ATE378345T1 - Verfahren zur aufreinigung von makroliden - Google Patents
Verfahren zur aufreinigung von makrolidenInfo
- Publication number
- ATE378345T1 ATE378345T1 AT04779384T AT04779384T ATE378345T1 AT E378345 T1 ATE378345 T1 AT E378345T1 AT 04779384 T AT04779384 T AT 04779384T AT 04779384 T AT04779384 T AT 04779384T AT E378345 T1 ATE378345 T1 AT E378345T1
- Authority
- AT
- Austria
- Prior art keywords
- purifying
- macrolids
- macrolide
- eluting
- tetrahydrofuran
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 2
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 abstract 1
- 239000003480 eluent Substances 0.000 abstract 1
- 239000011347 resin Substances 0.000 abstract 1
- 229920005989 resin Polymers 0.000 abstract 1
- 238000001179 sorption measurement Methods 0.000 abstract 1
- 229960001967 tacrolimus Drugs 0.000 abstract 1
- QJJXYPPXXYFBGM-SHYZHZOCSA-N tacrolimus Natural products CO[C@H]1C[C@H](CC[C@@H]1O)C=C(C)[C@H]2OC(=O)[C@H]3CCCCN3C(=O)C(=O)[C@@]4(O)O[C@@H]([C@H](C[C@H]4C)OC)[C@@H](C[C@H](C)CC(=C[C@@H](CC=C)C(=O)C[C@H](O)[C@H]2C)C)OC QJJXYPPXXYFBGM-SHYZHZOCSA-N 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49007003P | 2003-07-24 | 2003-07-24 | |
| US53936304P | 2004-01-26 | 2004-01-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE378345T1 true ATE378345T1 (de) | 2007-11-15 |
Family
ID=34107827
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04779384T ATE378345T1 (de) | 2003-07-24 | 2004-07-26 | Verfahren zur aufreinigung von makroliden |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7220357B2 (https=) |
| EP (1) | EP1558622B1 (https=) |
| JP (1) | JP2007521013A (https=) |
| KR (1) | KR20060052874A (https=) |
| AT (1) | ATE378345T1 (https=) |
| CA (1) | CA2533548C (https=) |
| DE (1) | DE602004010059T2 (https=) |
| DK (1) | DK1558622T3 (https=) |
| ES (1) | ES2297481T3 (https=) |
| PL (1) | PL1558622T3 (https=) |
| PT (1) | PT1558622E (https=) |
| TW (1) | TW200523266A (https=) |
| WO (1) | WO2005010015A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7645876B2 (en) * | 2004-12-01 | 2010-01-12 | TEVA Gyógyszergyár Zártkörúen Müködö Részvénytársaság | Processes for producing crystalline macrolides |
| RU2317991C1 (ru) * | 2003-12-05 | 2008-02-27 | Байокон Лимитид | Способ выделения и очистки макролидов |
| WO2006069333A1 (en) * | 2004-12-22 | 2006-06-29 | Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg | Method of purifying macrolides |
| BRPI0619592A2 (pt) * | 2005-12-07 | 2016-09-06 | Wyeth Corp | métodos para medir a qualidade da partícula de um composto de rapamicina, para determinar o tamanho de partícula médio de uma amostra e a cristalinidade de um composto de rapamicina, e para a purificação de rapamicina |
| KR100859670B1 (ko) * | 2006-09-13 | 2008-09-23 | 동국제약 주식회사 | 타크로리무스를 고수율 및 고순도로 정제하는 방법 |
| CA2668134A1 (en) * | 2006-11-06 | 2008-05-15 | Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag | Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof |
| KR100891313B1 (ko) * | 2007-08-17 | 2009-03-31 | (주) 제노텍 | 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법 |
| PL2792254T3 (pl) * | 2009-04-16 | 2017-06-30 | Ocean Spray Cranberries, Inc. | Ekstrakcja związków fenolowych i ich zastosowanie w kompozycjach z kwasem fumarowym |
| CN106478664B (zh) * | 2016-08-29 | 2017-12-05 | 广东蓝宝制药有限公司 | 一种发酵液中提取纯化他克莫司的方法 |
| PL3619215T3 (pl) | 2017-05-01 | 2022-03-21 | Meda Pharma Gmbh & Co. Kg | Sposób przekształcania surowej askomycyny w oczyszczony pimecrolimus |
| CN108409751A (zh) * | 2018-02-24 | 2018-08-17 | 海正药业(杭州)有限公司 | 一种子囊霉素的纯化方法 |
| CN111693635A (zh) * | 2020-07-23 | 2020-09-22 | 北京和合医学诊断技术股份有限公司 | 检测血液中雷帕霉素含量的方法 |
| CN113325108B (zh) * | 2021-06-04 | 2022-12-09 | 山东霆科药业有限公司 | 一种他克莫司软膏的样品前处理方法 |
| CN115716839A (zh) * | 2022-11-15 | 2023-02-28 | 无锡福祈制药有限公司 | 一种依维莫司杂质的合成方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2121517C3 (de) | 1971-04-30 | 1974-06-27 | Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion) | Verfahren zur Gewinnung von Amphoterizin B |
| US3993749A (en) | 1974-04-12 | 1976-11-23 | Ayerst Mckenna And Harrison Ltd. | Rapamycin and process of preparation |
| US4160861A (en) * | 1977-10-03 | 1979-07-10 | Merck & Co., Inc. | Method for the separation of antibiotic macrolides |
| US4894366A (en) | 1984-12-03 | 1990-01-16 | Fujisawa Pharmaceutical Company, Ltd. | Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same |
| JP2639737B2 (ja) | 1990-01-23 | 1997-08-13 | 寳酒造株式会社 | 新規ｒ１０６類化合物 |
| US5116756A (en) | 1991-01-28 | 1992-05-26 | Merck & Co., Inc. | Process for producing FK-506 |
| JPH06501026A (ja) | 1991-04-11 | 1994-01-27 | ファイザー・インコーポレーテッド | ストレプトミセス・ブレジェンシス由来の新規の免疫抑制剤 |
| US5091389A (en) | 1991-04-23 | 1992-02-25 | Merck & Co., Inc. | Lipophilic macrolide useful as an immunosuppressant |
| WO1993018042A1 (en) | 1992-03-02 | 1993-09-16 | Pfizer Inc. | Desosamino derivatives of macrolides as immunosuppressants and antifungal agents |
| UA41884C2 (uk) | 1993-11-05 | 2001-10-15 | Амерікан Хоум Продактс Корпорейшн | Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів |
| US5622866A (en) | 1994-06-23 | 1997-04-22 | Merck & Co., Inc. | Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces |
| GB9618952D0 (en) | 1996-09-11 | 1996-10-23 | Sandoz Ltd | Process |
| GB9826882D0 (en) | 1998-12-07 | 1999-01-27 | Novartis Ag | Organic compounds |
| TW553946B (en) * | 1999-09-08 | 2003-09-21 | Fujisawa Pharmaceutical Co | Method for separating lactone-containing high-molecular weight compounds |
| ES2177373B1 (es) | 1999-11-26 | 2003-11-01 | Astur Pharma Sa | Preparacion de azitromicina en su forma no cristalina |
| FR2803307A1 (fr) * | 1999-12-30 | 2001-07-06 | Centre Nat Rech Scient | Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo |
| HRP20020683A2 (en) | 2000-02-24 | 2004-12-31 | Biogal Gyogyszergyar | Method of purifying a fermentation broth |
| AUPQ801700A0 (en) * | 2000-06-07 | 2000-06-29 | Peplin Research Pty Ltd | Enzyme and viral activation |
| AUPQ923100A0 (en) * | 2000-08-07 | 2000-08-31 | Peplin Research Pty Ltd | Treatment of prostate cancer |
| MXPA04007847A (es) | 2002-02-13 | 2005-02-24 | Biogal Gyogyszergyar | Metodo para extraer un macrolido de biomateria. |
-
2004
- 2004-07-26 TW TW093122295A patent/TW200523266A/zh unknown
- 2004-07-26 AT AT04779384T patent/ATE378345T1/de active
- 2004-07-26 DE DE602004010059T patent/DE602004010059T2/de not_active Expired - Lifetime
- 2004-07-26 PL PL04779384T patent/PL1558622T3/pl unknown
- 2004-07-26 DK DK04779384T patent/DK1558622T3/da active
- 2004-07-26 JP JP2006521315A patent/JP2007521013A/ja not_active Ceased
- 2004-07-26 PT PT04779384T patent/PT1558622E/pt unknown
- 2004-07-26 CA CA2533548A patent/CA2533548C/en not_active Expired - Fee Related
- 2004-07-26 ES ES04779384T patent/ES2297481T3/es not_active Expired - Lifetime
- 2004-07-26 WO PCT/US2004/024318 patent/WO2005010015A1/en not_active Ceased
- 2004-07-26 EP EP04779384A patent/EP1558622B1/en not_active Expired - Lifetime
- 2004-07-26 KR KR1020067001618A patent/KR20060052874A/ko not_active Abandoned
- 2004-07-26 US US10/899,757 patent/US7220357B2/en not_active Expired - Fee Related
-
2007
- 2007-01-17 US US11/654,758 patent/US20070117976A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1558622E (pt) | 2007-12-04 |
| WO2005010015B1 (en) | 2005-03-17 |
| US7220357B2 (en) | 2007-05-22 |
| DE602004010059D1 (de) | 2007-12-27 |
| PL1558622T3 (pl) | 2008-06-30 |
| DK1558622T3 (da) | 2008-02-25 |
| DE602004010059T2 (de) | 2008-09-11 |
| KR20060052874A (ko) | 2006-05-19 |
| CA2533548C (en) | 2010-02-16 |
| ES2297481T3 (es) | 2008-05-01 |
| TW200523266A (en) | 2005-07-16 |
| JP2007521013A (ja) | 2007-08-02 |
| EP1558622B1 (en) | 2007-11-14 |
| US20050027112A1 (en) | 2005-02-03 |
| EP1558622A1 (en) | 2005-08-03 |
| US20070117976A1 (en) | 2007-05-24 |
| CA2533548A1 (en) | 2005-02-03 |
| WO2005010015A1 (en) | 2005-02-03 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE378345T1 (de) | Verfahren zur aufreinigung von makroliden | |
| ATE469908T1 (de) | Verfahren zur herstellung von pimecrolimus | |
| IL177467A (en) | A method for producing a botulinum toxin with biological activity | |
| DE602004004016D1 (de) | Verfahren zur Ventilsteuerung eines Abgassystems | |
| ATE525087T1 (de) | Verfahren zur aufreinigung von antikörpern | |
| DE60325388D1 (de) | Verfahren zur abwasserbehandlung mit schlammpartikel | |
| DE10341106A8 (de) | System und Verfahren zur Motorsteuerung | |
| ATE542432T1 (de) | Mikroorganismus zur entgiftung von fumonisinen sowie verwendung desselben, verfahren zum entgiften von fumonisinen und futtermittelzusatz, enthaltend den mikroorganismus | |
| ATE449104T1 (de) | Verfahren zur reinigung von fibrinogen | |
| DE602005017052D1 (de) | Filter und Verfahren zur Unterdrückung von Effekten von Nachbarkanalstörungen | |
| ATE442380T1 (de) | Verfahren zur reiningung von vancomycin- hydrochlorid | |
| EP1786465A4 (en) | METHODS FOR DETECTION AND TREATMENT OF AUTOIMMUNE DISORDERS | |
| DE602007011696D1 (de) | Verfahren und System zur Reduktion von Interferenz durch Antennenlecksignale | |
| ATE542591T1 (de) | Verfahren zur beseitigung von in organischen abwässern oder abgasen enthaltenen sauerstoffhaltigen organischen molekülen unter verwendung von aluminiumoxidagglomeraten | |
| TW200500136A (en) | Method for selectively binding substrate to sorbent by way of at least bivalent bond | |
| ATE340634T1 (de) | Verfahren zur verringerung einer adsorptionsneigung von molekülen oder biologischen zellen an einer materialoberfläche | |
| DE60331527D1 (de) | Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren | |
| DE602004022076D1 (de) | Verfahren zur reduzierung von stickoxidemissionen toranordnung | |
| ATE517858T1 (de) | Verfahren zur aufreinigung von (meth)acrylaten | |
| DE60306055D1 (de) | Verfahren zur Regeneration eines immobilisierten Enzyms | |
| ATE408681T1 (de) | Verfahren zur reinigung einer rhizomucor aspartat-protease | |
| HRP20040008B1 (en) | Plant and method for purification of water coming from a desulphuration kerosene plant | |
| ATE279126T1 (de) | Verfahren zur isolierung von antioxidantien | |
| MY146257A (en) | Method for the distillative processing of tetrahydrofuran | |
| WO2005118838A3 (en) | Adjustable test system for the determination of the presence of an antibiotic in a fluid |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1558622 Country of ref document: EP |