AU2003276286A1 - Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation - Google Patents

Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation Download PDF

Info

Publication number
AU2003276286A1
AU2003276286A1 AU2003276286A AU2003276286A AU2003276286A1 AU 2003276286 A1 AU2003276286 A1 AU 2003276286A1 AU 2003276286 A AU2003276286 A AU 2003276286A AU 2003276286 A AU2003276286 A AU 2003276286A AU 2003276286 A1 AU2003276286 A1 AU 2003276286A1
Authority
AU
Australia
Prior art keywords
group
substituted
groups
unprotected
terminus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003276286A
Other languages
English (en)
Inventor
Paolo Botti
Hubert Gaertner
Sonia Manganiello
Matteo Villain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geneprot Inc
Original Assignee
Geneprot Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprot Inc filed Critical Geneprot Inc
Publication of AU2003276286A1 publication Critical patent/AU2003276286A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
AU2003276286A 2002-06-10 2003-06-10 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation Abandoned AU2003276286A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38780302P 2002-06-10 2002-06-10
US60/387,803 2002-06-10
US40753002P 2002-08-30 2002-08-30
US60/407,530 2002-08-30
PCT/IB2003/005087 WO2003106615A2 (en) 2002-06-10 2003-06-09 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation

Publications (1)

Publication Number Publication Date
AU2003276286A1 true AU2003276286A1 (en) 2003-12-31

Family

ID=29739962

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003276286A Abandoned AU2003276286A1 (en) 2002-06-10 2003-06-10 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation

Country Status (9)

Country Link
US (1) US7781488B2 (https=)
EP (1) EP1529056B1 (https=)
JP (1) JP4559219B2 (https=)
AT (1) ATE458745T1 (https=)
AU (1) AU2003276286A1 (https=)
CA (1) CA2487342A1 (https=)
DE (1) DE60331437D1 (https=)
ES (1) ES2340376T3 (https=)
WO (1) WO2003106615A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2877946B1 (fr) * 2004-11-12 2011-02-11 Commissariat Energie Atomique Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet
CA2612274A1 (en) * 2005-06-16 2006-12-21 Amylin Pharmaceuticals, Inc. Side-chain extended ligation
EP1770099A1 (en) * 2005-09-28 2007-04-04 University of Geneva Method of producing a modified (poly)peptide
WO2007100358A2 (en) * 2005-10-07 2007-09-07 University Of Chicago Convergent synthesis of proteins by kinetically controlled ligation
US8404804B2 (en) 2007-08-28 2013-03-26 Ipsen Pharma S.A.S. Methods and intermediates for chemical synthesis of polypeptides and proteins
EP2197895A4 (en) * 2007-09-04 2012-12-26 Ipsen Pharma Sas METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
US9175053B2 (en) 2010-02-09 2015-11-03 Ben-Gurion University Of The Negev Research And Development Authority Chemical preparation of ubiquitin thioesters and modifications thereof
JP2018528164A (ja) 2015-07-02 2018-09-27 ノーバス・インターナショナル・インコーポレイテッドＮｏｖｕｓ Ｉｎｔｅｒｎａｔｉｏｎａｌ，Ｉｎｃ． 陰イオン界面活性剤
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
WO2022143532A1 (zh) * 2020-12-28 2022-07-07 江苏金斯瑞生物科技有限公司 一种肽硫酯及其首尾酰胺环肽的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU745094B2 (en) * 1997-06-13 2002-03-14 Gryphon Sciences Solid phase native chemical ligation of unprotected or N-terminal cysteine protected peptides in aqueous solution
KR20030046389A (ko) * 2000-09-01 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법
KR20030057529A (ko) * 2000-09-08 2003-07-04 그리폰 테라퓨틱스, 인코포레이티드 합성 적혈구생성 자극 단백질
BR0113623A (pt) * 2000-09-08 2004-06-22 Gryphon Therapeutics Inc Proteìnas sintéticas de estìmulo da eritropoiese
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components

Also Published As

Publication number Publication date
US20070059792A1 (en) 2007-03-15
WO2003106615A3 (en) 2004-09-16
WO2003106615A2 (en) 2003-12-24
EP1529056B1 (en) 2010-02-24
ATE458745T1 (de) 2010-03-15
CA2487342A1 (en) 2003-12-24
EP1529056A2 (en) 2005-05-11
ES2340376T3 (es) 2010-06-02
DE60331437D1 (de) 2010-04-08
JP2005529186A (ja) 2005-09-29
US7781488B2 (en) 2010-08-24
JP4559219B2 (ja) 2010-10-06

Similar Documents

Publication Publication Date Title
Albericio Developments in peptide and amide synthesis
Kang et al. Peptide and protein thioester synthesis via N→ S acyl transfer
JP4327589B2 (ja) ３つまたはそれ以上の成分を用いた改良された自然化学的連結
JP4399627B2 (ja) ３つまたはそれ以上の成分による化学ペプチド連結
US7781488B2 (en) Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation
US20040138412A1 (en) Extended native chemical ligation
JP2008150393A (ja) 拡張天然型化学的ライゲーション
KR20030046389A (ko) 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법
JP4327718B2 (ja) オリゴペプチドの化学連結における酸性ｃ末端アミノ酸についてのカルボキシ保護ストラテジー
AU2001288937A1 (en) Extended native chemical ligation
AU2002363612A1 (en) Extended native chemical ligation of three or more peptide fragments
AU2002319850A1 (en) Improved native chemical ligation with three or more components

Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period