ATE477336T1 - Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistung - Google Patents
Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistungInfo
- Publication number
- ATE477336T1 ATE477336T1 AT03796622T AT03796622T ATE477336T1 AT E477336 T1 ATE477336 T1 AT E477336T1 AT 03796622 T AT03796622 T AT 03796622T AT 03796622 T AT03796622 T AT 03796622T AT E477336 T1 ATE477336 T1 AT E477336T1
- Authority
- AT
- Austria
- Prior art keywords
- solid surface
- assay
- performance
- biomolecule delivery
- biomolecule
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/644—Transferrin, e.g. a lactoferrin or ovotransferrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/341,059 US20040138154A1 (en) | 2003-01-13 | 2003-01-13 | Solid surface for biomolecule delivery and high-throughput assay |
PCT/US2003/038498 WO2004065636A1 (en) | 2003-01-13 | 2003-12-04 | Solid surface for biomolecule delivery and high-throughput assay |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE477336T1 true ATE477336T1 (de) | 2010-08-15 |
Family
ID=32711435
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03796622T ATE477336T1 (de) | 2003-01-13 | 2003-12-04 | Feste oberfläche für biomolekülabgabe und assay mit hoher durchlaufleistung |
Country Status (12)
Country | Link |
---|---|
US (3) | US20040138154A1 (de) |
EP (2) | EP2253718B1 (de) |
JP (1) | JP4580764B2 (de) |
KR (1) | KR100863774B1 (de) |
CN (1) | CN1738911B (de) |
AT (1) | ATE477336T1 (de) |
AU (1) | AU2003298863B2 (de) |
CA (1) | CA2512144C (de) |
DE (1) | DE60333793D1 (de) |
DK (1) | DK2253718T3 (de) |
HK (1) | HK1088637A1 (de) |
WO (1) | WO2004065636A1 (de) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
US20070269891A9 (en) * | 2003-01-13 | 2007-11-22 | Yasunobu Tanaka | Solid surface with immobilized degradable cationic polymer for transfecting eukaryotic cells |
US7358223B2 (en) * | 2004-10-04 | 2008-04-15 | Nitto Denko Corporation | Biodegradable cationic polymers |
JP4739352B2 (ja) * | 2004-12-17 | 2011-08-03 | 日東電工株式会社 | 真核細胞をトランスフェクトするための固定化分解性カチオンポリマーを持つ固体表面 |
US20120269886A1 (en) | 2004-12-22 | 2012-10-25 | Nitto Denko Corporation | Therapeutic agent for pulmonary fibrosis |
CN101102795B (zh) | 2004-12-22 | 2011-12-07 | 日东电工株式会社 | 用于抑制纤维化的药物载体和药物载体试剂盒 |
US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
US7700541B2 (en) * | 2006-04-06 | 2010-04-20 | Nitto Denko Corporation | Biodegradable cationic polymers |
DE602007013559D1 (de) * | 2006-07-07 | 2011-05-12 | Univ Aarhus | Nanoteilchen zur abgabe von nukleinsäure |
TWI407971B (zh) | 2007-03-30 | 2013-09-11 | Nitto Denko Corp | Cancer cells and tumor-related fibroblasts |
US20080312174A1 (en) * | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
JP2010539245A (ja) * | 2007-09-14 | 2010-12-16 | 日東電工株式会社 | 薬物担体 |
EP2323693B1 (de) * | 2008-07-30 | 2017-11-08 | Nitto Denko Corporation | Arzneimittelträger |
CN102010508B (zh) * | 2010-10-19 | 2012-10-03 | 北京大学 | 一种阳离子聚合物及其制备方法和应用 |
US9637775B2 (en) | 2012-02-13 | 2017-05-02 | Neumodx Molecular, Inc. | System and method for processing biological samples |
US9604213B2 (en) | 2012-02-13 | 2017-03-28 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
US9101930B2 (en) * | 2012-02-13 | 2015-08-11 | Neumodx Molecular, Inc. | Microfluidic cartridge for processing and detecting nucleic acids |
US11485968B2 (en) | 2012-02-13 | 2022-11-01 | Neumodx Molecular, Inc. | Microfluidic cartridge for processing and detecting nucleic acids |
US11931740B2 (en) | 2012-02-13 | 2024-03-19 | Neumodx Molecular, Inc. | System and method for processing and detecting nucleic acids |
DK2912174T3 (da) | 2012-10-25 | 2019-08-26 | Neumodx Molecular Inc | Fremgangsmåde og materialer til isolering af nukleinsyrematerialer |
US11293021B1 (en) | 2016-06-23 | 2022-04-05 | Inscripta, Inc. | Automated cell processing methods, modules, instruments, and systems |
US9982279B1 (en) | 2017-06-23 | 2018-05-29 | Inscripta, Inc. | Nucleic acid-guided nucleases |
US10011849B1 (en) | 2017-06-23 | 2018-07-03 | Inscripta, Inc. | Nucleic acid-guided nucleases |
PT3645719T (pt) | 2017-06-30 | 2022-05-18 | Inscripta Inc | Métodos, módulos, instrumentos e sistemas automatizados de processamento de células |
US10858761B2 (en) | 2018-04-24 | 2020-12-08 | Inscripta, Inc. | Nucleic acid-guided editing of exogenous polynucleotides in heterologous cells |
US10526598B2 (en) | 2018-04-24 | 2020-01-07 | Inscripta, Inc. | Methods for identifying T-cell receptor antigens |
CA3108767A1 (en) | 2018-06-30 | 2020-01-02 | Inscripta, Inc. | Instruments, modules, and methods for improved detection of edited sequences in live cells |
US11142740B2 (en) | 2018-08-14 | 2021-10-12 | Inscripta, Inc. | Detection of nuclease edited sequences in automated modules and instruments |
US11214781B2 (en) | 2018-10-22 | 2022-01-04 | Inscripta, Inc. | Engineered enzyme |
US10815467B2 (en) | 2019-03-25 | 2020-10-27 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
US11001831B2 (en) | 2019-03-25 | 2021-05-11 | Inscripta, Inc. | Simultaneous multiplex genome editing in yeast |
CA3139122C (en) | 2019-06-06 | 2023-04-25 | Inscripta, Inc. | Curing for recursive nucleic acid-guided cell editing |
US11203762B2 (en) | 2019-11-19 | 2021-12-21 | Inscripta, Inc. | Methods for increasing observed editing in bacteria |
CA3157127A1 (en) | 2019-12-18 | 2021-06-24 | Aamir MIR | Cascade/dcas3 complementation assays for in vivo detection of nucleic acid-guided nuclease edited cells |
WO2021130215A1 (en) * | 2019-12-23 | 2021-07-01 | Universidad Del País Vasco/Euskal Herriko Unibertsitatea | Golden lipid nanoparticles for gene therapy |
AU2021213705A1 (en) | 2020-01-27 | 2022-06-16 | Inscripta, Inc. | Electroporation modules and instrumentation |
US20210332388A1 (en) | 2020-04-24 | 2021-10-28 | Inscripta, Inc. | Compositions, methods, modules and instruments for automated nucleic acid-guided nuclease editing in mammalian cells |
WO2022060749A1 (en) | 2020-09-15 | 2022-03-24 | Inscripta, Inc. | Crispr editing to embed nucleic acid landing pads into genomes of live cells |
US11512297B2 (en) | 2020-11-09 | 2022-11-29 | Inscripta, Inc. | Affinity tag for recombination protein recruitment |
EP4271802A1 (de) | 2021-01-04 | 2023-11-08 | Inscripta, Inc. | Mad-nukleasen |
WO2022150269A1 (en) | 2021-01-07 | 2022-07-14 | Inscripta, Inc. | Mad nucleases |
US11884924B2 (en) | 2021-02-16 | 2024-01-30 | Inscripta, Inc. | Dual strand nucleic acid-guided nickase editing |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5264618A (en) * | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
US6509032B1 (en) * | 1991-08-28 | 2003-01-21 | Mcmaster University | Cationic amphiphiles |
US5283185A (en) * | 1991-08-28 | 1994-02-01 | University Of Tennessee Research Corporation | Method for delivering nucleic acids into cells |
US5919455A (en) * | 1993-10-27 | 1999-07-06 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
JPH11505505A (ja) * | 1994-06-27 | 1999-05-21 | ザ・ジョンズ・ホプキンス・ユニバーシティー | ターゲッティングされた遺伝子輸送システム |
US5767168A (en) * | 1995-03-30 | 1998-06-16 | The Proctor & Gamble Company | Biodegradable and/or compostable polymers made from conjugated dienes such as isoprene and 2,3-dimethyl-1, 3-butadiene |
US6051429A (en) | 1995-06-07 | 2000-04-18 | Life Technologies, Inc. | Peptide-enhanced cationic lipid transfections |
JP3851369B2 (ja) * | 1995-08-24 | 2006-11-29 | ミレニウム・バイオロジクス・インコーポレイテッド | マルチウェル骨細胞培養装置 |
JP2001508815A (ja) | 1996-05-29 | 2001-07-03 | セル ジェネシス,インコーポレイテッド | カチオン性ポリマー/脂質核酸送達ビヒクル |
EP0920339A2 (de) * | 1996-07-09 | 1999-06-09 | The Johns Hopkins University | System zur freigabe genetischen materials |
DE19743135A1 (de) | 1997-09-30 | 1999-04-01 | Hoechst Marion Roussel De Gmbh | Biologisch verträgliche niedermolekular Polyethylenimine |
US6072101A (en) * | 1997-11-19 | 2000-06-06 | Amcol International Corporation | Multicomponent superabsorbent gel particles |
US6475994B2 (en) * | 1998-01-07 | 2002-11-05 | Donald A. Tomalia | Method and articles for transfection of genetic material |
WO2001020015A1 (en) * | 1999-09-17 | 2001-03-22 | Whitehead Institute For Biomedical Research | Reverse transfection method |
