ATE458057T1 - Varianten der faktor-vii- oder -viia-gla-domäne - Google Patents

Varianten der faktor-vii- oder -viia-gla-domäne

Info

Publication number
ATE458057T1
ATE458057T1 AT04738925T AT04738925T ATE458057T1 AT E458057 T1 ATE458057 T1 AT E458057T1 AT 04738925 T AT04738925 T AT 04738925T AT 04738925 T AT04738925 T AT 04738925T AT E458057 T1 ATE458057 T1 AT E458057T1
Authority
AT
Austria
Prior art keywords
variants
factor vii
gla domain
human factor
amino acid
Prior art date
Application number
AT04738925T
Other languages
English (en)
Inventor
Jesper Haaning
Kim Andersen
Claus Bornaes
Original Assignee
Bayer Healthcare Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Healthcare Llc filed Critical Bayer Healthcare Llc
Application granted granted Critical
Publication of ATE458057T1 publication Critical patent/ATE458057T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6437—Coagulation factor VIIa (3.4.21.21)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/647—Blood coagulation factors not provided for in a preceding group or according to more than one of the proceeding groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21021—Coagulation factor VIIa (3.4.21.21)
AT04738925T 2003-06-19 2004-06-18 Varianten der faktor-vii- oder -viia-gla-domäne ATE458057T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47978003P 2003-06-19 2003-06-19
DKPA200400930 2004-06-15
PCT/DK2004/000428 WO2004111242A1 (en) 2003-06-19 2004-06-18 FACTOR VII OR VIIa GLA DOMAIN VARIANTS

Publications (1)

Publication Number Publication Date
ATE458057T1 true ATE458057T1 (de) 2010-03-15

Family

ID=33553697

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04738925T ATE458057T1 (de) 2003-06-19 2004-06-18 Varianten der faktor-vii- oder -viia-gla-domäne

Country Status (24)

Country Link
US (5) US20050164932A1 (de)
EP (1) EP1644504B8 (de)
JP (2) JP4915918B2 (de)
KR (1) KR101191779B1 (de)
CN (1) CN1839203B (de)
AT (1) ATE458057T1 (de)
AU (2) AU2004247799B2 (de)
BR (1) BRPI0411650A (de)
CA (1) CA2529828C (de)
CY (1) CY1109984T1 (de)
DE (1) DE602004025576D1 (de)
DK (1) DK1644504T3 (de)
ES (1) ES2338425T3 (de)
HK (1) HK1095357A1 (de)
HR (1) HRP20100264T1 (de)
IL (1) IL172364A (de)
MX (1) MXPA05013769A (de)
NZ (2) NZ573412A (de)
PL (1) PL1644504T3 (de)
PT (1) PT1644504E (de)
RU (1) RU2373282C2 (de)
SI (1) SI1644504T1 (de)
WO (1) WO2004111242A1 (de)
ZA (1) ZA200600539B (de)

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JP2003521930A (ja) 2000-02-11 2003-07-22 マキシゲン・エイピーエス 第ＶＩＩ因子または第ＶＩＩａ因子様分子
AU2003221469A1 (en) * 2002-04-30 2003-11-17 Bayer Healthcare Llc FACTOR VII OR VIIa POLYPEPTIDE VARIANTS
JP4847856B2 (ja) 2003-03-20 2011-12-28 バイエル ヘルスケア エルエルシー ＦＶＩＩおよびＦＶＩＩａの変種
PT1644504E (pt) 2003-06-19 2010-03-22 Bayer Healthcare Llc Variantes do domínio gla dos factores vii ou viia
DE602005021509D1 (de) 2004-08-17 2010-07-08 Csl Behring Gmbh Modifizierte vitamin-k-abhängige polypeptide
WO2006114105A2 (en) * 2005-04-26 2006-11-02 Maxygen Holdings Ltd. Use of modified factor vii for treating bleeding
ES2553160T3 (es) 2005-06-17 2015-12-04 Novo Nordisk Health Care Ag Reducción y derivatización selectivas de proteínas Factor VII transformadas por ingeniería que comprenden al menos una cisteína no nativa
EP1904528B1 (de) 2005-07-13 2012-10-31 Novo Nordisk Health Care AG Wirtszellenprotein-knock-out-zellen zur herstellung therapeutischer proteine
PT1907540E (pt) * 2005-07-22 2013-02-04 Bayer Healthcare Llc Activação do factor vii em solução
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WO2007149406A2 (en) * 2006-06-19 2007-12-27 Nautilus Technology Llc Modified coagulation factor ix polypeptides and use thereof for treatment
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TWI538916B (zh) 2008-04-11 2016-06-21 介控生化科技公司 經修飾的因子vii多肽和其用途
WO2010149172A2 (en) 2009-06-24 2010-12-29 Rigshospitalet SYSTEMIC PRO-HEMOSTATIC EFFECT OF CLOTTING FACTORS IN COMBINATION WITH SYMPATHICOMIMETICS WITH AGONISTIC EFFECTS ON α-ADRENERGIC AND/OR β-ADRENERGIC RECEPTORS OF THE SYMPATHETIC NERVOUS SYSTEM, RELATED TO IMPROVED CLOT STRENGTH.
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TWI557135B (zh) 2010-11-03 2016-11-11 介控生化科技公司 經修飾之第九因子多胜肽及其用途
DK3165232T3 (da) * 2012-12-24 2019-09-16 Coagulant Therapeutics Corp Faktor vii-polypeptider med kortvarig virkning
HRP20230527T1 (hr) * 2013-03-15 2023-08-04 GLAdiator Biosciences, Inc. Gla domene kao ciljni agensi
CN104211802B (zh) * 2013-05-29 2018-07-27 成都渊源生物科技有限公司 人凝血因子轻链蛋白及其应用
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Also Published As

Publication number Publication date
KR101191779B1 (ko) 2013-01-14
KR20060022283A (ko) 2006-03-09
MXPA05013769A (es) 2006-03-08
AU2010200793A1 (en) 2010-03-25
RU2373282C2 (ru) 2009-11-20
US20070117756A1 (en) 2007-05-24
US20060252128A1 (en) 2006-11-09
ZA200600539B (en) 2006-12-27
CA2529828C (en) 2013-01-15
ES2338425T3 (es) 2010-05-07
JP4915918B2 (ja) 2012-04-11
IL172364A (en) 2014-01-30
US7807638B2 (en) 2010-10-05
DK1644504T3 (da) 2010-05-25
HRP20100264T1 (hr) 2010-08-31
DE602004025576D1 (de) 2010-04-01
US20060241041A1 (en) 2006-10-26
EP1644504B8 (de) 2010-06-02
PL1644504T3 (pl) 2010-08-31
CA2529828A1 (en) 2004-12-23
NZ573412A (en) 2010-09-30
US8987202B2 (en) 2015-03-24
SI1644504T1 (sl) 2010-06-30
HK1095357A1 (en) 2007-05-04
EP1644504A1 (de) 2006-04-12
JP2012105650A (ja) 2012-06-07
CN1839203B (zh) 2011-11-16
PT1644504E (pt) 2010-03-22
JP2006527982A (ja) 2006-12-14
WO2004111242A1 (en) 2004-12-23
AU2004247799B2 (en) 2009-12-03
US20060240526A1 (en) 2006-10-26
JP5580283B2 (ja) 2014-08-27
RU2006101391A (ru) 2006-06-10
NZ544728A (en) 2009-04-30
BRPI0411650A (pt) 2006-08-08
AU2010200793B2 (en) 2013-04-04
US20050164932A1 (en) 2005-07-28
EP1644504B1 (de) 2010-02-17
CY1109984T1 (el) 2014-09-10
CN1839203A (zh) 2006-09-27
AU2004247799A1 (en) 2004-12-23

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