ATE369379T1 - Peptide und auf ihnen basierende pharmazeutische zusammensetzungen zur behandlung von störungen und krankheiten die mit der abnormalen proteinfaltung in amyloiden oder amyloid- ähnlichen ablagerungen zusammenhängen - Google Patents
Peptide und auf ihnen basierende pharmazeutische zusammensetzungen zur behandlung von störungen und krankheiten die mit der abnormalen proteinfaltung in amyloiden oder amyloid- ähnlichen ablagerungen zusammenhängenInfo
- Publication number
- ATE369379T1 ATE369379T1 AT96918482T AT96918482T ATE369379T1 AT E369379 T1 ATE369379 T1 AT E369379T1 AT 96918482 T AT96918482 T AT 96918482T AT 96918482 T AT96918482 T AT 96918482T AT E369379 T1 ATE369379 T1 AT E369379T1
- Authority
- AT
- Austria
- Prior art keywords
- amyloid
- deposits
- peptides
- diseases associated
- disorders
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 3
- 230000002159 abnormal effect Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 230000012846 protein folding Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000014644 Brain disease Diseases 0.000 abstract 1
- 208000032274 Encephalopathy Diseases 0.000 abstract 1
- 102000029797 Prion Human genes 0.000 abstract 1
- 108091000054 Prion Proteins 0.000 abstract 1
- 125000000539 amino acid group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
- C07K5/0823—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Urology & Nephrology (AREA)
- Neurology (AREA)
- Biophysics (AREA)
- Neurosurgery (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Pathology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Physics & Mathematics (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Chemical Kinetics & Catalysis (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US47832695A | 1995-06-07 | 1995-06-07 | |
US08/630,645 US5948763A (en) | 1995-06-07 | 1996-04-10 | Peptides and pharmaceutical compositions thereof for treatment of disorders or diseases associated with abnormal protein folding into amyloid or amyloid-like deposits |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE369379T1 true ATE369379T1 (de) | 2007-08-15 |
Family
ID=27045861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT96918482T ATE369379T1 (de) | 1995-06-07 | 1996-06-06 | Peptide und auf ihnen basierende pharmazeutische zusammensetzungen zur behandlung von störungen und krankheiten die mit der abnormalen proteinfaltung in amyloiden oder amyloid- ähnlichen ablagerungen zusammenhängen |
Country Status (8)
Country | Link |
---|---|
US (3) | US5948763A (de) |
EP (1) | EP0843516B1 (de) |
JP (1) | JP2001519753A (de) |
AT (1) | ATE369379T1 (de) |
AU (1) | AU715662B2 (de) |
CA (1) | CA2222690A1 (de) |
DE (1) | DE69637199T2 (de) |
WO (1) | WO1996039834A1 (de) |
Families Citing this family (94)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1997021728A1 (en) | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
US6942963B1 (en) | 1997-01-10 | 2005-09-13 | Massachusetts Institute Of Technology | Methods for identifying treatments for neurotoxicity in Alzheimer's disease caused by β-amyloid peptides |
WO1998030229A1 (en) | 1997-01-10 | 1998-07-16 | Massachusetts Institute Of Technology | TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE BY β-AMYLOID PEPTIDES |
ATE338116T1 (de) * | 1997-02-14 | 2006-09-15 | Deutsches Krebsforsch | Hemmung der prion-vermehrung durch dominant- negative prionprotein-mutanten |
DE19725619A1 (de) * | 1997-06-17 | 1998-12-24 | Fraunhofer Ges Forschung | Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien |
GB9714276D0 (en) | 1997-07-08 | 1997-09-10 | Univ Dundee | Peptides and related compounds |
US6472140B1 (en) | 1997-09-05 | 2002-10-29 | The General Hospital Corporation | α-2- macroglobulin therapies and drug screening methods for Alzheimer's disease. |
US6342350B1 (en) | 1997-09-05 | 2002-01-29 | The General Hospital Corporation | Alpha-2-macroglobulin diagnostic test |
US7212924B1 (en) * | 1997-10-02 | 2007-05-01 | Akiko Itai | Method of inferring three-dimensional structure of protein |
US8003612B2 (en) * | 1997-10-08 | 2011-08-23 | Proteotech Inc. | Small peptides for the treatment of Alzheimer's disease and other beta-amyloid protein disorders |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7790856B2 (en) | 1998-04-07 | 2010-09-07 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
US7799535B1 (en) | 1997-12-09 | 2010-09-21 | Arch Development Corporation | Methods for identifying factors that control the folding of amyloid proteins of diverse origin |
US6211149B1 (en) | 1998-08-03 | 2001-04-03 | The United States Of America As Represented By The Department Of Health And Human Services | Inhibitors of formation of protease resistant prion protein |
GB2348203B (en) | 1998-11-04 | 2002-06-19 | Imp College Innovations Ltd | Solube beta-forms of prion proteins, methods of preparation and use |
EP1158996A4 (de) * | 1999-02-18 | 2005-01-12 | Kaken Pharma Co Ltd | Neue amidderivate als wachstumshormonsekretionsförderer |
US7060670B1 (en) * | 1999-05-05 | 2006-06-13 | Neurochem (International) Limited | Stereoselective antifibrillogenic peptides and peptidomimetics thereof |
UA81216C2 (en) * | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
US7041807B1 (en) | 1999-06-23 | 2006-05-09 | Caprion Pharmaceuticals, Inc. | Antibodies to a YYX epitope of a mammalian prion protein |
ES2235926T3 (es) | 1999-08-04 | 2005-07-16 | The University Of Southern California | Ensamblaje globular de proteina beta amiloide y sus usos. |
US6689753B1 (en) | 1999-11-05 | 2004-02-10 | Axonyx, Inc. | β sheet breaker peptide analogs that inhibit β pleated sheet formation in amyloid β-peptide |
BR0015513A (pt) * | 1999-11-05 | 2004-07-06 | Axonyx Inc | Análogos e miméticos de peptìdeo adequados para emprego in vivo no tratamento de doenças associadas com dobra de proteìna anormal em depósitos de amilóide, tipo amilóide ou precursor patológico rico em lâmina beta destes |
MXPA02006196A (es) | 1999-12-23 | 2002-12-09 | Neurochem Inc | Compuestos y metodos para modular la angiopatia amiloide cerebral. |
DE60108111T2 (de) | 2000-05-22 | 2005-12-08 | New York University | Synthetische immunogene jedoch nicht amyloidogene peptide, die homolog zu amyloid beta sind und deren verwendung zur induktion einer immunantwort gegen amyloid beta und amyloidaggregate |
IL148202A0 (en) * | 2000-06-20 | 2002-09-12 | Caprion Pharmaceuticals Inc | Copolymers and methods of treating prion-related diseases |
US7067550B2 (en) * | 2000-11-03 | 2006-06-27 | Massachusetts Institute Of Technology | Treatments for neurotoxicity in Alzheimer's Disease |
WO2002035987A2 (en) * | 2000-11-03 | 2002-05-10 | Massachusetts Institute Of Technology | METHODS FOR IDENTIFYING TREATMENTS FOR NEUROTOXICITY IN ALZHEIMER'S DISEASE CAUSED BY β-AMYLOID PEPTIDES |
US6716589B2 (en) | 2000-11-20 | 2004-04-06 | Alphabeta Ab | Discordant helix stabilization for prevention of amyloid formation |
US7700751B2 (en) | 2000-12-06 | 2010-04-20 | Janssen Alzheimer Immunotherapy | Humanized antibodies that recognize β-amyloid peptide |
DE10104480A1 (de) * | 2001-01-31 | 2002-08-14 | November Ag Molekulare Medizin | Verfahren, Verwendung und Kit zum Auffinden von Wirkstoffen gegen mit spezifischen Proteinen assoziierte Krankheiten |
US20030130484A1 (en) * | 2001-03-20 | 2003-07-10 | Gordon David J. | Inhibitors and disassemblers of fibrillogenesis |
US6613505B2 (en) | 2001-04-12 | 2003-09-02 | Bioresource International, Inc. | Composition and method for destruction of infetious prion proteins |
US7521479B2 (en) * | 2001-04-16 | 2009-04-21 | Panacea Pharmaceuticals, Inc. | Methods of treating prion disease in mammals |
JP4235544B2 (ja) * | 2001-05-31 | 2009-03-11 | アドライフ インコーポレーティッド | 欠陥折畳み蛋白質センサー方法 |
CA2466841A1 (en) * | 2001-11-21 | 2003-06-05 | New York University | Synthetic immunogenic but non-deposit-forming polypeptides and peptides homologous to amyloid .beta., prion protein, amylin, .alpha.-synuclein, or polyglutamine repeats for induction of an immune response thereto |
US20060057107A1 (en) * | 2001-12-21 | 2006-03-16 | Shaked Ze Ev | Combination treatment for multiple sclerosis |
AU2004203461B2 (en) * | 2002-01-31 | 2009-09-03 | Tel Aviv University Future Technology Development L.P. | Peptides Antibodies Directed Thereagainst and Methods Using Same for Diagnosing and Treating Amyloid-Associated Diseases |
US20040052928A1 (en) | 2002-09-06 | 2004-03-18 | Ehud Gazit | Peptides and methods using same for diagnosing and treating amyloid-associated diseases |
EP1820806A1 (de) * | 2006-02-16 | 2007-08-22 | Crossbeta Biosciences B.V. | Affinitätsbereiche |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
GB0209384D0 (en) * | 2002-04-24 | 2002-06-05 | Pepsyn Ltd | Peptide composition |
DE10221052A1 (de) * | 2002-05-10 | 2003-12-04 | Transmit Technologietransfer | Wirkstoffe zu Therapie, Diagnostik und Prophylaxe von Erkrankungen, bei denen abnorme Proteinstrukturen auftreten |
WO2003105677A2 (en) * | 2002-06-01 | 2003-12-24 | Praecis Pharmaceuticals, Inc. | Methods for treating viral diseases using modulators of amyloidogenic peptide aggregation |
DE10230141B4 (de) * | 2002-07-04 | 2004-07-15 | Priontype Gmbh | Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc) |
US20070003552A1 (en) * | 2002-07-09 | 2007-01-04 | Gebbink Martijn F B | Cross-beta structure comprising amyloid binding proteins and methods for detection of the cross-beta structure, for modulating cross-beta structures fibril formation and for modulating cross-beta structure-mediated toxicity and method for interfering with blood coagulation |
EP1380290A1 (de) * | 2002-07-09 | 2004-01-14 | Universitair Medisch Centrum Utrecht | Cross-Beta-Strukturweg und seine therapeutische Relevanz |
US20040072236A1 (en) | 2002-09-27 | 2004-04-15 | Neil Cashman | PrPSc -interacting molecules and uses thereof |
US20060281686A1 (en) * | 2002-12-02 | 2006-12-14 | Lopez Areiza John J | Aza-peptides |
EP1573323B1 (de) * | 2002-12-03 | 2011-10-19 | Pathogen Removal and Diagnostic Technologies, Inc. | Prionproteinliganden und verfahren zu ihrer verwendung |
US20070010435A1 (en) * | 2002-12-19 | 2007-01-11 | New York University | Method for treating amyloid disease |
CA2516726A1 (en) * | 2003-03-18 | 2004-09-30 | Applied Research Systems Ars Holding N.V. | Amylin aggregation inhibitors and use thereof |
WO2004087733A2 (en) * | 2003-03-28 | 2004-10-14 | New York University | Prevention and treatment of alzheimer amyloid deposition |
US7335644B2 (en) * | 2003-03-31 | 2008-02-26 | Council Of Scientific And Industrial Research | Anti-hypertensive molecules and process for preparation thereof |
WO2004111652A1 (en) * | 2003-06-19 | 2004-12-23 | Applied Research Systems Ars Holding N.V. | Use of prion conversion modulating agents |
EP2719394B1 (de) | 2003-06-30 | 2015-07-29 | Tel Aviv University Future Technology Development L.P. | Peptide zur Behandlung von amyloidbedingten Erkrankungen |
CA2535261C (en) | 2003-08-13 | 2015-11-24 | Chiron Corporation | Prion-specific peptide reagents |
EP1725870A1 (de) * | 2004-03-18 | 2006-11-29 | Applied Research Systems ARS Holding N.V. | Anti-lipid-rafts-antikörper |
CA2590337C (en) | 2004-12-15 | 2017-07-11 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
EP1848830A4 (de) * | 2005-01-13 | 2009-05-06 | Novartis Vaccines & Diagnostic | Isolierung pathogener prione |
WO2006076683A2 (en) * | 2005-01-13 | 2006-07-20 | Novartis Vaccines And Diagnostics Inc. | Isolation and detection of pathogenic prions |
US20070015133A1 (en) * | 2005-07-13 | 2007-01-18 | Umc Utrecht Holding B.V. | Method for detecting and/or removing protein and/or peptide comprising a cross-beta structure from an aqueous solution comprising a protein |
BRPI0613525A2 (pt) * | 2005-07-13 | 2011-05-31 | Crossbeta Biosciences Bv | métodos para produzir uma composição imunogênica, para melhorar a imunogenicidade de uma composição, para intensificar a imunogenicidade de uma composição de vacina, e para determinar a quantidade de estruturas beta-cruzadas em uma composição de vacina, usos de estruturas beta-cruzadas, e de uma composição imunogênica, vacina de subunidade, e, composição imunogênica |
ATE554394T1 (de) * | 2005-07-13 | 2012-05-15 | Crossbeta Biosciences Bv | Cross-beta-struktur-bindende verbindungen |
US8114832B2 (en) * | 2005-07-13 | 2012-02-14 | Crossbeta Biosciences B.V. | Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition |
NZ594844A (en) * | 2005-09-09 | 2013-04-26 | Novartis Ag | Prion-specific peptoid reagents |
US8784810B2 (en) | 2006-04-18 | 2014-07-22 | Janssen Alzheimer Immunotherapy | Treatment of amyloidogenic diseases |
WO2007126111A1 (ja) | 2006-04-28 | 2007-11-08 | Kagoshima University | アミロイドβ線維化阻害ペプチド |
WO2008022035A2 (en) * | 2006-08-10 | 2008-02-21 | The Scripps Research Institute | Methods for identifying cellular modulators of disaggregation activity or aggregation activity in an animal |
US20100204230A1 (en) | 2007-02-12 | 2010-08-12 | Peter Blurton | Piperazine derivatives for treatment of ad and related conditions |
US8003097B2 (en) | 2007-04-18 | 2011-08-23 | Janssen Alzheimer Immunotherapy | Treatment of cerebral amyloid angiopathy |
US9217036B2 (en) * | 2007-04-26 | 2015-12-22 | Yale University | Prion protein as a receptor for amyloid-β oligomers |
SI2182983T1 (sl) | 2007-07-27 | 2014-09-30 | Janssen Alzheimer Immunotherapy | Zdravljenje amiloidogenih bolezni s humaniziranimi protitelesi proti abeta |
CA2694434A1 (en) * | 2007-08-09 | 2009-02-12 | Sylvan Pharmaceuticals Pty Ltd. | Treatment of prion protein related diseases |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
EP2058001A1 (de) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Steigerung der Immunogenizität von Antigenen |
EP2058000A1 (de) * | 2007-11-08 | 2009-05-13 | Crossbeta Biosciences B.V. | Zur Aktivierung von T-Zellen fähige immunogene Zusammensetzung |
BRPI0910550A2 (pt) * | 2008-04-30 | 2015-09-29 | Novartis Ag | ensaio para confôrmeros patogênicos |
WO2009140683A1 (en) * | 2008-05-16 | 2009-11-19 | Research Foundation Of The City University Of New York | Living copolymer protein/peptide hybrids for biomedical applications |
US20110182948A1 (en) * | 2008-05-22 | 2011-07-28 | Beka Solomon | Method for treating disease characterized by plaque |
US20100099609A1 (en) * | 2008-07-28 | 2010-04-22 | Buck Institute For Age Research | eAPP AND DERIVATIVES FOR TREATMENT OF ALZHEIMER'S DISEASE |
US8445438B2 (en) * | 2008-10-27 | 2013-05-21 | Recombinant Technologies Llc | Compositions comprising capture peptides for A β-amyloid peptide |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US8409584B2 (en) | 2009-05-05 | 2013-04-02 | New York University | Immunotherapy targeting of the shared abnormal conformational state of amyloidogenic peptides/proteins |
EP2273273A1 (de) * | 2009-07-11 | 2011-01-12 | Rheinische Friedrich-Wilhelms-Universität Bonn | Inhibitoren der Nitrierung von Amyloid-ß-Peptiden und ihre Verwendung bei der Diagnose und Behandlung von Morbus Alzheimer |
MX2013005413A (es) | 2010-11-15 | 2014-02-27 | Univ Ramot | Analogos de dipeptidos para el tratamiento de afecciones asociadas con la formacion de fibrillas amiloides. |
SG187271A1 (en) * | 2011-07-07 | 2013-02-28 | Agency Science Tech & Res | Anti-amyloidogenic, alpha-helix breaking ultra-small peptide therapeutic |
US8906382B2 (en) | 2011-07-19 | 2014-12-09 | New York University | Method for treating amyloid disease |
US9926353B2 (en) | 2011-07-19 | 2018-03-27 | New York University | Immunotherapeutic modulation of amyloidogenic disease using non-fibrillogenic, non-amyloidogenic polymerized proteins and peptides |
CA2860226C (en) | 2011-12-22 | 2022-10-18 | Randolph S. Watnick | Saposin-a derived peptides and uses thereof |
EP3443008A1 (de) | 2016-04-15 | 2019-02-20 | Medimmune Limited | Anti-prp-antikörper und verwendungen davon |
CN114057858B (zh) * | 2020-08-10 | 2023-03-21 | 上海瑞吉康生物医药有限公司 | 对引起神经变性和神经退行性疾病的蛋白聚集具有解聚作用的多肽 |
DE202022107272U1 (de) | 2022-12-28 | 2023-01-30 | Centurion University of Technology and Management | Ein System zur Analyse der Infektion mit Pseudomonas Syringae durch gezielte Ansprache von Cochaperonen, die eine J-Domäne enthalten |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5135736A (en) * | 1988-08-15 | 1992-08-04 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5169933A (en) * | 1988-08-15 | 1992-12-08 | Neorx Corporation | Covalently-linked complexes and methods for enhanced cytotoxicity and imaging |
US5434050A (en) * | 1991-08-13 | 1995-07-18 | Regents Of The University Of Minnesota | Labelled β-amyloid peptide and methods of screening for Alzheimer's disease |
NZ246059A (en) * | 1991-12-03 | 1995-08-28 | Proteus Molecular Design | Synthetic polypeptides with at least one antigenic site of a prion protein, methods of their use and manufacture, antibodies thereto, compositions and kits |
TW327194B (en) * | 1992-05-01 | 1998-02-21 | American Cyanamid Co | Novel amyloid precursor proteins and methods of using same |
US6696061B1 (en) * | 1992-08-11 | 2004-02-24 | President And Fellows Of Harvard College | Immunomodulatory peptides |
US6120765A (en) * | 1993-04-02 | 2000-09-19 | Shiseido Co. Ltd. | Urokinase plasminogen activator fragments |
US5470951A (en) * | 1993-09-29 | 1995-11-28 | City Of Hope | Peptides for antagonizing the effects of amyloid βprotein |
US5547931A (en) * | 1994-02-23 | 1996-08-20 | Immtech International Inc. | Methods of stimulatory thrombocytopoiesis using modified C-reactive protein |
JP3542181B2 (ja) * | 1994-10-21 | 2004-07-14 | 日本たばこ産業株式会社 | 新規タンパク |
DE19504302A1 (de) * | 1995-02-09 | 1996-08-14 | Boehringer Mannheim Gmbh | Methode zur serologischen Typisierung mittels typspezifischer Antigene |
US5854215A (en) | 1995-03-14 | 1998-12-29 | Praecis Pharmaceuticals Incorporated | Modulators of β-amyloid peptide aggregation |
DE69621607T2 (de) * | 1995-03-14 | 2003-01-02 | Praecis Pharm Inc | VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN |
US5817626A (en) | 1995-03-14 | 1998-10-06 | Praecis Pharmaceuticals Incorporated | Modulators of beta-amyloid peptide aggregation |
US5985242A (en) | 1995-10-27 | 1999-11-16 | Praecis Pharmaceuticals, Inc. | Modulators of β-amyloid peptide aggregation comprising D-amino acids |
WO1997021728A1 (en) * | 1995-12-12 | 1997-06-19 | Karolinska Innovations Ab | PEPTIDE BINDING THE KLVFF-SEQUENCE OF AMYLOID $g(b) |
-
1996
- 1996-04-10 US US08/630,645 patent/US5948763A/en not_active Expired - Lifetime
- 1996-06-06 AU AU61129/96A patent/AU715662B2/en not_active Ceased
- 1996-06-06 JP JP50224597A patent/JP2001519753A/ja active Pending
- 1996-06-06 AT AT96918482T patent/ATE369379T1/de not_active IP Right Cessation
- 1996-06-06 CA CA002222690A patent/CA2222690A1/en not_active Abandoned
- 1996-06-06 DE DE69637199T patent/DE69637199T2/de not_active Expired - Lifetime
- 1996-06-06 WO PCT/US1996/010220 patent/WO1996039834A1/en active IP Right Grant
- 1996-06-06 EP EP96918482A patent/EP0843516B1/de not_active Expired - Lifetime
- 1996-12-12 US US08/766,596 patent/US6462171B1/en not_active Expired - Lifetime
-
2002
- 2002-09-06 US US10/235,483 patent/US20030087407A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP0843516A1 (de) | 1998-05-27 |
US20030087407A1 (en) | 2003-05-08 |
EP0843516B1 (de) | 2007-08-08 |
DE69637199D1 (de) | 2007-09-20 |
DE69637199T2 (de) | 2008-04-24 |
WO1996039834A1 (en) | 1996-12-19 |
US5948763A (en) | 1999-09-07 |
JP2001519753A (ja) | 2001-10-23 |
AU715662B2 (en) | 2000-02-10 |
AU6112996A (en) | 1996-12-30 |
EP0843516A4 (de) | 2002-08-14 |
US6462171B1 (en) | 2002-10-08 |
CA2222690A1 (en) | 1996-12-19 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE369379T1 (de) | Peptide und auf ihnen basierende pharmazeutische zusammensetzungen zur behandlung von störungen und krankheiten die mit der abnormalen proteinfaltung in amyloiden oder amyloid- ähnlichen ablagerungen zusammenhängen | |
EA200101250A1 (ru) | Предупреждение и терапия амилоидогенного заболевания | |
DE602004009705T2 (de) | Methoden der Verhinderung und Behandlung der Alzheimer'schen Krankheit | |
DE69429527D1 (de) | Inhibitoren von beta-amyloid-protein-herstellung | |
NO20092874L (no) | Forhindring og behandling av amyloidogen sykdom | |
EA200200755A1 (ru) | Опосредованная рецептором nogo блокада роста аксонов | |
EA200602015A1 (ru) | Гуманизированные антитела, распознающие бета-амилоидный пептид | |
ATE108662T1 (de) | Antimikrobielle peptide, zusammensetzungen, die diese enthalten, und verwendungen daraus. | |
CA2598080A1 (en) | Amyloid-binding peptides, analogues and uses thereof | |
DE69943107D1 (de) | Behandlung von autoimmunerkrankungen | |
GEP20053423B (en) | Method of Inhibiting Amyloid Protein Aggregation and Method for Imaging of Amyloid Deposits | |
EP1373502B8 (de) | Das Überleben dopaminerger Neuronen fördernde Faktoren und deren Verwendungen | |
ATE215830T1 (de) | Verfahren zur detektion und behandlung von individuen mit abnormal hla-a2/tyrosinase- peptidantigenen exprimierenden zellen | |
AU2003253341B2 (en) | Method for isolating an intestinal cholesterol binding protein | |
WO2001019851A3 (en) | Opaminergic neuronal survival-promoting factors and uses thereof | |
EP1381627B1 (de) | Polypeptide, abgeleitet von der amyloid vorläuferprotein (app), und ihre verwendungen | |
ATE147978T1 (de) | Verwendung von (e) - 2 - (p -fluorophenethyl)- 3 - fluoroallylamine zur behandlung der alzheimerschen krankheit | |
ATE201993T1 (de) | Verwendung von olanzapine zur herstellung eines arzneimittels zur behandlung der zerebralen fokalen ischämie | |
WO2003104811A3 (en) | DIAGNOSTIC AND THERAPEUTIC USE OF THE ACUTE STEROIDOGEN RESPONSE REGULATORY PROTEIN FOR TREATING NEURODEGENERATIVE DISEASES | |
CA2315294A1 (fr) | Utilisation de peptides citrullines derives de la filaggrine dans le cadre du traitement de maladies autoimmunes | |
AU2003208857A8 (en) | Diagnostic and therapeutic use of caps | |
KR940011479A (ko) | 시클로 펩티드 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |