ATE414170T1 - Wellenlängen verschiebende proben und primer - Google Patents

Wellenlängen verschiebende proben und primer

Info

Publication number
ATE414170T1
ATE414170T1 AT99937602T AT99937602T ATE414170T1 AT E414170 T1 ATE414170 T1 AT E414170T1 AT 99937602 T AT99937602 T AT 99937602T AT 99937602 T AT99937602 T AT 99937602T AT E414170 T1 ATE414170 T1 AT E414170T1
Authority
AT
Austria
Prior art keywords
primers
harvester
wavelength
probes
fluorescence
Prior art date
Application number
AT99937602T
Other languages
English (en)
Inventor
Sanjay Tyagi
Fred Kramer
Salvatore Marras
Original Assignee
Phri Properties Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22410742&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE414170(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Phri Properties Inc filed Critical Phri Properties Inc
Application granted granted Critical
Publication of ATE414170T1 publication Critical patent/ATE414170T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6818—Hybridisation assays characterised by the detection means involving interaction of two or more labels, e.g. resonant energy transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Electrochromic Elements, Electrophoresis, Or Variable Reflection Or Absorption Elements (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AT99937602T 1998-07-28 1999-07-28 Wellenlängen verschiebende proben und primer ATE414170T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/123,764 US6037130A (en) 1998-07-28 1998-07-28 Wavelength-shifting probes and primers and their use in assays and kits

Publications (1)

Publication Number Publication Date
ATE414170T1 true ATE414170T1 (de) 2008-11-15

Family

ID=22410742

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99937602T ATE414170T1 (de) 1998-07-28 1999-07-28 Wellenlängen verschiebende proben und primer

Country Status (8)

Country Link
US (1) US6037130A (de)
EP (1) EP1100971B1 (de)
JP (1) JP3851088B2 (de)
AT (1) ATE414170T1 (de)
AU (1) AU763106B2 (de)
CA (1) CA2336489C (de)
DE (1) DE69939902D1 (de)
WO (1) WO2000006778A1 (de)

Families Citing this family (153)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6576419B1 (en) * 1993-07-23 2003-06-10 University Of Utah Research Foundation Assay procedure using fluorogenic tracers
US20070269799A9 (en) * 1994-06-22 2007-11-22 Zhang David Y Nucleic acid amplification methods
US20020055101A1 (en) * 1995-09-11 2002-05-09 Michel G. Bergeron Specific and universal probes and amplification primers to rapidly detect and identify common bacterial pathogens and antibiotic resistance genes from clinical specimens for routine diagnosis in microbiology laboratories
US5854033A (en) * 1995-11-21 1998-12-29 Yale University Rolling circle replication reporter systems
CA2246238A1 (en) * 1996-03-01 1997-09-04 E.I. Du Pont De Nemours And Company A method for the amplification and detection of a nucleic acid fragment of interest
US20030049636A1 (en) * 1999-05-03 2003-03-13 Bergeron Michel G. Species-specific, genus-specific and universal DNA probes and amplification primers to rapidly detect and identify common bacterial and fungal pathogens and associated antibiotic resistance genes from clinical specimens for diagnosis in microbiology laboratories
