ATE440593T1 - Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlíslichkeit - Google Patents

Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlíslichkeit

Info

Publication number
ATE440593T1
ATE440593T1 AT02737899T AT02737899T ATE440593T1 AT E440593 T1 ATE440593 T1 AT E440593T1 AT 02737899 T AT02737899 T AT 02737899T AT 02737899 T AT02737899 T AT 02737899T AT E440593 T1 ATE440593 T1 AT E440593T1
Authority
AT
Austria
Prior art keywords
biologically active
lipid particles
container
lipophilic
solubilizing
Prior art date
Application number
AT02737899T
Other languages
German (de)
English (en)
Inventor
Steve Leigh
Mathew Louis Steven Leigh
Hoogevest Peter Van
Henricus Tiemessen
Original Assignee
Phares Pharm Res Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phares Pharm Res Nv filed Critical Phares Pharm Res Nv
Application granted granted Critical
Publication of ATE440593T1 publication Critical patent/ATE440593T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
AT02737899T 2001-03-27 2002-03-26 Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlíslichkeit ATE440593T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01302841 2001-03-27
PCT/EP2002/003371 WO2002080883A2 (en) 2001-03-27 2002-03-26 Method and composition for solubilising a biologically active compound with low water solubility

Publications (1)

Publication Number Publication Date
ATE440593T1 true ATE440593T1 (de) 2009-09-15

Family

ID=8181836

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02737899T ATE440593T1 (de) 2001-03-27 2002-03-26 Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlíslichkeit

Country Status (11)

