ATE362473T1 - 1,5-disubstituierte 3,4-dihydro-1h-4,5- döpyrimidin-2-on-verbindungen und ihre verwendung in der behandlung von durch csbp/p38 kinase beeinflussten krankheiten - Google Patents

1,5-disubstituierte 3,4-dihydro-1h-4,5- döpyrimidin-2-on-verbindungen und ihre verwendung in der behandlung von durch csbp/p38 kinase beeinflussten krankheiten

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Publication number
ATE362473T1
ATE362473T1 AT01914625T AT01914625T ATE362473T1 AT E362473 T1 ATE362473 T1 AT E362473T1 AT 01914625 T AT01914625 T AT 01914625T AT 01914625 T AT01914625 T AT 01914625T AT E362473 T1 ATE362473 T1 AT E362473T1
Authority
AT
Austria
Prior art keywords
döpyrimidine
csbp
disubstituted
dihydro
kinase
Prior art date
Application number
AT01914625T
Other languages
German (de)
English (en)
Inventor
Jerry Adams
Jeffrey Boehm
Ralph Hall
John Taggart
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE362473T1 publication Critical patent/ATE362473T1/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P33/00—Antiparasitic agents
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    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Psychiatry (AREA)
  • Ophthalmology & Optometry (AREA)
AT01914625T 2000-03-02 2001-03-02 1,5-disubstituierte 3,4-dihydro-1h-4,5- döpyrimidin-2-on-verbindungen und ihre verwendung in der behandlung von durch csbp/p38 kinase beeinflussten krankheiten ATE362473T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18641900P 2000-03-02 2000-03-02

Publications (1)

Publication Number Publication Date
ATE362473T1 true ATE362473T1 (de) 2007-06-15

Family

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AT01914625T ATE362473T1 (de) 2000-03-02 2001-03-02 1,5-disubstituierte 3,4-dihydro-1h-4,5- döpyrimidin-2-on-verbindungen und ihre verwendung in der behandlung von durch csbp/p38 kinase beeinflussten krankheiten

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EP (1) EP1265900B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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AR (2) AR030053A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AT (1) ATE362473T1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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ZA200207017B (en) 2004-02-26
DE60128457T2 (de) 2008-01-17
AR040075A2 (es) 2005-03-16
ES2287107T3 (es) 2007-12-16
KR100806978B1 (ko) 2008-02-25
HUP0204431A1 (hu) 2003-04-28
EP1265900A1 (en) 2002-12-18
DE60128457D1 (de) 2007-06-28
CY1106816T1 (el) 2012-01-25
NO326409B1 (no) 2008-12-01
HK1052932A1 (en) 2003-10-03
MXPA02008588A (es) 2003-02-24
HUP0204431A3 (en) 2006-01-30
TWI290926B (en) 2007-12-11
PT1265900E (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2007-08-22
AR030053A1 (es) 2003-08-13
CN100482664C (zh) 2009-04-29
AU2001239992B2 (en) 2005-09-01
IL189865A0 (en) 2008-08-07
NO20024134D0 (no) 2002-08-30
CN1422273A (zh) 2003-06-04
NZ520914A (en) 2004-03-26
EP1265900A4 (en) 2004-11-10
WO2001064679A1 (en) 2001-09-07
JP2003525295A (ja) 2003-08-26
EP1265900B1 (en) 2007-05-16
AU3999201A (en) 2001-09-12
NO20024134L (no) 2002-10-24
PL358280A1 (en) 2004-08-09
KR20020082858A (ko) 2002-10-31
CA2402092A1 (en) 2001-09-07
BR0108715A (pt) 2004-04-27
MY141144A (en) 2010-03-15
IL151426A (en) 2011-01-31
IL151426A0 (en) 2003-04-10
CZ20022933A3 (cs) 2003-02-12
DK1265900T3 (da) 2007-09-24
CA2402092C (en) 2012-01-24

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