US20020006664A1 (en) * | 1999-09-17 | 2002-01-17 | Sabatini David M. | Arrayed transfection method and uses related thereto |
US8143195B2 (en) * | 2000-01-24 | 2012-03-27 | Yingjian Wang | Arrays for bringing two or more reagents in contact with one or more biological targets and methods for making and using the arrays |
US6319715B1 (en) | 2000-04-21 | 2001-11-20 | Cornell Research Foundation, Inc. | Method of enhancing the delivery of nucleic acids using silica nanoparticles |
US20020009807A1 (en) | 2000-05-18 | 2002-01-24 | Lance Kam | Lipid bilayer array method and devices |
US20040120979A1 (en) * | 2000-06-02 | 2004-06-24 | Roessler Blake J. | Delivery systems comprising biocompatible and bioerodable membranes |
US6696038B1 (en) | 2000-09-14 | 2004-02-24 | Expression Genetics, Inc. | Cationic lipopolymer as biocompatible gene delivery agent |
CA2427916C (en) * | 2000-11-03 | 2012-01-17 | The Regents Of The University Of Michigan | Surface transfection and expression procedure |
US6897067B2 (en) * | 2000-11-03 | 2005-05-24 | Regents Of The University Of Michigan | Surface transfection and expression procedure |
US20040234586A1 (en) * | 2001-06-11 | 2004-11-25 | Sylvain Meloche | Compositions and methods for enhancing nucleic acid transfer into cells |
US6586524B2 (en) * | 2001-07-19 | 2003-07-01 | Expression Genetics, Inc. | Cellular targeting poly(ethylene glycol)-grafted polymeric gene carrier |
US20030215395A1 (en) * | 2002-05-14 | 2003-11-20 | Lei Yu | Controllably degradable polymeric biomolecule or drug carrier and method of synthesizing said carrier |
US20040048260A1 (en) * | 2002-09-10 | 2004-03-11 | Fu-Hsiung Chang | Transfection of nucleic acid |
US20040138154A1 (en) * | 2003-01-13 | 2004-07-15 | Lei Yu | Solid surface for biomolecule delivery and high-throughput assay |
US7125709B2 (en) * | 2004-02-10 | 2006-10-24 | Nitto Denko Corporation | Culture device and method for eukaryotic cell transfection |
-
2003
- 2003-01-13 US US10/341,059 patent/US20040138154A1/en not_active Abandoned
- 2003-12-04 EP EP10075260A patent/EP2253718B1/de not_active Expired - Lifetime
- 2003-12-04 CN CN2003801086781A patent/CN1738911B/zh not_active Expired - Fee Related
- 2003-12-04 KR KR1020057012842A patent/KR100863774B1/ko not_active IP Right Cessation
- 2003-12-04 WO PCT/US2003/038498 patent/WO2004065636A1/en active Application Filing
- 2003-12-04 AT AT03796622T patent/ATE477336T1/de not_active IP Right Cessation
- 2003-12-04 DK DK10075260.9T patent/DK2253718T3/da active
- 2003-12-04 DE DE60333793T patent/DE60333793D1/de not_active Expired - Lifetime
- 2003-12-04 JP JP2004566927A patent/JP4580764B2/ja not_active Expired - Fee Related
- 2003-12-04 CA CA2512144A patent/CA2512144C/en not_active Expired - Fee Related
- 2003-12-04 EP EP03796622A patent/EP1587954B1/de not_active Expired - Lifetime
- 2003-12-04 AU AU2003298863A patent/AU2003298863B2/en not_active Ceased
-
2006
- 2006-08-15 HK HK06109068.2A patent/HK1088637A1/xx not_active IP Right Cessation
- 2006-09-26 US US11/527,134 patent/US8192989B2/en not_active Expired - Fee Related
- 2006-09-26 US US11/526,927 patent/US20070020761A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
KR20050096130A (ko) | 2005-10-05 |
EP1587954A1 (de) | 2005-10-26 |
JP2006513703A (ja) | 2006-04-27 |
AU2003298863B2 (en) | 2008-04-24 |
US8192989B2 (en) | 2012-06-05 |
DE60333793D1 (de) | 2010-09-23 |
DK2253718T3 (da) | 2012-10-08 |
HK1088637A1 (en) | 2006-11-10 |
WO2004065636A1 (en) | 2004-08-05 |
CN1738911A (zh) | 2006-02-22 |
US20070072171A1 (en) | 2007-03-29 |
EP2253718A3 (de) | 2010-12-15 |
CN1738911B (zh) | 2012-09-05 |
CA2512144C (en) | 2013-07-02 |
US20040138154A1 (en) | 2004-07-15 |
EP1587954A4 (de) | 2006-04-12 |
AU2003298863A1 (en) | 2004-08-13 |
EP2253718A2 (de) | 2010-11-24 |
CA2512144A1 (en) | 2004-08-05 |
EP1587954B1 (de) | 2010-08-11 |
EP2253718B1 (de) | 2012-07-04 |
KR100863774B1 (ko) | 2008-10-16 |
JP4580764B2 (ja) | 2010-11-17 |
US20070020761A1 (en) | 2007-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |