ATE469986T1 - Senp1 als krebsmarker - Google Patents

Senp1 als krebsmarker

Info

Publication number
ATE469986T1
ATE469986T1 AT05737453T AT05737453T ATE469986T1 AT E469986 T1 ATE469986 T1 AT E469986T1 AT 05737453 T AT05737453 T AT 05737453T AT 05737453 T AT05737453 T AT 05737453T AT E469986 T1 ATE469986 T1 AT E469986T1
Authority
AT
Austria
Prior art keywords
senp1
cancer marker
detecting
telomerase
sample
Prior art date
Application number
AT05737453T
Other languages
English (en)
Inventor
Cherie Holcomb
Russell Higuchi
Nancy Schoenbrunner
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE469986T1 publication Critical patent/ATE469986T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
AT05737453T 2004-05-06 2005-05-04 Senp1 als krebsmarker ATE469986T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56922004P 2004-05-06 2004-05-06
US59931804P 2004-08-05 2004-08-05
PCT/EP2005/004839 WO2005108603A1 (en) 2004-05-06 2005-05-04 Senp1 as a marker for cancer

Publications (1)

Publication Number Publication Date
ATE469986T1 true ATE469986T1 (de) 2010-06-15

Family

ID=35004240

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05737453T ATE469986T1 (de) 2004-05-06 2005-05-04 Senp1 als krebsmarker

Country Status (8)

Country Link
US (2) US7939251B2 (de)
EP (3) EP2110439B1 (de)
JP (1) JP4729038B2 (de)
AT (1) ATE469986T1 (de)
CA (1) CA2564484C (de)
DE (1) DE602005021634D1 (de)
ES (3) ES2345720T3 (de)
WO (1) WO2005108603A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE550067T1 (de) * 2003-07-22 2012-04-15 Kci Licensing Inc Negativdruck-wundbehandlungskompresse
US7939251B2 (en) * 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
EP3103423B1 (de) * 2007-02-09 2018-01-24 KCI Licensing, Inc. Atmungsschnittstellensystem für reduzierten topischen druck
US8377017B2 (en) 2008-01-03 2013-02-19 Kci Licensing, Inc. Low-profile reduced pressure treatment system
JP2011525106A (ja) * 2008-06-04 2011-09-15 ジ・アリゾナ・ボード・オブ・リージェンツ・オン・ビハーフ・オブ・ザ・ユニバーシティ・オブ・アリゾナ 瀰漫性b大細胞型リンパ腫のマーカーおよびその使用方法
US20120070842A1 (en) * 2009-06-01 2012-03-22 Harley Calvin B Assay for Telomerase Activity Using Microfluidic Device
CN108383894A (zh) 2010-02-16 2018-08-10 阿尔特公司 多肽及其应用
JP2012072063A (ja) * 2010-09-27 2012-04-12 Japan Health Science Foundation 細胞の造腫瘍性試験方法及び腫瘍マーカー
CN102827927A (zh) * 2012-06-25 2012-12-19 中国人民解放军南京军区南京总医院 检测食管癌terc基因扩增的荧光实时定量pcr试剂盒
US9791447B2 (en) * 2013-04-05 2017-10-17 City Of Hope Methods of identifying SENP1 inhibitors
CN112500465B (zh) * 2020-12-01 2022-07-12 大连理工大学 一种sumo化修饰捕获探针的合成方法及应用
CN114891761B (zh) * 2022-03-25 2024-01-12 上海威高医疗技术发展有限公司 Tth DNA聚合酶突变体及其应用

Family Cites Families (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US695072A (en) 1901-10-28 1902-03-11 Frank Mossberg Wrench.
US4376110A (en) 1980-08-04 1983-03-08 Hybritech, Incorporated Immunometric assays using monoclonal antibodies
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
US4517288A (en) 1981-01-23 1985-05-14 American Hospital Supply Corp. Solid phase system for ligand assay
US4994373A (en) 1983-01-27 1991-02-19 Enzo Biochem, Inc. Method and structures employing chemically-labelled polynucleotide probes
US4948882A (en) 1983-02-22 1990-08-14 Syngene, Inc. Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis
US5118802A (en) 1983-12-20 1992-06-02 California Institute Of Technology DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside
US5118605A (en) 1984-10-16 1992-06-02 Chiron Corporation Polynucleotide determination with selectable cleavage sites
US4767700A (en) 1985-02-15 1988-08-30 Beckman Research Institute Of The City Of Hope Detection of particular nucleotide sequences
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
DE3529478A1 (de) 1985-08-16 1987-02-19 Boehringer Mannheim Gmbh 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4851331A (en) 1986-05-16 1989-07-25 Allied Corporation Method and kit for polynucleotide assay including primer-dependant DNA polymerase
US5352600A (en) 1986-08-22 1994-10-04 Hoffmann-La Roche Inc. Purified thermostable enzyme
US5079352A (en) 1986-08-22 1992-01-07 Cetus Corporation Purified thermostable enzyme
US5405774A (en) 1986-08-22 1995-04-11 Hoffmann-La Roche Inc. DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17
US5618711A (en) 1986-08-22 1997-04-08 Hoffmann-La Roche Inc. Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5795762A (en) 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5455170A (en) 1986-08-22 1995-10-03 Hoffmann-La Roche Inc. Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05
US5466591A (en) 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5135717A (en) 1986-12-24 1992-08-04 British Technology Group Usa Inc. Tetrabenztriazaporphyrin reagents and kits containing the same
US4914210A (en) 1987-10-02 1990-04-03 Cetus Corporation Oligonucleotide functionalizing reagents
DE3734442A1 (de) 1987-10-12 1989-04-27 Kernforschungsanlage Juelich Verfahren und vorrichtung zur bestrahlung grosser flaechen mit ionen
US5525465A (en) 1987-10-28 1996-06-11 Howard Florey Institute Of Experimental Physiology And Medicine Oligonucleotide-polyamide conjugates and methods of production and applications of the same
DE3803275A1 (de) 1988-02-04 1989-08-17 Dornier Medizintechnik Piezoelektrische stosswellenquelle
IE61148B1 (en) 1988-03-10 1994-10-05 Ici Plc Method of detecting nucleotide sequences
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5118801A (en) 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
ATE142272T1 (de) 1989-01-19 1996-09-15 Behringwerke Ag Nukleinsäure-amplifikation unter verwendung eines einzelprimers
GB8902689D0 (en) 1989-02-07 1989-03-30 Ici Plc Assay method
US5856092A (en) 1989-02-13 1999-01-05 Geneco Pty Ltd Detection of a nucleic acid sequence or a change therein
WO1990010716A1 (en) 1989-03-10 1990-09-20 Gene-Trak Systems Immobilized oligonucleotide probes and uses therefor
US5234809A (en) 1989-03-23 1993-08-10 Akzo N.V. Process for isolating nucleic acid
US5232829A (en) 1989-09-29 1993-08-03 Hoffmann-La Roche Inc. Detection of chlamydia trachomatis by polymerase chain reaction using biotin labelled lina primers and capture probes
US5955589A (en) 1991-12-24 1999-09-21 Isis Pharmaceuticals Inc. Gapped 2' modified oligonucleotides
CA2039517C (en) 1990-04-03 2006-11-07 David Segev Dna probe signal amplification
US5102784A (en) 1990-05-04 1992-04-07 Oncor, Inc. Restriction amplification assay
US5880287A (en) 1990-05-15 1999-03-09 Hyperion, Inc. Polyoxyhydrocarbyl related products and methods for fluorescence assays
