ATE399803T1 - Gleichmässig hinhaltend ein aminosäurederivat freisetzendes polymer, kosmetikum und faserkonstrukt mit dem polymer, herstellungsverfahren dafür und regenerationsverfahren dafür - Google Patents

Gleichmässig hinhaltend ein aminosäurederivat freisetzendes polymer, kosmetikum und faserkonstrukt mit dem polymer, herstellungsverfahren dafür und regenerationsverfahren dafür

Info

Publication number
ATE399803T1
ATE399803T1 AT04747593T AT04747593T ATE399803T1 AT E399803 T1 ATE399803 T1 AT E399803T1 AT 04747593 T AT04747593 T AT 04747593T AT 04747593 T AT04747593 T AT 04747593T AT E399803 T1 ATE399803 T1 AT E399803T1
Authority
AT
Austria
Prior art keywords
polymer
amino acid
acid derivative
cosmetic
fiber construct
Prior art date
Application number
AT04747593T
Other languages
English (en)
Inventor
Masao Ieno
Kiyonori Furuta
Original Assignee
Japan Exlan Co Ltd
Toyo Boseki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Exlan Co Ltd, Toyo Boseki filed Critical Japan Exlan Co Ltd
Application granted granted Critical
Publication of ATE399803T1 publication Critical patent/ATE399803T1/de

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Classifications

    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/325—Amines
    • D06M13/342—Amino-carboxylic acids; Betaines; Aminosulfonic acids; Sulfo-betaines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/16—Powdering or granulating by coagulating dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6953—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a fibre, a textile, a slab or a sheet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
    • A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q15/00—Anti-perspirants or body deodorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
    • C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
    • C08F220/04—Acids; Metal salts or ammonium salts thereof
    • C08F220/06—Acrylic acid; Methacrylic acid; Metal salts or ammonium salts thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
    • C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
    • C08J3/05—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media from solid polymers
    • D—TEXTILES; PAPER
    • D06—TREATMENT OF TEXTILES OR THE LIKE; LAUNDERING; FLEXIBLE MATERIALS NOT OTHERWISE PROVIDED FOR
    • D06M—TREATMENT, NOT PROVIDED FOR ELSEWHERE IN CLASS D06, OF FIBRES, THREADS, YARNS, FABRICS, FEATHERS OR FIBROUS GOODS MADE FROM SUCH MATERIALS
    • D06M13/00—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment
    • D06M13/322—Treating fibres, threads, yarns, fabrics or fibrous goods made from such materials, with non-macromolecular organic compounds; Such treatment combined with mechanical treatment with compounds containing nitrogen
    • D06M13/325—Amines
    • D06M13/338—Organic hydrazines; Hydrazinium compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/57—Compounds covalently linked to a(n inert) carrier molecule, e.g. conjugates, pro-fragrances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up
    • A61Q1/02—Preparations containing skin colorants, e.g. pigments
    • A61Q1/04—Preparations containing skin colorants, e.g. pigments for lips
    • A61Q1/06—Lipsticks

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Birds (AREA)
  • Polymers & Plastics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Textile Engineering (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
  • Chemical Or Physical Treatment Of Fibers (AREA)
  • Artificial Filaments (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
AT04747593T 2003-07-18 2004-07-15 Gleichmässig hinhaltend ein aminosäurederivat freisetzendes polymer, kosmetikum und faserkonstrukt mit dem polymer, herstellungsverfahren dafür und regenerationsverfahren dafür ATE399803T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003276373 2003-07-18

Publications (1)

Publication Number Publication Date
ATE399803T1 true ATE399803T1 (de) 2008-07-15

Family

ID=34074587

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04747593T ATE399803T1 (de) 2003-07-18 2004-07-15 Gleichmässig hinhaltend ein aminosäurederivat freisetzendes polymer, kosmetikum und faserkonstrukt mit dem polymer, herstellungsverfahren dafür und regenerationsverfahren dafür

Country Status (9)

Country Link
US (1) US20060153903A1 (de)
EP (1) EP1657263B1 (de)
JP (1) JP4796845B2 (de)
KR (1) KR101161459B1 (de)
CN (1) CN100424104C (de)
AT (1) ATE399803T1 (de)
DE (1) DE602004014783D1 (de)
ES (1) ES2305803T3 (de)
WO (1) WO2005007714A1 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4792312B2 (ja) * 2006-03-27 2011-10-12 日本エクスラン工業株式会社 洗濯耐久性に優れたアミノ酸誘導体徐放性繊維、該繊維を含有する繊維構造物、及びそれらの製造方法
JP4888830B2 (ja) * 2006-09-20 2012-02-29 日本エクスラン工業株式会社 アミノ酸誘導体含有アクリル繊維及びその製造方法並びに該繊維を含有する繊維構造物
JP4895026B2 (ja) * 2007-02-28 2012-03-14 日本エクスラン工業株式会社 導電性繊維およびその製造方法
JP2008223159A (ja) * 2007-03-09 2008-09-25 Tamaki:Kk 繊維製品の洗濯方法、供給方法および洗濯された繊維製品ならびに人間の皮膚に接し得る製品へ癒される感覚等を付与する方法
FR2947276B1 (fr) * 2009-06-24 2012-10-26 Seppic Sa Composition cosmetique a base de resines echangeuses d'ions chargees avec des lipoaminoacides
WO2012014732A1 (ja) * 2010-07-28 2012-02-02 東亞合成株式会社 重合体微粒子及びこれを含む皮膚外用組成物
CN103930611B (zh) * 2011-11-10 2015-09-23 日本爱克兰工业株式会社 吸湿除臭纤维、其制造方法及含有该纤维的纤维结构物
JP2014009178A (ja) * 2012-06-28 2014-01-20 Pola Chem Ind Inc 化粧料
WO2017034871A1 (en) 2015-08-21 2017-03-02 G&P Holding, Inc. Silver and copper itaconates and poly itaconates
JP7298142B2 (ja) * 2017-12-07 2023-06-27 日本エクスラン工業株式会社 アクネ菌および表皮ブドウ球菌を減少させることなく黄色ブドウ球菌を減少させる選択的抗菌用繊維構造物および該繊維構造物を含有する抗菌用製品

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4713244A (en) * 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
JPH0745393B2 (ja) * 1986-01-08 1995-05-17 サンスタ−株式会社 弱酸性ゲル状化粧料
AU8951191A (en) * 1990-10-29 1992-05-26 Dekalb Plant Genetics Isolation of biological materials using magnetic particles
US5807364A (en) * 1992-08-17 1998-09-15 Weyerhaeuser Company Binder treated fibrous webs and products
JP2992802B2 (ja) * 1994-08-10 1999-12-20 セーレン株式会社 スキンケア繊維製品
JPH08301723A (ja) * 1995-05-11 1996-11-19 Keiichirou Yukimitsu 保湿性化粧料
JP3489917B2 (ja) * 1995-07-21 2004-01-26 セーレン株式会社 機能性繊維製品およびその製造方法
JP3369380B2 (ja) * 1995-11-29 2003-01-20 東洋紡績株式会社 改善された高吸放湿性繊維及びその製造方法
FR2752843B1 (fr) * 1996-08-30 1998-10-16 Sod Conseils Rech Applic Copolymeres reticules a base de polymeres polycarboxyliques et leur utilisation comme support de composition pharmaceutique
JP3812604B2 (ja) 1997-02-27 2006-08-23 日本エクスラン工業株式会社 ｐＨ緩衝・調湿性重合体及びその製造方法ならびに該重合体を含有したシートまたは化粧料
US6229009B1 (en) * 1997-08-29 2001-05-08 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) Polycarboxylic based cross-linked copolymers
JPH1179945A (ja) * 1997-09-05 1999-03-23 Mitsubishi Chem Corp 毛髪化粧料組成物
JP3484361B2 (ja) * 1998-11-02 2004-01-06 花王株式会社 皮膚化粧料
US6361768B1 (en) * 1998-12-29 2002-03-26 Pmd Holdings Corp. Hydrophilic ampholytic polymer
KR100345214B1 (ko) * 1999-08-17 2002-07-25 이강춘 생체적합성 고분자가 수식된 펩타이드의 비점막 전달
JP2001072764A (ja) 1999-09-02 2001-03-21 Mitsui Chemicals Inc 基 材
JP3858143B2 (ja) * 2000-04-28 2006-12-13 グンゼ株式会社 繊維製品
JP2002038375A (ja) 2000-05-16 2002-02-06 Toyobo Co Ltd 吸放湿性布帛及びその製造方法
JP5031947B2 (ja) * 2001-02-15 2012-09-26 石原薬品株式会社 水性硬表面保護艶出し剤
JP2002284619A (ja) * 2001-03-23 2002-10-03 Ajinomoto Co Inc 化粧料の製造方法
US7273501B2 (en) * 2001-07-25 2007-09-25 Japan Exlan Company, Limited Fiber structure having high whiteness and high moisture-absorbing and releasing property, and method for production thereof
JP3895217B2 (ja) * 2002-06-05 2007-03-22 美津濃株式会社 繊維製品およびその製造方法
JP2004018490A (ja) * 2002-06-19 2004-01-22 Pola Chem Ind Inc 角層バリア強化用の皮膚外用剤
JP2004123575A (ja) * 2002-09-30 2004-04-22 Rohto Pharmaceut Co Ltd 外用ゲル状組成物

Also Published As

Publication number Publication date
CN100424104C (zh) 2008-10-08
WO2005007714A1 (ja) 2005-01-27
DE602004014783D1 (de) 2008-08-14
US20060153903A1 (en) 2006-07-13
JPWO2005007714A1 (ja) 2007-09-20
KR20070004511A (ko) 2007-01-09
ES2305803T3 (es) 2008-11-01
JP4796845B2 (ja) 2011-10-19
KR101161459B1 (ko) 2012-07-02
EP1657263A1 (de) 2006-05-17
CN1826359A (zh) 2006-08-30
EP1657263B1 (de) 2008-07-02
EP1657263A4 (de) 2007-02-14

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