BR9914568A - Formulação aquosa de insulina, preparação de insulina e método de tratamento de diabetes do tipo i ou do tipo ii - Google Patents
Formulação aquosa de insulina, preparação de insulina e método de tratamento de diabetes do tipo i ou do tipo iiInfo
- Publication number
- BR9914568A BR9914568A BR9914568-5A BR9914568A BR9914568A BR 9914568 A BR9914568 A BR 9914568A BR 9914568 A BR9914568 A BR 9914568A BR 9914568 A BR9914568 A BR 9914568A
- Authority
- BR
- Brazil
- Prior art keywords
- insulin
- type
- formulation
- diabetes
- aqueous formulation
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 16
- 102000004877 Insulin Human genes 0.000 title abstract 8
- 108090001061 Insulin Proteins 0.000 title abstract 8
- 229940125396 insulin Drugs 0.000 title abstract 8
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 title abstract 2
- 239000013011 aqueous formulation Substances 0.000 title 1
- 238000009472 formulation Methods 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 5
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 abstract 2
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 abstract 2
- 229940041616 menthol Drugs 0.000 abstract 2
- 150000002500 ions Chemical class 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- 230000002685 pulmonary effect Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
"FORMULAçãO AQUOSA DE INSULINA, PREPARAçãO DE INSULINA E MéTODO DE TRATAMENTO DE DIABETES DO TIPO I OU DO TIPO II". é apresentada uma formulação de insulina estável, aquosa, adequada para aporte pulmonar. A formulação é composta de insulina ou um análogo da mesma, 2 a 5 íons de Zn^ 2+^ por 6 moléculas de insulina, 3 a 18 moléculas fenólicas por 6 moléculas de insulina, e mentol. O cheiro característico de mentol mascara a presença de fenóis na formulação sem afetar a estabilidade química e física da formulação.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA199801326 | 1998-10-16 | ||
| PCT/DK1999/000557 WO2000023099A1 (en) | 1998-10-16 | 1999-10-15 | Insulin preparations for pulmonary delivery containing menthol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9914568A true BR9914568A (pt) | 2001-07-03 |
Family
ID=8103609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9914568-5A BR9914568A (pt) | 1998-10-16 | 1999-10-15 | Formulação aquosa de insulina, preparação de insulina e método de tratamento de diabetes do tipo i ou do tipo ii |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1121145B1 (pt) |
| JP (1) | JP2002527488A (pt) |
| KR (1) | KR20010080132A (pt) |
| CN (1) | CN1323220A (pt) |
| AT (1) | ATE216258T1 (pt) |
| AU (1) | AU758108B2 (pt) |
| BR (1) | BR9914568A (pt) |
| CA (1) | CA2346884A1 (pt) |
| CZ (1) | CZ20011133A3 (pt) |
| DE (1) | DE69901314T2 (pt) |
| DK (1) | DK1121145T3 (pt) |
| ES (1) | ES2177324T3 (pt) |
| HU (1) | HUP0103606A3 (pt) |
| IL (1) | IL142002A0 (pt) |
| NO (1) | NO20011841L (pt) |
| PL (1) | PL347171A1 (pt) |
| PT (1) | PT1121145E (pt) |
| UA (1) | UA67798C2 (pt) |
| WO (1) | WO2000023099A1 (pt) |
| ZA (1) | ZA200102068B (pt) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7089053B1 (en) | 1999-10-14 | 2006-08-08 | Pola Chemical Industries Inc | Compositions for drug administration by electroporation |
| EP1222931B1 (en) * | 1999-10-15 | 2006-06-07 | Pola Chemical Industries Inc. | Percutaneous absorption promoters for electroporation |
| DE10114178A1 (de) | 2001-03-23 | 2002-10-10 | Aventis Pharma Gmbh | Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität |
| MX349717B (es) | 2008-10-17 | 2017-08-09 | Sanofi Aventis Deutschland | Combinación de una insulina y un agonista de glp-1. |
| HUE037735T2 (hu) | 2009-11-13 | 2018-09-28 | Sanofi Aventis Deutschland | DesPro36exendin-4(1-39)-Lys6-NH2-t és metionint tartalmazó gyógyszerkészítmény |
| TR201809460T4 (tr) | 2009-11-13 | 2018-07-23 | Sanofi Aventis Deutschland | Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim. |
| SI2611458T1 (sl) | 2010-08-30 | 2017-01-31 | Sanofi-Aventis Deutschland Gmbh | Uporaba AVE0010 za izdelavo zdravila za zdravljenje sladkorne bolezni tipa 2 |
| US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
| RU2650616C2 (ru) | 2011-08-29 | 2018-04-16 | Санофи-Авентис Дойчланд Гмбх | Фармацевтическая комбинация для применения при гликемическом контроле у пациентов с сахарным диабетом 2 типа |
| TWI559929B (en) | 2011-09-01 | 2016-12-01 | Sanofi Aventis Deutschland | Pharmaceutical composition for use in the treatment of a neurodegenerative disease |
| SI3229828T1 (sl) | 2014-12-12 | 2023-06-30 | Sanofi-Aventis Deutschland Gmbh | Formulacija s fiksnim razmerjem inzulin glargin/liksisenatid |
| TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患治療 |
| TW201705975A (zh) | 2015-03-18 | 2017-02-16 | 賽諾菲阿凡提斯德意志有限公司 | 第２型糖尿病病患之治療 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5506203C1 (en) * | 1993-06-24 | 2001-02-06 | Astra Ab | Systemic administration of a therapeutic preparation |
| US5474978A (en) * | 1994-06-16 | 1995-12-12 | Eli Lilly And Company | Insulin analog formulations |
| US5504188A (en) * | 1994-06-16 | 1996-04-02 | Eli Lilly And Company | Preparation of stable zinc insulin analog crystals |
| US5635161A (en) * | 1995-06-07 | 1997-06-03 | Abbott Laboratories | Aerosol drug formulations containing vegetable oils |
| ATE369146T1 (de) * | 1996-06-20 | 2007-08-15 | Novo Nordisk As | Insulinpreparation mit mannitol |
| JP2001518916A (ja) * | 1997-03-20 | 2001-10-16 | ノボ ノルディスク アクティーゼルスカブ | 結晶インスリンを含有する肺投与のための治療用粉末調合物 |
-
1999
- 1999-10-15 PL PL99347171A patent/PL347171A1/xx unknown
- 1999-10-15 JP JP2000576872A patent/JP2002527488A/ja not_active Withdrawn
- 1999-10-15 AT AT99948726T patent/ATE216258T1/de not_active IP Right Cessation
- 1999-10-15 KR KR1020017004638A patent/KR20010080132A/ko not_active Application Discontinuation
- 1999-10-15 UA UA2001042149A patent/UA67798C2/uk unknown
- 1999-10-15 ES ES99948726T patent/ES2177324T3/es not_active Expired - Lifetime
- 1999-10-15 BR BR9914568-5A patent/BR9914568A/pt not_active IP Right Cessation
- 1999-10-15 CZ CZ20011133A patent/CZ20011133A3/cs unknown
- 1999-10-15 WO PCT/DK1999/000557 patent/WO2000023099A1/en not_active Application Discontinuation
- 1999-10-15 CA CA002346884A patent/CA2346884A1/en not_active Abandoned
- 1999-10-15 DE DE69901314T patent/DE69901314T2/de not_active Expired - Fee Related
- 1999-10-15 HU HU0103606A patent/HUP0103606A3/hu unknown
- 1999-10-15 PT PT99948726T patent/PT1121145E/pt unknown
- 1999-10-15 DK DK99948726T patent/DK1121145T3/da active
- 1999-10-15 CN CN99812209A patent/CN1323220A/zh active Pending
- 1999-10-15 IL IL14200299A patent/IL142002A0/xx unknown
- 1999-10-15 EP EP99948726A patent/EP1121145B1/en not_active Expired - Lifetime
- 1999-10-15 AU AU61890/99A patent/AU758108B2/en not_active Ceased
-
2001
- 2001-03-13 ZA ZA200102068A patent/ZA200102068B/en unknown
- 2001-04-10 NO NO20011841A patent/NO20011841L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2346884A1 (en) | 2000-04-27 |
| DE69901314T2 (de) | 2002-11-21 |
| WO2000023099A1 (en) | 2000-04-27 |
| NO20011841L (no) | 2001-06-15 |
| CZ20011133A3 (cs) | 2001-08-15 |
| ZA200102068B (en) | 2001-10-12 |
| DK1121145T3 (da) | 2002-08-12 |
| AU6189099A (en) | 2000-05-08 |
| KR20010080132A (ko) | 2001-08-22 |
| EP1121145A1 (en) | 2001-08-08 |
| EP1121145B1 (en) | 2002-04-17 |
| NO20011841D0 (no) | 2001-04-10 |
| AU758108B2 (en) | 2003-03-13 |
| HUP0103606A2 (hu) | 2002-02-28 |
| UA67798C2 (uk) | 2004-07-15 |
| IL142002A0 (en) | 2002-03-10 |
| PL347171A1 (en) | 2002-03-25 |
| HUP0103606A3 (en) | 2002-05-28 |
| PT1121145E (pt) | 2002-09-30 |
| JP2002527488A (ja) | 2002-08-27 |
| DE69901314D1 (de) | 2002-05-23 |
| ES2177324T3 (es) | 2002-12-01 |
| ATE216258T1 (de) | 2002-05-15 |
| CN1323220A (zh) | 2001-11-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A, 7A E 8A ANUIDADES. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007. |