Country Link
US (2) US20040115255A1 (enExample)
EP (1) EP1389089B1 (enExample)
JP (3) JP2004524368A (enExample)
AT (1) ATE440593T1 (enExample)
AU (1) AU2002312777B2 (enExample)
CA (1) CA2442539C (enExample)
DE (1) DE60233484D1 (enExample)
DK (1) DK1389089T3 (enExample)
ES (1) ES2332584T3 (enExample)
PT (1) PT1389089E (enExample)
WO (1) WO2002080883A2 (enExample)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7444383B2 (en) 2000-06-17 2008-10-28 Microsoft Corporation Bounded-deferral policies for guiding the timing of alerting, interaction and communications using local sensory information
US6951656B2 (en) 2000-12-22 2005-10-04 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US6884436B2 (en) 2000-12-22 2005-04-26 Baxter International Inc. Method for preparing submicron particle suspensions
US6977085B2 (en) 2000-12-22 2005-12-20 Baxter International Inc. Method for preparing submicron suspensions with polymorph control
US8067032B2 (en) 2000-12-22 2011-11-29 Baxter International Inc. Method for preparing submicron particles of antineoplastic agents
US7193084B2 (en) 2000-12-22 2007-03-20 Baxter International Inc. Polymorphic form of itraconazole
US9700866B2 (en) 2000-12-22 2017-07-11 Baxter International Inc. Surfactant systems for delivery of organic compounds
US6607784B2 (en) 2000-12-22 2003-08-19 Baxter International Inc. Microprecipitation method for preparing submicron suspensions
US20060003012A9 (en) 2001-09-26 2006-01-05 Sean Brynjelsen Preparation of submicron solid particle suspensions by sonication of multiphase systems
AU2002337692B2 (en) 2001-09-26 2007-09-13 Baxter International Inc. Preparation of submicron sized nanoparticles via dispersion and solvent or liquid phase removal
US7112340B2 (en) 2001-10-19 2006-09-26 Baxter International Inc. Compositions of and method for preparing stable particles in a frozen aqueous matrix
DE10203923B4 (de) * 2002-01-31 2011-06-01 Klinipharm Gmbh Verfahren zur Erhöhung der Wasserlöslichkeit lipophiler Wirkstoffe, Herstellung von hochkonzentrierten wässrigen Zusammensetzungen dieser Wirkstoffe, derartige Produkte und ihre Verwendung
CA2539486A1 (en) * 2003-10-02 2005-04-07 Sembiosys Genetics Inc. Methods for preparing oil bodies comprising active ingredients
WO2005065677A1 (ja) * 2004-01-09 2005-07-21 Otsuka Pharmaceutical Factory, Inc. パクリタキセルまたはドセタキセルを溶解または分散させるための脂肪乳剤
US7345093B2 (en) 2004-04-27 2008-03-18 Formatech, Inc. Methods of enhancing solubility of compounds
US7659310B2 (en) 2004-04-27 2010-02-09 Formatech, Inc. Methods of enhancing solubility of agents
DK1748759T3 (da) * 2004-04-27 2013-04-22 Javeri Indu Fremgangsmåder til at forøge hydrofobe forbindelsers opløselighed i vand af ved micellære dispersioner
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
ES2372499T3 (es) 2004-05-19 2012-01-20 Los Angeles Biomedical Research Institute At Harbor-Ucla Medical Center Uso de un detergente para la eliminación no quirúrgica de grasa.
US20060127468A1 (en) 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
EP1809254A2 (en) * 2004-10-28 2007-07-25 Alza Corporation Lyophilized liposome formulations and method
JP4929158B2 (ja) * 2005-03-14 2012-05-09 株式会社大塚製薬工場 難水溶性薬物を含有する医薬組成物
JP5342834B2 (ja) * 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
US9572886B2 (en) 2005-12-22 2017-02-21 Nitto Denko Corporation Agent for treating myelofibrosis
KR101919093B1 (ko) * 2008-05-23 2018-11-16 더 유니버시티 오브 브리티쉬 콜롬비아 리포좀 나노입자에 사용하기 위한 변형된 약물
EP2344198B1 (en) * 2008-09-27 2020-11-04 Jina Pharmaceuticals Inc. Lipid based pharmaceutical preparations for topical application
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
US10143652B2 (en) 2009-09-23 2018-12-04 Curirx Inc. Methods for the preparation of liposomes
WO2011038068A1 (en) 2009-09-23 2011-03-31 Formatech, Inc. Methods for the preparation of liposomes
US20170340563A1 (en) * 2009-09-23 2017-11-30 Curirx Inc. Methods for the Preparation of Liposomes Comprising Drugs
CN101926757B (zh) 2010-09-01 2013-01-02 北京大学 一种难溶性药物的液体组合物及其制备方法
BR112013014291A2 (pt) * 2010-12-08 2016-09-20 Hoffmann La Roche formulação lipossômica de calcetrapib
CA2827643C (en) 2011-02-18 2019-05-07 Kythera Biopharmaceuticals, Inc. Treatment of submental fat
US8653058B2 (en) 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
WO2013176223A1 (ja) * 2012-05-23 2013-11-28 国立大学法人大阪大学 炎症性疾患治療用医薬組成物
EP2682106A1 (en) 2012-07-03 2014-01-08 Phares Pharmaceutical Research N.V. Method of solubilizing biologically active compounds
IL259246B2 (en) 2015-12-07 2024-11-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Compositions for oral administration comprising at least one cannabinoid, a method for the preparation thereof and use of same
IL266198B2 (en) 2016-10-28 2023-11-01 Servier Lab Liposomal formulation for use in cancer treatment
CA3063395A1 (en) * 2017-05-12 2018-11-15 Curinanorx, Llc Methods for the preparation of liposomes comprising drugs

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1202370B (it) * 1976-07-12 1989-02-09 Hoffmann La Roche Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti
EP0158441B2 (en) * 1984-03-08 2001-04-04 Phares Pharmaceutical Research N.V. Liposome-forming composition
MX9203808A (es) * 1987-03-05 1992-07-01 Liposome Co Inc Formulaciones de alto contenido de medicamento: lipido, de agentes liposomicos-antineoplasticos.
US5616334A (en) * 1987-03-05 1997-04-01 The Liposome Company, Inc. Low toxicity drug-lipid systems
CA1338702C (en) * 1987-03-05 1996-11-12 Lawrence D. Mayer High drug:lipid formulations of liposomal- antineoplastic agents
US5811119A (en) * 1987-05-19 1998-09-22 Board Of Regents, The University Of Texas Formulation and use of carotenoids in treatment of cancer
WO1989002265A1 (fr) * 1987-09-07 1989-03-23 Teijin Limited Emulsion grasse contenant un medicament, du type prepare immediatement avant l'utilisation, et procede de preparation d'une telle emulsion grasse contenant un medicament
IL91664A (en) * 1988-09-28 1993-05-13 Yissum Res Dev Co Ammonium transmembrane gradient system for efficient loading of liposomes with amphipathic drugs and their controlled release
US5741513A (en) * 1990-02-08 1998-04-21 A. Natterman & Cie. Gmbh Alcoholic aqueous gel-like phospholipid composition, its use and topical preparations containing it
US5091188A (en) * 1990-04-26 1992-02-25 Haynes Duncan H Phospholipid-coated microcrystals: injectable formulations of water-insoluble drugs
JP3533215B2 (ja) * 1990-07-31 2004-05-31 ザ リポソーム カンパニー，インコーポレイテッド アミノ酸及びペプチドのリポソーム内への蓄積
US5763413A (en) * 1993-03-04 1998-06-09 Mect Corporation Lewis-associated compound, process for producing the same, and anti-inflammatory
DE19609538A1 (de) * 1996-03-11 1997-09-18 Basf Ag Feinverteilte Carotinoid- und Retinoidsuspensionen und Verfahren zu ihrer Herstellung
DE69429511T2 (de) * 1993-05-21 2002-05-16 The Liposome Co., Inc. Reduzierung von durch liposome induzierte physiologischen gegenreaktionen
EP0633024A1 (en) * 1993-07-09 1995-01-11 Ciba-Geigy Ag Topically administrable zinc phthalocyanine compositions
US5415869A (en) * 1993-11-12 1995-05-16 The Research Foundation Of State University Of New York Taxol formulation
DE69503629T2 (de) * 1994-05-23 1998-11-26 B. Braun Medical Inc., Bethlehem, Pa. 18018 Vorrichtung zur herstellung einer formulierung
JP2740153B2 (ja) * 1995-03-07 1998-04-15 エフ・ホフマン−ラ ロシユ アーゲー 混合ミセル
US6447800B2 (en) * 1996-01-18 2002-09-10 The University Of British Columbia Method of loading preformed liposomes using ethanol
US6096336A (en) * 1996-01-30 2000-08-01 The Stehlin Foundation For Cancer Research Liposomal prodrugs comprising derivatives of camptothecin and methods of treating cancer using these prodrugs
US6056973A (en) * 1996-10-11 2000-05-02 Sequus Pharmaceuticals, Inc. Therapeutic liposome composition and method of preparation
EP0974364A4 (en) * 1996-10-25 2000-12-20 Yoshitomi Pharmaceutical METHOD FOR PREVENTING THE PREPARATION OF MEDICINAL PRODUCTS
ES2200144T3 (es) * 1996-12-13 2004-03-01 Vesifact Ag Preparaciones cosmeticas.
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
WO2000002534A1 (fr) * 1998-07-10 2000-01-20 Welfide Corporation Kit a preparer avant usage avec preparation contenant un medicament et solvant destine a cette fin
DE19843968A1 (de) * 1998-09-24 2000-04-13 Hans Dietl Taxane enthaltende pharmazeutische Zubereitung zur intravenösen Applikation und Verfahren zu ihrer Herstellung
US6682758B1 (en) * 1998-12-22 2004-01-27 The United States Of America As Represented By The Department Of Health And Human Services Water-insoluble drug delivery system
WO2000059473A1 (en) * 1999-04-01 2000-10-12 Inex Pharmaceuticals Corp. Compositions and methods for treating lymphoma
US20030144570A1 (en) * 1999-11-12 2003-07-31 Angiotech Pharmaceuticals, Inc. Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors
US20020001613A1 (en) * 2000-02-08 2002-01-03 Susan Niemiec Method of manufacturing liposomes

