ATE477486T1 - Antikörperabhängiger zellulärer zytotoxizitätstest - Google Patents

Antikörperabhängiger zellulärer zytotoxizitätstest

Info

Publication number
ATE477486T1
ATE477486T1 AT07717805T AT07717805T ATE477486T1 AT E477486 T1 ATE477486 T1 AT E477486T1 AT 07717805 T AT07717805 T AT 07717805T AT 07717805 T AT07717805 T AT 07717805T AT E477486 T1 ATE477486 T1 AT E477486T1
Authority
AT
Austria
Prior art keywords
dependent cellular
cellular cytotoxicity
methods
assay medium
cytotoxicity test
Prior art date
Application number
AT07717805T
Other languages
English (en)
Inventor
John Kunich
Cheng Liu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Application granted granted Critical
Publication of ATE477486T1 publication Critical patent/ATE477486T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT07717805T 2006-01-04 2007-01-04 Antikörperabhängiger zellulärer zytotoxizitätstest ATE477486T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75630106P 2006-01-04 2006-01-04
PCT/US2007/060108 WO2007082138A2 (en) 2006-01-04 2007-01-04 Antibody-dependent cellular cytotoxicity assay

Publications (1)

Publication Number Publication Date
ATE477486T1 true ATE477486T1 (de) 2010-08-15

Family

ID=38222750

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07717805T ATE477486T1 (de) 2006-01-04 2007-01-04 Antikörperabhängiger zellulärer zytotoxizitätstest

Country Status (17)

Country Link
US (1) US20090155821A1 (de)
EP (2) EP1977241B1 (de)
JP (1) JP2009522583A (de)
KR (1) KR20080085080A (de)
CN (1) CN101395471A (de)
AT (1) ATE477486T1 (de)
AU (1) AU2007204777B2 (de)
BR (1) BRPI0706420A2 (de)
CA (1) CA2636183A1 (de)
DE (1) DE602007008357D1 (de)
ES (1) ES2349885T3 (de)
IL (1) IL192546A (de)
MX (1) MX2008008700A (de)
PL (1) PL1977241T3 (de)
PT (1) PT1977241E (de)
RU (1) RU2409816C2 (de)
WO (1) WO2007082138A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8263375B2 (en) 2002-12-20 2012-09-11 Acea Biosciences Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology
US11346797B2 (en) 2002-12-20 2022-05-31 Agilent Technologies, Inc. System and method for monitoring cardiomyocyte beating, viability, morphology and electrophysiological properties
EP1692258A4 (de) 2003-11-12 2007-03-21 Xiao Xu Elektronische echtzeit-zellwahrnehmungssysteme und anwendungen für tests auf zellbasis
JP2009244197A (ja) * 2008-03-31 2009-10-22 Hioki Ee Corp 薬剤感受性試験方法及び装置
WO2009137440A1 (en) 2008-05-05 2009-11-12 Acea Biosciences, Inc. Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution
US20120309016A1 (en) * 2010-02-11 2012-12-06 Hoffmann-La Roche Inc. 3d adcc nk facs assay
EA024436B1 (ru) * 2012-10-29 2016-09-30 Общество С Ограниченной Ответственностью "Диатек" Способ ранней диагностики онкологических заболеваний
CN105143435A (zh) * 2013-02-28 2015-12-09 远程医疗零距离公司 用于评估样品的微生物含量的诊断装置
CN103278539B (zh) * 2013-06-07 2015-06-17 浙江大学 检测海洋水产品腹泻性毒素的细胞阻抗传感器装置及方法
CN103675031B (zh) * 2013-12-18 2015-09-02 江苏大学 一种高通量细胞毒性检测方法
US12066428B2 (en) 2015-11-20 2024-08-20 Agilent Technologies, Inc. Cell-substrate impedance monitoring of cancer cells
HK1258798A1 (zh) * 2015-11-20 2019-11-22 安捷伦科技有限公司 癌细胞的细胞基质阻抗监测
GB201619909D0 (en) * 2016-11-24 2017-01-11 Cell Therapy Catapult Ltd Impedance assay
EP3589299B1 (de) 2017-03-03 2025-04-09 Agilent Technologies, Inc. Verfahren und systeme zur funktionellen reifung von kardiomyozyten aus ipsc und esc
EP3662281B1 (de) * 2017-08-01 2026-04-08 Agilent Technologies, Inc. Überwachung der zellsubstratimpedanz von krebszellen verschiedener abstammung, herkunft oder phase
CN110320352A (zh) * 2019-07-25 2019-10-11 上海轩锋生物科技有限公司 基于抗体依赖的细胞介导细胞毒性的抗体效价检测方法
EP4010461B1 (de) 2019-08-05 2026-04-01 ImmunityBio, Inc. Künstliche zielzellen für in-vitro-car-zytotoxizität und adcc-validierung
USD941488S1 (en) 2020-02-07 2022-01-18 Agilent Technologies, Inc. Instrument for analyzing biological cells
US20210301245A1 (en) 2020-03-29 2021-09-30 Agilent Technologies, Inc. Systems and methods for electronically and optically monitoring biological samples
EP4445136A4 (de) * 2021-12-06 2025-12-31 Wuxi Biologics Ireland Ltd 3d-bioassays zur messung der antikörperabhängigen zellvermittelten zytotoxizität

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0302435A1 (de) * 1987-07-31 1989-02-08 Neorx Corporation Verfahren zur Augmentierung von antikörperabhängiger zellularer Zytotoxizität
US5840313A (en) * 1990-09-27 1998-11-24 Syntello Vaccine Development Kb Peptides for use in vaccination and induction of neutralizing antibodies against human immunodeficiency virus
WO1997021094A1 (en) * 1995-12-01 1997-06-12 Innogenetics N.V. Impedimetric detection system and method of production thereof
GB9812783D0 (en) * 1998-06-12 1998-08-12 Cenes Ltd High throuoghput screen
CA2704600C (en) * 1999-04-09 2016-10-25 Kyowa Kirin Co., Ltd. A method for producing antibodies with increased adcc activity
US7468255B2 (en) * 2002-12-20 2008-12-23 Acea Biosciences Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology
US7470533B2 (en) 2002-12-20 2008-12-30 Acea Biosciences Impedance based devices and methods for use in assays
CA2493101C (en) * 2002-07-20 2012-05-08 Acea Biosciences, Inc. Impedance based apparatuses and methods for analyzing cells and particles
KR20060041205A (ko) * 2003-07-01 2006-05-11 이뮤노메딕스, 인코오포레이티드 양특이성 항체들의 다가 담체들
EP1692258A4 (de) * 2003-11-12 2007-03-21 Xiao Xu Elektronische echtzeit-zellwahrnehmungssysteme und anwendungen für tests auf zellbasis
CN101400780B (zh) 2004-02-09 2012-06-20 美国艾森生物科学公司 实时细胞电子分析系统及其在细胞毒性检测和化合物分析上的应用
EP1773980B1 (de) * 2004-08-04 2015-07-01 Acea Biosciences, Inc. Verfahren zur untersuchung auf natürliche killerzellen, cytotoxisches t-lymphozyt- und neutrophilvermitteltes töten von targetzellen unter verwendung von mikroelektronischer zellenabtasttechnologie in echtzeit
JP2008535491A (ja) * 2005-04-07 2008-09-04 ノバルティス ヴァクシンズ アンド ダイアグノスティクス， インコーポレイテッド 癌に関連した遺伝子（ＰＴＰε）

Also Published As

Publication number Publication date
CA2636183A1 (en) 2007-07-19
IL192546A0 (en) 2009-08-03
EP2246700A1 (de) 2010-11-03
KR20080085080A (ko) 2008-09-22
PL1977241T3 (pl) 2011-02-28
BRPI0706420A2 (pt) 2011-03-29
ES2349885T3 (es) 2011-01-12
MX2008008700A (es) 2009-05-21
AU2007204777A1 (en) 2007-07-19
PT1977241E (pt) 2010-09-16
DE602007008357D1 (de) 2010-09-23
CN101395471A (zh) 2009-03-25
EP1977241A2 (de) 2008-10-08
HK1116253A1 (en) 2008-12-19
EP1977241B1 (de) 2010-08-11
IL192546A (en) 2012-02-29
RU2409816C2 (ru) 2011-01-20
US20090155821A1 (en) 2009-06-18
RU2008131931A (ru) 2010-02-10
AU2007204777B2 (en) 2011-12-01
WO2007082138A2 (en) 2007-07-19
WO2007082138A3 (en) 2007-09-13
JP2009522583A (ja) 2009-06-11

Similar Documents

Publication Publication Date Title
IL192546A0 (en) Antibody-dependent cellular cytotoxicity assay
Li et al. Group III nitride nanomaterials for biosensing
EP2663857A2 (de) Proteinnachweisverfahren
CY1117023T1 (el) Διεργασια για την παρασκευη τροποποιημενων ηλεκτροδιων, ηλεκτροδια παρασκευασμενα με την εν λογω διεργασια και ενζυμικοι βιοαισθητηρες που περιλαμβανουν τα εν λογω ηλεκτροδιa
WO2008066584A3 (en) Rapid analyte measurement assay
NO20076662L (no) Deteksjon av et malantigen uavhengig av tilstedevaerelse eller fravaer av et korresponderende terapeutisk antistoff
ATE514787T1 (de) Nachweis von proteasen
WO2012075506A3 (en) Methods for predicting and treating infection-induced illnesses and predicting the severity of infection-induced illnesses
EP2064488A4 (de) Substrate, systeme und verfahren zum analysieren von materialien
NZ609824A (en) Immunochromatography devices, methods and kits
JP2007518074A5 (de)
WO2008150010A1 (ja) γ-セクレターゼの新規基質EphA4を利用したスクリーニング方法
RU2017107871A (ru) Способ детектирования молекулы-мишени и набор для использования в этом способе
NO20083293L (no) Elektrokjemisk sensorsystem som anvender et substrat med en apning samt en fremgangsmate for fremstilling av samme
SG159463A1 (en) Method for detecting biomolecules and use thereof
WO2008034622A3 (en) A method of detecting and/or quantifying expression of a target protein candidate in a cell, and a method of identifying a target protein of a small molecule modulator
ATE553386T1 (de) Bluttypisierung
WO2009064006A1 (ja) γ-セクレターゼの新規基質EphA7を利用したスクリーニング方法
WO2009017234A1 (ja) γ-セクレターゼの新規基質c-Retを利用したスクリーニング方法
AR054146A1 (es) Anticuerpos monoclonales, lineas de celulas de hibridomas metodos y conjuntos de elementos para detectar fitasa
WO2014004587A3 (en) Protein detection using fet
ATE460487T1 (de) Screening-test für ribosomale antibiotika
ATE466884T1 (de) Holo-transcobalamin bindungspartner und ihre verwendung in cobalamintest
ATE533053T1 (de) Nicht-elispot-test
WO2006099537A3 (en) The use of antibody-surrogate antigen systems for detection of analytes

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1977241

Country of ref document: EP