ATE414146T1 - Methoden zur herstellung von helpervirusfreien präparationen von freien rekombinenten aav- vektoren mit hohem titer - Google Patents
Methoden zur herstellung von helpervirusfreien präparationen von freien rekombinenten aav- vektoren mit hohem titerInfo
- Publication number
- ATE414146T1 ATE414146T1 AT99968678T AT99968678T ATE414146T1 AT E414146 T1 ATE414146 T1 AT E414146T1 AT 99968678 T AT99968678 T AT 99968678T AT 99968678 T AT99968678 T AT 99968678T AT E414146 T1 ATE414146 T1 AT E414146T1
- Authority
- AT
- Austria
- Prior art keywords
- free
- producing
- helpervirus
- methods
- aav vectors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14151—Methods of production or purification of viral material
- C12N2750/14152—Methods of production or purification of viral material relating to complementing cells and packaging systems for producing virus or viral particles
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14247498A | 1998-09-04 | 1998-09-04 | |
| US12368599P | 1999-03-10 | 1999-03-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE414146T1 true ATE414146T1 (de) | 2008-11-15 |
Family
ID=26821785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99968678T ATE414146T1 (de) | 1998-09-04 | 1999-09-07 | Methoden zur herstellung von helpervirusfreien präparationen von freien rekombinenten aav- vektoren mit hohem titer |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP1109892B1 (de) |
| JP (1) | JP4472182B2 (de) |
| AT (1) | ATE414146T1 (de) |
| CA (1) | CA2342849C (de) |
| CY (1) | CY1110695T1 (de) |
| DE (1) | DE69939903D1 (de) |
| DK (1) | DK1109892T3 (de) |
| ES (2) | ES2317709T3 (de) |
| PT (2) | PT1109892E (de) |
| WO (1) | WO2000014205A2 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6924128B2 (en) | 1994-12-06 | 2005-08-02 | Targeted Genetics Corporation | Packaging cell lines for generation of high titers of recombinant AAV vectors |
| US6989264B2 (en) | 1997-09-05 | 2006-01-24 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| DK1944362T3 (en) * | 1997-09-05 | 2016-01-25 | Genzyme Corp | Fremgangsmåder til fremstilling af hjælpevirusfri præparater med høj titer af rekombinante AAV-vektorer |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| DK1180159T3 (da) | 1999-05-28 | 2008-11-17 | Targeted Genetics Corp | Fremgangsmåder og sammensætninger til at sænke niveauet af Tumor-Nekrose-Faktor (TNF) i TNF-associerede lidelser |
| EP1939300A1 (de) | 1999-05-28 | 2008-07-02 | Targeted Genetics Corporation | Verfahren und Zusammensetzung zur Senkung des Spiegels des Tumornekrosefaktors (TNF) bei TNF-assoziierten Leiden |
| ES2308989T3 (es) | 1999-08-09 | 2008-12-16 | Targeted Genetics Corporation | Aumento de la expresion de una secuencia nucleotidica heterologa a partir de vectores viricos recombinantes que contienen una secuencia que forman pares de bases intracatenarios. |
| US7115391B1 (en) | 1999-10-01 | 2006-10-03 | Genovo, Inc. | Production of recombinant AAV using adenovirus comprising AAV rep/cap genes |
| EP1833961B1 (de) * | 2004-10-15 | 2011-07-20 | Monell Chemical Senses Center | Verfahren zur kultivierung von geschmackszellen aus säugern |
| ES2619936T3 (es) * | 2004-11-05 | 2017-06-27 | Wellstat Biologics Corporation | Formulaciones de virus envueltos estables y filtrables |
| CA2759801C (en) | 2009-05-02 | 2019-04-02 | Marco A. Passini | Gene therapy for neurodegenerative disorders |
| EP2686423A4 (de) * | 2011-03-14 | 2015-01-28 | Nat Res Council Canada | Verfahren zur herstellung von viren in zellen |
| CN105339495A (zh) | 2013-07-11 | 2016-02-17 | 宝生物工程株式会社 | 制备无包膜病毒的方法 |
| WO2016006658A1 (ja) | 2014-07-10 | 2016-01-14 | タカラバイオ株式会社 | 非エンベロープウイルス粒子の製造方法 |
| CN107109374B (zh) | 2015-01-09 | 2021-04-06 | 宝生物工程株式会社 | 用于生产无包膜病毒颗粒的方法 |
| CA3023473A1 (en) * | 2016-05-25 | 2017-11-30 | Lonza Houston Inc. | Methods for isolating adeno-associated virus using a polydiallyldialkylammonium salt |
| EP3526321A4 (de) * | 2016-10-14 | 2020-05-13 | Ultragenyx Pharmaceutical Inc. | Verwendung von tonifizierenden mitteln zur verbesserung der ausbeute von rekombinantem adeno-assoziiertem virus |
| US20230323395A1 (en) * | 2021-12-15 | 2023-10-12 | Homology Medicines, Inc. | Methods and compositions for the production of adeno-associated virus |
| WO2024194280A1 (en) | 2023-03-21 | 2024-09-26 | F. Hoffmann-La Roche Ag | Method for the production of recombinant aav particle preparations |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6686200B1 (en) * | 1993-08-31 | 2004-02-03 | Uab Research Foundation | Methods and compositions for the large scale production of recombinant adeno-associated virus |
| WO1997008298A1 (en) * | 1995-08-30 | 1997-03-06 | Genzyme Corporation | Chromatographic purification of adenovirus and aav |
| US5910434A (en) * | 1995-12-15 | 1999-06-08 | Systemix, Inc. | Method for obtaining retroviral packaging cell lines producing high transducing efficiency retroviral supernatant |
| FR2750433B1 (fr) * | 1996-07-01 | 1998-08-14 | Rhone Poulenc Rorer Sa | Procede de production d'adenovirus recombinants |
| DK1944362T3 (en) * | 1997-09-05 | 2016-01-25 | Genzyme Corp | Fremgangsmåder til fremstilling af hjælpevirusfri præparater med høj titer af rekombinante AAV-vektorer |
-
1999
- 1999-09-07 JP JP2000568952A patent/JP4472182B2/ja not_active Expired - Lifetime
- 1999-09-07 CA CA2342849A patent/CA2342849C/en not_active Expired - Lifetime
- 1999-09-07 DK DK99968678T patent/DK1109892T3/da active
- 1999-09-07 PT PT99968678T patent/PT1109892E/pt unknown
- 1999-09-07 AT AT99968678T patent/ATE414146T1/de active
- 1999-09-07 EP EP99968678A patent/EP1109892B1/de not_active Expired - Lifetime
- 1999-09-07 DE DE69939903T patent/DE69939903D1/de not_active Expired - Lifetime
- 1999-09-07 PT PT70241377T patent/PT1930418E/pt unknown
- 1999-09-07 WO PCT/US1999/020524 patent/WO2000014205A2/en active IP Right Grant
- 1999-09-07 ES ES99968678T patent/ES2317709T3/es not_active Expired - Lifetime
- 1999-09-07 ES ES07024137.7T patent/ES2541540T3/es not_active Expired - Lifetime
-
2009
- 2009-02-04 CY CY20091100126T patent/CY1110695T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000014205A3 (en) | 2000-05-25 |
| DK1109892T3 (da) | 2009-02-09 |
| EP1109892B1 (de) | 2008-11-12 |
| CA2342849A1 (en) | 2000-03-16 |
| EP1109892A2 (de) | 2001-06-27 |
| JP4472182B2 (ja) | 2010-06-02 |
| PT1109892E (pt) | 2009-02-17 |
| PT1930418E (pt) | 2015-08-26 |
| ES2317709T3 (es) | 2009-04-16 |
| WO2000014205A9 (en) | 2000-09-08 |
| WO2000014205A2 (en) | 2000-03-16 |
| CY1110695T1 (el) | 2015-06-10 |
| JP2002524070A (ja) | 2002-08-06 |
| ES2541540T3 (es) | 2015-07-21 |
| DE69939903D1 (de) | 2008-12-24 |
| CA2342849C (en) | 2013-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE414146T1 (de) | Methoden zur herstellung von helpervirusfreien präparationen von freien rekombinenten aav- vektoren mit hohem titer | |
| ATE542891T1 (de) | Verfahren zur herstellung von biologischen produkten in protein-freier kultur | |
| ATE549347T1 (de) | Gene von säugetiere, und damit verbundene reagentien, methoden | |
| GB9712512D0 (en) | A method for in vitro molecular evolution of protein function | |
| DE69938302D1 (de) | Neisseria meningitidis antigene und zusammenstellungen | |
| DE69111440D1 (de) | Methoden und zusammensetzungen zur impfung gegen hiv. | |
| DE69934242D1 (de) | Polyketid synthase enzyme und rekombinante dna konstrukte dafür, zur herstellung von mit fk-506 und fk-520 verwandten verbindungen | |
| CY1111831T1 (el) | Παραγωγα ογκο-συναφους αντιγονου απο την οικογενεια mage και αλληλουχιες νουκλεϊνικου οξεος που κωδικοποιουν αυτα, που χρησιμοποιουνται για την παρασκευη πρωτεϊνων συντηξης και συνθεσεων για εμβολιασμο | |
| ATE452183T1 (de) | Eine verbesserte methode zur herstellung und reinigung von adenoviralen vektoren | |
| DE69737023D1 (de) | Methode zur behandlung von krebs und pathogenen infektionen unter verwendung von antigen-präsentierenden zellen beladen mit rna | |
| ATE218579T1 (de) | Zusammensetzungen und methoden zur behandlung von infektionen unter verwendung von indolicidin- analogen | |
| ATE270342T1 (de) | Endosomolytisch wirksame partikel | |
| ATE293690T1 (de) | Verwendung vom krebs-assoziierten antigen 5t4 zur immuntherapie | |
| CY1106111T1 (el) | Ανασυνδυασμενος σταθepος κυτταρικος κλωνος, η παρασκευη και χρησιμοποιηση του | |
| DE60134136D1 (de) | Zytokinrezeptoruntereinheit-proteine aus säugetieren, damit zusammenhängende reagenzien und methoden | |
| DE60023860D1 (de) | Verfahren zur herstellung von rekombinanten peptiden | |
| DE69839403D1 (de) | Adenovirale vektoren und eine methode zur reduktion von homologer rekombination | |
| WO2001032882A3 (en) | Nucleic acids and proteins from group b streptococcus | |
| DE69627526D1 (de) | Rekombinantes pockenvirus der infektiösen peritonitis der katze, dessen zusammensetzungen und methoden zur herstellung und verwendung | |
| AR022150A1 (es) | Acidos nucleicos derivados de monocitos y composiciones y metodos relacionados | |
| CY1116753T1 (el) | Μεθοδοι για την παραγωγη παρασκευασματων υψηλου τιτλου χωρις βοηθους των αποδεσμευμενων ανασυνδυασμενων φορεων aav | |
| WO2002077648A3 (en) | Pathogenic and commensal vaccine antigens | |
| ECSP055740A (es) | Método para la obtención de líneas celulares en medio libre de proteína y líneas celulares obtenidas por este método. | |
| SE9604439D0 (sv) | New receptor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1109892 Country of ref document: EP |