Also Published As

Publication number Publication date
CA2442539C (en) 2011-11-08
US20040115255A1 (en) 2004-06-17
CA2442539A1 (en) 2002-10-17
JP2004524368A (ja) 2004-08-12
DK1389089T3 (da) 2009-12-21
US20080131499A1 (en) 2008-06-05
EP1389089A2 (en) 2004-02-18
PT1389089E (pt) 2009-11-30
WO2002080883A2 (en) 2002-10-17
WO2002080883A3 (en) 2003-12-11
DE60233484D1 (de) 2009-10-08
JP2012207042A (ja) 2012-10-25
EP1389089B1 (en) 2009-08-26
ES2332584T3 (es) 2010-02-09
AU2002312777B2 (en) 2007-07-05
AU2002312777A2 (en) 2002-10-21
JP2010013461A (ja) 2010-01-21

Similar Documents

Publication Publication Date Title
DE60233484D1 (de) Verfahren und zusammensetzung zur solubilisierung einer biologisch wirksamen verbindung mit geringer wasserlöslichkeit
ATE260651T1 (de) Pharmazeutische ciclosporin-formulierung mit verbesserten biopharmazeutischen eigenschaften, erhöhter physikalischer qualität & stabilität sowie verfahren zur herstellung
US5736151A (en) Antibiotic oil suspensions
BR0011772A (pt) Conjugado de droga-oligÈmero, composição farmacêutica, método de solubilização de uma droga em uma microemulsão, e, métodos para fornecer um conjugado de droga ativa - hidrófilo e um conjugado de droga ativa - peg a um sìtio de um indivìduo
BR0116377A (pt) Métodos para preparar partìculas submicronicamente dimensionadas de um composto orgânico, e para preparar uma suspensão de um composto farmaceuticamente ativo, e, composição de matéria
HUT44168A (en) Process for production of composition assuring eventual homogene suspension of particles containing active substance
JP2003512341A5 (enExample)
FR2561916B1 (fr) Forme galenique pour administration orale et son procede de preparation par lyophilisation d'une emission huile dans eau
ATE307611T1 (de) Flüssiges hochvisköses system mit gesteuerter freisetzung und medizinische oder chirurgische vorrichtung
NO992068D0 (no) Mikroemulsjon og fremgangsmÕte for fremstilling av denne
EP1226109A4 (en) PHENYLAMINE CARBOXYLIC ACID COMPOUNDS AND COMPOSITIONS FOR DISPENSING ACTIVE AGENTS
DE602005022911D1 (de) Von thrombozyten stammende wachstumsfaktorzusammensetzungen und anwendungsverfahren dafür
DK1429731T3 (da) Nanopartikelformuleringer indeholdende insulin
BR0307278A (pt) Formulação oral de liberação imediata, e, método para preparar uma formulação
DE602004019777D1 (de) STABILE PHARMAZEUTISCHE ZUBEREITUNGEN MIT 2-AZA-BICYCLOi3.3.0 -OCTAN-3-CARBOXYLSÄURE-DERIVATEN
CA2463681A1 (en) Ready-to-use paracetamol injection solutions containing propylene glycol as the only cosolvent
HRP20040882B1 (hr) Stabilni farmaceutski pripravak koji sadrži faktor viii
ID27765A (id) Plester gel yang mengandung steroid dan proses pembuatannya
DE69414521D1 (de) Verfahren zur herstellung von iodierten biopolymeren mit desinfizierender und vernarbungsfördernder wirkung und darnach hergestellte iodierte biopolymeren
CA2452395A1 (en) Pharmaceutically stable hemostatic compositions
HUP9603489A2 (hu) Gyógyszerkészítmény és eljárás előállítására
ATE352287T1 (de) Flüssige pharmazeutische zusammensetzungen auf wasserbasis in suspensionsform zur oralen verabreichung von ibuprofen
DE69229857D1 (de) Zusammensetzung zur verwendung in der transdermalen verabreichung
ATE358507T1 (de) Herstellung von dialysekonzentrat aus einer hochverdichteten konzentratvorstufe und vorrichtung zur anwendung am dialyseplatz.
ATE298567T1 (de) Pharmazeutische zusammensetzung enthaltend ibuprofen und ein verfahren zur deren herstellung

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties