ATE398460T1 - Vorbeuge- und/oder heilmittel für das multiple organversagen - Google Patents
Vorbeuge- und/oder heilmittel für das multiple organversagenInfo
- Publication number
- ATE398460T1 ATE398460T1 AT98907158T AT98907158T ATE398460T1 AT E398460 T1 ATE398460 T1 AT E398460T1 AT 98907158 T AT98907158 T AT 98907158T AT 98907158 T AT98907158 T AT 98907158T AT E398460 T1 ATE398460 T1 AT E398460T1
- Authority
- AT
- Austria
- Prior art keywords
- multiple organ
- failure
- organ failure
- preventing
- agent
- Prior art date
Links
- 208000034486 Multi-organ failure Diseases 0.000 title abstract 3
- 208000010718 Multiple Organ Failure Diseases 0.000 title abstract 3
- 208000029744 multiple organ dysfunction syndrome Diseases 0.000 title abstract 3
- 230000003449 preventive effect Effects 0.000 title 1
- 208000030507 AIDS Diseases 0.000 abstract 2
- 102000003745 Hepatocyte Growth Factor Human genes 0.000 abstract 2
- 108090000100 Hepatocyte Growth Factor Proteins 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 206010006895 Cachexia Diseases 0.000 abstract 1
- 206010009192 Circulatory collapse Diseases 0.000 abstract 1
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 abstract 1
- 208000032456 Hemorrhagic Shock Diseases 0.000 abstract 1
- 206010033645 Pancreatitis Diseases 0.000 abstract 1
- 206010033647 Pancreatitis acute Diseases 0.000 abstract 1
- 108010094028 Prothrombin Proteins 0.000 abstract 1
- 206010049771 Shock haemorrhagic Diseases 0.000 abstract 1
- 201000003229 acute pancreatitis Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 abstract 1
- 231100000433 cytotoxic Toxicity 0.000 abstract 1
- 230000001472 cytotoxic effect Effects 0.000 abstract 1
- 230000006866 deterioration Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 208000009190 disseminated intravascular coagulation Diseases 0.000 abstract 1
- 201000011200 hepatorenal syndrome Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000000302 ischemic effect Effects 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 235000016709 nutrition Nutrition 0.000 abstract 1
- 230000005855 radiation Effects 0.000 abstract 1
- 206010040560 shock Diseases 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Dermatology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Jib Cranes (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7437297 | 1997-03-11 | ||
| JP15764597A JP4006058B2 (ja) | 1997-03-11 | 1997-05-30 | 多臓器不全予防及び／又は治療剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE398460T1 true ATE398460T1 (de) | 2008-07-15 |
Family
ID=26415513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98907158T ATE398460T1 (de) | 1997-03-11 | 1998-03-11 | Vorbeuge- und/oder heilmittel für das multiple organversagen |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20010051146A1 (de) |
| EP (1) | EP0914829B1 (de) |
| JP (1) | JP4006058B2 (de) |
| AT (1) | ATE398460T1 (de) |
| AU (1) | AU725441B2 (de) |
| CA (1) | CA2252711A1 (de) |
| DE (1) | DE69839621D1 (de) |
| ES (1) | ES2308802T3 (de) |
| WO (1) | WO1998040096A1 (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| AU734766B2 (en) | 1997-03-14 | 2001-06-21 | Atlas Pharmaceuticals Inc. | Agent for preventing and/or treating cachexia |
| JPH1129493A (ja) * | 1997-07-14 | 1999-02-02 | Snow Brand Milk Prod Co Ltd | 放射線障害予防及び／又は治療剤 |
| US20040091453A1 (en) * | 2000-06-02 | 2004-05-13 | Hiroshi Okamoto | Pancreatic langerhans beta cell proliferation promoter and apoptosis inhibitor, and screening of candidate compounds for the e drugs |
| GB0110430D0 (en) * | 2001-04-27 | 2001-06-20 | Medical Res Council | Protein variants and uses thereof |
| WO2003037365A1 (en) * | 2001-11-01 | 2003-05-08 | The Johns Hopkins University | Methods and compositions for treating vascular leak using hepatocyte growth factor |
Family Cites Families (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3904753A (en) | 1970-02-20 | 1975-09-09 | Research Corp | Clinically active bovine growth hormone fraction |
| US4076701A (en) | 1975-07-29 | 1978-02-28 | Immunology Research Foundation, Inc. | Tumor complement fraction recovery method and product |
| US4490549A (en) | 1977-04-19 | 1984-12-25 | The Upjohn Company | Enlarged-hetero-ring prostacyclin analogs |
| US4481137A (en) | 1982-02-26 | 1984-11-06 | Mochida Pharmaceutical Co., Ltd. | Glycoproteins and processes for their production |
| JPS60112718A (ja) | 1983-11-21 | 1985-06-19 | Kyorin Pharmaceut Co Ltd | 抗腫瘍作用を示す蛋白性物質及びその製造方法 |
| US4650674A (en) | 1984-07-05 | 1987-03-17 | Genentech, Inc. | Synergistic cytotoxic composition |
| ATE41159T1 (de) | 1985-08-29 | 1989-03-15 | Berol Kemi Ab | Traeger mit einer immobilisierten biologischaktiven substanz, verfahren zur herstellung und seine verwendung. |
| US4870163A (en) | 1985-08-29 | 1989-09-26 | New York Blood Center, Inc. | Preparation of pure human tumor necrosis factor and hybridomas producing monoclonal antibodies to human tumor necrosis factor |
| US4822605A (en) | 1986-02-18 | 1989-04-18 | Exovir, Inc. | Compositions and methods employing the same for the treatment of viral and cancerous skin lesions and the like |
| KR890009412A (ko) | 1987-12-22 | 1989-08-01 | 마쓰시따 렌조오 | 종양 세포 억제 인자 |
| JPH0296598A (ja) | 1988-10-03 | 1990-04-09 | Sapporo Breweries Ltd | リンフォカイン活性化キラー細胞誘導抑制因子ｌａｋｓｆ，その製造法およびそれを有効成分とする免疫抑制剤 |
| NZ232813A (en) | 1989-03-10 | 1992-08-26 | Snow Brand Milk Products Co Ltd | Human fibroblast glycoprotein, cell differentiation, blood vessel endothelial cell growth factor, cellular immunology inforcing factor of 78 or 74 thousand daltons plus or minus two thousand daltons |
| US5035887A (en) | 1989-09-07 | 1991-07-30 | Institute Of Moelcular Biology, Inc. | Wound healing composition of IL-1 and PDGF or IGF-1 |
| US5362716A (en) | 1989-12-27 | 1994-11-08 | The United States Of America As Represented By The Department Of Health And Human Services | Methods for stimulating hematopoietic progenitors using hepatocyte growth factor and lymphokines |
| US5648273A (en) | 1989-12-27 | 1997-07-15 | The United States Of America, As Represented By The Department Of Health And Human Services | Hepatic growth factor receptor is the MET proto-oncogene |
| JP2784455B2 (ja) | 1990-05-09 | 1998-08-06 | 敏一 中村 | 肝硬変治療剤 |
| DE69133492T2 (de) | 1990-06-11 | 2006-08-10 | Nakamura, Toshikazu | Rekombinanter menschlicher Hepatozytwachstumsfaktor und Verfahren zu seiner Herstellung |
| JP2750372B2 (ja) * | 1990-06-19 | 1998-05-13 | 敏一 中村 | 賢疾患治療剤 |
| JP2634323B2 (ja) | 1990-07-13 | 1997-07-23 | 雪印乳業株式会社 | Ｔｃｆ‐▲ｉｉ▼のアミノ酸配列をコードするｄｎａを含むプラスミド，形質転換細胞及びこれを用いて生理活性物質を生産する方法 |
| US5821223A (en) | 1990-09-14 | 1998-10-13 | The United States Of America As Represented By The Department Of Health And Human Services | Method of stimulating cell growth with a novel broad spectrum human lung fibroblast-derived mitogen |
| HUT60282A (en) | 1991-02-08 | 1992-08-28 | Sankyo Co | Process for producing new beta-amino-alpha-hydroxycarboxylic acid derivatives and pharmaceutical compositions comprising such compounds |
| JPH0597A (ja) | 1991-06-21 | 1993-01-08 | Snow Brand Milk Prod Co Ltd | 新規抗ｔｃｆ−ｉｉモノクローナル抗体及びそれを用いるｔｃｆ−ｉｉの測定方法 |
| JP3394982B2 (ja) | 1991-11-07 | 2003-04-07 | 敏一 中村 | ガン療法用副作用防止剤 |
| ZA929869B (en) | 1991-12-20 | 1994-06-20 | Syntex Inc | Hiv protease inhibitors |
| JP3123617B2 (ja) | 1992-03-04 | 2001-01-15 | 雪印乳業株式会社 | シアル酸結合を有する化合物の製造法 |
| NO178729C (no) | 1992-03-31 | 1996-05-22 | Daiichi Seiyaku Co | Terapeutisk aktive sukkerderivater |
| JPH0625273A (ja) * | 1992-03-31 | 1994-02-01 | Dai Ichi Seiyaku Co Ltd | アミノ糖誘導体 |
| US5315000A (en) | 1992-05-14 | 1994-05-24 | Children's Hospital Medical Center | Gene encoding for a L5/3 growth factor and its CDNA |
| JPH07508420A (ja) | 1992-05-18 | 1995-09-21 | ジェネンテク，インコーポレイテッド | 肝細胞成長因子変異体 |
| JP3380573B2 (ja) * | 1992-07-16 | 2003-02-24 | 第一製薬株式会社 | Ｔｃｆ−ｉｉを有効成分とする蛋白合成促進剤 |
| DE69334087T2 (de) * | 1992-07-16 | 2007-07-05 | Daiichi Pharmaceutical Co., Ltd. | Arzneimittelzusammensetzung enthaltend TCF-II |
| JPH0656692A (ja) * | 1992-08-10 | 1994-03-01 | Snow Brand Milk Prod Co Ltd | Ｔｃｆ−ｉｉを有効成分とする創傷治療剤 |
| JP3619526B2 (ja) | 1992-07-16 | 2005-02-09 | 第一製薬株式会社 | Ｔｃｆ−ｉｉを有効成分とする肝臓疾患治療剤 |
| DE69330960T2 (de) | 1992-07-16 | 2002-04-11 | Snow Brand Milk Products Co., Ltd. | Normalisierer der blutkoagulation enthaltend tcf-ii als aktiven bestandteil |
| JP3697460B2 (ja) * | 1992-07-17 | 2005-09-21 | 敏一 中村 | Ｈｇｆ含有製剤 |
| FI933472A7 (fi) | 1992-08-07 | 1994-02-08 | Sankyo Co | Peptider med foermaoga att inhibera effekten av HIV-proteas, deras framstaellning och terapeutiska anvaendning |
| JP3402476B2 (ja) | 1992-08-24 | 2003-05-06 | 生化学工業株式会社 | リポ多糖結合性タンパク質及びその製造法 |
| EP0661993B1 (de) | 1992-09-16 | 1997-05-07 | Genentech, Inc. | Schutz gegen leberschäden mit hgf |
| US5703047A (en) | 1992-09-21 | 1997-12-30 | Board Of Regents, The University Of Texas System | Methods and treatments for corneal healing with growth factors |
| US5589451A (en) | 1992-09-21 | 1996-12-31 | Board Of Regents, The University Of Texas System | Methods and treaments for corneal healing with hepatocyte and keratinocyte growth factors |
| JPH06116299A (ja) | 1992-10-02 | 1994-04-26 | Snow Brand Milk Prod Co Ltd | 特定の糖鎖構造により高い生物活性を有する遺伝子組換え型ｔｃｆ |
| US5554653A (en) | 1992-12-22 | 1996-09-10 | Eli Lilly And Company | Inhibitors of HIV protease useful for the treatment of AIDS |
| MX9308016A (es) | 1992-12-22 | 1994-08-31 | Lilly Co Eli | Compuestos inhibidores de la proteasa del virus de la inmunodeficiencia humana, procedimiento para su preparacion y formulacion farmaceutica que los contiene. |
| WO1994014845A1 (en) | 1992-12-28 | 1994-07-07 | Snow Brand Milk Products Co., Ltd. | Modified tcf |
| JP3552240B2 (ja) * | 1993-02-23 | 2004-08-11 | 第一製薬株式会社 | 高濃度ｔｃｆ製剤 |
| JPH07258298A (ja) | 1994-03-18 | 1995-10-09 | Snow Brand Milk Prod Co Ltd | モノクローナル抗体 |
| JP3962097B2 (ja) | 1994-03-18 | 2007-08-22 | 敏一 中村 | 免疫抑制剤による副作用の軽減剤 |
| US5707624A (en) | 1994-06-03 | 1998-01-13 | The Regents Of The University Of Michigan | Treatment of Kaposi's sarcoma by inhibition of scatter factor |
| US6399744B1 (en) | 1994-12-27 | 2002-06-04 | Daiichi Pharmaceutical Co., Ltd. | TCF mutant |
| JPH08176007A (ja) | 1994-12-27 | 1996-07-09 | Snow Brand Milk Prod Co Ltd | 脂質代謝異常治療剤 |
| JPH08231418A (ja) | 1995-02-24 | 1996-09-10 | Mitsubishi Chem Corp | 腸疾患治療剤 |
| WO1996028423A1 (en) | 1995-03-15 | 1996-09-19 | Sankyo Company, Limited | Dipeptide compounds having ahpba structure |
| EP0823256A4 (de) | 1995-04-21 | 2000-06-21 | Mitsubishi Chem Corp | Mittel zur vorsorge und/oder heilmittel zur behandlung von ischämischen erkrankungen |
| JPH10194986A (ja) | 1996-06-10 | 1998-07-28 | Snow Brand Milk Prod Co Ltd | 移植肝機能改善・再生促進剤 |
| JP3887435B2 (ja) | 1996-07-12 | 2007-02-28 | 第一製薬株式会社 | スフェロイド形成促進剤 |
| JPH1068400A (ja) | 1996-08-28 | 1998-03-10 | Tetsuo Taira | 液体を押し出すボトルポンプ及びその方法と製造方法 |
| JP4006058B2 (ja) | 1997-03-11 | 2007-11-14 | 第一三共株式会社 | 多臓器不全予防及び／又は治療剤 |
| AU734766B2 (en) | 1997-03-14 | 2001-06-21 | Atlas Pharmaceuticals Inc. | Agent for preventing and/or treating cachexia |
| JP3961064B2 (ja) | 1997-03-28 | 2007-08-15 | 第一製薬株式会社 | 腎疾患予防及び／又は治療剤 |
| JPH1129493A (ja) | 1997-07-14 | 1999-02-02 | Snow Brand Milk Prod Co Ltd | 放射線障害予防及び／又は治療剤 |
| JPH11269091A (ja) | 1998-03-19 | 1999-10-05 | Snow Brand Milk Prod Co Ltd | 敗血症予防及び／又は治療剤 |
-
1997
- 1997-05-30 JP JP15764597A patent/JP4006058B2/ja not_active Expired - Fee Related
-
1998
- 1998-03-11 ES ES98907158T patent/ES2308802T3/es not_active Expired - Lifetime
- 1998-03-11 WO PCT/JP1998/000998 patent/WO1998040096A1/ja not_active Ceased
- 1998-03-11 EP EP98907158A patent/EP0914829B1/de not_active Expired - Lifetime
- 1998-03-11 CA CA002252711A patent/CA2252711A1/en not_active Abandoned
- 1998-03-11 US US09/180,599 patent/US20010051146A1/en not_active Abandoned
- 1998-03-11 DE DE69839621T patent/DE69839621D1/de not_active Expired - Fee Related
- 1998-03-11 AT AT98907158T patent/ATE398460T1/de not_active IP Right Cessation
- 1998-03-11 AU AU63092/98A patent/AU725441B2/en not_active Ceased
-
2002
- 2002-12-11 US US10/317,011 patent/US7306791B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20010051146A1 (en) | 2001-12-13 |
| JP4006058B2 (ja) | 2007-11-14 |
| WO1998040096A1 (en) | 1998-09-17 |
| EP0914829A1 (de) | 1999-05-12 |
| AU6309298A (en) | 1998-09-29 |
| EP0914829A4 (de) | 2004-06-16 |
| AU725441B2 (en) | 2000-10-12 |
| DE69839621D1 (de) | 2008-07-31 |
| EP0914829B1 (de) | 2008-06-18 |
| JPH10310535A (ja) | 1998-11-24 |
| ES2308802T3 (es) | 2008-12-01 |
| CA2252711A1 (en) | 1998-09-17 |
| US20030153489A1 (en) | 2003-08-14 |
| US7306791B2 (en) | 2007-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |