ATE404571T1 - Verfahren zur herstellung von phosphorodiamiditen - Google Patents
Verfahren zur herstellung von phosphorodiamiditenInfo
- Publication number
- ATE404571T1 ATE404571T1 AT03782645T AT03782645T ATE404571T1 AT E404571 T1 ATE404571 T1 AT E404571T1 AT 03782645 T AT03782645 T AT 03782645T AT 03782645 T AT03782645 T AT 03782645T AT E404571 T1 ATE404571 T1 AT E404571T1
- Authority
- AT
- Austria
- Prior art keywords
- product
- phosphorodiamidites
- producing
- phosphorodiamidite
- polar solvent
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005265 dialkylamine group Chemical group 0.000 abstract 2
- ZLRAAUUPULJGTL-UHFFFAOYSA-N diaminophosphinous acid Chemical compound NP(N)O ZLRAAUUPULJGTL-UHFFFAOYSA-N 0.000 abstract 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000006184 cosolvent Substances 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- -1 hydroxylalkyl compound Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000012454 non-polar solvent Substances 0.000 abstract 1
- 229910052698 phosphorus Inorganic materials 0.000 abstract 1
- 239000011574 phosphorus Substances 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/2408—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic of hydroxyalkyl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Luminescent Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0230095.2A GB0230095D0 (en) | 2002-12-24 | 2002-12-24 | Phosphorodiamidite |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE404571T1 true ATE404571T1 (de) | 2008-08-15 |
Family
ID=9950379
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT03782645T ATE404571T1 (de) | 2002-12-24 | 2003-12-18 | Verfahren zur herstellung von phosphorodiamiditen |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7276620B2 (de) |
| EP (1) | EP1583766B1 (de) |
| JP (1) | JP4511368B2 (de) |
| KR (1) | KR100889897B1 (de) |
| CN (1) | CN100338078C (de) |
| AT (1) | ATE404571T1 (de) |
| AU (1) | AU2003290281A1 (de) |
| CA (1) | CA2511609C (de) |
| DE (1) | DE60322960D1 (de) |
| GB (1) | GB0230095D0 (de) |
| WO (1) | WO2004058779A1 (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106132973B (zh) * | 2014-01-15 | 2018-10-16 | 罗地亚经营管理公司 | 纯化的亚磷酰二胺的制备 |
| EP3733680A4 (de) | 2017-12-27 | 2021-12-29 | KNC Laboratories Co., Ltd | Herstellung von hochfettlöslichem phosphoramidit |
| CN111057108B (zh) * | 2018-10-16 | 2023-08-15 | 中国石油化工股份有限公司 | 一种胺基磷酸酯化合物及其制备方法、用途 |
| CN117362336B (zh) * | 2023-09-22 | 2026-03-13 | 天津兴博润生物制药有限公司 | 一种二胺基亚磷酸酯化合物的纯化方法和制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS62212395A (ja) | 1986-03-11 | 1987-09-18 | Nippon Zeon Co Ltd | リンアミド化合物の製造法 |
| DE10208828A1 (de) * | 2002-03-01 | 2003-09-11 | Bayer Ag | Verfahren zur Reduktion von 3-Heteroaryl-3-oxopropionsäurederivaten |
| US7057062B2 (en) | 2002-04-11 | 2006-06-06 | Isis Pharmaceuticals, Inc. | Process for manufacturing purified phosphorodiamidite |
| US7034177B2 (en) * | 2002-06-13 | 2006-04-25 | Rhodia Inc | Process of making phosphordiamidite compounds |
-
2002
- 2002-12-24 GB GBGB0230095.2A patent/GB0230095D0/en not_active Ceased
-
2003
- 2003-12-18 EP EP03782645A patent/EP1583766B1/de not_active Expired - Lifetime
- 2003-12-18 DE DE60322960T patent/DE60322960D1/de not_active Expired - Lifetime
- 2003-12-18 AU AU2003290281A patent/AU2003290281A1/en not_active Abandoned
- 2003-12-18 JP JP2004563342A patent/JP4511368B2/ja not_active Expired - Lifetime
- 2003-12-18 WO PCT/GB2003/005544 patent/WO2004058779A1/en not_active Ceased
- 2003-12-18 CA CA2511609A patent/CA2511609C/en not_active Expired - Lifetime
- 2003-12-18 US US10/540,160 patent/US7276620B2/en not_active Expired - Lifetime
- 2003-12-18 KR KR1020057011547A patent/KR100889897B1/ko not_active Expired - Lifetime
- 2003-12-18 AT AT03782645T patent/ATE404571T1/de not_active IP Right Cessation
- 2003-12-18 CN CNB2003801074642A patent/CN100338078C/zh not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| GB0230095D0 (en) | 2003-01-29 |
| KR20050085831A (ko) | 2005-08-29 |
| US7276620B2 (en) | 2007-10-02 |
| CN1732176A (zh) | 2006-02-08 |
| AU2003290281A1 (en) | 2004-07-22 |
| KR100889897B1 (ko) | 2009-03-20 |
| JP2006512386A (ja) | 2006-04-13 |
| CA2511609A1 (en) | 2004-07-15 |
| EP1583766B1 (de) | 2008-08-13 |
| EP1583766A1 (de) | 2005-10-12 |
| US20060128951A1 (en) | 2006-06-15 |
| CA2511609C (en) | 2012-09-25 |
| DE60322960D1 (de) | 2008-09-25 |
| WO2004058779A1 (en) | 2004-07-15 |
| JP4511368B2 (ja) | 2010-07-28 |
| CN100338078C (zh) | 2007-09-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |