, principios activos y/o compuestos de interes en celulas vivas y que comprende medir y cuantificar los parametros electricos en membranas expuestas a dichos agreg
US20100306868A1 (en) * 2007-11-01 2010-12-02 Bernd Bohrmann Quadruple transgenic non-human animal
US20110214195A1 (en) * 2008-11-10 2011-09-01 The Regents Of The University Of Colorado, A Body Corporate Methods For Treating Clinical Conditions Associated With Lipoprotein Lipase Activity

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2155099T3 (es) 1993-10-27 2001-05-01 Elan Pharm Inc Animales transgenicos que albergan alelos app que presentan una mutacion sueca.
JPH07132033A (ja) 1993-11-12 1995-05-23 Hoechst Japan Ltd アルツハイマー病モデルトランスジェニック動物
WO1995020666A2 (en) * 1994-01-27 1995-08-03 Regents Of The University Of Minnesota Transgenic non-human mammals with progressive neurologic disease
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
EP0832205A1 (en) * 1995-06-07 1998-04-01 Athena Neurosciences, Inc. Method for identifying alzheimer's disease therapeutics using transgenic animal models
US5894078A (en) 1996-02-26 1999-04-13 Advanced Bioconcept, Inc. Transgenic mouse expressing C-100 app
WO1999009150A1 (en) * 1996-08-15 1999-02-25 Bayer Corporation Method of introducing modifications into a gene
US5898094A (en) * 1996-10-21 1999-04-27 University Of South Florida Transgenic mice expressing APPK670N,M671L and a mutant presenilin transgenes
TWI239847B (en) 1997-12-02 2005-09-21 Elan Pharm Inc N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease

Also Published As

Publication number Publication date
CA2407847A1 (en) 2001-12-27
JP4938956B2 (ja) 2012-05-23
DE60118913D1 (de) 2006-05-24
EP1728423A2 (en) 2006-12-06
JP2009178162A (ja) 2009-08-13
JP5070236B2 (ja) 2012-11-07
CY1105122T1 (el) 2010-03-03
DE60144164D1 (de) 2011-04-14
AU2001270377A1 (en) 2002-01-02
EP1292187A2 (en) 2003-03-19
EP2263453A1 (en) 2010-12-22
EP1728423B1 (en) 2011-03-02
EP1292187B1 (en) 2006-04-19
EP2263453B1 (en) 2018-06-13
EP1728423A3 (en) 2007-02-28
WO2001097607A2 (en) 2001-12-27
SI1292187T1 (sl) 2006-10-31
MXPA02011516A (es) 2005-07-01
DK1292187T3 (da) 2006-08-21
WO2001097607A3 (en) 2002-12-12
PT1292187E (pt) 2006-07-31
JP2003535605A (ja) 2003-12-02
DE60118913T2 (de) 2007-01-25
ATE323408T1 (de) 2006-05-15
ES2262662T3 (es) 2006-12-01
CA2407847C (en) 2013-08-27
JP2011172600A (ja) 2011-09-08

Similar Documents

Publication Publication Date Title
MX9708270A (es) Secuencias geneticas y proteinas relacionadas con la enfermedad de alzheimer, y uso de las mismas.
EP1319408A4 (en) MEDICINAL PRODUCTS FOR HEART FAILURE
DK0845939T3 (da) Lysosomale proteiner produceret i mælk fra ikke-humane transgene dyr
ATE343792T1 (de) Diagnostika und therapeutika für maculare degeneration
PL362437A1 (en) Diagnostics and therapeutics for glaucoma
ATE541923T1 (de) Transgener c. elegans als modellorganismus für untersuchungen zur alzheimer'schen krankheit
AU6264996A (en) Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
DE60118913D1 (de) Transgenes tiermodell für neurodegenerative erkrankungen
WO2001087055A3 (en) New screening tool for analyzing the behavior of laboratory animals
AU6168396A (en) Method for identifying alzheimer's disease therapeutics usin g transgenic animal models
WO2003026395A3 (en) Mo54 gene disruptions, compositions and methods related thereto
ATE511348T1 (de) Transgenes modell für morbus alzheimer
CY1110788T1 (el) Διαγονιδιακα ζωα τα οποια παρουσιαζουν σημαντικες διαταραχες σχετικες με την νοσο alzheimer
NO20020010L (no) Transgene dyr som modeller for neurodegenerativ sykdom
DE60325519D1 (de) Doppel-transgenisches, nicht-humanes Säugertiermodell für die Alzheimer Krankheit
ATE473009T1 (de) Hemmung der neurodegeneration
DE60121324D1 (de) Tiermodel für neurodegenerative erkrankungen
WO2002048342A3 (en) Knockout mice for trp6 gene
WO2002101232A3 (en) Bace interacting proteins
WO2002003788A3 (en) Transgenic mice containing targeted phosphatase gene disruptions
EP1391506A4 (en) ANIMAL WITH GENE HYPOEXPRESSION
BR0107845A (pt) Diagnóstico do risco de uma pessoa desenvolver alcoolismo
WO2004062627A3 (en) In vivo screening models for treatment of alzheimer's disease and other neurodegenerative disorders
WO2002045493A3 (en) Transgenic mice containing phosphatase target gene disruptions

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties