ATE446678T1 - Zusammensetzungen von zu schnellem wachstum fähigen, restriktierten zellen, die proliferation unterdrückende materialien produzieren und ihre verwendung - Google Patents

Zusammensetzungen von zu schnellem wachstum fähigen, restriktierten zellen, die proliferation unterdrückende materialien produzieren und ihre verwendung

Info

Publication number
ATE446678T1
ATE446678T1 AT99971668T AT99971668T ATE446678T1 AT E446678 T1 ATE446678 T1 AT E446678T1 AT 99971668 T AT99971668 T AT 99971668T AT 99971668 T AT99971668 T AT 99971668T AT E446678 T1 ATE446678 T1 AT E446678T1
Authority
AT
Austria
Prior art keywords
compositions
growing
rapid
restricted cells
suppressing materials
Prior art date
Application number
AT99971668T
Other languages
English (en)
Inventor
Shirin Asina
Kanti Jain
Albert Rubin
Barry Smith
Kurt Stenzel
Original Assignee
Rogosin Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rogosin Inst filed Critical Rogosin Inst
Application granted granted Critical
Publication of ATE446678T1 publication Critical patent/ATE446678T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/13—Tumour cells, irrespective of tissue of origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0693—Tumour cells; Cancer cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Dispersion Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
AT99971668T 1998-11-09 1999-11-09 Zusammensetzungen von zu schnellem wachstum fähigen, restriktierten zellen, die proliferation unterdrückende materialien produzieren und ihre verwendung ATE446678T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/188,476 US6224912B1 (en) 1996-04-03 1998-11-09 Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
PCT/US1999/026413 WO2000027207A1 (en) 1998-11-09 1999-11-09 Compositions of restricted cells capable of rapid growth which produce proliferation suppressive materials, and uses thereof

Publications (1)

Publication Number Publication Date
ATE446678T1 true ATE446678T1 (de) 2009-11-15

Family

ID=22693322

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99971668T ATE446678T1 (de) 1998-11-09 1999-11-09 Zusammensetzungen von zu schnellem wachstum fähigen, restriktierten zellen, die proliferation unterdrückende materialien produzieren und ihre verwendung

Country Status (19)

