ATE477486T1 - Antikörperabhängiger zellulärer zytotoxizitätstest - Google Patents

Antikörperabhängiger zellulärer zytotoxizitätstest

Info

Publication number
ATE477486T1
ATE477486T1 AT07717805T AT07717805T ATE477486T1 AT E477486 T1 ATE477486 T1 AT E477486T1 AT 07717805 T AT07717805 T AT 07717805T AT 07717805 T AT07717805 T AT 07717805T AT E477486 T1 ATE477486 T1 AT E477486T1
Authority
AT
Austria
Prior art keywords
dependent cellular
cellular cytotoxicity
methods
assay medium
cytotoxicity test
Prior art date
Application number
AT07717805T
Other languages
English (en)
Inventor
John Kunich
Cheng Liu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE477486T1 publication Critical patent/ATE477486T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07717805T 2006-01-04 2007-01-04 Antikörperabhängiger zellulärer zytotoxizitätstest ATE477486T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75630106P 2006-01-04 2006-01-04
PCT/US2007/060108 WO2007082138A2 (en) 2006-01-04 2007-01-04 Antibody-dependent cellular cytotoxicity assay

Publications (1)

Publication Number Publication Date
ATE477486T1 true ATE477486T1 (de) 2010-08-15

Family

ID=38222750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07717805T ATE477486T1 (de) 2006-01-04 2007-01-04 Antikörperabhängiger zellulärer zytotoxizitätstest

Country Status (17)

Country Link
US (1) US20090155821A1 (de)
EP (2) EP2246700A1 (de)
JP (1) JP2009522583A (de)
KR (1) KR20080085080A (de)
CN (1) CN101395471A (de)
AT (1) ATE477486T1 (de)
AU (1) AU2007204777B2 (de)
BR (1) BRPI0706420A2 (de)
CA (1) CA2636183A1 (de)
DE (1) DE602007008357D1 (de)
ES (1) ES2349885T3 (de)
IL (1) IL192546A (de)
MX (1) MX2008008700A (de)
PL (1) PL1977241T3 (de)
PT (1) PT1977241E (de)
RU (1) RU2409816C2 (de)
WO (1) WO2007082138A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US7192752B2 (en) 2002-12-20 2007-03-20 Acea Biosciences Real time electronic cell sensing systems and applications for cell-based assays
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
JP2009244197A (ja) * 2008-03-31 2009-10-22 Hioki Ee Corp 薬剤感受性試験方法及び装置
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
ES2459122T3 (es) 2010-02-11 2014-05-08 F. Hoffmann-La Roche Ag Ensayo FACS de ADCC de NK en 3D
EA024436B1 (ru) * 2012-10-29 2016-09-30 Общество С Ограниченной Ответственностью "Диатек" Способ ранней диагностики онкологических заболеваний
EP2961826A4 (de) * 2013-02-28 2017-01-11 Telemedicine Up Close, Inc. Diagnostische vorrichtung zur bestimmung des mikrobengehalts einer probe
CN103278539B (zh) * 2013-06-07 2015-06-17 浙江大学 检测海洋水产品腹泻性毒素的细胞阻抗传感器装置及方法
CN103675031B (zh) * 2013-12-18 2015-09-02 江苏大学 一种高通量细胞毒性检测方法
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
WO2017087945A1 (en) * 2015-11-20 2017-05-26 Acea Biosciences, Inc. Cell-substrate impedance monitoring of cancer cells
GB201619909D0 (en) * 2016-11-24 2017-01-11 Cell Therapy Catapult Ltd Impedance assay
EP4549553A3 (de) 2017-03-03 2025-07-16 Agilent Technologies, Inc. Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc
CN111492239A (zh) * 2017-08-01 2020-08-04 安捷伦科技有限公司 不同谱系、起源或分期的癌细胞的细胞-基质阻抗监测
CN110320352A (zh) * 2019-07-25 2019-10-11 上海轩锋生物科技有限公司 基于抗体依赖的细胞介导细胞毒性的抗体效价检测方法
US20210040175A1 (en) 2019-08-05 2021-02-11 Nantkwest, Inc. Artificial Target Cells for in-vitro CAR Cytotoxicity and ADCC validation
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
US20250035613A1 (en) * 2021-12-06 2025-01-30 WuXi Biologics Ireland Limited 3d bioassays to measure antibody-dependent cell-mediated cytotoxicity

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302435A1 (de) * 1987-07-31 1989-02-08 Neorx Corporation Verfahren zur Augmentierung von antikörperabhängiger zellularer Zytotoxizität
US5840313A (en) * 1990-09-27 1998-11-24 Syntello Vaccine Development Kb Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
DE69632921T2 (de) * 1995-12-01 2005-07-14 Innogenetics N.V. System und verfahren zur bestimmung der impedanz und herstellungsverfahren
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
EP1176195B1 (de) * 1999-04-09 2013-05-22 Kyowa Hakko Kirin Co., Ltd. Verfahren zur kontrolle der aktivität von immunologisch funktionellem molekül
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
CA2493101C (en) * 2002-07-20 2012-05-08 Acea Biosciences, Inc. Impedance based apparatuses and methods for analyzing cells and particles
US7192752B2 (en) * 2002-12-20 2007-03-20 Acea Biosciences Real time electronic cell sensing systems and applications for cell-based assays
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
WO2005077104A2 (en) 2004-02-09 2005-08-25 Xiao Xu Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays
US20050100543A1 (en) * 2003-07-01 2005-05-12 Immunomedics, Inc. Multivalent carriers of bi-specific antibodies
CA2575573A1 (en) * 2004-08-04 2006-02-16 Acea Biosciences, Inc. Dynamic monitoring of activation of g-protein (gpcr) and receptor tyrosine kinase (rtk) in living cells using real-time microelectronic cell sensing technology
US20090317391A1 (en) * 2005-04-07 2009-12-24 Novartis Vaccines And Diagnostics Inc. Cancer Related Genes (PTPE)

Also Published As

Publication number Publication date
PT1977241E (pt) 2010-09-16
EP1977241B1 (de) 2010-08-11
DE602007008357D1 (de) 2010-09-23
AU2007204777A1 (en) 2007-07-19
RU2008131931A (ru) 2010-02-10
HK1116253A1 (en) 2008-12-19
KR20080085080A (ko) 2008-09-22
BRPI0706420A2 (pt) 2011-03-29
JP2009522583A (ja) 2009-06-11
IL192546A (en) 2012-02-29
CA2636183A1 (en) 2007-07-19
WO2007082138A2 (en) 2007-07-19
CN101395471A (zh) 2009-03-25
EP1977241A2 (de) 2008-10-08
WO2007082138A3 (en) 2007-09-13
US20090155821A1 (en) 2009-06-18
ES2349885T3 (es) 2011-01-12
IL192546A0 (en) 2009-08-03
AU2007204777B2 (en) 2011-12-01
EP2246700A1 (de) 2010-11-03
PL1977241T3 (pl) 2011-02-28
RU2409816C2 (ru) 2011-01-20
MX2008008700A (es) 2009-05-21

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