ATE458745T1 - Nachspaltige sulfurentschützung zur konvergenten proteinherstellung beim verfahren von chemischer ligation - Google Patents
Nachspaltige sulfurentschützung zur konvergenten proteinherstellung beim verfahren von chemischer ligationInfo
- Publication number
- ATE458745T1 ATE458745T1 AT03760111T AT03760111T ATE458745T1 AT E458745 T1 ATE458745 T1 AT E458745T1 AT 03760111 T AT03760111 T AT 03760111T AT 03760111 T AT03760111 T AT 03760111T AT E458745 T1 ATE458745 T1 AT E458745T1
- Authority
- AT
- Austria
- Prior art keywords
- chemical ligation
- convergent
- oligopeptide
- deprotection
- post
- Prior art date
Links
- 239000000126 substance Substances 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 3
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 title 1
- 238000010511 deprotection reaction Methods 0.000 title 1
- 229910052717 sulfur Inorganic materials 0.000 title 1
- 239000011593 sulfur Substances 0.000 title 1
- 230000014616 translation Effects 0.000 title 1
- 108010038807 Oligopeptides Proteins 0.000 abstract 5
- 102000015636 Oligopeptides Human genes 0.000 abstract 5
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 210000004899 c-terminal region Anatomy 0.000 abstract 2
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 238000003786 synthesis reaction Methods 0.000 abstract 2
- 102000007079 Peptide Fragments Human genes 0.000 abstract 1
- 108010033276 Peptide Fragments Proteins 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
- 150000007970 thio esters Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
- C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Analytical Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38780302P | 2002-06-10 | 2002-06-10 | |
| US40753002P | 2002-08-30 | 2002-08-30 | |
| PCT/IB2003/005087 WO2003106615A2 (en) | 2002-06-10 | 2003-06-09 | Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE458745T1 true ATE458745T1 (de) | 2010-03-15 |
Family
ID=29739962
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03760111T ATE458745T1 (de) | 2002-06-10 | 2003-06-09 | Nachspaltige sulfurentschützung zur konvergenten proteinherstellung beim verfahren von chemischer ligation |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7781488B2 (https=) |
| EP (1) | EP1529056B1 (https=) |
| JP (1) | JP4559219B2 (https=) |
| AT (1) | ATE458745T1 (https=) |
| AU (1) | AU2003276286A1 (https=) |
| CA (1) | CA2487342A1 (https=) |
| DE (1) | DE60331437D1 (https=) |
| ES (1) | ES2340376T3 (https=) |
| WO (1) | WO2003106615A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2877946B1 (fr) * | 2004-11-12 | 2011-02-11 | Commissariat Energie Atomique | Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet |
| CA2612274A1 (en) * | 2005-06-16 | 2006-12-21 | Amylin Pharmaceuticals, Inc. | Side-chain extended ligation |
| EP1770099A1 (en) * | 2005-09-28 | 2007-04-04 | University of Geneva | Method of producing a modified (poly)peptide |
| WO2007100358A2 (en) * | 2005-10-07 | 2007-09-07 | University Of Chicago | Convergent synthesis of proteins by kinetically controlled ligation |
| US8404804B2 (en) | 2007-08-28 | 2013-03-26 | Ipsen Pharma S.A.S. | Methods and intermediates for chemical synthesis of polypeptides and proteins |
| EP2197895A4 (en) * | 2007-09-04 | 2012-12-26 | Ipsen Pharma Sas | METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS |
| US9175053B2 (en) | 2010-02-09 | 2015-11-03 | Ben-Gurion University Of The Negev Research And Development Authority | Chemical preparation of ubiquitin thioesters and modifications thereof |
| JP2018528164A (ja) | 2015-07-02 | 2018-09-27 | ノーバス・インターナショナル・インコーポレイテッドＮｏｖｕｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ，Ｉｎｃ． | 陰イオン界面活性剤 |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
| WO2022143532A1 (zh) * | 2020-12-28 | 2022-07-07 | 江苏金斯瑞生物科技有限公司 | 一种肽硫酯及其首尾酰胺环肽的合成方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU745094B2 (en) * | 1997-06-13 | 2002-03-14 | Gryphon Sciences | Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution |
| KR20030046389A (ko) * | 2000-09-01 | 2003-06-12 | 그리폰 테라퓨틱스, 인코포레이티드 | 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법 |
| KR20030057529A (ko) * | 2000-09-08 | 2003-07-04 | 그리폰 테라퓨틱스, 인코포레이티드 | 합성 적혈구생성 자극 단백질 |
| BR0113623A (pt) * | 2000-09-08 | 2004-06-22 | Gryphon Therapeutics Inc | Proteìnas sintéticas de estìmulo da eritropoiese |
| GB0113657D0 (en) * | 2001-06-05 | 2001-07-25 | Geneprot Inc | Improved native chemical ligation with three or more components |
-
2003
- 2003-06-09 US US10/516,118 patent/US7781488B2/en not_active Expired - Fee Related
- 2003-06-09 EP EP03760111A patent/EP1529056B1/en not_active Expired - Lifetime
- 2003-06-09 WO PCT/IB2003/005087 patent/WO2003106615A2/en not_active Ceased
- 2003-06-09 AT AT03760111T patent/ATE458745T1/de not_active IP Right Cessation
- 2003-06-09 ES ES03760111T patent/ES2340376T3/es not_active Expired - Lifetime
- 2003-06-09 CA CA002487342A patent/CA2487342A1/en not_active Abandoned
- 2003-06-09 DE DE60331437T patent/DE60331437D1/de not_active Expired - Lifetime
- 2003-06-09 JP JP2004513428A patent/JP4559219B2/ja not_active Expired - Fee Related
- 2003-06-10 AU AU2003276286A patent/AU2003276286A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20070059792A1 (en) | 2007-03-15 |
| WO2003106615A3 (en) | 2004-09-16 |
| WO2003106615A2 (en) | 2003-12-24 |
| EP1529056B1 (en) | 2010-02-24 |
| CA2487342A1 (en) | 2003-12-24 |
| EP1529056A2 (en) | 2005-05-11 |
| ES2340376T3 (es) | 2010-06-02 |
| DE60331437D1 (de) | 2010-04-08 |
| AU2003276286A1 (en) | 2003-12-31 |
| JP2005529186A (ja) | 2005-09-29 |
| US7781488B2 (en) | 2010-08-24 |
| JP4559219B2 (ja) | 2010-10-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |