JP4559219B2 - 化学連結による収束性タンパク質合成のための開裂後硫黄脱保護 - Google Patents

化学連結による収束性タンパク質合成のための開裂後硫黄脱保護 Download PDF

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JP4559219B2
JP4559219B2 JP2004513428A JP2004513428A JP4559219B2 JP 4559219 B2 JP4559219 B2 JP 4559219B2 JP 2004513428 A JP2004513428 A JP 2004513428A JP 2004513428 A JP2004513428 A JP 2004513428A JP 4559219 B2 JP4559219 B2 JP 4559219B2
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oligopeptide
substituted
unprotected
terminus
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JP2005529186A5 (https=
JP2005529186A (ja
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パオロ ボッティ
マテオ ビラン
ソニア マンガニエロ
ヒューバート ギャエルトナー
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エミリン ファーマシューティカルズ インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
JP2004513428A 2002-06-10 2003-06-09 化学連結による収束性タンパク質合成のための開裂後硫黄脱保護 Expired - Fee Related JP4559219B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38780302P 2002-06-10 2002-06-10
US40753002P 2002-08-30 2002-08-30
PCT/IB2003/005087 WO2003106615A2 (en) 2002-06-10 2003-06-09 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation

Publications (3)

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JP2005529186A JP2005529186A (ja) 2005-09-29
JP2005529186A5 JP2005529186A5 (https=) 2006-03-09
JP4559219B2 true JP4559219B2 (ja) 2010-10-06

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JP2004513428A Expired - Fee Related JP4559219B2 (ja) 2002-06-10 2003-06-09 化学連結による収束性タンパク質合成のための開裂後硫黄脱保護

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US (1) US7781488B2 (https=)
EP (1) EP1529056B1 (https=)
JP (1) JP4559219B2 (https=)
AT (1) ATE458745T1 (https=)
AU (1) AU2003276286A1 (https=)
CA (1) CA2487342A1 (https=)
DE (1) DE60331437D1 (https=)
ES (1) ES2340376T3 (https=)
WO (1) WO2003106615A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2877946B1 (fr) * 2004-11-12 2011-02-11 Commissariat Energie Atomique Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet
EP1904515B1 (en) * 2005-06-16 2010-12-08 Amylin Pharmaceuticals, Inc. Side-chain extended ligation
EP1770099A1 (en) * 2005-09-28 2007-04-04 University of Geneva Method of producing a modified (poly)peptide
US7674881B2 (en) * 2005-10-07 2010-03-09 The University Of Chicago Convergent synthesis of proteins by kinetically controlled ligation
JP2010537984A (ja) * 2007-08-28 2010-12-09 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ポリペプチドおよび蛋白質の化学合成のための方法および中間体
EP2197895A4 (en) * 2007-09-04 2012-12-26 Ipsen Pharma Sas METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
US9175053B2 (en) 2010-02-09 2015-11-03 Ben-Gurion University Of The Negev Research And Development Authority Chemical preparation of ubiquitin thioesters and modifications thereof
PL3317390T3 (pl) 2015-07-02 2021-04-19 Novus International Inc. Anionowe środki powierzchniowo czynne
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
US20240076311A1 (en) * 2020-12-28 2024-03-07 Jiangsu Genscript Biotech Co., Ltd. Method for synthesizing peptide thioesters and head-to-tail amide cyclic peptide thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE285415T1 (de) * 1997-06-13 2005-01-15 Gryphon Therapeutics Inc Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen
KR20030046389A (ko) * 2000-09-01 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법
BR0113579A (pt) * 2000-09-08 2003-06-17 Gryphon Therapeutics Inc Proteìnas sintéticas modificadas por polìmero
EE200300089A (et) * 2000-09-08 2005-02-15 Gryphon Therapeutics, Inc. Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components

Also Published As

Publication number Publication date
AU2003276286A1 (en) 2003-12-31
EP1529056B1 (en) 2010-02-24
WO2003106615A2 (en) 2003-12-24
ES2340376T3 (es) 2010-06-02
ATE458745T1 (de) 2010-03-15
EP1529056A2 (en) 2005-05-11
US7781488B2 (en) 2010-08-24
DE60331437D1 (de) 2010-04-08
CA2487342A1 (en) 2003-12-24
WO2003106615A3 (en) 2004-09-16
US20070059792A1 (en) 2007-03-15
JP2005529186A (ja) 2005-09-29

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