US5606045A (en) 1990-05-15 1997-02-25 Diatron Corporation Nucleic acid probes and methods
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
YU187991A (sh) 1990-12-11 1994-09-09 Hoechst Aktiengesellschaft 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba
US5525462A (en) 1991-05-02 1996-06-11 Toyo Boseki Kabushiki Kaisha Nucleic acid sequence amplification method, detection method, and reagent kit therefor
US5155018A (en) 1991-07-10 1992-10-13 Hahnemann University Process and kit for isolating and purifying RNA from biological sources
US5294534A (en) 1991-08-13 1994-03-15 Miles, Inc. Amplification method for polynucleotide assays
CA2075858C (en) 1991-08-15 1998-05-19 Scott J. Eisenbeis Detection of complementary nucleotide sequences
EP0656065A1 (de) 1991-10-31 1995-06-07 University Of Pittsburgh Reverse dot-blot-hybridisierung mittels sonden, die tandem kopf-an-fuss-monomere enthalten, welche durch gestaffelte komlimentäre primer synthetisiert werden.
US6033854A (en) 1991-12-16 2000-03-07 Biotronics Corporation Quantitative PCR using blocking oligonucleotides
US5464746A (en) 1991-12-17 1995-11-07 Abbott Laboratories Haptens, tracers, immunogens and antibodies for carbazole and dibenzofuran derivatives
US5424414A (en) 1991-12-17 1995-06-13 Abbott Laboratories Haptens, tracers, immunogens and antibodies for 3-phenyl-1-adamantaneacetic acids
US5652099A (en) 1992-02-12 1997-07-29 Conrad; Michael J. Probes comprising fluorescent nucleosides and uses thereof
US5888723A (en) 1992-02-18 1999-03-30 Johnson & Johnson Clinical Diagnostics, Inc. Method for nucleic acid amplification and detection using adhered probes
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US6007989A (en) 1992-05-13 1999-12-28 Board Of Regents, The University Of Texas System Methods of screening for compounds that derepress or increase telomerase activity
US5989807A (en) 1992-05-13 1999-11-23 Geron Corporation & Board Of Regents Detecting cancerous conditions by assaying for telomerase activity
US5837453A (en) 1992-05-13 1998-11-17 Geron Corporation Telomerase activity assays
US5981176A (en) 1992-06-17 1999-11-09 City Of Hope Method of detecting and discriminating between nucleic acid sequences
US5710028A (en) 1992-07-02 1998-01-20 Eyal; Nurit Method of quick screening and identification of specific DNA sequences by single nucleotide primer extension and kits therefor
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5556959A (en) 1993-01-22 1996-09-17 Pharmacia P-L Biochemicals Inc. Indocarbocyanine-linked phosphoramidites
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
US5679510A (en) 1993-04-27 1997-10-21 Hybridon, Inc. Quantitative detection of specific nucleic acid sequences using lambdoid bacteriophages linked by oligonucleotides to solid support
DE4321904B4 (de) 1993-07-01 2013-05-16 Qiagen Gmbh Verfahren zur chromatographischen Reinigung und Trennung von Nucleinsäuregemischen
WO1995006137A1 (en) 1993-08-27 1995-03-02 Australian Red Cross Society Detection of genes
CA2105364A1 (en) 1993-09-01 1995-03-02 Eric T. Kool Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US5808036A (en) 1993-09-01 1998-09-15 Research Corporation Technologies Inc. Stem-loop oligonucleotides containing parallel and antiparallel binding domains
US5446137B1 (en) 1993-12-09 1998-10-06 Behringwerke Ag Oligonucleotides containing 4'-substituted nucleotides
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5547861A (en) 1994-04-18 1996-08-20 Becton, Dickinson And Company Detection of nucleic acid amplification
DE4415370A1 (de) 1994-05-02 1995-11-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
WO1995035390A1 (en) 1994-06-22 1995-12-28 Mount Sinai School Of Medicine Of The City University Of New York Ligation-dependent amplification for the detection of infectious pathogens and abnormal genes
US5876924A (en) 1994-06-22 1999-03-02 Mount Sinai School Of Medicine Nucleic acid amplification method hybridization signal amplification method (HSAM)
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5597696A (en) 1994-07-18 1997-01-28 Becton Dickinson And Company Covalent cyanine dye oligonucleotide conjugates
US5491063A (en) 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
DE4438918A1 (de) 1994-11-04 1996-05-09 Hoechst Ag Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung
US5571673A (en) 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
JP3189000B2 (ja) 1994-12-01 2001-07-16 東ソー株式会社 特定核酸配列の検出方法
EP1260593A3 (de) 1994-12-23 2003-12-03 Dade Behring Inc. Nachweis von Nukleinsäuren durch Nuklease-katalysierte Produktbildung
US6174998B1 (en) 1996-03-12 2001-01-16 Roche Diagnostics Gmbh C-nucleoside derivatives and their use in the detection of nucleic acids
US5683875A (en) 1995-05-04 1997-11-04 Hewlett-Packard Company Method for detecting a target nucleic acid analyte in a sample
US5648245A (en) 1995-05-09 1997-07-15 Carnegie Institution Of Washington Method for constructing an oligonucleotide concatamer library by rolling circle replication
US5882867A (en) 1995-06-07 1999-03-16 Dade Behring Marburg Gmbh Detection of nucleic acids by formation of template-dependent product
US5994063A (en) 1995-06-23 1999-11-30 Metzker; Michael L. Substituted 4,4-difluoro-4-bora-3A,4A-diaza-s-indacene compounds for homogenous amplification/detection assays
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US5800989A (en) 1995-11-15 1998-09-01 Becton, Dickinson And Company Method for detection of nucleic acid targets by amplification and fluorescence polarization
US5641633A (en) 1995-11-15 1997-06-24 Becton, Dickinson And Company Fluorescence polarization detection of nucleic acids
US6582904B2 (en) 1995-11-16 2003-06-24 Michael W. Dahm Method of quantifying tumour cells in a body fluid and a suitable test kit
US5854033A (en) 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
WO1997022719A1 (en) 1995-12-18 1997-06-26 Washington University Method for nucleic acid analysis using fluorescence resonance energy transfer
US6607898B1 (en) 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
PT912766E (pt) 1996-06-04 2009-07-16 Univ Utah Res Found Monitorização da hibridização durante a pcr
EP0930369B1 (de) 1996-06-28 2005-11-09 Rebio Gen, Inc. Verfahren zum entdecken von telomerase-aktivität
US5866336A (en) 1996-07-16 1999-02-02 Oncor, Inc. Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US5853990A (en) 1996-07-26 1998-12-29 Edward E. Winger Real time homogeneous nucleotide assay
US6361944B1 (en) 1996-07-29 2002-03-26 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US6506564B1 (en) 1996-07-29 2003-01-14 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
US5691145A (en) 1996-08-27 1997-11-25 Becton, Dickinson And Company Detection of nucleic acids using G-quartets
US6352827B1 (en) 1996-08-28 2002-03-05 President And Fellows Of Harvard College Detection of multiple nucleic acid sequences in a fluid sample
US5846723A (en) * 1996-12-20 1998-12-08 Geron Corporation Methods for detecting the RNA component of telomerase
ATE280177T1 (de) 1997-03-20 2004-11-15 Hoffmann La Roche Modifizierte primer
US6558901B1 (en) 1997-05-02 2003-05-06 Biomerieux Vitek Nucleic acid assays
US5846726A (en) 1997-05-13 1998-12-08 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US5928869A (en) 1997-05-30 1999-07-27 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
US6103657A (en) 1997-07-02 2000-08-15 Union Carbide Chemicals & Plastics Technology Corporation Catalyst for the production of olefin polymers
US5935791A (en) 1997-09-23 1999-08-10 Becton, Dickinson And Company Detection of nucleic acids by fluorescence quenching
JP3161519B2 (ja) 1997-12-26 2001-04-25 株式会社遠藤製作所 ゴルフクラブ及びそのセット
US6080868A (en) 1998-01-23 2000-06-27 The Perkin-Elmer Corporation Nitro-substituted non-fluorescent asymmetric cyanine dye compounds
