ATE460162T1 - Neue kristallformen von irinotecan-hydrochlorid - Google Patents
Neue kristallformen von irinotecan-hydrochloridInfo
- Publication number
- ATE460162T1 ATE460162T1 AT06803842T AT06803842T ATE460162T1 AT E460162 T1 ATE460162 T1 AT E460162T1 AT 06803842 T AT06803842 T AT 06803842T AT 06803842 T AT06803842 T AT 06803842T AT E460162 T1 ATE460162 T1 AT E460162T1
- Authority
- AT
- Austria
- Prior art keywords
- crystal forms
- irinotecan hydrochloride
- new crystal
- irinotecan
- hydrochloride
- Prior art date
Links
- 229960000779 irinotecan hydrochloride Drugs 0.000 title 1
- GURKHSYORGJETM-WAQYZQTGSA-N irinotecan hydrochloride (anhydrous) Chemical compound Cl.C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 GURKHSYORGJETM-WAQYZQTGSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71882705P | 2005-09-20 | 2005-09-20 | |
| PCT/US2006/036437 WO2007035709A2 (en) | 2005-09-20 | 2006-09-19 | Novel crystal forms of irinotecan hydrochloride |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE460162T1 true ATE460162T1 (de) | 2010-03-15 |
Family
ID=37889452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT06803842T ATE460162T1 (de) | 2005-09-20 | 2006-09-19 | Neue kristallformen von irinotecan-hydrochlorid |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7435818B2 (enExample) |
| EP (2) | EP2082741A1 (enExample) |
| JP (1) | JP5119153B2 (enExample) |
| KR (1) | KR101150504B1 (enExample) |
| CN (1) | CN101277694B (enExample) |
| AR (1) | AR056082A1 (enExample) |
| AT (1) | ATE460162T1 (enExample) |
| AU (1) | AU2006292328B2 (enExample) |
| BR (1) | BRPI0616308A2 (enExample) |
| CA (1) | CA2623117C (enExample) |
| DE (1) | DE602006012871D1 (enExample) |
| ES (1) | ES2343204T3 (enExample) |
| NZ (1) | NZ566807A (enExample) |
| WO (1) | WO2007035709A2 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101318964B (zh) * | 2007-06-07 | 2010-12-15 | 上海迪赛诺医药发展有限公司 | 盐酸伊立替康新晶型及其制备方法 |
| US7572803B2 (en) * | 2007-10-25 | 2009-08-11 | The Christus Stehlin Foundation For Cancer Research | Hydrated crystalline esters of camptothecin |
| IT1391757B1 (it) * | 2008-11-11 | 2012-01-27 | Antibioticos Spa | Irinotecan cloridrato cristallino e metodi per la sua preparazione |
| US8546573B2 (en) | 2009-11-18 | 2013-10-01 | Cadila Healthcare Limited | Process for the preparation of 7-ethyl-10-[4-(1-piperidino)-1-piperdino] carbonyloxy-camptothecin hydrochloride trihydrate |
| WO2012007952A1 (en) * | 2010-07-12 | 2012-01-19 | Hetero Research Foundation | Novel polymorph of irinotecan hydrochloride |
| CN102311443B (zh) * | 2011-08-24 | 2014-07-16 | 上海北卡医药技术有限公司 | 盐酸伊立替康的新晶型及其制备方法 |
| CN102617584B (zh) * | 2012-03-14 | 2013-10-16 | 海南锦瑞制药股份有限公司 | 一种盐酸伊立替康化合物及其药物组合物 |
| CN102850363B (zh) * | 2012-09-18 | 2013-07-10 | 山东罗欣药业股份有限公司 | 盐酸伊立替康化合物及其药物组合物 |
| CA2909642A1 (en) * | 2013-04-15 | 2014-10-23 | Regeneron Pharmaceuticals, Inc. | Markers of tumor cell response to anti-cancer therapy |
| CN105713004A (zh) * | 2016-03-23 | 2016-06-29 | 杭州华东医药集团新药研究院有限公司 | 一种高品质盐酸伊立替康三水合物晶型的制备方法 |
| US10919905B2 (en) * | 2019-05-16 | 2021-02-16 | Scinopharm Taiwan, Ltd. | Polymorphism for irinotecan free base |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6019790A (ja) | 1983-07-14 | 1985-01-31 | Yakult Honsha Co Ltd | 新規なカンプトテシン誘導体 |
