DE3881281D1 - Stabilisierter attenuierter lebender impfstoff und seine herstellung. - Google Patents

Stabilisierter attenuierter lebender impfstoff und seine herstellung.

Info

Publication number
DE3881281D1
DE3881281D1 DE8888305166T DE3881281T DE3881281D1 DE 3881281 D1 DE3881281 D1 DE 3881281D1 DE 8888305166 T DE8888305166 T DE 8888305166T DE 3881281 T DE3881281 T DE 3881281T DE 3881281 D1 DE3881281 D1 DE 3881281D1
Authority
DE
Germany
Prior art keywords
stabilized
production
living vaccine
attenuated living
vaccine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8888305166T
Other languages
English (en)
Other versions
DE3881281T2 (de
Inventor
Satoshi Makino
Keiko Sasaki
Masaharu Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kitasato Institute
Original Assignee
Kitasato Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kitasato Institute filed Critical Kitasato Institute
Application granted granted Critical
Publication of DE3881281D1 publication Critical patent/DE3881281D1/de
Publication of DE3881281T2 publication Critical patent/DE3881281T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/20—Rubella virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
    • C12N2760/18734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
DE8888305166T 1987-06-08 1988-06-07 Stabilisierter attenuierter lebender impfstoff und seine herstellung. Expired - Fee Related DE3881281T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62142465A JPS63307827A (ja) 1987-06-08 1987-06-08 安定化された生ウイルスワクチンおよびその製造法

Publications (2)

Publication Number Publication Date
DE3881281D1 true DE3881281D1 (de) 1993-07-01
DE3881281T2 DE3881281T2 (de) 1993-09-09

Family

ID=15315947

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8888305166T Expired - Fee Related DE3881281T2 (de) 1987-06-08 1988-06-07 Stabilisierter attenuierter lebender impfstoff und seine herstellung.

Country Status (8)

Country Link
US (1) US4985244A (de)
EP (1) EP0295043B1 (de)
JP (1) JPS63307827A (de)
KR (1) KR910009346B1 (de)
AT (1) ATE89742T1 (de)
BE (1) BE1001533A3 (de)
DE (1) DE3881281T2 (de)
ES (1) ES2041796T3 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3045581B2 (ja) * 1991-10-14 2000-05-29 社団法人北里研究所 麻疹ワクチンウイルス株同定方法
CA2075521C (en) * 1992-05-05 1995-11-28 Kuniaki Koyama Stabilized live vaccine
EP0736089A4 (de) * 1993-12-21 1999-08-11 Merck & Co Inc Thermostabiler varicella zoster virus
JP2000507963A (ja) * 1996-12-20 2000-06-27 メルク エンド カンパニー インコーポレーテッド 凍結乾燥ワクチン用安定剤
US6290967B1 (en) * 1996-12-20 2001-09-18 Merck & Co., Inc. Stabilizers for lyophilized vaccines
US6051238A (en) * 1996-12-20 2000-04-18 Merck & Co., Inc. Stabilizers for lyophilized mumps vaccines
US6210683B1 (en) 1997-09-05 2001-04-03 Merck & Co., Inc. Stabilizers containing recombinant human serum albumin for live virus vaccines
GB9808922D0 (en) 1998-04-24 1998-06-24 Cantab Pharmaceuticals Res Ltd Virus preparations
US6586411B1 (en) * 2000-08-16 2003-07-01 Mayo Foundation For Medical Education And Research System for monitoring the location of transgenes
US6896881B1 (en) 1999-09-24 2005-05-24 Mayo Foundation For Medical Education And Research Therapeutic methods and compositions using viruses of the recombinant paramyxoviridae family
EP1232262B1 (de) * 1999-11-12 2008-08-20 Fibrogen, Inc. Rekombinantes gelatin in impstoffen
GB9930882D0 (en) * 1999-12-30 2000-02-23 Nps Allelix Corp GLP-2 formulations
RU2158134C1 (ru) * 2000-03-10 2000-10-27 Унитарное Государственное "Московское Предприятие По Производству Бактерийных Препаратов" Способ получения ассоциированной паротитно-коревой вакцины
US7118740B1 (en) * 2000-09-22 2006-10-10 Mayo Foundation For Medical Education And Research Method for limiting the growth of cancer cells using an attenuated measles virus
US20060141483A1 (en) * 2004-12-23 2006-06-29 Calton Gary J Stabilization of viral compositions
US9951117B2 (en) 2010-09-02 2018-04-24 Mayo Foundation For Medical Education And Research Vesicular stomatitis viruses
KR101911964B1 (ko) 2010-09-02 2018-10-25 메이오 파운데이션 포 메디칼 에쥬케이션 앤드 리써치 수포성 구내염 바이러스
EP2895191B1 (de) 2012-09-14 2019-06-05 The U.S.A. as represented by the Secretary, Department of Health and Human Services Brachyury-protein, adenovirale vektoren zur codierung von brachyury-protein und deren verwendung
CN103599530B (zh) * 2013-10-30 2015-04-22 天津津斯特疫苗有限责任公司 一种用无血清培养基制备风疹减毒活疫苗的方法
US10532093B2 (en) * 2014-07-18 2020-01-14 Mds Wellcome Trust Hilleman Laboratories Pvt. Ltd. Thermostable freeze dried rotavirus vaccine formulation and process to prepare thereof
BR112017013009A2 (pt) * 2014-12-18 2018-06-26 Amgen Inc formulação de vírus herpes simplex congelada estável
JP7048482B2 (ja) 2015-08-03 2022-04-05 アメリカ合衆国 Ｂｒａｃｈｙｕｒｙ欠失変異体、Ｂｒａｃｈｙｕｒｙ欠失変異体をコードする非酵母ベクター、及びそれらの使用
US20210187100A1 (en) * 2018-09-06 2021-06-24 Bavarian Nordic A/S Storage Improved Poxvirus Compositions

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2424031A1 (fr) * 1978-04-24 1979-11-23 Merck & Co Inc Stabilisateur de vaccin
PT71926B (en) * 1979-10-29 1982-03-31 Merck & Co Inc Process for preparing a liquid vaccine comprising a stabilizer
US4337242A (en) * 1980-02-05 1982-06-29 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
US4338335A (en) * 1980-02-05 1982-07-06 Merck & Co., Inc. Vaccine stabilizer containing L-glutamic acid and L-arginine
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
DE3601922A1 (de) * 1986-01-23 1987-07-30 Behringwerke Ag Stabilisiertes virus-antigen, verfahren zu seiner herstellung und seine verwendung

Also Published As

Publication number Publication date
ATE89742T1 (de) 1993-06-15
DE3881281T2 (de) 1993-09-09
JPS63307827A (ja) 1988-12-15
ES2041796T3 (es) 1993-12-01
EP0295043B1 (de) 1993-05-26
KR910009346B1 (ko) 1991-11-12
BE1001533A3 (fr) 1989-11-21
KR890000107A (ko) 1989-03-11
US4985244A (en) 1991-01-15
EP0295043A3 (en) 1989-07-26
EP0295043A2 (de) 1988-12-14

Similar Documents

Publication Publication Date Title
DE3881281T2 (de) Stabilisierter attenuierter lebender impfstoff und seine herstellung.
ATE272394T1 (de) Zubereitung mit verzögerter freisetzung
DK0529584T3 (da) Viralt agens forbundet med "Mystery Swine Disease"
DK0442671T3 (da) Mikrokapsler med forlænget frigivelse
FI873672A0 (fi) Kompositioner innehaollande l-3,4-dihydroxifenylalanin.
DK0472327T3 (da) Præparat på form af øjendråber
DE58900183D1 (de) Ifosfamid-mesna-lyophilisat und verfahren zu dessen herstellung.
FI923347A0 (fi) Blodfaktorer producerade med rekombinant-dna-teknik och foerfarande foer expression av naemnda blodfaktorer samt i naemnda foerfarande anvaenda rekombinanta kokoppvirus.
DK0414007T3 (da) Hidtil ukendt arginindeiminase, dens fremstillingsmetode og et anti-cancermiddel indeholdende dette enzym som en effektiv ingrediens
ATE223235T1 (de) Chitosan induzierte verstärkung
DE69015305D1 (de) Stabile immunogene Zusammensetzung.
PT89055A (pt) Processo para a preparacao de um sistema de administracao de libertacao sustida para bloqueadores de canal de calcio a base de di-hidropiridinas substituidas
DE69216732T2 (de) Impfstoff gegen den Geflügelanämieerreger
ATE121420T1 (de) Verfahren zur herstellung von 3-(l-pyroglutamyl)- l-thiazolidin-4-carbonsäure-derivaten.
NO883520L (no) Fremgangsmaate for fremstilling av et injeksjonspreparat.
NO176163C (no) Fremgangsmåte for fremstilling av en levende herpesvirusvaksine
NZ228232A (en) Live combined vaccine comprising at least one live infectious bronchitis virus and at least one other virus infectious to poultry
ES2067302T3 (es) Suspension a base de acido alginico.
ATE53205T1 (de) Methioninsubstituierte 1,4-dihydropyridine, verfahren zur herstellung und ihre verwendung.
KR920021163A (ko) 비-자극성 백신 조성물
IT1223171B (it) Procedimento per la preparazione di un ceppo mutante migliorato di bordetella bronchiseptica utile per un vaccino attenuato vivo per la protezione da infezioni di b. bronchiseptica e vaccino ar vivo attenuato cosi' ottenuto
DE59304579D1 (de) Verfahren zur Herstellung von 1,3-Dialkyl-5-hydroxyoxindolen und deren Etherderivaten
ATE96029T1 (de) Zusammensetzung und verfahren zur behandlung von hepatitisvirusinfektionen unter verwendung von 1(2'-deoxy-2'-fluoro-beta-d-arabinofuranosyl)-5- ethyluracil.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee