ATE373012T1 - An caml bindender lymphozyteoberflächenrezeptor, nukleinsäuren die dafür kodieren und verfahren zur verwendung - Google Patents

An caml bindender lymphozyteoberflächenrezeptor, nukleinsäuren die dafür kodieren und verfahren zur verwendung

Info

Publication number
ATE373012T1
ATE373012T1 AT98908948T AT98908948T ATE373012T1 AT E373012 T1 ATE373012 T1 AT E373012T1 AT 98908948 T AT98908948 T AT 98908948T AT 98908948 T AT98908948 T AT 98908948T AT E373012 T1 ATE373012 T1 AT E373012T1
Authority
AT
Austria
Prior art keywords
caml
code
nucleic acids
receptor binding
surface receptor
Prior art date
Application number
AT98908948T
Other languages
English (en)
Inventor
Richard Bram
Bulow Gotz Von
Original Assignee
St Jude Childrens Res Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by St Jude Childrens Res Hospital filed Critical St Jude Childrens Res Hospital
Application granted granted Critical
Publication of ATE373012T1 publication Critical patent/ATE373012T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00Genetically modified animals
    • A01K2217/07Animals genetically altered by homologous recombination
    • A01K2217/075Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75Agonist effect on antigen
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82Proteins from microorganisms
AT98908948T 1997-03-03 1998-03-03 An caml bindender lymphozyteoberflächenrezeptor, nukleinsäuren die dafür kodieren und verfahren zur verwendung ATE373012T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/810,572 US5969102A (en) 1997-03-03 1997-03-03 Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof

Publications (1)

Publication Number Publication Date
ATE373012T1 true ATE373012T1 (de) 2007-09-15

Family

ID=25204137

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98908948T ATE373012T1 (de) 1997-03-03 1998-03-03 An caml bindender lymphozyteoberflächenrezeptor, nukleinsäuren die dafür kodieren und verfahren zur verwendung

Country Status (11)

Country Link
US (7) US5969102A (de)
EP (3) EP1632500B1 (de)
JP (1) JP3594975B2 (de)
AT (1) ATE373012T1 (de)
AU (1) AU732119B2 (de)
CA (1) CA2284078C (de)
DE (1) DE69838417T2 (de)
DK (1) DK0964874T3 (de)
ES (2) ES2552095T3 (de)
PT (1) PT964874E (de)
WO (1) WO1998039361A1 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6830751B1 (en) * 1994-03-14 2004-12-14 Genetics Institute, Llc Use of IL-12 antagonists in the treatment of rheumatoid arthritis
ZA95960B (en) * 1994-03-14 1995-10-10 Genetics Inst Use of interleukin-12 antagonists in the treatment of autoimmune diseases
US6812327B1 (en) * 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
US8212004B2 (en) * 1999-03-02 2012-07-03 Human Genome Sciences, Inc. Neutrokine-alpha fusion proteins
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
WO2001060397A1 (en) 2000-02-16 2001-08-23 Genentech, Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
US7488590B2 (en) 1998-10-23 2009-02-10 Amgen Inc. Modified peptides as therapeutic agents
GB9828628D0 (en) 1998-12-23 1999-02-17 Glaxo Group Ltd Novel ligand
ATE437227T1 (de) * 1999-01-07 2009-08-15 Zymogenetics Inc Verfahren zur therapeutischen verwendung von löslichen rezeptoren br43x2
AU2005200008B2 (en) * 1999-01-07 2008-03-06 Zymogenetics, Inc. Soluble receptor BR43x2 and methods of using
US20060067933A1 (en) * 1999-01-07 2006-03-30 Gross Jane A Soluble receptor BR43x2 and methods of using
US7833529B1 (en) 1999-01-07 2010-11-16 Zymogenetics, Inc. Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
CZ299819B6 (cs) * 1999-01-25 2008-12-03 Biogen Idec Ma Inc. Farmaceutické kompozice obsahující protilátky specifické pro rozpustný BAFF
US20030095967A1 (en) * 1999-01-25 2003-05-22 Mackay Fabienne BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders
US20050100548A1 (en) * 2001-07-24 2005-05-12 Biogen Idec Ma Inc. BAFF, inhibitors thereof and their use in the modulation of B-cell response
AU3633000A (en) * 1999-03-26 2000-10-16 Human Genome Sciences, Inc. Neutrokine-alpha binding proteins and methods based thereon
US20030022233A1 (en) * 1999-04-30 2003-01-30 Raymond G. Goodwin Methods of use of the taci/taci-l interaction
EE05673B1 (et) 1999-08-17 2013-08-15 Biogen, Inc. BAFF-retseptor (BCMA), immunoregulatoorne agens
UA74798C2 (uk) * 1999-10-06 2006-02-15 Байоджен Айдек Ма Інк. Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
AU3695801A (en) * 2000-02-11 2001-11-20 Amgen, Inc. Receptor from tnf family
US6969519B2 (en) * 2000-03-10 2005-11-29 Human Genome Sciences, Inc. Methods of using an agonistic antibody human tumor necrosis factor receptor (TR17)
NZ521540A (en) 2000-04-11 2004-09-24 Genentech Inc Multivalent antibodies and uses therefor
EP1746106A3 (de) * 2000-04-27 2007-03-14 Biogen Idec MA Inc. Verwendung von TACI als Antitumormittel
CA2404945C (en) * 2000-04-27 2010-02-09 Biogen, Inc. Taci as an anti-tumor agent
US20040013674A1 (en) * 2001-04-27 2004-01-22 Christine Ambrose Taci as an anti-tumor agent
MXPA02011130A (es) * 2000-05-12 2003-03-10 Amgen Inc Metodos y composiciones de materia que se refieren a april/g70, bcma, blys/agp-3, y taci.
WO2001096528A2 (en) 2000-06-15 2001-12-20 Human Genome Sciences, Inc. Human tumor necrosis factor delta and epsilon
US7879328B2 (en) 2000-06-16 2011-02-01 Human Genome Sciences, Inc. Antibodies that immunospecifically bind to B lymphocyte stimulator
NZ522700A (en) * 2000-06-16 2006-02-24 Human Genome Sciences Inc Antibodies that immunospecifically bind to blys
BR0112263A (pt) * 2000-07-07 2003-06-24 Eisai Co Ltd Gene da sìntese da parede celular de fungos
EP1303293B1 (de) 2000-07-27 2008-12-03 Genentech, Inc. Sequentielle verabreichung von cpt-11 und apo-2l polypeptid
WO2002016411A2 (en) * 2000-08-18 2002-02-28 Human Genome Sciences, Inc. Binding polypeptides and methods based thereon
UA83458C2 (uk) * 2000-09-18 2008-07-25 Байоджен Айдек Ма Інк. Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
AU2002215753A1 (en) * 2000-12-07 2002-06-18 The University Of British Columbia Caml-binding peptides
EP2301971A1 (de) * 2001-02-20 2011-03-30 ZymoGenetics, L.L.C. Antikörper, die sowohl BCMA als auch TACI binden
CA2446189C (en) * 2001-05-11 2011-10-18 Amgen, Inc. Peptides and related molecules that bind to tall-1
RS20120253A1 (en) * 2001-05-24 2013-02-28 Zymogenetics Inc. TACI-IMUNOGLOBULINSKI PROTEIN FUNCTIONS
CA2451955C (en) 2001-06-26 2015-09-29 Abgenix, Inc. Antibodies to opgl
DE10131922A1 (de) * 2001-07-02 2003-01-30 Brahms Ag Verwendung des Calcineurin B Homologen Proteins (CHP) für die Diagnose und Therapie von Entzündungserkrankungen und Sepsis
US7252994B2 (en) 2001-07-03 2007-08-07 Genentech, Inc. Human DR4 antibodies and uses thereof
CN1526011A (zh) * 2001-07-10 2004-09-01 IDECҩ�﹫˾ 抑制凋亡过程及改善细胞性能
CN1636067A (zh) * 2001-08-03 2005-07-06 杰南技术公司 TACls和BR3多肽及其用途
US6551615B1 (en) * 2001-10-18 2003-04-22 M/S. Strides Arcolab Limited Dexibuprofen-containing soft gelatin capsules and process for preparing the same
WO2003072713A2 (en) * 2002-02-21 2003-09-04 Biogen Idec Ma Inc. Use of bcma as an immunoregulatory agent
US20040038303A1 (en) * 2002-04-08 2004-02-26 Unger Gretchen M. Biologic modulations with nanoparticles
US8025873B2 (en) * 2002-06-20 2011-09-27 Paladin Labs, Inc. Chimeric antigens for eliciting an immune response
US6890725B2 (en) * 2002-07-23 2005-05-10 Rigel Pharmaceuticals, Inc. Modulators of B-lymphocyte activation, myosin-1F compositions and methods of use
CN1692127A (zh) * 2002-07-25 2005-11-02 健泰科生物技术公司 Taci抗体及其用途
DE60329116D1 (de) * 2002-10-11 2009-10-15 Zymogenetics Inc Herstellung von homotrimeren fusionsproteinen
AU2004233164B2 (en) 2003-03-28 2009-10-08 Biogen Ma Inc. Truncated BAFF receptors
US20050163775A1 (en) * 2003-06-05 2005-07-28 Genentech, Inc. Combination therapy for B cell disorders
PT2272868E (pt) * 2003-06-05 2015-07-07 Genentech Inc Terapêutica de combinação para distúrbios de células b
US7211407B2 (en) * 2003-07-15 2007-05-01 Chan Test, Inc. High throughput assay systems and methods for identifying agents that alter surface expression of integral membrane proteins
CA2554526A1 (en) * 2004-01-29 2005-08-18 Genentech, Inc. Variants of the extracellular domain of bcma and uses thereof
EP1732946B1 (de) 2004-03-08 2011-07-27 ZymoGenetics, Inc. Dimere fusionsproteine und materialien und verfahren zu deren herstellung
WO2006052493A1 (en) * 2004-11-04 2006-05-18 Genentech, Inc. Polypeptides that bind baff and/or april
AU2006209237B2 (en) * 2005-01-28 2010-06-24 Biogen Ma Inc. Use of BAFF to treat Th2-mediated conditions
CA2618763A1 (en) * 2005-08-09 2007-02-15 Zymogenetics, Inc. Methods for the treatment and prevention of abnormal cell proliferation using taci-fusion molecules
EA016083B1 (ru) * 2005-08-09 2012-02-28 Займоджинетикс, Инк. СПОСОБ ЛЕЧЕНИЯ НЕХОДЖКИНСКОЙ ЛИМФОМЫ С ПОМОЩЬЮ СЛИТОЙ МОЛЕКУЛЫ TACI-Ig
WO2007142667A2 (en) * 2005-10-13 2007-12-13 Human Genome Sciences, Inc. Treatment of patients with autoantibody positive disease
US9168286B2 (en) * 2005-10-13 2015-10-27 Human Genome Sciences, Inc. Methods and compositions for use in treatment of patients with autoantibody positive disease
PE20070684A1 (es) 2005-11-14 2007-08-06 Amgen Inc MOLECULAS QUIMERICAS DE ANTICUERPO RANKL-PTH/PTHrP
WO2007062090A2 (en) * 2005-11-23 2007-05-31 Genentech, Inc. Methods and compositions related to b cell assays
WO2007123765A2 (en) 2006-03-31 2007-11-01 Human Genome Sciences Inc. Neutrokine-alpha and neutrokine-alpha splice variant
MX2008014365A (es) * 2006-05-15 2008-11-27 Ares Trading Sa Metodos para tratar enfermedades autoinmunitarias utilizando una molecula de fusion del activador de transmembrana-inmunoglobulina.
US20100267932A1 (en) * 2006-08-28 2010-10-21 Alex Eon-Duval Process for the purification of fc-fusion proteins
PT2061803T (pt) 2006-08-28 2019-11-21 Ares Trading Sa Processo de purificação de proteinas contendo fc
ATE509107T1 (de) 2007-01-26 2011-05-15 Merck Serono Sa Aufreinigung von fc-tact-fusionsproteinen unter verwendung der ölkörper-technik
WO2009052293A1 (en) 2007-10-16 2009-04-23 Zymogenetics, Inc. Combination of blys inhibition and anti-cd 20 agents for treatment of autoimmune disease
US20110014190A1 (en) * 2009-02-12 2011-01-20 Human Genome Sciences, Inc. Use of b lymphocyte stimulator protein antagonists to promote transplantation tolerance
WO2011109280A1 (en) 2010-03-05 2011-09-09 Lerner Research Institute Methods and compositions to treat immune-mediated disorders
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
JOP20140087B1 (ar) 2013-03-13 2021-08-17 Amgen Inc بروتينات مخصصة ل baff و b7rp1 وإستخداماتها
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US11311576B2 (en) 2018-01-22 2022-04-26 Seattle Children's Hospital Methods of use for CAR T cells
CN116903727A (zh) 2020-05-08 2023-10-20 高山免疫科学股份有限公司 具有和不具有t细胞抑制蛋白的april和baff抑制性免疫调节蛋白及其使用方法
WO2022131889A1 (ko) * 2020-12-16 2022-06-23 주식회사 굳티셀 Taci 단백질의 용도
AU2022325359A1 (en) 2021-08-10 2023-05-18 Remegen Co., Ltd. Method for treating iga nephropathy with taci-fc fusion protein
US20240018212A1 (en) 2021-09-30 2024-01-18 RemeGen Co., Ltd Method for treating sjogren's syndrome using taci-fc fusion protein

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
NL7807532A (nl) 1978-07-13 1980-01-15 Akzo Nv Metaal-immunotest.
NL8000173A (nl) 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
US4650764A (en) 1983-04-12 1987-03-17 Wisconsin Alumni Research Foundation Helper cell
US4703017C1 (en) 1984-02-14 2001-12-04 Becton Dickinson Co Solid phase assay with visual readout
US4751181A (en) * 1984-12-31 1988-06-14 Duke University Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
US4631211A (en) 1985-03-25 1986-12-23 Scripps Clinic & Research Foundation Means for sequential solid phase organic synthesis and methods using the same
CA1338860C (en) 1987-04-13 1997-01-21 Peter Parker Radiolabelling of proteins
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
EP0280559B1 (de) 1987-02-27 1993-10-20 EASTMAN KODAK COMPANY (a New Jersey corporation) Agglutinationsimmunotest und Satz zur Bestimmung einer mehrwertigen Immunspezies unter Verwendung einer gepufferten Salzwasch-Lösung
EP0281327B1 (de) 1987-02-27 1993-06-30 EASTMAN KODAK COMPANY (a New Jersey corporation) Immunoreaktives Reagens, Verfahren zu seiner Herstellung und seine Verwendung zur Bestimmung einer immunoreaktiven Spezies
US4857453A (en) 1987-04-07 1989-08-15 Syntex (U.S.A.) Inc. Immunoassay device
EP1248112A3 (de) 1987-04-27 2004-08-25 Inverness Medical Switzerland GmbH Immunochromatographische Spezifischebindungsassayvorrichtung
US4980289A (en) 1987-04-27 1990-12-25 Wisconsin Alumni Research Foundation Promoter deficient retroviral vector
JPH02500329A (ja) 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
US5132405A (en) 1987-05-21 1992-07-21 Creative Biomolecules, Inc. Biosynthetic antibody binding sites
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
IL92124A (en) 1988-10-28 1996-10-31 Sidney Pestka Recombinant proteins modified to contain post-phosphorylation that do not occur in nature
US5124263A (en) 1989-01-12 1992-06-23 Wisconsin Alumni Research Foundation Recombination resistant retroviral helper cell and products produced thereby
US5354844A (en) 1989-03-16 1994-10-11 Boehringer Ingelheim International Gmbh Protein-polycation conjugates
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
US5139749A (en) 1990-06-22 1992-08-18 Tas, Inc. Fluidized calcining process
DE69123241T2 (de) 1990-12-14 1997-04-17 Cell Genesys Inc Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen
AU1570292A (en) 1991-02-07 1992-09-07 Board Of Trustees Of The University Of Illinois, The Conformationally restricted mimetics of beta turns and beta bulges and peptides containing the same
DE69434998T2 (de) 1993-05-27 2008-03-13 Aventis Pharmaceuticals Inc. Topologisch getrennte, kodierende Festphasen-Bibliotheken
EP0711354A1 (de) 1993-07-30 1996-05-15 University Of Medicine & Dentistry Of New Jersey Effiziente gentransfer in primäre maus-lymphozyten ohne den gebrauch einer arzneimittelselektion
US5650550A (en) * 1993-10-01 1997-07-22 The United States Of America As Represented By The Department Of Health And Human Services Mutant mice having a deficit of functional estrogen receptors
CA2187818A1 (en) 1994-04-15 1995-10-26 Robert W. Overell Gene delivery fusion proteins
US5523227A (en) * 1994-06-17 1996-06-04 The Board Of Trustees Of The Leland Stanford Junior Univ. DNA encoding calcium-signal modulating cyclophilin ligand
ES2292172T3 (es) * 1994-12-15 2008-03-01 Yeda Research And Development Co., Ltd. Moduladores de la funcion de los receptores fas/apo1.
US5837544A (en) 1995-02-02 1998-11-17 Cell Genesys, Inc. Method of inducing a cell to proliferate using a chimeric receptor comprising janus kinase
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US6103521A (en) 1995-02-06 2000-08-15 Cell Genesys, Inc. Multispecific chimeric receptors
US5969102A (en) * 1997-03-03 1999-10-19 St. Jude Children's Research Hospital Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
US6685728B2 (en) * 2002-01-25 2004-02-03 Stryker Endoscopy Threaded suture anchor and method of use
US9002545B2 (en) 2011-01-07 2015-04-07 Wabtec Holding Corp. Data improvement system and method

Also Published As

Publication number Publication date
EP2292654A2 (de) 2011-03-09
PT964874E (pt) 2007-12-21
CA2284078A1 (en) 1998-09-11
US20050183148A1 (en) 2005-08-18
US20060101529A1 (en) 2006-05-11
EP1632500A2 (de) 2006-03-08
EP2292654A3 (de) 2012-07-25
US20030082173A1 (en) 2003-05-01
AU6685498A (en) 1998-09-22
DE69838417T2 (de) 2008-05-29
EP0964874B1 (de) 2007-09-12
WO1998039361A1 (en) 1998-09-11
ES2292201T3 (es) 2008-03-01
DE69838417D1 (de) 2007-10-25
US6500428B1 (en) 2002-12-31
JP2001518080A (ja) 2001-10-09
US20090226473A1 (en) 2009-09-10
EP0964874A1 (de) 1999-12-22
EP1632500A3 (de) 2007-05-30
DK0964874T3 (da) 2007-12-10
US5969102A (en) 1999-10-19
AU732119B2 (en) 2001-04-12
CA2284078C (en) 2014-09-09
JP3594975B2 (ja) 2004-12-02
ES2552095T3 (es) 2015-11-25
EP1632500B1 (de) 2015-08-05
US6316222B1 (en) 2001-11-13
US7355005B2 (en) 2008-04-08

Similar Documents

Publication Publication Date Title
ATE373012T1 (de) An caml bindender lymphozyteoberflächenrezeptor, nukleinsäuren die dafür kodieren und verfahren zur verwendung
DE69723860D1 (de) VERFAHREN ZUR BESTIMMUNG VON IgE
DE60042617D1 (de) Verfahren zur therapeutischen Verwendung von löslichen rezeptoren BR43X2
ATE195927T1 (de) Verfahren zur oligomerisierung von olefinen
DE69707709T2 (de) Verfahren zur umwandlung von kohlenwasserstoffen
ATE529509T1 (de) Selektion von proteinen unter verwendung von rna- protein-fusionen
DE69706430T2 (de) Verfahren zur sequenzierung von dna
DE69508236T2 (de) Verfahren zur herstellung von fluorierten olefinen und fluorkohlenwasserstoffen unter verwendung von fluoriertem olefin
DE69709959D1 (de) Verwendung von polymorphischen dateipaketen zur aktualisierung von softwarekomponenten
DE69518550T2 (de) Verfahren zur bereitung von kohlenwasserstoffe
ATE217636T1 (de) Verfahren zur gewinnung von insulinvorläufern mit korrekt verbundenen cystinbrücken
DE69711439D1 (de) Verfahren zur hydrierung ungesättigter kohlenwasserstoffe
ATE220558T1 (de) Verbessertes verfahren zur stabilisierung von proteinen
DE69602534D1 (de) Verfahren zur verwendung von metallocenkatalysatoren
DE69835345D1 (de) Verfahren zur kodierung von mehrwortinformation
DE69715006D1 (de) Verfahren zur sequenzierung von nukleinsäuren
DE69822629D1 (de) Verfahren zur gerüstisomerisierung von olefinen
DE69830556D1 (de) Verfahren zur Bestimmung von glykosylierten Proteinen
ATE341633T1 (de) Verfahren zur spaltung von fusionproteinen
DE69703110D1 (de) Verfahren zur vorschwefelung von kohlenwasserstoffumwandlungskatalysatoren
DE69808040T2 (de) Abwechselndes Verfahren zur Metathese von Olefinen
DE59505524D1 (de) Verfahren zur carbonylierung von olefinen
DE69706300D1 (de) Verfahren zur vorschwefelung von kohlenwasserstoffumwandlungskatalysatoren
DE69807148D1 (de) Verfahren zur Hydroformylierung von Olefininen
ATA110696A (de) Verfahren zur gewinnung und reinigung von rekombinantem, nicht-lipidiertem osp-protein

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0964874

Country of ref document: EP