AU2003276286A1 - Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation - Google Patents

Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation Download PDF

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Publication number
AU2003276286A1
AU2003276286A1 AU2003276286A AU2003276286A AU2003276286A1 AU 2003276286 A1 AU2003276286 A1 AU 2003276286A1 AU 2003276286 A AU2003276286 A AU 2003276286A AU 2003276286 A AU2003276286 A AU 2003276286A AU 2003276286 A1 AU2003276286 A1 AU 2003276286A1
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AU
Australia
Prior art keywords
group
substituted
groups
unprotected
terminus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003276286A
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English (en)
Inventor
Paolo Botti
Hubert Gaertner
Sonia Manganiello
Matteo Villain
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Geneprot Inc
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Geneprot Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Geneprot Inc filed Critical Geneprot Inc
Publication of AU2003276286A1 publication Critical patent/AU2003276286A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C07K1/026—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution by fragment condensation in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
AU2003276286A 2002-06-10 2003-06-10 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation Abandoned AU2003276286A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US38780302P 2002-06-10 2002-06-10
US60/387,803 2002-06-10
US40753002P 2002-08-30 2002-08-30
US60/407,530 2002-08-30
PCT/IB2003/005087 WO2003106615A2 (en) 2002-06-10 2003-06-09 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation

Publications (1)

Publication Number Publication Date
AU2003276286A1 true AU2003276286A1 (en) 2003-12-31

Family

ID=29739962

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003276286A Abandoned AU2003276286A1 (en) 2002-06-10 2003-06-10 Post-cleavage sulfur deprotection for convergent protein synthesis by chemical ligation

Country Status (9)

Country Link
US (1) US7781488B2 (https=)
EP (1) EP1529056B1 (https=)
JP (1) JP4559219B2 (https=)
AT (1) ATE458745T1 (https=)
AU (1) AU2003276286A1 (https=)
CA (1) CA2487342A1 (https=)
DE (1) DE60331437D1 (https=)
ES (1) ES2340376T3 (https=)
WO (1) WO2003106615A2 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2877946B1 (fr) * 2004-11-12 2011-02-11 Commissariat Energie Atomique Peptides derives de la maurocalcine utilisables comme vecteurs pour l'adressage intracellulaire de molecules d'interet
EP1904515B1 (en) * 2005-06-16 2010-12-08 Amylin Pharmaceuticals, Inc. Side-chain extended ligation
EP1770099A1 (en) * 2005-09-28 2007-04-04 University of Geneva Method of producing a modified (poly)peptide
US7674881B2 (en) * 2005-10-07 2010-03-09 The University Of Chicago Convergent synthesis of proteins by kinetically controlled ligation
JP2010537984A (ja) * 2007-08-28 2010-12-09 イプセン ファルマ ソシエテ パール アクシオン サンプリフィエ ポリペプチドおよび蛋白質の化学合成のための方法および中間体
EP2197895A4 (en) * 2007-09-04 2012-12-26 Ipsen Pharma Sas METHODS AND INTERMEDIATES FOR CHEMICAL SYNTHESIS OF POLYPEPTIDES AND PROTEINS
US9175053B2 (en) 2010-02-09 2015-11-03 Ben-Gurion University Of The Negev Research And Development Authority Chemical preparation of ubiquitin thioesters and modifications thereof
PL3317390T3 (pl) 2015-07-02 2021-04-19 Novus International Inc. Anionowe środki powierzchniowo czynne
US10584306B2 (en) 2017-08-11 2020-03-10 Board Of Regents Of The University Of Oklahoma Surfactant microemulsions
US20240076311A1 (en) * 2020-12-28 2024-03-07 Jiangsu Genscript Biotech Co., Ltd. Method for synthesizing peptide thioesters and head-to-tail amide cyclic peptide thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE285415T1 (de) * 1997-06-13 2005-01-15 Gryphon Therapeutics Inc Festphasige native chemische ligation von ungeschützten oder n-cystein-geschützten peptiden in wässrigen lösungen
KR20030046389A (ko) * 2000-09-01 2003-06-12 그리폰 테라퓨틱스, 인코포레이티드 친핵체에 안정한 티오에스테르 발생 화합물, 제조 및 사용방법
BR0113579A (pt) * 2000-09-08 2003-06-17 Gryphon Therapeutics Inc Proteìnas sintéticas modificadas por polìmero
EE200300089A (et) * 2000-09-08 2005-02-15 Gryphon Therapeutics, Inc. Sünteetilised erütropoeesi stimuleerivad valgud, nende valmistamismeetodid ning kasutamine
GB0113657D0 (en) * 2001-06-05 2001-07-25 Geneprot Inc Improved native chemical ligation with three or more components

Also Published As

Publication number Publication date
EP1529056B1 (en) 2010-02-24
WO2003106615A2 (en) 2003-12-24
ES2340376T3 (es) 2010-06-02
ATE458745T1 (de) 2010-03-15
EP1529056A2 (en) 2005-05-11
JP4559219B2 (ja) 2010-10-06
US7781488B2 (en) 2010-08-24
DE60331437D1 (de) 2010-04-08
CA2487342A1 (en) 2003-12-24
WO2003106615A3 (en) 2004-09-16
US20070059792A1 (en) 2007-03-15
JP2005529186A (ja) 2005-09-29

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Legal Events

Date Code Title Description
MK1 Application lapsed section 142(2)(a) - no request for examination in relevant period