Country Link
US (4) US6224912B1 (de)
EP (1) EP1128731B1 (de)
JP (2) JP4294223B2 (de)
KR (3) KR20050055797A (de)
CN (1) CN1325271A (de)
AT (1) ATE446678T1 (de)
AU (1) AU769411B2 (de)
CA (1) CA2334483C (de)
DE (1) DE69941599D1 (de)
DK (1) DK1128731T3 (de)
EG (1) EG24212A (de)
ES (1) ES2335723T3 (de)
HK (1) HK1039439A1 (de)
IL (3) IL139704A0 (de)
NO (2) NO20012152L (de)
NZ (1) NZ511220A (de)
PT (1) PT1128731E (de)
RU (2) RU2236855C2 (de)
WO (1) WO2000027207A1 (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE39542E1 (en) * 1994-01-13 2007-04-03 The Rogosin Institute Preparation of agarose coated, solid agarose-collagen beads containing secretory cells
PT1418228E (pt) * 1994-01-13 2006-09-29 Rogosin Inst Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.
US7297331B2 (en) * 1996-04-03 2007-11-20 The Rogosin Institute Beads containing restricted cancer cells producing material suppressing cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment
US20050053586A1 (en) 2003-09-04 2005-03-10 Bryan Conn Entrapped stem cells and uses thereof
WO2006053052A2 (en) * 2004-11-11 2006-05-18 The Rogosin Institute Method for treating patients with implants of islets which have been kept in long term, in vitro culture
CA2622529C (en) * 2005-09-26 2014-02-18 Lawrence Gazda Secretory cell-containing macrobeads comprising seakem gold agarose, and uses thereof
WO2008149930A1 (ja) 2007-06-08 2008-12-11 Hamamatsu Photonics K.K. 分光モジュール
JP5094742B2 (ja) 2007-06-08 2012-12-12 浜松ホトニクス株式会社 分光器
EP2063239A4 (de) 2007-06-08 2013-12-25 Hamamatsu Photonics Kk Spektroskopisches modul
JP4891841B2 (ja) 2007-06-08 2012-03-07 浜松ホトニクス株式会社 分光モジュール
JP4891840B2 (ja) 2007-06-08 2012-03-07 浜松ホトニクス株式会社 分光モジュール
EP2075555A4 (de) 2007-06-08 2014-01-01 Hamamatsu Photonics Kk Spektroskopisches modul
JP4887221B2 (ja) 2007-06-08 2012-02-29 浜松ホトニクス株式会社 分光モジュール
MX2010001993A (es) 2007-08-23 2010-03-11 Intrexon Corp Metodos y composiciones para diagnosticar una enfermedad.
EP2205249B1 (de) 2007-09-28 2018-11-07 Intrexon Corporation Therapeutische genschalterkonstrukte und bioreaktoren zur expression biotherapeutischer moleküle und ihre verwendung
EP2801802A1 (de) 2008-03-04 2014-11-12 Hamamatsu Photonics K.K. Spektroskopiemodul
JP5207938B2 (ja) 2008-05-15 2013-06-12 浜松ホトニクス株式会社 分光モジュール及び分光モジュールの製造方法
JP5205240B2 (ja) 2008-05-15 2013-06-05 浜松ホトニクス株式会社 分光モジュールの製造方法及び分光モジュール
JP5415060B2 (ja) 2008-05-15 2014-02-12 浜松ホトニクス株式会社 分光モジュール
JP5205241B2 (ja) 2008-05-15 2013-06-05 浜松ホトニクス株式会社 分光モジュール
JP2009300418A (ja) 2008-05-15 2009-12-24 Hamamatsu Photonics Kk 分光モジュール
JP5512961B2 (ja) 2008-05-15 2014-06-04 浜松ホトニクス株式会社 分光モジュール及びその製造方法
JP5205238B2 (ja) 2008-05-15 2013-06-05 浜松ホトニクス株式会社 分光モジュール
EP2412800A1 (de) * 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Leberorganoid, Verwendungen davon und Kultivierungsverfahren zum Erhalten davon
US8572921B2 (en) * 2009-03-27 2013-11-05 Davinci Roofscapes, Llc One piece hip and ridge shingle
KR101853418B1 (ko) * 2010-06-16 2018-05-02 미네르바 바이오테크놀로지 코포레이션 암 세포의 역분화
JP2013533319A (ja) * 2010-08-12 2013-08-22 ヤンセン バイオテツク，インコーポレーテツド 膵内分泌腺前駆体細胞による糖尿病の治療
PL2777398T3 (pl) * 2010-11-23 2017-09-29 The Rogosin Institute, Inc. Sposób izolowania opornych na środek chemioterapeutyczny komórek rakowych o właściwościach komórek macierzystych
HUE034618T2 (en) 2012-01-31 2018-02-28 The Rogosin Inst Inc An improved process for producing macros
EP3403098B1 (de) 2016-01-12 2021-09-22 BioAtla, Inc. Diagnostika mit bedingt aktiven antikörpern
US10697972B2 (en) 2016-01-12 2020-06-30 Bioatla, Llc Diagnostics using conditionally active antibodies
KR200485213Y1 (ko) 2016-11-02 2017-12-07 고수한 높이 조절이 가능한 조립식평상
US20200363402A1 (en) * 2018-02-02 2020-11-19 Wake Forest University Health Sciences Organoids related to immunotherapy and methods of preparing and using the same

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3865689A (en) 1972-11-09 1975-02-11 Hoffmann La Roche Method of producing carcinoembryonic antigens
US4285930A (en) 1977-12-08 1981-08-25 Likhite Vilas V Antigens comprising immunostimulant adjuvants and their use in immunotherapy
US4409331A (en) 1979-03-28 1983-10-11 Damon Corporation Preparation of substances with encapsulated cells
US4391909A (en) 1979-03-28 1983-07-05 Damon Corporation Microcapsules containing viable tissue cells
US4352883A (en) 1979-03-28 1982-10-05 Damon Corporation Encapsulation of biological material
DE3032931C2 (de) 1980-09-02 1982-07-29 Robert Bürkle GmbH & Co, 7290 Freudenstadt Verfahren und Anordnung zur Herstellung von Mehrschicht-Leiterplatten
SE441009B (sv) 1982-03-08 1985-09-02 Kjell Nilsson Sett att immobilisera levande biomaterial i perlformiga polymerer
US4798786A (en) 1982-05-06 1989-01-17 Stolle Research And Development Corporation Living cells encapsulated in crosslinked protein
JPS5933223A (ja) 1982-08-20 1984-02-23 Koken Kk 人の悪性腫瘍細胞増殖抑制剤
CA1196862A (en) 1983-06-01 1985-11-19 Anthony M.F. Sun Microencapsulation of living tissue and cells
US4663286A (en) 1984-02-13 1987-05-05 Damon Biotech, Inc. Encapsulation of materials
US4680174A (en) 1984-05-24 1987-07-14 Damon Biotech, Inc. Induction of immune response by immunization with encapsulated antigen-producing cells
JPS6118721A (ja) 1984-07-06 1986-01-27 Kyowa Hakko Kogyo Co Ltd 新規抗腫瘍性物質
US4997443A (en) 1985-08-26 1991-03-05 Hana Biologics, Inc. Transplantable artificial tissue and process
US4902295A (en) 1985-08-26 1990-02-20 Hana Biologics, Inc. Transplantable artificial tissue
US5618715A (en) 1985-12-20 1997-04-08 Oncogen Limited Partnership Oncostatin M and novel compositions having anti-neoplastic activity
SE8604684L (sv) 1986-11-03 1988-05-04 Excorim Kommanditbolag Sett att belegga fasta partiklar med en hydrofil gel samt genom settet belagda partiklar
JPS6463395A (en) 1987-05-04 1989-03-09 Oncogen Oncostatin m and novel composition having antitumor activity
JPH0216994A (ja) 1988-07-05 1990-01-19 Nippon Mining Co Ltd 細胞増殖阻害因子及びその製造方法
US5053332A (en) 1989-07-24 1991-10-01 Cook Richard B Agarose beads, preferably incorporating biological materials
US5227298A (en) 1990-08-17 1993-07-13 The Trustees Of Columbia University In The City Of New York Method for microencapuslation of cells or tissue
US5800829A (en) 1991-04-25 1998-09-01 Brown University Research Foundation Methods for coextruding immunoisolatory implantable vehicles with a biocompatible jacket and a biocompatible matrix core
JP4215273B2 (ja) 1991-04-25 2009-01-28 ブラウン ユニヴァーシティ リサーチ ファンデーション 選択された治療物質放出用の移植可能で生体適合性の免疫遮断性ビークル
NZ250363A (en) * 1992-12-04 1996-11-26 Susanna Elizabeth Chalmers A topical dressing containing a dessicant and an antimicrobial or antiseptic agent
AU7568094A (en) 1993-08-12 1995-03-14 Cytotherapeutics, Inc. Improved compositions and methods for the delivery of biologically active molecules using genetically altered cells contained in biocompatible immunoisolatory capsules
PT1418228E (pt) * 1994-01-13 2006-09-29 Rogosin Inst Processo de preparacao de uma biblioteca multicombinatoria de vectores de expressao de genes de anticorpos.
ES2125630T3 (es) 1994-07-08 1999-03-01 Baxter Int Dispositivo implantable que contiene celulas tumorales, para el tratamiento del cancer.
DE69725317T2 (de) 1996-04-03 2004-07-29 The Rogosin Institute Implantierbare agarose-kollagenkügelchen enthaltende zellen, die ein diffusionsfähiges biologisches produkt bilden und ihre verwendung
US5888497A (en) * 1996-04-03 1999-03-30 The Rogosin Institute Agarose coated agarose beads containing cancer cells that produce material which suppresses cancer cell proliferation
US6224912B1 (en) * 1996-04-03 2001-05-01 The Rogo Institute Cancer-cell proliferation-suppressing material produced by cancer cells restricted by entrapment

Also Published As

Publication number Publication date
US6818230B2 (en) 2004-11-16
KR20020013465A (ko) 2002-02-20
NO20101615L (no) 2001-07-05
KR20050055797A (ko) 2005-06-13
DK1128731T3 (da) 2010-01-25
RU2268735C1 (ru) 2006-01-27
IL139704A0 (en) 2002-02-10
NO20012152L (no) 2001-07-05
AU1472600A (en) 2000-05-29
CA2334483A1 (en) 2000-05-18
CA2334483C (en) 2012-01-10
US7041504B2 (en) 2006-05-09
EG24212A (en) 2008-10-28
IL139704A (en) 2006-12-31
NO20012152D0 (no) 2001-05-02
WO2000027207A1 (en) 2000-05-18
AU769411B2 (en) 2004-01-29
JP4294223B2 (ja) 2009-07-08
KR20040075922A (ko) 2004-08-30
US6224912B1 (en) 2001-05-01
US20030143739A1 (en) 2003-07-31
IL177967A (en) 2010-12-30
JP2002529060A (ja) 2002-09-10
EP1128731B1 (de) 2009-10-28
US6808705B2 (en) 2004-10-26
EP1128731A4 (de) 2003-06-04
RU2004115040A (ru) 2005-10-27
PT1128731E (pt) 2010-02-02
HK1039439A1 (zh) 2002-04-26
EP1128731A1 (de) 2001-09-05
CN1325271A (zh) 2001-12-05
ES2335723T3 (es) 2010-03-31
RU2236855C2 (ru) 2004-09-27
NZ511220A (en) 2003-12-19
JP2005343899A (ja) 2005-12-15
IL177967A0 (en) 2006-12-31
US20030143281A1 (en) 2003-07-31
WO2000027207A8 (en) 2000-09-21
US20020168415A1 (en) 2002-11-14
DE69941599D1 (de) 2009-12-10

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