ATE429488T1 - Verfahren zur stabilisierung von alkalischer phosphatase - Google Patents
Verfahren zur stabilisierung von alkalischer phosphataseInfo
- Publication number
- ATE429488T1 ATE429488T1 AT02738901T AT02738901T ATE429488T1 AT E429488 T1 ATE429488 T1 AT E429488T1 AT 02738901 T AT02738901 T AT 02738901T AT 02738901 T AT02738901 T AT 02738901T AT E429488 T1 ATE429488 T1 AT E429488T1
- Authority
- AT
- Austria
- Prior art keywords
- alkaline phosphatase
- preparation
- stabilizing
- freeze
- stabilizing alkaline
- Prior art date
Links
- 102000002260 Alkaline Phosphatase Human genes 0.000 title abstract 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000000087 stabilizing effect Effects 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 abstract 3
- 102000009027 Albumins Human genes 0.000 abstract 1
- 108010088751 Albumins Proteins 0.000 abstract 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 229930091371 Fructose Natural products 0.000 abstract 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 abstract 1
- 239000005715 Fructose Substances 0.000 abstract 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 229930182830 galactose Natural products 0.000 abstract 1
- 239000008101 lactose Substances 0.000 abstract 1
- 230000007774 longterm Effects 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicinal Preparation (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001200612 | 2001-07-02 | ||
| PCT/JP2002/006673 WO2003004633A1 (fr) | 2001-07-02 | 2002-07-02 | Procede de stabilisation de la phosphatase alcaline |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE429488T1 true ATE429488T1 (de) | 2009-05-15 |
Family
ID=19037707
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT02738901T ATE429488T1 (de) | 2001-07-02 | 2002-07-02 | Verfahren zur stabilisierung von alkalischer phosphatase |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20040197885A1 (de) |
| EP (1) | EP1418229B1 (de) |
| JP (1) | JP4169344B2 (de) |
| CN (1) | CN1306029C (de) |
| AT (1) | ATE429488T1 (de) |
| DE (1) | DE60232080D1 (de) |
| ES (1) | ES2322132T3 (de) |
| WO (1) | WO2003004633A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008501639A (ja) * | 2004-04-23 | 2008-01-24 | ノベシン リミテッド | タンパク質を安定化、保護及び可溶化させるための方法及びキット |
| US8158152B2 (en) * | 2005-11-18 | 2012-04-17 | Scidose Llc | Lyophilization process and products obtained thereby |
| CN102109430B (zh) | 2009-12-25 | 2013-11-06 | 深圳迈瑞生物医疗电子股份有限公司 | 有核红细胞模拟粒子，血液质控物及其制备方法和用途 |
| CN102115737B (zh) * | 2009-12-31 | 2015-06-03 | 深圳迈瑞生物医疗电子股份有限公司 | 稳定碱性磷酸酶或其标记物的试剂和方法 |
| CN102269761A (zh) | 2010-06-04 | 2011-12-07 | 深圳迈瑞生物医疗电子股份有限公司 | 一种碱性磷酸酶结合物的合成工艺 |
| CN102269762B (zh) | 2010-06-04 | 2014-12-10 | 深圳迈瑞生物医疗电子股份有限公司 | 结合物的制备方法及相关试剂盒 |
| US9994827B2 (en) | 2012-01-13 | 2018-06-12 | Toyobo Co., Ltd. | Method for producing fructosyl valyl histidine oxidase preparation |
| CN102628863B (zh) * | 2012-04-19 | 2016-05-11 | 上海蓝怡科技有限公司 | 标记了碱性磷酸酶抗原抗体稀释液 |
| CN102636639A (zh) * | 2012-04-19 | 2012-08-15 | 上海蓝怡科技有限公司 | 碱性磷酸酶标记物的稀释液 |
| JP6520153B2 (ja) * | 2015-01-29 | 2019-05-29 | 東ソー株式会社 | 酵素結合小分子の製造方法 |
| CN109900900B (zh) * | 2019-04-18 | 2022-02-01 | 珠海丽珠试剂股份有限公司 | 一种适用于碱性磷酸酶标记降钙素原抗原或抗体的稀释液及其试剂盒 |
| CN112680502A (zh) * | 2020-12-07 | 2021-04-20 | 郑州标源生物科技有限公司 | 一种碱性磷酸酶质控物及其制备方法 |
| CN117050969B (zh) * | 2023-08-18 | 2024-04-02 | 北京中检葆泰生物技术有限公司 | 一种碱性磷酸酶的制备方法 |
| WO2025252914A1 (en) | 2024-06-06 | 2025-12-11 | Roche Diagnostics Gmbh | Protection of sh-group containing polypeptides against inactivation by isothiazolinone type compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK159276C (da) * | 1980-03-31 | 1991-02-18 | Takeda Chemical Industries Ltd | Fremgangsmaade til isolering af specifikke antistoffer og enzym-immunbestemmelsesmetode med anvendelse af det isolerede antistof |
| AU650045B2 (en) * | 1990-09-12 | 1994-06-09 | Lifecell Corporation | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions |
| JP3140797B2 (ja) * | 1991-04-26 | 2001-03-05 | 生化学工業株式会社 | 安定化コンドロイチナーゼａｂｃ、その保存方法及び治療剤 |
| JPH06284885A (ja) * | 1993-04-02 | 1994-10-11 | Tosoh Corp | 組換えヒト小腸アルカリフォスファタ−ゼ |
| US5955448A (en) * | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| WO1996003034A1 (en) * | 1994-07-27 | 1996-02-08 | Massachusetts Institute Of Technology | Method for retroviral vector insertion in fish |
| JPH08131171A (ja) * | 1994-11-11 | 1996-05-28 | Asahi Chem Ind Co Ltd | 逆転写酵素の安定化組成物 |
| JP3219181B2 (ja) * | 1995-01-10 | 2001-10-15 | 東洋紡績株式会社 | コレステロールオキシダーゼの安定化法 |
| JPH08228774A (ja) * | 1995-02-27 | 1996-09-10 | Toagosei Co Ltd | ペルオキシダーゼまたはペルオキシダーゼ標識抗体の安定化方法 |
| US5876992A (en) * | 1996-07-03 | 1999-03-02 | Molecular Biology Resources, Inc. | Method and formulation for stabilization of enzymes |
| GB9705588D0 (en) * | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
-
2002
- 2002-07-02 AT AT02738901T patent/ATE429488T1/de not_active IP Right Cessation
- 2002-07-02 JP JP2003510792A patent/JP4169344B2/ja not_active Expired - Lifetime
- 2002-07-02 EP EP02738901A patent/EP1418229B1/de not_active Expired - Lifetime
- 2002-07-02 WO PCT/JP2002/006673 patent/WO2003004633A1/ja not_active Ceased
- 2002-07-02 DE DE60232080T patent/DE60232080D1/de not_active Expired - Lifetime
- 2002-07-02 US US10/482,704 patent/US20040197885A1/en not_active Abandoned
- 2002-07-02 ES ES02738901T patent/ES2322132T3/es not_active Expired - Lifetime
- 2002-07-02 CN CNB028132696A patent/CN1306029C/zh not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1418229B1 (de) | 2009-04-22 |
| CN1522298A (zh) | 2004-08-18 |
| DE60232080D1 (de) | 2009-06-04 |
| CN1306029C (zh) | 2007-03-21 |
| JP4169344B2 (ja) | 2008-10-22 |
| WO2003004633A1 (fr) | 2003-01-16 |
| ES2322132T3 (es) | 2009-06-17 |
| US20040197885A1 (en) | 2004-10-07 |
| EP1418229A4 (de) | 2005-04-27 |
| JPWO2003004633A1 (ja) | 2004-10-28 |
| EP1418229A1 (de) | 2004-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |