ATE419353T1 - Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten - Google Patents

Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten

Info

Publication number
ATE419353T1
ATE419353T1 AT06026306T AT06026306T ATE419353T1 AT E419353 T1 ATE419353 T1 AT E419353T1 AT 06026306 T AT06026306 T AT 06026306T AT 06026306 T AT06026306 T AT 06026306T AT E419353 T1 ATE419353 T1 AT E419353T1
Authority
AT
Austria
Prior art keywords
vertebrates
immunological compositions
modulating myostatin
myostatin
modulating
Prior art date
Application number
AT06026306T
Other languages
English (en)
Inventor
Christopher A Barker
Mohamad Morsey
Original Assignee
Metamorphix International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metamorphix International Inc filed Critical Metamorphix International Inc
Application granted granted Critical
Publication of ATE419353T1 publication Critical patent/ATE419353T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Transplantation (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT06026306T 1998-02-19 1999-02-19 Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten ATE419353T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7521398P 1998-02-19 1998-02-19

Publications (1)

Publication Number Publication Date
ATE419353T1 true ATE419353T1 (de) 2009-01-15

Family

ID=22124285

Family Applications (2)

Application Number Title Priority Date Filing Date
AT06026306T ATE419353T1 (de) 1998-02-19 1999-02-19 Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten
AT99904660T ATE352619T1 (de) 1998-02-19 1999-02-19 Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT99904660T ATE352619T1 (de) 1998-02-19 1999-02-19 Immunologische zusammensetzungen zur modulierung von myostatin in vertebraten

Country Status (18)

Country Link
US (2) US6369201B1 (de)
EP (3) EP1056845B1 (de)
JP (1) JP2002504326A (de)
KR (1) KR20010041111A (de)
AR (1) AR019818A1 (de)
AT (2) ATE419353T1 (de)
AU (1) AU765014B2 (de)
BR (1) BR9907995A (de)
CA (2) CA2687533C (de)
CY (2) CY1108074T1 (de)
DE (2) DE69940230D1 (de)
DK (2) DK1770162T3 (de)
ES (3) ES2280115T3 (de)
IL (1) IL137831A0 (de)
NZ (1) NZ506911A (de)
PT (2) PT1770162E (de)
WO (1) WO1999042573A1 (de)
ZA (1) ZA991369B (de)

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US7566768B1 (en) * 1995-10-26 2009-07-28 The Johns Hopkins University School Of Medicine Promyostatin peptides and methods of using same
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US7332575B2 (en) 1994-03-18 2008-02-19 The Johns Hopkins University School Of Medicine Growth differentiation factor-8 nucleic acid and polypeptide from aquatic species, and transgenic aquatic species
MXPA01007366A (es) * 1999-01-21 2002-06-04 Metamorphix Inc Inhibidores de factores de crecimiento y diferenciacion y usos de los mismos.
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US7037501B2 (en) * 2001-01-04 2006-05-02 Regents Of The University Of Minnesota Myostatin immnoconjugate
TW200526779A (en) * 2001-02-08 2005-08-16 Wyeth Corp Modified and stabilized GDF propeptides and uses thereof
US7320789B2 (en) 2001-09-26 2008-01-22 Wyeth Antibody inhibitors of GDF-8 and uses thereof
KR20040094709A (ko) * 2002-02-21 2004-11-10 와이어쓰 폴리스타틴 도메인을 포함하는 단백질
PL374966A1 (en) * 2002-02-21 2005-11-14 Wyeth Follistatin domain containing proteins
AU2003267246A1 (en) * 2002-09-16 2004-04-30 The Johns Hopkins University Metalloprotease activation of myostatin, and methods of modulating myostatin activity
US7261893B2 (en) 2002-10-22 2007-08-28 Wyeth Neutralizing antibodies against GDF-8 and uses therefor
US20040223966A1 (en) * 2002-10-25 2004-11-11 Wolfman Neil M. ActRIIB fusion polypeptides and uses therefor
EP2272864A3 (de) * 2002-12-20 2011-02-16 Amgen Inc. Bindende Wirkstoffe zum Hemmen von Myostatin
CN1829532A (zh) * 2003-06-02 2006-09-06 惠氏公司 肌肉抑制素（gdf8）抑制剂和皮质类固醇联合用于治疗神经肌肉紊乱的用途
SG153874A1 (en) * 2003-12-31 2009-07-29 Schering Plough Ltd Neutralizing epitope-based growth enhancing vaccine
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CA2575563A1 (en) * 2004-08-12 2006-02-23 Wyeth Combination therapy for diabetes, obesity, and cardiovascular diseases using gdf-8 inhibitors
ATE552272T1 (de) * 2004-09-30 2012-04-15 Orico Ltd Myostatin-isoform
US7432079B2 (en) * 2004-12-30 2008-10-07 Schering-Plough Animal Health Corporation Plant virus coat fusion proteins with GDF8 epitopes and vaccines thereof
NZ538097A (en) * 2005-02-07 2006-07-28 Ovita Ltd Method and compositions for improving wound healing
CN101137906A (zh) * 2005-03-23 2008-03-05 惠氏公司 对gdf-8调节剂的免疫应答的检测
CA2856436A1 (en) * 2005-12-06 2007-06-14 Amgen Inc. Uses of myostatin antagonists
JP2009545313A (ja) * 2006-08-03 2009-12-24 オリコ・リミテッド ミオスタチンアンタゴニスト
AU2013231037B2 (en) * 2006-08-03 2016-05-12 Myostin Therapeutics Pty Ltd Myostatin antagonists
WO2008030706A2 (en) 2006-09-05 2008-03-13 Eli Lilly And Company Anti-myostatin antibodies
US8501713B2 (en) 2007-08-03 2013-08-06 Summit Corporation Plc Drug combinations for the treatment of duchenne muscular dystrophy
GB0715087D0 (en) 2007-08-03 2007-09-12 Summit Corp Plc Drug combinations for the treatment of duchenne muscular dystrophy
KR100857861B1 (ko) * 2007-10-15 2008-09-11 주식회사 바이오리더스 Ｍｙｏ－２ 펩타이드 중합체와 마이오스타틴의 융합단백질표면발현용 벡터 및 상기 벡터로 형질전환된 미생물
EP3711771A1 (de) 2012-08-01 2020-09-23 Ikaika Therapeutics, LLC Abschwächung von gewebeverletzungen und fibrose mithilfe des latenten transformierenden wachstumsfaktor-beta-bindenden proteins (ltbp4)
CN104391628B (zh) * 2014-04-02 2018-02-23 贵阳朗玛信息技术股份有限公司 进程切换方法及装置
EP2960653A1 (de) * 2014-06-24 2015-12-30 Stichting Kwaliteitsgarantie Vleeskalversector Diagnosekit und Verfahren zur Identifizierung der Manipulation der Muskelmasse bei einem Haustier
US20220143136A1 (en) 2018-12-21 2022-05-12 Northwestern University Use of annexins in preventing and treating muscle membrane injury
US20220062299A1 (en) 2018-12-26 2022-03-03 Northwestern University Use of glucocorticoid steroids in preventing and treating conditions of muscle wasting, aging and metabolic disorder
CN113474013A (zh) 2019-03-01 2021-10-01 神户天然物化学株式会社 肌肉生长抑制素剪接变体衍生蛋白对肌肉生长抑制素信号的抑制及其利用

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Also Published As

Publication number Publication date
AR019818A1 (es) 2002-03-20
DK1056845T3 (da) 2007-05-29
IL137831A0 (en) 2001-10-31
DK1770162T3 (da) 2009-04-14
CA2687533C (en) 2016-02-02
EP1770162A1 (de) 2007-04-04
PT1056845E (pt) 2007-04-30
ATE352619T1 (de) 2007-02-15
DE69940230D1 (de) 2009-02-12
US6369201B1 (en) 2002-04-09
EP1056845B1 (de) 2007-01-24
ZA991369B (en) 1999-08-20
DE69934970D1 (de) 2007-03-15
AU765014B2 (en) 2003-09-04
JP2002504326A (ja) 2002-02-12
EP2018871A1 (de) 2009-01-28
CY1108074T1 (el) 2014-02-12
CY1108889T1 (el) 2014-07-02
EP1770162B1 (de) 2008-12-31
CA2323607C (en) 2009-12-22
EP2018871B1 (de) 2014-10-08
EP1056845A1 (de) 2000-12-06
US20030065137A1 (en) 2003-04-03
KR20010041111A (ko) 2001-05-15
ES2280115T3 (es) 2007-09-01
AU2507399A (en) 1999-09-06
ES2527410T3 (es) 2015-01-23
PT1770162E (pt) 2009-03-24
CA2687533A1 (en) 1999-08-26
BR9907995A (pt) 2001-05-15
ES2318654T3 (es) 2009-05-01
CA2323607A1 (en) 1999-08-26
DE69934970T2 (de) 2007-10-25
NZ506911A (en) 2003-09-26
WO1999042573A1 (en) 1999-08-26

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