| MA24682A1 (fr) * | 1997-10-23 | 1999-07-01 | Smithkline Beecham Corp | Formes polymorphes nouvelles de cipamfylline, procede pour leur preparation et compositions les contenant |
| AU2930501A (en) * | 2000-01-07 | 2001-07-24 | Transform Pharmaceuticals, Inc. | High-throughput formation, identification, and analysis of diverse solid-forms |
| DE60314378T2 (de) * | 2002-03-01 | 2008-02-28 | Pfizer Italia S.R.L. | Kristalline polymorphe form von irinotecanhydrochlorid |
| CZ20022250A3 (cs) * | 2002-06-27 | 2004-02-18 | Pliva-Lachema A. S. | Způsob výroby irinotekanu |
| KR101095382B1 (ko) | 2003-02-25 | 2011-12-16 | 가부시키가이샤 야쿠르트 혼샤 | 이리노테칸 염산염의 결정다형의 제조방법 |
| WO2006016203A1 (en) * | 2004-08-09 | 2006-02-16 | Shilpa Medicare Limited | An improved process for the preparation of irinotecan hydrochloride trihydrate |
| US20060046993A1 (en) * | 2004-09-01 | 2006-03-02 | Pharmacia Italia S.P.A. | Crystalline polymorphic form of irinotecan hydrochloride |
| EP1846412B1 (en) * | 2005-02-07 | 2009-10-21 | Fermion Oy | Process for the manufacturing of 7-ethyl-10-hydroxy camptothecin |
| JP5133704B2 (ja) * | 2005-02-08 | 2013-01-30 | フェルミオン オサケ ユキチュア | 製造方法 |
-
2006
- 2006-09-19 WO PCT/US2006/036437 patent/WO2007035709A2/en not_active Ceased
- 2006-09-19 EP EP09155420A patent/EP2082741A1/en not_active Withdrawn
- 2006-09-19 CA CA2623117A patent/CA2623117C/en not_active Expired - Fee Related
- 2006-09-19 CN CN2006800345941A patent/CN101277694B/zh not_active Expired - Fee Related
- 2006-09-19 NZ NZ566807A patent/NZ566807A/en unknown
- 2006-09-19 US US11/523,367 patent/US7435818B2/en not_active Expired - Fee Related
- 2006-09-19 ES ES06803842T patent/ES2343204T3/es active Active
- 2006-09-19 AU AU2006292328A patent/AU2006292328B2/en not_active Ceased
- 2006-09-19 DE DE602006012871T patent/DE602006012871D1/de active Active
- 2006-09-19 KR KR1020087009534A patent/KR101150504B1/ko not_active Expired - Fee Related
- 2006-09-19 JP JP2008531427A patent/JP5119153B2/ja not_active Expired - Fee Related
- 2006-09-19 BR BRPI0616308-4A patent/BRPI0616308A2/pt not_active IP Right Cessation
- 2006-09-19 EP EP06803842A patent/EP1951235B1/en not_active Not-in-force
- 2006-09-19 AT AT06803842T patent/ATE460162T1/de not_active IP Right Cessation
- 2006-09-21 AR ARP060104123A patent/AR056082A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101277694A (zh) | 2008-10-01 |
| EP1951235B1 (en) | 2010-03-10 |
| EP2082741A1 (en) | 2009-07-29 |
| BRPI0616308A2 (pt) | 2011-06-14 |
| ES2343204T3 (es) | 2010-07-26 |
| AU2006292328A1 (en) | 2007-03-29 |
| CA2623117A1 (en) | 2007-03-29 |
| CN101277694B (zh) | 2011-04-20 |
| JP2009508874A (ja) | 2009-03-05 |
| NZ566807A (en) | 2011-05-27 |
| JP5119153B2 (ja) | 2013-01-16 |
| WO2007035709A2 (en) | 2007-03-29 |
| US20070072890A1 (en) | 2007-03-29 |
| KR20080059244A (ko) | 2008-06-26 |
| AU2006292328B2 (en) | 2012-12-20 |
| EP1951235A4 (en) | 2008-10-29 |
| WO2007035709A3 (en) | 2007-10-25 |
| AR056082A1 (es) | 2007-09-19 |
| CA2623117C (en) | 2013-12-10 |
| EP1951235A2 (en) | 2008-08-06 |
| US7435818B2 (en) | 2008-10-14 |
| DE602006012871D1 (de) | 2010-04-22 |
| KR101150504B1 (ko) | 2012-07-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |