KR920021163A - 비-자극성 백신 조성물 - Google Patents

비-자극성 백신 조성물 Download PDF

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Publication number
KR920021163A
KR920021163A KR1019920008517A KR920008517A KR920021163A KR 920021163 A KR920021163 A KR 920021163A KR 1019920008517 A KR1019920008517 A KR 1019920008517A KR 920008517 A KR920008517 A KR 920008517A KR 920021163 A KR920021163 A KR 920021163A
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KR
South Korea
Prior art keywords
virus
composition
mumps
measles
rubella
Prior art date
Application number
KR1019920008517A
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English (en)
Inventor
제이. 프로보스트 필립
알. 날린 데이비드
Original Assignee
제임스 에프.노턴
머크 앤드 캄파니, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by 제임스 에프.노턴, 머크 앤드 캄파니, 인코포레이티드 filed Critical 제임스 에프.노턴
Publication of KR920021163A publication Critical patent/KR920021163A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0015—Combination vaccines based on measles-mumps-rubella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
    • A61K39/165—Mumps or measles virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/20—Rubella virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
    • C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/18011—Paramyxoviridae
    • C12N2760/18711—Rubulavirus, e.g. mumps virus, parainfluenza 2,4
    • C12N2760/18734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36211—Rubivirus, e.g. rubella virus
    • C12N2770/36234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Inorganic Chemistry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음.

Description

비-자극성 백신 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 약화시킨 생 홍역 바이러스, 유행성이하선염 바이러스 및 풍진 바이러스; 안정화제; 및 pH를 약 6.0 내지 7.0으로 유지시키되, 투여시 자극하지 않을 정도의 ℓ당 약 0.005 내지 약 0.75몰의 완충 인산염을 포함하는 백신 조성물.
  2. 제1항에 있어서, 최종 인산염 농도가 ℓ당 약 0. 0075몰인 조성물.
  3. 제2항에 있어서, 1000TDID50이상의 흥역 및 풍진 바이러스 및 20,000TCID50이상의 유행성이하선염 바이러스를 포함하는 조성물.
  4. 제2항에 있어서, 풍진 바이러스가 5%이고, 홍역 바이러스가 10%이며 유행선이하선염 바이러스가 10%인 조성물.
  5. 제1항 내지 제4항중 어느 한 항에 있어서, 동결건조된 형태의 조성물.
  6. 홍역, 유행성이하선염 또는 풍진 바이러스 감염중 하나이상에 의해 야기되는 질병을 예방하기 위해 사람에게 예방 접종하기 위한 제1항의 조성물을 투여 부위에 최소의 자극이 발생하도록 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920008517A 1991-05-17 1992-05-18 비-자극성 백신 조성물 KR920021163A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70191891A 1991-05-17 1991-05-17
US07/701,918 1991-05-17

Publications (1)

Publication Number Publication Date
KR920021163A true KR920021163A (ko) 1992-12-18

Family

ID=24819190

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920008517A KR920021163A (ko) 1991-05-17 1992-05-18 비-자극성 백신 조성물

Country Status (12)

Country Link
EP (1) EP0514208A1 (ko)
JP (1) JPH05221876A (ko)
KR (1) KR920021163A (ko)
CN (1) CN1068268A (ko)
AU (1) AU1633092A (ko)
CA (1) CA2068742A1 (ko)
IE (1) IE921577A1 (ko)
IL (1) IL101890A0 (ko)
LT (1) LTIP461A (ko)
MX (1) MX9202293A (ko)
WO (1) WO1992020375A1 (ko)
ZA (1) ZA923548B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2657801C1 (ru) * 2016-12-22 2018-06-15 Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации (ФГУП "НПО "Микроген" Минздрава России) Комбинированная вакцина для иммунопрофилактики кори, эпидемического паротита и краснухи
TR202016134A2 (tr) * 2020-10-09 2022-04-21 Miracle Labs Ilac Sanayi Ve Ticaret Anonim Sirketi Covi̇d-19 vi̇rüs aşisi

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT71926B (en) * 1979-10-29 1982-03-31 Merck & Co Inc Process for preparing a liquid vaccine comprising a stabilizer
FR2505657A1 (fr) * 1981-05-13 1982-11-19 Pasteur Institut Perfectionnements apportes aux agents de stabilisation de virus vivants pour la preparation de vaccins, et vaccins stabilises contenant lesdits agents de stabilisation
ZA874625B (en) * 1986-06-30 1988-10-26 Smith Kline Rit Stabilizers for live vaccines,process for their preparation and vaccines containing them

Also Published As

Publication number Publication date
CA2068742A1 (en) 1992-11-18
CN1068268A (zh) 1993-01-27
JPH05221876A (ja) 1993-08-31
ZA923548B (en) 1992-12-30
WO1992020375A1 (en) 1992-11-26
IL101890A0 (en) 1992-12-30
LTIP461A (en) 1994-10-25
IE921577A1 (en) 1992-11-18
MX9202293A (es) 1992-11-01
AU1633092A (en) 1992-11-19
EP0514208A1 (en) 1992-11-19

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