DE69939896D1 (de) 1998-03-05 2008-12-24 Johnson & Johnson Res Pty Ltd Methoden zur detektion von nukleinsäuren unter verwendung von zymogenen und dazugehörige kits
EP2082806A3 (de) 1998-05-01 2010-04-28 Gen-Probe Incorporated Automatisches Diagnoseanalysegerät und Verfahren
US6383756B1 (en) 1998-05-06 2002-05-07 Genprofile Ag Method for non-radioactive detection of membrane-bonded nucleic acids and test kit
GB9812768D0 (en) 1998-06-13 1998-08-12 Zeneca Ltd Methods
US6180408B1 (en) 1998-08-21 2001-01-30 Washington University Fluorescence polarization in nucleic acid analysis
US20030045491A1 (en) 2001-02-23 2003-03-06 Christoph Reinhard TTK in diagnosis and as a therapeutic target in cancer
US6261779B1 (en) 1998-11-10 2001-07-17 Bio-Pixels Ltd. Nanocrystals having polynucleotide strands and their use to form dendrimers in a signal amplification system
WO2000042222A2 (en) 1999-01-15 2000-07-20 Gene Logic Inc. Immobilized nucleic acid hybridization reagent and method
WO2000048991A1 (en) 1999-02-18 2000-08-24 The Regents Of The University Of California Salicylamide-lanthanide complexes for use as luminescent markers
JP4555484B2 (ja) 1999-04-07 2010-09-29 デニス マイケル コノリー 高解像度のdna検出の方法および装置
EP1090073B1 (de) 1999-04-23 2003-03-05 Molecular Probes Inc. Xanthenfarbstoffe und ihre anwendung als lumineszenzlöschende verbindungen
WO2000070350A1 (en) 1999-05-12 2000-11-23 Cme Telemetrix Inc. METHOD AND APPARATUS FOR RAPID MEASUREMENT OF HbA¿1c?
US6180349B1 (en) 1999-05-18 2001-01-30 The Regents Of The University Of California Quantitative PCR method to enumerate DNA copy number
AU5552400A (en) 1999-06-22 2001-01-09 School Of Pharmacy, University Of London, The Treatment of cancer
CA2378408C (en) 1999-07-23 2010-07-06 Gen-Probe Incorporated Polynucleotide amplification method
US6596527B1 (en) * 1999-07-31 2003-07-22 Board Of Regents, The University Of Texas Sytem Composition and methods relating to SENP 1- a sentrin-specific protease
US6379888B1 (en) 1999-09-27 2002-04-30 Becton, Dickinson And Company Universal probes and methods for detection of nucleic acids
WO2001022920A2 (en) 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
US6528254B1 (en) 1999-10-29 2003-03-04 Stratagene Methods for detection of a target nucleic acid sequence
JP2003514383A (ja) 1999-11-17 2003-04-15 ロシュ ダイアグノスティクス ゲゼルシャフト ミット ベシュレンクテル ハフツング 磁性ガラス粒子、それらの製造方法、及びそれらの使用
US6664046B1 (en) 1999-12-16 2003-12-16 Roche Molecular Systems, Inc. Quantitation of hTERT mRNA expression
US6221603B1 (en) 2000-02-04 2001-04-24 Molecular Dynamics, Inc. Rolling circle amplification assay for nucleic acid analysis
US6221604B1 (en) 2000-02-07 2001-04-24 Pe Corporation Electron-deficient nitrogen heterocycle-substituted fluorescein dyes
US20030170631A1 (en) 2000-04-03 2003-09-11 Corixa Corporation Methods, compositions and kits for the detection and monitoring of breast cancer
US6350580B1 (en) 2000-10-11 2002-02-26 Stratagene Methods for detection of a target nucleic acid using a probe comprising secondary structure
US20040029114A1 (en) 2001-01-24 2004-02-12 Eos Technology, Inc. Methods of diagnosis of breast cancer, compositions and methods of screening for modulators of breast cancer
US20040076955A1 (en) * 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
CN1703524B (zh) 2002-09-30 2010-04-07 肿瘤疗法科学股份有限公司 与人胰腺癌相关的基因和多肽
TW200413539A (en) 2002-09-30 2004-08-01 Oncotherapy Science Inc Genes and polypeptides relating to prostate cancers
US20040253606A1 (en) 2002-11-26 2004-12-16 Protein Design Labs, Inc. Methods of detecting soft tissue sarcoma, compositions and methods of screening for soft tissue sarcoma modulators
US7939251B2 (en) 2004-05-06 2011-05-10 Roche Molecular Systems, Inc. SENP1 as a marker for cancer
US7579152B2 (en) 2004-08-27 2009-08-25 Board Of Regents, The University Of Texas System SENP1 as a marker of cancer development and target for cancer therapy
JO3421B1 (ar) 2011-06-20 2019-10-20 H Lundbeck As طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية

Also Published As

Publication number Publication date
EP1761640A1 (de) 2007-03-14
ES2391079T3 (es) 2012-11-21
EP2258876A1 (de) 2010-12-08
ES2345720T3 (es) 2010-09-30
DE602005021634D1 (de) 2010-07-15
CA2564484A1 (en) 2005-11-17
EP1761640B1 (de) 2010-06-02
US20090162846A1 (en) 2009-06-25
WO2005108603A1 (en) 2005-11-17
JP2008500028A (ja) 2008-01-10
US7776539B2 (en) 2010-08-17
US7939251B2 (en) 2011-05-10
JP4729038B2 (ja) 2011-07-20
US20060014171A1 (en) 2006-01-19
EP2110439A1 (de) 2009-10-21
EP2110439B1 (de) 2014-03-12
CA2564484C (en) 2013-01-08
ES2464719T3 (es) 2014-06-03
EP2258876B1 (de) 2012-07-11

Similar Documents

Publication Publication Date Title
DE602005025805D1 (de) Stabilisierte polymer-thiol-reagenzien
MX2007010349A (es) Composiciones y metodos para clasificar muestras biologicas.
EP1947990A4 (de) Mikrofluidische zellkulturvorrichtung
ATE469986T1 (de) Senp1 als krebsmarker
WO2008008257A3 (en) Oriented magnetic particle-fluorescence detectable moiety compositions and methods of making and using the same
DE602005026343D1 (de) Schlüsselverteilung mit Erkennung von unbekannten Formaten
DK1874818T3 (da) TGF-Beta 1-specifikke antistoffer
CR10372A (es) Anticuerpos anti-tat226 e inmunoconjugados
ATE531705T1 (de) Substituierte 2-chinolyloxazole geeignet als pde4 inhibitoren
WO2006089125A3 (en) Methods of detecting ovarian cancer
ATE478868T1 (de) Pyrrolodihydroisochinoline als pde10- inhibitoren
ATE536425T1 (de) Mit metabolischem alter verbundene biomarker und verfahren zur verwendung davon
DK2434024T3 (da) Urinmarkører til påvisning af blærecancer
EP1751590A4 (de) Auf einem planarresonator basierende optische chemo- und biosensoren
DK2024747T3 (da) Anvendelse af protein SATB2 som prognotisk markør for colerectal cancer
WO2006094149A3 (en) Methods and compositions for detecting adenoma
DE602004021269D1 (de) 5-arylpyrimidine als anti-krebs-mittel
DK1858921T3 (da) Fotoproteiner med forbedret bioluminescens og anvendelse af disse som intracellulære calciumindikatorer
EP1988804A4 (de) Mikrofluidzellkulturmedien
ATE555385T1 (de) N1,n12-diacetylspermin als tumormarker
ATE467128T1 (de) Kolloidale metallkonjugate
DE602005007582D1 (de) In biologischen proben
DE602004030231D1 (de) Pyrimidinonverbindungen als calcilytica
ATE455770T1 (de) N-alkynyl-2-heteroaryloxyalkylamide zur verwendung als fungizide
EP1799857A4 (de) Nachweis von krebszellen in körperflüssigkeiten

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1761640

Country of ref document: EP