ATE369146T1 - Insulinpreparation mit mannitol - Google Patents

Insulinpreparation mit mannitol

Info

Publication number
ATE369146T1
ATE369146T1 AT97927018T AT97927018T ATE369146T1 AT E369146 T1 ATE369146 T1 AT E369146T1 AT 97927018 T AT97927018 T AT 97927018T AT 97927018 T AT97927018 T AT 97927018T AT E369146 T1 ATE369146 T1 AT E369146T1
Authority
AT
Austria
Prior art keywords
carbohydrate
mannitol
carbon atoms
insulin preparation
water
Prior art date
Application number
AT97927018T
Other languages
English (en)
Inventor
Lone Kimer
Per Balschmidt
Steen Jensen
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Application granted granted Critical
Publication of ATE369146T1 publication Critical patent/ATE369146T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
AT97927018T 1996-06-20 1997-06-19 Insulinpreparation mit mannitol ATE369146T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK68496 1996-06-20
DK89996 1996-08-27

Publications (1)

Publication Number Publication Date
ATE369146T1 true ATE369146T1 (de) 2007-08-15

Family

ID=26064448

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97927018T ATE369146T1 (de) 1996-06-20 1997-06-19 Insulinpreparation mit mannitol

Country Status (16)

Country Link
EP (1) EP0910402B1 (de)
JP (2) JP4472027B2 (de)
KR (1) KR20000022030A (de)
CN (1) CN1198643C (de)
AT (1) ATE369146T1 (de)
AU (1) AU719361B2 (de)
BR (1) BR9709844A (de)
CA (1) CA2258099A1 (de)
CZ (1) CZ297682B6 (de)
DE (1) DE69737995T2 (de)
ES (1) ES2292189T3 (de)
HU (1) HUP9904156A3 (de)
IL (1) IL127365A0 (de)
NO (1) NO324276B1 (de)
PL (1) PL188736B1 (de)
WO (1) WO1997048413A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1111799A (en) 1997-10-24 1999-05-17 Eli Lilly And Company Fatty acid-acylated insulin analogs
EP0911035A3 (de) * 1997-10-24 2002-08-21 Eli Lilly And Company Unlösliche insulinzusammensetzungen
US6531448B1 (en) 1997-12-23 2003-03-11 Eli Lilly And Company Insoluble compositions for controlling blood glucose
EP1396272A1 (de) * 1997-12-23 2004-03-10 Eli Lilly & Company Unlöslische Insulin Zusammensetzungen zur Regelung der Blutglukose
AU2827199A (en) * 1998-03-24 1999-10-18 Klavs Holger Jorgensen Novel preparation of protracted acting human insulin
GB9806462D0 (en) * 1998-03-26 1998-05-27 Glaxo Group Ltd Improved compositions for inhalation
BR9914568A (pt) * 1998-10-16 2001-07-03 Novo Nordisk As Formulação aquosa de insulina, preparação de insulina e método de tratamento de diabetes do tipo i ou do tipo ii
US6635617B1 (en) 1998-10-16 2003-10-21 Novo Nordisk A/S Insulin preparations for pulmonary delivery containing menthol
CZ20011134A3 (cs) * 1998-10-16 2001-08-15 Novo Nordisk A/S Stabilní koncentrované insulinové přípravky pro plicní podávání
US6211144B1 (en) 1998-10-16 2001-04-03 Novo Nordisk A/S Stable concentrated insulin preparations for pulmonary delivery
ATE390126T1 (de) * 2003-05-01 2008-04-15 Ltt Bio Pharma Co Ltd Zubereitungen mit verzögerter freigabe enthaltend zink, und herstellung derselben
CA2581798A1 (en) 2004-10-05 2006-04-13 Petter Lybeck A pharmaceutical formulation comprising crystalline insulin and dissolved insulin
CN101060856B (zh) * 2004-11-22 2011-01-19 诺和诺德公司 可溶、稳定的含胰岛素制剂
CN1931360B (zh) * 2006-09-22 2013-02-13 江苏万邦生化医药股份有限公司 双时相精蛋白锌胰岛素注射液(30%)及其制备方法
BRPI0907371A2 (pt) 2008-01-09 2015-11-24 Sanofi Aventis Deutschland derivados de insulina com um perfil de tempo-ação muito retardado
HUE037449T2 (hu) 2008-10-17 2018-08-28 Sanofi Aventis Deutschland Egy inzulin és egy GLP-1 agonista kombinációja
RU2537239C2 (ru) 2009-11-13 2014-12-27 Санофи-Авентис Дойчланд Гмбх Фармацевтическая композиция, включающая агонист glp-1, инсулин и метионин
PE20121316A1 (es) 2009-11-13 2012-10-05 Sanofi Aventis Deutschland Composicion farmaceutica que comprende un agonista de glp-1 y metionina
PT2611458T (pt) 2010-08-30 2016-12-16 Sanofi Aventis Deutschland Utilização de ave0010 para o fabrico de um medicamento para o tratamento da diabetes mellitus tipo 2
US9821032B2 (en) 2011-05-13 2017-11-21 Sanofi-Aventis Deutschland Gmbh Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
PT2750699E (pt) 2011-08-29 2015-11-03 Sanofi Aventis Deutschland Acelerómetro pendular
TWI559929B (en) 2011-09-01 2016-12-01 Sanofi Aventis Deutschland Pharmaceutical composition for use in the treatment of a neurodegenerative disease
TWI780236B (zh) 2013-02-04 2022-10-11 法商賽諾菲公司 胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
JP2020114861A (ja) * 2014-01-09 2020-07-30 サノフイＳａｎｏｆｉ インスリンアナログおよび／またはインスリン誘導体の、グリセリンを含まない安定化された医薬製剤
JP7173953B2 (ja) * 2014-01-09 2022-11-16 サノフイ インスリンアナログおよび／またはインスリン誘導体の安定化された医薬製剤
WO2015104314A1 (en) * 2014-01-09 2015-07-16 Sanofi Stabilized pharmaceutical formulations of insulin analogues and/or insulin derivatives
RU2016132386A (ru) * 2014-01-09 2018-02-14 Санофи Стабилизированные фармацевтические составы без глицерина на основе инсулиновых аналогов и/или инсулиновых производных
AU2015205620A1 (en) * 2014-01-09 2016-07-14 Sanofi Stabilized pharmaceutical formulations of insulin aspart
JP2020143105A (ja) * 2014-01-09 2020-09-10 サノフイＳａｎｏｆｉ インスリンアスパルトの安定化された医薬製剤
CA2970200A1 (en) 2014-12-12 2016-06-16 Sanofi-Aventis Deutschland Gmbh Insulin glargine/lixisenatide fixed ratio formulation
TWI748945B (zh) 2015-03-13 2021-12-11 德商賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患治療
TW201705975A (zh) 2015-03-18 2017-02-16 賽諾菲阿凡提斯德意志有限公司 第２型糖尿病病患之治療
WO2017163159A1 (en) * 2016-03-21 2017-09-28 Wockhardt Limited Biphasic pharmaceutical composition of insulin human

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439181A (en) * 1981-01-26 1984-03-27 Regents Of The University Of Minnesota Polyol-hormone mixture for use in chronic parenteral hormone administration
US4839341A (en) * 1984-05-29 1989-06-13 Eli Lilly And Company Stabilized insulin formulations
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
DE122006000015I1 (de) * 1993-06-21 2006-06-29 Novo Nordisk As Asp-B28-Insulinkristalle

Also Published As

Publication number Publication date
CZ395798A3 (cs) 1999-05-12
NO324276B1 (no) 2007-09-17
DE69737995T2 (de) 2008-04-24
CN1198643C (zh) 2005-04-27
ES2292189T3 (es) 2008-03-01
NO985978D0 (no) 1998-12-18
IL127365A0 (en) 1999-10-28
PL188736B1 (pl) 2005-04-29
AU3166597A (en) 1998-01-07
CZ297682B6 (cs) 2007-03-07
HUP9904156A2 (hu) 2000-06-28
JP2000513343A (ja) 2000-10-10
PL330828A1 (en) 1999-06-07
DE69737995D1 (de) 2007-09-20
BR9709844A (pt) 1999-08-10
AU719361B2 (en) 2000-05-04
HUP9904156A3 (en) 2000-07-28
KR20000022030A (ko) 2000-04-25
JP4472027B2 (ja) 2010-06-02
EP0910402B1 (de) 2007-08-08
JP2009242400A (ja) 2009-10-22
NO985978L (no) 1999-02-19
CN1222084A (zh) 1999-07-07
CA2258099A1 (en) 1997-12-24
WO1997048413A1 (en) 1997-12-24
EP0910402A1 (de) 1999-04-28

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