ATE454160T1 - Monodisperse gemische aus calcitonin-arzneimittel-oligomer-konjugaten mit polyethylenglycol, ihre verwendung und verfahren zu ihrer herstellung - Google Patents

Monodisperse gemische aus calcitonin-arzneimittel-oligomer-konjugaten mit polyethylenglycol, ihre verwendung und verfahren zu ihrer herstellung

Info

Publication number
ATE454160T1
ATE454160T1 AT02732030T AT02732030T ATE454160T1 AT E454160 T1 ATE454160 T1 AT E454160T1 AT 02732030 T AT02732030 T AT 02732030T AT 02732030 T AT02732030 T AT 02732030T AT E454160 T1 ATE454160 T1 AT E454160T1
Authority
AT
Austria
Prior art keywords
calcitonin
mixture
production
polyethylene glycol
oligomer conjugates
Prior art date
Application number
AT02732030T
Other languages
English (en)
Inventor
Nnochiri Ekwuribe
Christopher Price
Aslam Ansari
Amy Odenbaugh
Original Assignee
Biocon Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biocon Ltd filed Critical Biocon Ltd
Application granted granted Critical
Publication of ATE454160T1 publication Critical patent/ATE454160T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/585—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
AT02732030T 2001-06-04 2002-06-04 Monodisperse gemische aus calcitonin-arzneimittel-oligomer-konjugaten mit polyethylenglycol, ihre verwendung und verfahren zu ihrer herstellung ATE454160T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/873,777 US6713452B2 (en) 2001-06-04 2001-06-04 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
PCT/US2002/017575 WO2002098451A1 (en) 2001-06-04 2002-06-04 Mixtures of calcitonin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same

Publications (1)

Publication Number Publication Date
ATE454160T1 true ATE454160T1 (de) 2010-01-15

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
AT02732030T ATE454160T1 (de) 2001-06-04 2002-06-04 Monodisperse gemische aus calcitonin-arzneimittel-oligomer-konjugaten mit polyethylenglycol, ihre verwendung und verfahren zu ihrer herstellung

Country Status (13)

Country Link
US (2) US6713452B2 (de)
EP (1) EP1404360B1 (de)
JP (1) JP4272510B2 (de)
KR (1) KR100930606B1 (de)
CN (1) CN100515492C (de)
AT (1) ATE454160T1 (de)
CA (1) CA2449686A1 (de)
CY (1) CY1109932T1 (de)
DE (1) DE60235010D1 (de)
DK (1) DK1404360T3 (de)
ES (1) ES2339224T3 (de)
MX (1) MXPA03011283A (de)
WO (1) WO2002098451A1 (de)

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KR20040004694A (ko) 2004-01-13
JP2004534782A (ja) 2004-11-18
KR100930606B1 (ko) 2009-12-09
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US20030060606A1 (en) 2003-03-27
US20040180831A1 (en) 2004-09-16
JP4272510B2 (ja) 2009-06-03
CN100515492C (zh) 2009-07-22
CA2449686A1 (en) 2002-12-12
DE60235010D1 (de) 2010-02-25
DK1404360T3 (da) 2010-05-03
MXPA03011283A (es) 2004-03-26
CY1109932T1 (el) 2014-09-10
EP1404360B1 (de) 2010-01-06
EP1404360A4 (de) 2006-04-12
EP1404360A1 (de) 2004-04-07
ES2339224T3 (es) 2010-05-18
US6713452B2 (en) 2004-03-30
US7084121B2 (en) 2006-08-01

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