ATE378345T1 - Verfahren zur aufreinigung von makroliden - Google Patents

Verfahren zur aufreinigung von makroliden

Info

Publication number
ATE378345T1
ATE378345T1 AT04779384T AT04779384T ATE378345T1 AT E378345 T1 ATE378345 T1 AT E378345T1 AT 04779384 T AT04779384 T AT 04779384T AT 04779384 T AT04779384 T AT 04779384T AT E378345 T1 ATE378345 T1 AT E378345T1
Authority
AT
Austria
Prior art keywords
purifying
macrolids
macrolide
eluting
tetrahydrofuran
Prior art date
Application number
AT04779384T
Other languages
English (en)
Inventor
Vilmos Keri
Zoltan Czovek
Ferenc Rantal
Andrea Csorvasi
Original Assignee
Teva Gyogyszergyar Zartkoeruee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee
Application granted granted Critical
Publication of ATE378345T1 publication Critical patent/ATE378345T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04779384T 2003-07-24 2004-07-26 Verfahren zur aufreinigung von makroliden ATE378345T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49007003P 2003-07-24 2003-07-24
US53936304P 2004-01-26 2004-01-26

Publications (1)

Publication Number Publication Date
ATE378345T1 true ATE378345T1 (de) 2007-11-15

Family

ID=34107827

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04779384T ATE378345T1 (de) 2003-07-24 2004-07-26 Verfahren zur aufreinigung von makroliden

Country Status (13)

Country Link
US (2) US7220357B2 (de)
EP (1) EP1558622B1 (de)
JP (1) JP2007521013A (de)
KR (1) KR20060052874A (de)
AT (1) ATE378345T1 (de)
CA (1) CA2533548C (de)
DE (1) DE602004010059T2 (de)
DK (1) DK1558622T3 (de)
ES (1) ES2297481T3 (de)
PL (1) PL1558622T3 (de)
PT (1) PT1558622E (de)
TW (1) TW200523266A (de)
WO (1) WO2005010015A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2548297C (en) * 2003-12-05 2011-06-14 Biocon Limited Process for the purification of macrolides
WO2006060616A1 (en) * 2004-12-01 2006-06-08 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Processes for producing crystalline macrolides
MX2007005868A (es) * 2004-12-22 2007-07-04 Teva Gyogyszergyar Zartkoeruen Mukoedo Reszvenytarsasag Metodo de purificar tacrolimus.
KR20080077147A (ko) * 2005-12-07 2008-08-21 와이어쓰 결정성 라파마이신의 제조 방법 및 시차 주사 열량계를사용하는 라파마이신 화합물의 결정화도의 측정 방법
KR100859670B1 (ko) * 2006-09-13 2008-09-23 동국제약 주식회사 타크로리무스를 고수율 및 고순도로 정제하는 방법
CA2668134A1 (en) * 2006-11-06 2008-05-15 Teva Gyogyszergyar Zartkoerueen Muekoedoe Reszvenytarsasag Ascomycin and pimecrolimus having reduced levels of des-methylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
US9113655B2 (en) 2009-04-16 2015-08-25 Ocean Spray Cranberries, Inc. Phenolics extraction and use
CN106478664B (zh) * 2016-08-29 2017-12-05 广东蓝宝制药有限公司 一种发酵液中提取纯化他克莫司的方法
EP3619215B1 (de) 2017-05-01 2021-11-17 MEDA Pharma GmbH & Co. KG Verfahren zur umwandlung von rohem ascomycin in gereinigtes pimecrolimus
CN108409751A (zh) * 2018-02-24 2018-08-17 海正药业(杭州)有限公司 一种子囊霉素的纯化方法
CN111693635A (zh) * 2020-07-23 2020-09-22 北京和合医学诊断技术股份有限公司 检测血液中雷帕霉素含量的方法
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
CN115716839A (zh) * 2022-11-15 2023-02-28 无锡福祈制药有限公司 一种依维莫司杂质的合成方法

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Publication number Priority date Publication date Assignee Title
DE2121517C3 (de) 1971-04-30 1974-06-27 Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion) Verfahren zur Gewinnung von Amphoterizin B
US3993749A (en) * 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4160861A (en) * 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4894366A (en) * 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JP2639737B2 (ja) * 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5116756A (en) * 1991-01-28 1992-05-26 Merck & Co., Inc. Process for producing FK-506
US5494820A (en) 1991-04-11 1996-02-27 Pfizer Inc. Streptomyces braegensis strain and its cultivation in a process for producing C9 -desoxo-FK-520
US5091389A (en) * 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
DE69330747T2 (de) * 1992-03-02 2002-05-29 Pfizer Inc., New York Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel
UA41884C2 (uk) 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5622866A (en) * 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
FR2803307A1 (fr) * 1999-12-30 2001-07-06 Centre Nat Rech Scient Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
CZ20022779A3 (cs) * 2000-02-24 2003-02-12 Biogal Gyogyszergyar Rt. Způsob purifikace fermentačního bujónu
AUPQ801700A0 (en) * 2000-06-07 2000-06-29 Peplin Research Pty Ltd Enzyme and viral activation
AUPQ923100A0 (en) * 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer
KR20040086369A (ko) * 2002-02-13 2004-10-08 비오갈 기오기스제르갸르 알티. 바이오매터로부터 마크롤라이드를 추출하는 방법

Also Published As

Publication number Publication date
DE602004010059T2 (de) 2008-09-11
US20050027112A1 (en) 2005-02-03
JP2007521013A (ja) 2007-08-02
CA2533548A1 (en) 2005-02-03
DK1558622T3 (da) 2008-02-25
EP1558622B1 (de) 2007-11-14
CA2533548C (en) 2010-02-16
DE602004010059D1 (de) 2007-12-27
US20070117976A1 (en) 2007-05-24
US7220357B2 (en) 2007-05-22
PL1558622T3 (pl) 2008-06-30
ES2297481T3 (es) 2008-05-01
EP1558622A1 (de) 2005-08-03
TW200523266A (en) 2005-07-16
WO2005010015B1 (en) 2005-03-17
WO2005010015A1 (en) 2005-02-03
KR20060052874A (ko) 2006-05-19
PT1558622E (pt) 2007-12-04

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