ATE378345T1 - Verfahren zur aufreinigung von makroliden - Google Patents

Verfahren zur aufreinigung von makroliden

Info

Publication number
ATE378345T1
ATE378345T1 AT04779384T AT04779384T ATE378345T1 AT E378345 T1 ATE378345 T1 AT E378345T1 AT 04779384 T AT04779384 T AT 04779384T AT 04779384 T AT04779384 T AT 04779384T AT E378345 T1 ATE378345 T1 AT E378345T1
Authority
AT
Austria
Prior art keywords
purifying
macrolids
macrolide
eluting
tetrahydrofuran
Prior art date
Application number
AT04779384T
Other languages
English (en)
Inventor
Vilmos Keri
Zoltan Czovek
Ferenc Rantal
Andrea Csorvasi
Original Assignee
Teva Gyogyszergyar Zartkoeruee
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teva Gyogyszergyar Zartkoeruee filed Critical Teva Gyogyszergyar Zartkoeruee
Application granted granted Critical
Publication of ATE378345T1 publication Critical patent/ATE378345T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT04779384T 2003-07-24 2004-07-26 Verfahren zur aufreinigung von makroliden ATE378345T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US49007003P 2003-07-24 2003-07-24
US53936304P 2004-01-26 2004-01-26

Publications (1)

Publication Number Publication Date
ATE378345T1 true ATE378345T1 (de) 2007-11-15

Family

ID=34107827

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04779384T ATE378345T1 (de) 2003-07-24 2004-07-26 Verfahren zur aufreinigung von makroliden

Country Status (13)

Country Link
US (2) US7220357B2 (de)
EP (1) EP1558622B1 (de)
JP (1) JP2007521013A (de)
KR (1) KR20060052874A (de)
AT (1) ATE378345T1 (de)
CA (1) CA2533548C (de)
DE (1) DE602004010059T2 (de)
DK (1) DK1558622T3 (de)
ES (1) ES2297481T3 (de)
PL (1) PL1558622T3 (de)
PT (1) PT1558622E (de)
TW (1) TW200523266A (de)
WO (1) WO2005010015A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2548297C (en) * 2003-12-05 2011-06-14 Biocon Limited Process for the purification of macrolides
DE602005021684D1 (de) 2004-12-01 2010-07-15 Teva Gyogyszergyar Zartkoeruen Verfahren zur herstellung von pimecrolimus
EP1828204A1 (de) * 2004-12-22 2007-09-05 Teva Gyogyszergyár Zártköruen Muködo Részvenytarsaság Verfahren zur aufreinigung von makroliden
AR058283A1 (es) * 2005-12-07 2008-01-30 Wyeth Corp Metodos para la preparacion de rapamicina cristalina y para la medicion de la cristalinidad de los compuestos de rapamicina utilizando calorimetria diferencial de barrido
KR100859670B1 (ko) * 2006-09-13 2008-09-23 동국제약 주식회사 타크로리무스를 고수율 및 고순도로 정제하는 방법
TW200837067A (en) * 2006-11-06 2008-09-16 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
KR100891313B1 (ko) * 2007-08-17 2009-03-31 (주) 제노텍 담체로 작용하는 흡착성 수지의 제공에 의한 트리사이클로화합물의 생산 및 추출 방법
EP2792254B1 (de) * 2009-04-16 2016-10-05 Ocean Spray Cranberries, Inc. Phenolextraktion und Verwendung in Zusammensetzungen mit Fumarsäure
CN106478664B (zh) * 2016-08-29 2017-12-05 广东蓝宝制药有限公司 一种发酵液中提取纯化他克莫司的方法
CN110741006B (zh) 2017-05-01 2023-04-07 美达药物有限及两合公司 将粗子囊霉素转化为纯化的吡美莫司的方法
CN108409751A (zh) * 2018-02-24 2018-08-17 海正药业(杭州)有限公司 一种子囊霉素的纯化方法
CN111693635A (zh) * 2020-07-23 2020-09-22 北京和合医学诊断技术股份有限公司 检测血液中雷帕霉素含量的方法
CN113325108B (zh) * 2021-06-04 2022-12-09 山东霆科药业有限公司 一种他克莫司软膏的样品前处理方法
CN115716839A (zh) * 2022-11-15 2023-02-28 无锡福祈制药有限公司 一种依维莫司杂质的合成方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2121517C3 (de) 1971-04-30 1974-06-27 Leningradskij Nautschno-Issledowatelskij Institut Antibiotikow, Ssr, Leningrad (Sowjetunion) Verfahren zur Gewinnung von Amphoterizin B
US3993749A (en) 1974-04-12 1976-11-23 Ayerst Mckenna And Harrison Ltd. Rapamycin and process of preparation
US4160861A (en) 1977-10-03 1979-07-10 Merck & Co., Inc. Method for the separation of antibiotic macrolides
US4894366A (en) 1984-12-03 1990-01-16 Fujisawa Pharmaceutical Company, Ltd. Tricyclo compounds, a process for their production and a pharmaceutical composition containing the same
JP2639737B2 (ja) 1990-01-23 1997-08-13 寳酒造株式会社 新規ｒ１０６類化合物
US5116756A (en) 1991-01-28 1992-05-26 Merck & Co., Inc. Process for producing FK-506
CA2107110C (en) 1991-04-11 1996-02-20 Walter Patrick Cullen Novel immunosuppressant agent from streptomyces braegensis
US5091389A (en) 1991-04-23 1992-02-25 Merck & Co., Inc. Lipophilic macrolide useful as an immunosuppressant
DE69330747T2 (de) 1992-03-02 2002-05-29 Pfizer Desosamino-derivate von makroliden als immunosuppressive und antifungale mittel
UA41884C2 (uk) 1993-11-05 2001-10-15 Амерікан Хоум Продактс Корпорейшн Спосіб відокремлення рапаміцину від кислотних, основних та неполярних нейтральних домішок, присутніх в концентраті екстрактів ферментаційного бульйону або маточних розчинів
US5622866A (en) 1994-06-23 1997-04-22 Merck & Co., Inc. Expression cassettes useful in construction of integrative and replicative expression vectors for Streptomyces
GB9618952D0 (en) 1996-09-11 1996-10-23 Sandoz Ltd Process
GB9826882D0 (en) 1998-12-07 1999-01-27 Novartis Ag Organic compounds
TW553946B (en) * 1999-09-08 2003-09-21 Fujisawa Pharmaceutical Co Method for separating lactone-containing high-molecular weight compounds
ES2177373B1 (es) 1999-11-26 2003-11-01 Astur Pharma Sa Preparacion de azitromicina en su forma no cristalina
FR2803307A1 (fr) * 1999-12-30 2001-07-06 Centre Nat Rech Scient Lignees de lymphocytes t cd4 specifiques de type th1 et procede pour leur induction ex vivo
US6387258B1 (en) 2000-02-24 2002-05-14 Biogal Gyogyszergyar Rt. Method of purifying statins from a fermentation broth
AUPQ801700A0 (en) * 2000-06-07 2000-06-29 Peplin Research Pty Ltd Enzyme and viral activation
AUPQ923100A0 (en) * 2000-08-07 2000-08-31 Peplin Research Pty Ltd Treatment of prostate cancer
PL374059A1 (en) 2002-02-13 2005-09-19 Teva Gyogyszergyar Reszvenytarsasag Method for extracting a macrolide from biomatter