US20100267012A1 (en) * 1997-11-04 2010-10-21 Bergeron Michel G Highly conserved genes and their use to generate probes and primers for detection of microorganisms
US6893868B2 (en) * 1997-02-20 2005-05-17 Onco Immunin, Inc. Homo-doubly labeled compositions for the detection of enzyme activity in biological samples
US6037137A (en) * 1997-02-20 2000-03-14 Oncoimmunin, Inc. Fluorogenic peptides for the detection of protease activity
US7312302B2 (en) 1997-02-20 2007-12-25 Oncolmmunin, Inc. Compositions for the detection of enzyme activity in biological samples and methods of use thereof
CA2286304C (en) 1997-04-10 2007-08-07 Diagnocure Inc. Pca3, pca3 genes, and methods of use
US6518017B1 (en) * 1997-10-02 2003-02-11 Oasis Biosciences Incorporated Combinatorial antisense library
US20030165888A1 (en) * 2001-07-18 2003-09-04 Brown Bob D. Oligonucleotide probes and primers comprising universal bases for diagnostic purposes
US7595189B2 (en) * 1999-01-08 2009-09-29 Applied Biosystems, Llc Integrated optics fiber array
WO2000042222A2 (en) * 1999-01-15 2000-07-20 Gene Logic Inc. Immobilized nucleic acid hybridization reagent and method
US6951722B2 (en) * 1999-03-19 2005-10-04 Takara Bio Inc. Method for amplifying nucleic acid sequence
IL145586A0 (en) * 1999-04-08 2002-06-30 Oasis Biosciences Inc Antisense oligonucleotides comprising universal and/or degenerate bases
US6680377B1 (en) * 1999-05-14 2004-01-20 Brandeis University Nucleic acid-based detection
WO2000070329A1 (en) * 1999-05-14 2000-11-23 Brandeis University Nucleic acid-based detection
US6277607B1 (en) 1999-05-24 2001-08-21 Sanjay Tyagi High specificity primers, amplification methods and kits
US7537886B1 (en) * 1999-06-22 2009-05-26 Life Technologies Corporation Primers and methods for the detection and discrimination of nucleic acids
US6830902B1 (en) 1999-07-02 2004-12-14 Invitrogen Corporation Compositions and methods for enhanced sensitivity and specificity of nucleic acid synthesis
US6613580B1 (en) 1999-07-06 2003-09-02 Caliper Technologies Corp. Microfluidic systems and methods for determining modulator kinetics
US6692915B1 (en) * 1999-07-22 2004-02-17 Girish N. Nallur Sequencing a polynucleotide on a generic chip
US6440706B1 (en) * 1999-08-02 2002-08-27 Johns Hopkins University Digital amplification
US6403319B1 (en) * 1999-08-13 2002-06-11 Yale University Analysis of sequence tags with hairpin primers
US6586177B1 (en) * 1999-09-08 2003-07-01 Exact Sciences Corporation Methods for disease detection
CA2906516C (en) * 1999-09-28 2017-03-07 Geneohm Sciences Canada Inc. Nucleic acids and methods for the detection of streptococcus
ES2260059T3 (es) * 1999-09-29 2006-11-01 Diagnocure Inc. Rna mensajero del pca3 en tejidos benignos y malignos de prostata.
JP4919568B2 (ja) * 1999-10-22 2012-04-18 ピーエイチアールアイ プロパティーズ，インコーポレイテッド 短い配列の変異体を検出するためのアッセイ
US6692965B1 (en) * 1999-11-23 2004-02-17 Chromocell Corporation Isolation of living cells and preparation of cell lines based on detection and quantification of preselected cellular ribonucleic acid sequences
US6919174B1 (en) * 1999-12-07 2005-07-19 Exact Sciences Corporation Methods for disease detection
US20020155427A1 (en) * 2000-04-03 2002-10-24 Cohenford Menashi A. Detection and typing of human papillomavirus using PNA probes
US6936443B2 (en) * 2000-04-03 2005-08-30 Cytyc Corporation Detection and typing of human papillomavirus using PNA probes
WO2001083820A1 (en) 2000-04-28 2001-11-08 Montclair Group Methods and compositions for the manufacture of molecular beacons
US7019129B1 (en) * 2000-05-09 2006-03-28 Biosearch Technologies, Inc. Dark quenchers for donor-acceptor energy transfer
US6887664B2 (en) 2000-06-06 2005-05-03 Applera Corporation Asynchronous primed PCR
US6323009B1 (en) * 2000-06-28 2001-11-27 Molecular Staging, Inc. Multiply-primed amplification of nucleic acid sequences
GB2368809B (en) 2000-09-15 2004-09-29 Norchip As Microfabricated reaction chamber system
US6815164B2 (en) 2000-10-06 2004-11-09 Nugen Technologies, Inc. Methods and probes for detection and/or quantification of nucleic acid sequences
WO2002050308A1 (en) * 2000-12-19 2002-06-27 Discoverx Strand displacement detection of target nucleic acid
US6573051B2 (en) * 2001-03-09 2003-06-03 Molecular Staging, Inc. Open circle probes with intramolecular stem structures
FR2822234B1 (fr) * 2001-03-14 2003-06-13 Univ Pasteur Procede de determination locale de parametres structuraux de molecules, notamment biochimiques ou pharmacologiques et utilisations dudit procede
DE60216445T2 (de) * 2001-04-17 2007-10-31 The New York Blood Center, Inc. Universelles nachweissystem für mehrere varianten
CA2446206A1 (en) * 2001-05-03 2002-11-14 Warnex Research Inc. A molecular tag code for monitoring a product and process using same
WO2003000917A2 (en) * 2001-06-21 2003-01-03 The Regents Of The University Of California Electrochemical detection of mismatch nucleic acids
US7297494B2 (en) * 2001-06-25 2007-11-20 Georgia Tech Research Corporation Activatable probes and methods for in vivo gene detection
WO2003000933A1 (en) * 2001-06-25 2003-01-03 Georgia Tech Research Corporation Dual resonance energy transfer nucleic acid probes
GB2378245A (en) 2001-08-03 2003-02-05 Mats Nilsson Nucleic acid amplification method
US20030082547A1 (en) * 2001-08-27 2003-05-01 Ewing Gregory J. Non-fluorescent quencher compounds and biomolecular assays
AU2002331777A1 (en) * 2001-08-30 2003-03-18 Spectral Genomics, Inc. Arrays comprising pre-labeled biological molecules and methods for making and using these arrays
ATE420351T1 (de) * 2001-08-31 2009-01-15 Gen Probe Inc Sonden mit affinitätsverschiebung zur quantifizierung von analytenpolynukleotiden
US7070933B2 (en) * 2001-09-28 2006-07-04 Gen-Probe Incorporated Inversion probes
CA2462000A1 (en) * 2001-10-09 2003-04-17 3-Dimensional Pharmaceuticals, Inc. Substituted diphenyloxazoles, the synthesis thereof, and the use thereof as fluorescence probes
US20030165859A1 (en) * 2001-10-23 2003-09-04 Invitrogen Corporation Primers and methods for the detection and discrimination of nucleic acids
WO2003040397A2 (en) * 2001-10-25 2003-05-15 Gorilla Genomics, Inc. Asymmetric pcr with nuclease-free polymerase or nuclease-resistant molecular beacons
GB0200526D0 (en) * 2002-01-11 2002-02-27 Science And Technology The Methods
US7553619B2 (en) * 2002-02-08 2009-06-30 Qiagen Gmbh Detection method using dissociated rolling circle amplification
AU2003230832A1 (en) * 2002-04-22 2003-11-03 Joseph F. Lawler Jr. Reagents for monitoring nuclei acid amplification and methods of using same
WO2003095666A2 (en) * 2002-05-13 2003-11-20 Nanocytometry Corporation Oligonucleotide probes for in vitro, in vivo and intracellular detection
WO2004000995A2 (en) * 2002-05-22 2003-12-31 Marshall University Methods, probes, and accessory molecules for detecting single nucleotide polymorphisms
JP4457001B2 (ja) * 2002-05-31 2010-04-28 セクレタリー・デパートメント・オブ・アトミック・エナジー ドナー／アクセプター部分が相補鎖上となる標的核酸検出のｍｅｔ／ｆｒｅｔに基づく方法
CA2433473A1 (en) * 2002-07-23 2004-01-23 F. Hoffmann-La Roche Ag Fluorescent hybridization probes with reduced background
WO2007116408A2 (en) * 2006-04-11 2007-10-18 Nanodiagnostics Israel Ltd. Pluripotent stem cells characterized by expression of germline specific genes
WO2004009758A2 (en) * 2002-07-23 2004-01-29 Nanodiagnostics, Inc. Embryonic stem cell markers and uses thereof
US7582470B2 (en) * 2002-07-31 2009-09-01 Gen-Probe Incorporated Device for amplifying and detecting a target nucleic acid
EP1565578A4 (de) * 2002-11-18 2007-11-07 Panomics Inc Sensoren auf rnai-basis, cagedinterferenz-rnas sowie verfahren zur verwendung davon
US20040121338A1 (en) * 2002-12-19 2004-06-24 Alsmadi Osama A. Real-time detection of rolling circle amplification products
US8275554B2 (en) * 2002-12-20 2012-09-25 Caliper Life Sciences, Inc. System for differentiating the lengths of nucleic acids of interest in a sample
AU2003302770B2 (en) 2002-12-20 2007-07-12 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA
CA2511381A1 (en) * 2002-12-20 2004-07-22 Stratagene California Compositions and methods for polynucleotide detection
US9487823B2 (en) * 2002-12-20 2016-11-08 Qiagen Gmbh Nucleic acid amplification
US20050042639A1 (en) * 2002-12-20 2005-02-24 Caliper Life Sciences, Inc. Single molecule amplification and detection of DNA length
WO2004068112A2 (en) * 2003-01-28 2004-08-12 Gorilla Genomics, Inc. Hairpin primer amplification
WO2004070056A2 (en) 2003-02-07 2004-08-19 Diagnocure Inc. Method to detect prostate cancer in a sample
CN100439515C (zh) * 2003-03-03 2008-12-03 清华大学 一种核酸分析芯片实验室系统与应用
US7238792B2 (en) * 2003-03-18 2007-07-03 Washington State University Research Foundation Foldable polymers as probes
US8043834B2 (en) * 2003-03-31 2011-10-25 Qiagen Gmbh Universal reagents for rolling circle amplification and methods of use
US20040248103A1 (en) * 2003-06-04 2004-12-09 Feaver William John Proximity-mediated rolling circle amplification
WO2005012548A2 (en) * 2003-08-01 2005-02-10 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
NZ597400A (en) * 2004-02-18 2013-06-28 Chromocell Corp Methods and Materials Using Signaling Probes
BRPI0509979A (pt) * 2004-04-20 2007-10-16 Genaco Biomedical Products Inc método para detectar ncrna
US7575863B2 (en) * 2004-05-28 2009-08-18 Applied Biosystems, Llc Methods, compositions, and kits comprising linker probes for quantifying polynucleotides
US7635598B2 (en) * 2004-07-08 2009-12-22 Biosearch Technologies, Inc. Inducible fluorescence assay
US7361469B2 (en) * 2004-08-13 2008-04-22 Stratagene California Dual labeled fluorescent probes
EP2186908A1 (de) * 2004-09-21 2010-05-19 Applied Biosystems, LLC Zweifarbige Echtzeit/Endpunkt-Quantifizierung von Mikro-RNAs (miRNAs)
US20060194222A1 (en) * 2004-10-20 2006-08-31 Stratagene California Triplex probe compositions and methods for polynucleotide detection
US20060275792A1 (en) * 2004-11-15 2006-12-07 Lee Jun E Enhancement of nucleic acid amplification using double-stranded DNA binding proteins
US20060105348A1 (en) * 2004-11-15 2006-05-18 Lee Jun E Compositions and methods for the detection and discrimination of nucleic acids
US7842794B2 (en) 2004-12-17 2010-11-30 Roche Molecular Systems, Inc. Reagents and methods for detecting Neisseria gonorrhoeae
CA2491067A1 (en) * 2004-12-24 2006-06-24 Stichting Katholieke Universiteit Mrna rations in urinary sediments and/or urine as a prognostic marker for prostate cancer
JP2008529528A (ja) * 2005-02-09 2008-08-07 ストラタジーン カリフォルニア ポリヌクレオチドの検出用のキープローブ組成物および方法
US8309303B2 (en) * 2005-04-01 2012-11-13 Qiagen Gmbh Reverse transcription and amplification of RNA with simultaneous degradation of DNA
GB2424886A (en) * 2005-04-04 2006-10-11 Dxs Ltd Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations
CA2603842A1 (en) * 2005-04-08 2006-10-19 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
US20070213293A1 (en) * 2005-04-08 2007-09-13 Nastech Pharmaceutical Company Inc. Rnai therapeutic for respiratory virus infection
JP2008539730A (ja) * 2005-05-02 2008-11-20 ストラタジーン カリフォルニア オリゴヌクレオチドのプローブ／プライマー組成物、及びポリヌクレオチドの検出方法
CA2611507A1 (en) * 2005-06-09 2006-12-21 Epoch Biosciences, Inc. Improved primer-based amplification methods
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US7741467B2 (en) 2005-10-05 2010-06-22 Roche Molecular Systems, Inc. Non-fluorescent energy transfer
PL1844164T3 (pl) * 2005-11-15 2010-12-31 Genoid Kft Sposób wykrywania patogenów z zastosowaniem sond typu "latarni molekularnych"
US7790392B2 (en) * 2005-11-25 2010-09-07 Hidex Oy Homogeneous luminescence bioassay
CN101535500B (zh) 2005-11-29 2013-12-11 剑桥企业有限公司 乳腺癌标志物
CA2644475A1 (en) * 2006-03-01 2007-09-07 Perlegen Sciences, Inc. Markers for addiction
US20110143344A1 (en) * 2006-03-01 2011-06-16 The Washington University Genetic polymorphisms and substance dependence
NZ571966A (en) * 2006-03-16 2011-09-30 Pentabase Aps Oligonucleotides comprising signalling pairs and hydrophobic nucleotides, stemless beacons, for detection of nucleic acids, methylation status and mutants of nucleic acids
RU2394915C2 (ru) * 2006-03-24 2010-07-20 Александр Борисович Четверин Бесконтактные способы обнаружения молекулярных колоний, наборы реагентов и устройство для их осуществления
US8313903B2 (en) 2006-03-31 2012-11-20 The Trustees Of Columbia University In The City Of New York Binary DNA probe for fluorescent analysis of nucleic acids
FR2900158A1 (fr) * 2006-04-25 2007-10-26 Biomerieux Sa Nouvelle sonde de detection agissant par reconnaissance moleculaire
ES2641272T3 (es) 2006-04-28 2017-11-08 Children's Hospital Medical Center Composiciones que comprenden proteínas o polipéptidos fusogénicos derivados de la prosaposina para aplicación en sistemas de suministro de fármacos transmembrana
DE102006020885A1 (de) * 2006-05-05 2007-11-08 Qiagen Gmbh Einführung von Sequenzelementen in Nukleinsäuren
EP2535427A3 (de) 2006-05-17 2013-04-24 California Institute of Technology Thermisches Wechselbeanspruchungssystem
US7833716B2 (en) 2006-06-06 2010-11-16 Gen-Probe Incorporated Tagged oligonucleotides and their use in nucleic acid amplification methods
US7972786B2 (en) * 2006-07-07 2011-07-05 Brandeis University Detection and analysis of influenza virus
US9045522B2 (en) 2006-07-31 2015-06-02 Wanli Bi Nucleic acid amplification using a reversibly modified oligonucleotide
CN101495657B (zh) * 2006-07-31 2016-08-10 毕万里 使用可逆修饰寡核苷酸扩增核酸
JP2009545317A (ja) * 2006-08-01 2009-12-24 アプライド バイオシステムズ， エルエルシー 分析物および核酸の検出
JP2010502573A (ja) 2006-08-11 2010-01-28 ユニヴァーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー 二重増感剤含有ルミネッセンス化合物および結合体、ならびにその使用
FR2906532B1 (fr) * 2006-09-28 2008-12-12 Biomerieux Sa Nouvel oligonucleotide marque
US9938641B2 (en) * 2006-12-18 2018-04-10 Fluidigm Corporation Selection of aptamers based on geometry
FI20070163A0 (fi) 2007-02-27 2007-02-27 Hidex Oy Parannettu homogeeninen luminesenssibiotesti
US8367899B2 (en) 2007-12-31 2013-02-05 E I Du Pont De Neumours And Company Gray leaf spot tolerant maize and methods of production
WO2009148651A1 (en) * 2008-02-28 2009-12-10 Board Of Regents, The University Of Texas System Compositions and methods for detection of small molecules using dyes derivatized with analyte responsive receptors in a chemiluminescent assay
EP2268608A4 (de) * 2008-04-01 2012-01-11 Biosearch Technologies Inc Sonden für stabilisierte nukleinsäure-dark-quencher-fluorophore
US20090270269A1 (en) * 2008-04-28 2009-10-29 Ashok Kumar Nano-scale fluoro-biosensors exhibiting a low false alarm rate for rapid detection of biological contaminants
JP5733796B2 (ja) * 2008-05-13 2015-06-10 ジェン−プロウブ インコーポレイテッド 標的核酸配列の選択的ハイブリダイゼーションおよび捕捉における使用のため不活化可能型標的捕捉オリゴマー
FR2933410B1 (fr) * 2008-07-04 2010-08-20 Biomerieux Sa Nouvelle sonde de detection
WO2010011884A2 (en) * 2008-07-25 2010-01-28 University Of Florida Research Foundation, Inc. Novel nucleic acid-based molecular probes
GB0912509D0 (en) 2009-07-17 2009-08-26 Norchip As A microfabricated device for metering an analyte
US20120220478A1 (en) 2009-07-20 2012-08-30 Bar Harbor Biotechnology, Inc. Methods for assessing disease risk
AU2010276236B2 (en) * 2009-07-21 2014-03-20 Gen-Probe Incorporated Methods and compositions for quantitative detection of nucleic acid sequences over an extended dynamic range
US8815515B1 (en) 2009-09-24 2014-08-26 University Of Utah Research Foundation Methods, compositions, and kits for rare allele detection
WO2011088193A2 (en) 2010-01-13 2011-07-21 University Of Medicine And Dentistry Of New Jersey Fluorophore chelated lanthanide luminiscent probes with improved quantum efficiency
US9611485B2 (en) 2010-01-26 2017-04-04 Pioneer Hi-Bred International, Inc. Polynucleotide and polypeptide sequences associated with herbicide tolerance
WO2012029224A1 (ja) * 2010-09-01 2012-03-08 日本電気株式会社 標的物質の検出方法、それに用いるアブタマーセット並びにセンサ及び装置
CA2822955A1 (en) 2010-12-30 2012-07-05 Pioneer Hi-Bred International, Inc. Methods of identifying aphid resistant soybeans
EP3733867A1 (de) 2011-01-17 2020-11-04 Life Technologies Corporation Enzymatische ligation von nukleinsäuren
DK3216878T3 (da) 2011-01-17 2019-06-11 Life Technologies Corp Arbejdsprocedure til påvisning af ligander ved anvendelse af nukleinsyrer
CN106190806B (zh) 2011-04-15 2018-11-06 贝克顿·迪金森公司 扫描实时微流体热循环仪和用于同步的热循环和扫描光学检测的方法
CN104040238B (zh) 2011-11-04 2017-06-27 汉迪拉布公司 多核苷酸样品制备装置
CA2862269C (en) 2011-12-29 2021-09-14 Pioneer Hi-Bred International, Inc. Methods of improving aphid resistance in soybeans
US9347105B2 (en) 2012-06-15 2016-05-24 Pioneer Hi Bred International Inc Genetic loci associated with resistance of soybean to cyst nematode and methods of use
US10301378B2 (en) 2013-06-18 2019-05-28 New York University Cellular factors involved in the cytotoxicity of Staphylococcus aureus leukocidins: novel therapeutic targets
WO2015061548A1 (en) 2013-10-25 2015-04-30 Pioneer Hi-Bred International, Inc. Stem canker tolerant soybeans and methods of use
EP3063317B1 (de) * 2013-10-28 2020-06-03 DOTS Technology Corp. Allergennachweis
US10555467B2 (en) 2015-01-29 2020-02-11 Pioneer Hi-Bred International, Inc. Polynucleotides and kits associated with soybean iron deficiency tolerance and methods of detection and breeding
US20160289734A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Methods of using oligonucleotide-guided argonaute proteins
WO2017106447A1 (en) 2015-12-18 2017-06-22 Pioneer Hi-Bred International, Inc. Genetic loci associated with reproductive growth phenotypes in soybean and methods of use
CA3004914A1 (en) 2016-02-05 2017-08-10 Pioneer Hi-Bred International, Inc. Genetic loci associated with brown stem rot resistance in soybean and methods of use
US11028453B2 (en) 2016-02-11 2021-06-08 Pioneer Hi-Bred International, Inc. QTLs associated with and methods for identifying lodging resistance in soybean
US10718017B2 (en) * 2016-03-31 2020-07-21 Arizona Board Of Regents On Behalf Of Arizona State University Probes and methods for measuring tandem repeats
WO2017196597A1 (en) 2016-05-12 2017-11-16 Pioneer Hi-Bred International, Inc. Methods for simultaneous pooled genotyping
US11242568B2 (en) 2017-12-29 2022-02-08 City Of Hope DNA methylation diagnostic test for breast cancer

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261968A (en) * 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
CA1190838A (en) * 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
US5260433A (en) * 1982-06-23 1993-11-09 Enzo Diagnostics, Inc. Saccharide specific binding system labeled nucleotides
US5241060A (en) * 1982-06-23 1993-08-31 Enzo Diagnostics, Inc. Base moiety-labeled detectable nucleatide
CA1223831A (en) * 1982-06-23 1987-07-07 Dean Engelhardt Modified nucleotides, methods of preparing and utilizing and compositions containing the same
US4766062A (en) * 1984-05-07 1988-08-23 Allied Corporation Displacement polynucleotide assay method and polynucleotide complex reagent therefor
EP0221108B1 (de) * 1985-05-02 1993-09-01 Genetics Institute, Inc. Verfahren und aufbau einer nukleinsäure zur erzeugung von reagenzienkomplexen zur verwendung bei der bestimmung von zielnukleotidsequenzen
US4822733A (en) * 1985-05-28 1989-04-18 Amoco Corporation Lifetime-resolved assay procedures
US4725537A (en) * 1985-09-19 1988-02-16 Allied Corporation Assay, reagent and kit employing nucleic acid strand displacement and restriction endonuclease cleavage
US4725536A (en) * 1985-09-19 1988-02-16 Genetics Institute, Inc. Reagent polynucleotide complex with multiple target binding regions, and kit and methods
US4752566A (en) * 1985-12-17 1988-06-21 Genetics Institute, Inc. Displacement polynucleotide method and reagent complex employing labeled probe polynucleotide
ATE88761T1 (de) * 1986-01-10 1993-05-15 Amoco Corp Kompetitiver homogener test.
US5082830A (en) * 1988-02-26 1992-01-21 Enzo Biochem, Inc. End labeled nucleotide probe
US5118801A (en) * 1988-09-30 1992-06-02 The Public Health Research Institute Nucleic acid process containing improved molecular switch
CA1339731C (en) * 1988-10-12 1998-03-17 Charles T. Caskey Multiplex genomic dna amplification for deletion detection
ATE199157T1 (de) * 1990-03-14 2001-02-15 Univ California Multichromophore fluoreszierende sonden
US5401847A (en) * 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
US5312921A (en) * 1990-03-14 1994-05-17 Regents Of The University Of California Dyes designed for high sensitivity detection of double-stranded DNA
US5210015A (en) * 1990-08-06 1993-05-11 Hoffman-La Roche Inc. Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
JP3085756B2 (ja) * 1991-10-30 2000-09-11 株式会社日立製作所 核酸の検出方法
US5411875A (en) * 1991-11-01 1995-05-02 University Of Iowa Research Foundation Method for retrieval of unknown flanking DNA sequence
US5565322A (en) * 1991-11-07 1996-10-15 Nanogen, Inc. Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfer system
US5348853A (en) * 1991-12-16 1994-09-20 Biotronics Corporation Method for reducing non-specific priming in DNA amplification
US5332659A (en) * 1992-04-09 1994-07-26 The United States Of America As Represented By The Secretary Of The Navy Light emission-or absorbance-based binding assays for polynucleic acids
EP0601889A2 (de) * 1992-12-10 1994-06-15 Maine Medical Center Research Institute Nukleinsäure-Sonden
CA2129787A1 (en) * 1993-08-27 1995-02-28 Russell G. Higuchi Monitoring multiple amplification reactions simultaneously and analyzing same
AU697841B2 (en) * 1993-11-12 1998-10-15 Phri Properties, Inc. Hybridization probes for nucleic acid detection, universal stems, methods and kits
US5925517A (en) * 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5538848A (en) * 1994-11-16 1996-07-23 Applied Biosystems Division, Perkin-Elmer Corp. Method for detecting nucleic acid amplification using self-quenching fluorescence probe
US5654419A (en) * 1994-02-01 1997-08-05 The Regents Of The University Of California Fluorescent labels and their use in separations
US5622821A (en) * 1994-06-29 1997-04-22 The Regents Of The University Of California Luminescent lanthanide chelates and methods of use
US5565554A (en) * 1994-07-29 1996-10-15 The Regents Of The University Of California Dimeric fluorescent energy transfer dyes comprising asymmetric cyanine azole-indolenine chromophores
US5491063A (en) * 1994-09-01 1996-02-13 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5571673A (en) * 1994-11-23 1996-11-05 Hoffmann-La Roche Inc. Methods for in-solution quenching of fluorescently labeled oligonucleotide probes
US5863504A (en) * 1995-03-16 1999-01-26 Bio-Rad Laboratories, Inc. Fluorescence imaging instrument utilizing fish
US5728528A (en) * 1995-09-20 1998-03-17 The Regents Of The University Of California Universal spacer/energy transfer dyes
WO1998010096A1 (en) * 1996-04-12 1998-03-12 The Public Health Research Institute Of The City Of New York, Inc. Detection probes, kits and assays
EP0892808B1 (de) * 1996-04-12 2008-05-14 PHRI Properties, Inc. Sonden, kits und assays
ES2205841T3 (es) * 1998-06-12 2004-05-01 Intergen Company Oligonucleotidos en horquilla de transferencia de energia multifluorescente.

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EP1100971A4 (de) 2004-11-24
US6037130A (en) 2000-03-14
EP1100971A1 (de) 2001-05-23
AU5240299A (en) 2000-02-21
CA2336489A1 (en) 2000-02-10
DE69939902D1 (de) 2008-12-24
CA2336489C (en) 2011-05-03
WO2000006778A1 (en) 2000-02-10
AU763106B2 (en) 2003-07-10
JP2002521069A (ja) 2002-07-16
EP1100971B1 (de) 2008-11-12
JP3851088B2 (ja) 2006-11-29

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