ATE386727T1 - Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf) - Google Patents
Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf)Info
- Publication number
- ATE386727T1 ATE386727T1 AT02722478T AT02722478T ATE386727T1 AT E386727 T1 ATE386727 T1 AT E386727T1 AT 02722478 T AT02722478 T AT 02722478T AT 02722478 T AT02722478 T AT 02722478T AT E386727 T1 ATE386727 T1 AT E386727T1
- Authority
- AT
- Austria
- Prior art keywords
- crf
- antagonists
- releasing factor
- corticotropin releasing
- condensed pyrimidines
- Prior art date
Links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0463—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
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- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0465—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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- C—CHEMISTRY; METALLURGY
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- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0110570A GB0110570D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110569A GB0110569D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0110567A GB0110567D0 (en) | 2001-04-30 | 2001-04-30 | Chemical compounds |
GB0117401A GB0117401D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117399A GB0117399D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0117420A GB0117420D0 (en) | 2001-07-17 | 2001-07-17 | Chemical compounds |
GB0203201A GB0203201D0 (en) | 2002-02-11 | 2002-02-11 | Chemical compounds |
GB0206834A GB0206834D0 (en) | 2002-03-22 | 2002-03-22 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE386727T1 true ATE386727T1 (de) | 2008-03-15 |
Family
ID=27571152
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02722478T ATE386727T1 (de) | 2001-04-30 | 2002-04-30 | Kondensierte pyrimidine als antagonisten des corticotropin releasing factor (crf) |
Country Status (19)
Families Citing this family (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1395591B1 (en) * | 2001-06-12 | 2008-06-04 | Glaxo Group Limited | Corticotropin releasing factor antagonists |
GB0117396D0 (en) * | 2001-07-17 | 2001-09-05 | Glaxo Group Ltd | Chemical compounds |
WO2004062665A1 (en) * | 2003-01-16 | 2004-07-29 | Sb Pharmco Puerto Rico Inc | Heteroaryl- substituted pyrrolo` 2, 3- b! pyridine derivatives as crf receptor antagonists |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
GB0308208D0 (en) * | 2003-04-09 | 2003-05-14 | Glaxo Group Ltd | Chemical compounds |
WO2004099209A1 (en) * | 2003-05-05 | 2004-11-18 | F. Hoffmann-La-Roche Ag | Fused pyrimidine derivatives with crf activity |
JP2007501822A (ja) | 2003-08-12 | 2007-02-01 | エフ.ホフマン−ラ ロシュ アーゲー | コルチコトロピン放出性因子(crf)アンタゴニストとしてのスピロ置換テトラヒドロキナゾリン |
WO2005014557A1 (en) | 2003-08-12 | 2005-02-17 | F.Hoffmann-La Roche Ag | Tetrahydroquinazoline derivatives as cfr antagonists |
NZ547990A (en) * | 2003-12-22 | 2010-04-30 | Smithkline Beecham Cork Ltd | CRF receptor antagonists and methods relating thereto |
RU2006128580A (ru) * | 2004-01-06 | 2008-02-20 | Тайсо Фармасьютикал Ко., Лтд. (Jp) | Производные тиенопиримидина и тиенопиридина, замещенные циклической аминогруппой |
JP2007526906A (ja) * | 2004-03-05 | 2007-09-20 | 大正製薬株式会社 | ピロロピリミジン誘導体 |
US7507740B2 (en) | 2004-06-02 | 2009-03-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
JP2008503443A (ja) * | 2004-06-25 | 2008-02-07 | 大正製薬株式会社 | テトラヒドロピリジンで置換されたピロロピリミジン及びピロロピリジンの誘導体 |
US7652035B2 (en) * | 2004-10-19 | 2010-01-26 | Neurocrine Bioscience, Inc. | CRF receptor antagonists and methods relating thereto |
GB0519957D0 (en) * | 2005-09-30 | 2005-11-09 | Sb Pharmco Inc | Chemical compound |
US8088779B2 (en) * | 2005-09-30 | 2012-01-03 | Smithkline Beecham (Cork) Limited | Pyrazolo [1,5-alpha] pyrimidinyl derivatives useful as corticotropin-releasing factor (CRF) receptor antagonists |
EP2049546B1 (en) | 2006-07-06 | 2010-12-29 | Array Biopharma, Inc. | Dihydrofuro pyrimidines as akt protein kinase inhibitors |
US8003651B2 (en) * | 2006-07-06 | 2011-08-23 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
SI2054418T1 (sl) | 2006-07-06 | 2012-02-29 | Array Biopharma Inc | Dihidrotieno pirimidini kot AKT protein kinazni inhibitorji |
US8063050B2 (en) * | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008008887A2 (en) * | 2006-07-13 | 2008-01-17 | Smithkline Beecham Corporation | Gpr119 agonists for treating metabolic disorders |
DE102007004303A1 (de) | 2006-08-04 | 2008-02-07 | Osram Opto Semiconductors Gmbh | Dünnfilm-Halbleiterbauelement und Bauelement-Verbund |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
NZ582692A (en) | 2007-07-05 | 2012-05-25 | Array Biopharma Inc | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
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- 2002-04-30 AR ARP020101597A patent/AR033295A1/es unknown
- 2002-04-30 KR KR10-2003-7014160A patent/KR20040015206A/ko not_active Application Discontinuation
- 2002-04-30 US US10/476,368 patent/US7279474B2/en not_active Expired - Fee Related
- 2002-04-30 BR BR0209267-0A patent/BR0209267A/pt not_active IP Right Cessation
- 2002-04-30 DE DE60225127T patent/DE60225127T2/de not_active Expired - Fee Related
- 2002-04-30 JP JP2002585397A patent/JP2004528349A/ja active Pending
- 2002-04-30 CZ CZ20032946A patent/CZ20032946A3/cs unknown
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- 2002-04-30 WO PCT/GB2002/002029 patent/WO2002088095A1/en active IP Right Grant
- 2002-04-30 HU HU0304054A patent/HUP0304054A2/hu unknown
- 2002-04-30 AT AT02722478T patent/ATE386727T1/de not_active IP Right Cessation
- 2002-04-30 CN CNA028107462A patent/CN1649848A/zh active Pending
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NO20034836D0 (no) | 2003-10-29 |
DE60225127T2 (de) | 2009-02-19 |
CA2446514A1 (en) | 2002-11-07 |
BR0209267A (pt) | 2004-06-15 |
NO20034836L (no) | 2003-10-29 |
ES2301633T3 (es) | 2008-07-01 |
AR033295A1 (es) | 2003-12-10 |
KR20040015206A (ko) | 2004-02-18 |
DE60225127D1 (en) | 2008-04-03 |
US20040176400A1 (en) | 2004-09-09 |
AU2002253357B2 (en) | 2006-08-24 |
JP2004528349A (ja) | 2004-09-16 |
WO2002088095A1 (en) | 2002-11-07 |
PL366934A1 (en) | 2005-02-07 |
EP1383747A1 (en) | 2004-01-28 |
MXPA03009938A (es) | 2005-09-07 |
IL158062A0 (en) | 2004-03-28 |
CN1649848A (zh) | 2005-08-03 |
EP1383747B1 (en) | 2008-02-20 |
HUP0304054A2 (hu) | 2004-04-28 |
US7279474B2 (en) | 2007-10-09 |
CZ20032946A3 (en) | 2004-05-12 |
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