Also Published As

Publication number Publication date
KR20060052874A (ko) 2006-05-19
US7220357B2 (en) 2007-05-22
DE602004010059T2 (de) 2008-09-11
ES2297481T3 (es) 2008-05-01
WO2005010015B1 (en) 2005-03-17
WO2005010015A1 (en) 2005-02-03
DE602004010059D1 (de) 2007-12-27
CA2533548A1 (en) 2005-02-03
EP1558622B1 (de) 2007-11-14
US20050027112A1 (en) 2005-02-03
PT1558622E (pt) 2007-12-04
CA2533548C (en) 2010-02-16
TW200523266A (en) 2005-07-16
PL1558622T3 (pl) 2008-06-30
US20070117976A1 (en) 2007-05-24
EP1558622A1 (de) 2005-08-03
JP2007521013A (ja) 2007-08-02
DK1558622T3 (da) 2008-02-25

Similar Documents

Publication Publication Date Title
ATE378345T1 (de) Verfahren zur aufreinigung von makroliden
TW200716669A (en) Method for the purification of antibodies
WO2006039507A3 (en) Ph stable chromatographic media using templated multilayer organic/inorganic grafting
DE602004004016D1 (de) Verfahren zur Ventilsteuerung eines Abgassystems
DE60325388D1 (de) Verfahren zur abwasserbehandlung mit schlammpartikel
DE10341106A8 (de) System und Verfahren zur Motorsteuerung
DE602005017052D1 (de) Filter und Verfahren zur Unterdrückung von Effekten von Nachbarkanalstörungen
EP1806321A4 (de) Adsorptionsmittel, herstellungsverfahren dafür und verfahren zur verarbeitung von ölhaltigem abwasser
ATE449104T1 (de) Verfahren zur reinigung von fibrinogen
ATE442380T1 (de) Verfahren zur reiningung von vancomycin- hydrochlorid
DE69621597D1 (de) Adsorbens für tumornekrosefaktor alpha, methode zur entfernung durch adsorption und adsorptionsvorrichtung unter verwendung des adsorbens
ATE542591T1 (de) Verfahren zur beseitigung von in organischen abwässern oder abgasen enthaltenen sauerstoffhaltigen organischen molekülen unter verwendung von aluminiumoxidagglomeraten
ATE517858T1 (de) Verfahren zur aufreinigung von (meth)acrylaten
TW200500136A (en) Method for selectively binding substrate to sorbent by way of at least bivalent bond
ATE340634T1 (de) Verfahren zur verringerung einer adsorptionsneigung von molekülen oder biologischen zellen an einer materialoberfläche
ATE412311T1 (de) Verfahren und system zur aufnahmeprogrammierung mittels sms-cb übertragung und programmierungsendgerät
DE60321355D1 (de) Verfahren zur reproduzierung von pleuromutilinen
MY146257A (en) Method for the distillative processing of tetrahydrofuran
DE60331527D1 (de) Gereinigtes lasofoxifen und verfahren zur aufreinigung von racemischem lasofoxifen durch umkristallisieren
WO2005118838A3 (en) Adjustable test system for the determination of the presence of an antibiotic in a fluid
ATE408681T1 (de) Verfahren zur reinigung einer rhizomucor aspartat-protease
HRP20040008B1 (en) Plant and method for purification of water coming from a desulphuration kerosene plant
ATE279126T1 (de) Verfahren zur isolierung von antioxidantien
ATE368634T1 (de) Anlage zur aufbereitung des wassers von stehenden gewässern
DE50110270D1 (de) Verfahren und mobile Reinigungsanlage zur Reinigung von mit organischen Verbindungen verunreinigten Abwässern

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1558622

Country of ref document: EP