ATE355373T1 - Immununterdrückung durch blockierung des t- zellencostimulierungssignales 2 (b7/cd28 interaktion) - Google Patents
Immununterdrückung durch blockierung des t- zellencostimulierungssignales 2 (b7/cd28 interaktion)Info
- Publication number
- ATE355373T1 ATE355373T1 AT99919418T AT99919418T ATE355373T1 AT E355373 T1 ATE355373 T1 AT E355373T1 AT 99919418 T AT99919418 T AT 99919418T AT 99919418 T AT99919418 T AT 99919418T AT E355373 T1 ATE355373 T1 AT E355373T1
- Authority
- AT
- Austria
- Prior art keywords
- recipient
- cells
- cell
- interaction
- stimulation
- Prior art date
Links
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 title abstract 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 3
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 230000020385 T cell costimulation Effects 0.000 title 1
- 230000008629 immune suppression Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 abstract 3
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 abstract 3
- 210000000056 organ Anatomy 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 102000043131 MHC class II family Human genes 0.000 abstract 1
- 108091054438 MHC class II family Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Devices Affording Protection Of Roads Or Walls For Sound Insulation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9809280.2A GB9809280D0 (en) | 1998-04-30 | 1998-04-30 | Immunosupression |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE355373T1 true ATE355373T1 (de) | 2006-03-15 |
Family
ID=10831274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99919418T ATE355373T1 (de) | 1998-04-30 | 1999-04-30 | Immununterdrückung durch blockierung des t- zellencostimulierungssignales 2 (b7/cd28 interaktion) |
Country Status (11)
Country | Link |
---|---|
US (3) | US7432344B1 (de) |
EP (2) | EP1854884A3 (de) |
JP (2) | JP2002513568A (de) |
AT (1) | ATE355373T1 (de) |
AU (1) | AU772239B2 (de) |
CA (1) | CA2326671C (de) |
DE (1) | DE69935318T2 (de) |
ES (1) | ES2284251T3 (de) |
GB (1) | GB9809280D0 (de) |
NZ (2) | NZ527297A (de) |
WO (1) | WO1999057266A2 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
AU2001255398A1 (en) * | 2000-04-12 | 2001-10-30 | Genetics Institute Inc. | Surface-bound antigen binding portions of antibodies that bind to ctla-4 and cd28 and uses therefor |
AU2001263466C1 (en) * | 2000-05-26 | 2006-10-26 | Bristol-Myers Squibb Company | Soluble CTLA4 mutant molecules and uses thereof |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
CN101684158A (zh) * | 2001-01-17 | 2010-03-31 | 特鲁比昂药品公司 | 结合域-免疫球蛋白融合蛋白 |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
ITRM20010408A1 (it) | 2001-07-10 | 2003-01-10 | Univ Napoli Federico Ii | Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2. |
US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
EP1539235A2 (de) | 2002-07-01 | 2005-06-15 | Human Genome Sciences, Inc. | Spezifisch an reg iv bindende antikörper |
EP1651050B1 (de) * | 2003-07-21 | 2012-08-22 | Lifecell Corporation | Zellfreie gewebsmatrize aus galactose-alpha-1,3-galactose-freiem gewebe |
EP1734814B1 (de) | 2004-03-17 | 2015-01-21 | Revivicor, Inc. | Gewebeprodukte aus tieren ohne jegliche expression einer funktionsfähigen alpha-1,3-galactosyltransferase |
WO2006047603A2 (en) | 2004-10-22 | 2006-05-04 | Revivicor, Inc. | Ungulates with genetically modified immune systems |
CN105012953B (zh) | 2005-07-25 | 2018-06-22 | 阿普泰沃研发有限责任公司 | 用cd37-特异性和cd20-特异性结合分子减少b-细胞 |
EP3138403A1 (de) | 2005-08-09 | 2017-03-08 | Revivicor, Inc. | Ctla4-ig exprimierende transgene huftiere und verwendungen davon |
RU2487888C2 (ru) | 2006-06-12 | 2013-07-20 | ЭМЕРДЖЕНТ ПРОДАКТ ДИВЕЛОПМЕНТ СИЭТЛ, ЭлЭлСи | Одноцепочечные мультивалентные связывающие белки с эффекторной функцией |
ATE513856T1 (de) | 2008-04-11 | 2011-07-15 | Emergent Product Dev Seattle | Cd37-immuntherapeutikum und kombination mit bifunktionellem chemotherapeutikum davon |
WO2010051288A1 (en) | 2008-10-27 | 2010-05-06 | Revivicor, Inc. | Immunocompromised ungulates |
CA3104704A1 (en) | 2009-08-14 | 2011-02-17 | Revivicor, Inc. | Multi-transgenic pigs for diabetes treatment |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
TW201134481A (en) | 2010-03-12 | 2011-10-16 | Abbott Biotherapeutics Corp | CTLA4 proteins and their uses |
EP2675901B1 (de) | 2011-02-14 | 2018-05-30 | Revivicor, Inc. | Genetisch modifizierte schweine für xenotransplantation von vaskularisierten xenotransplantaten und derivaten davon |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
WO2014138188A1 (en) * | 2013-03-07 | 2014-09-12 | The General Hospital Corporation | Human ctla4 mutants and use thereof |
AU2014341866B2 (en) | 2013-11-04 | 2018-07-05 | Lifecell Corporation | Methods of removing alpha-galactose |
TWI617319B (zh) * | 2015-09-01 | 2018-03-11 | 免疫功坊股份有限公司 | 用以治療病理性血栓的融合蛋白 |
CA2999138C (en) | 2015-09-21 | 2024-05-21 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
CN111214646B (zh) * | 2019-12-30 | 2023-08-01 | 中山大学·深圳 | Pd-l1/ctla-4在制备免疫抑制剂中的应用 |
CN117279502A (zh) | 2020-11-20 | 2023-12-22 | 雷维维科公司 | 用于异种移植的生长激素受体敲除的多转基因猪 |
US20230255185A1 (en) | 2021-09-20 | 2023-08-17 | Revivicor, Inc. | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10501815A (ja) * | 1994-06-07 | 1998-02-17 | リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミネソタ | 抗原特異的t細胞応答の阻害方法 |
ATE274064T1 (de) * | 1995-05-23 | 2004-09-15 | Morphosys Ag | Multimere proteine |
JP4751493B2 (ja) * | 1996-03-20 | 2011-08-17 | ブリストル−マイヤーズ スクイッブ カンパニー | Gp39/cd40およびctla4/cd28/b7経路のブロックによって免疫反応を阻止する方法およびそれに使用する組成物 |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
-
1998
- 1998-04-30 GB GBGB9809280.2A patent/GB9809280D0/en not_active Ceased
-
1999
- 1999-04-30 AT AT99919418T patent/ATE355373T1/de not_active IP Right Cessation
- 1999-04-30 CA CA2326671A patent/CA2326671C/en not_active Expired - Lifetime
- 1999-04-30 EP EP06077284A patent/EP1854884A3/de not_active Withdrawn
- 1999-04-30 EP EP99919418A patent/EP1073737B1/de not_active Expired - Lifetime
- 1999-04-30 JP JP2000547221A patent/JP2002513568A/ja active Pending
- 1999-04-30 NZ NZ527297A patent/NZ527297A/xx active IP Right Revival
- 1999-04-30 US US09/674,462 patent/US7432344B1/en not_active Expired - Fee Related
- 1999-04-30 ES ES99919418T patent/ES2284251T3/es not_active Expired - Lifetime
- 1999-04-30 NZ NZ507706A patent/NZ507706A/en not_active IP Right Cessation
- 1999-04-30 WO PCT/GB1999/001350 patent/WO1999057266A2/en active IP Right Grant
- 1999-04-30 DE DE69935318T patent/DE69935318T2/de not_active Expired - Lifetime
- 1999-04-30 AU AU37213/99A patent/AU772239B2/en not_active Expired
-
2008
- 2008-09-04 US US12/231,608 patent/US8097598B2/en not_active Expired - Fee Related
-
2011
- 2011-04-22 JP JP2011096600A patent/JP5706225B2/ja not_active Expired - Lifetime
- 2011-12-12 US US13/316,791 patent/US9090708B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP1073737A2 (de) | 2001-02-07 |
WO1999057266A3 (en) | 2000-04-20 |
AU3721399A (en) | 1999-11-23 |
DE69935318D1 (de) | 2007-04-12 |
AU772239B2 (en) | 2004-04-22 |
US8097598B2 (en) | 2012-01-17 |
NZ507706A (en) | 2004-01-30 |
US20100146648A1 (en) | 2010-06-10 |
JP2002513568A (ja) | 2002-05-14 |
WO1999057266A2 (en) | 1999-11-11 |
NZ527297A (en) | 2004-12-24 |
CA2326671C (en) | 2015-12-15 |
JP5706225B2 (ja) | 2015-04-22 |
EP1073737B1 (de) | 2007-02-28 |
EP1854884A2 (de) | 2007-11-14 |
US9090708B2 (en) | 2015-07-28 |
JP2011144205A (ja) | 2011-07-28 |
EP1854884A3 (de) | 2009-07-29 |
US20130078266A1 (en) | 2013-03-28 |
ES2284251T3 (es) | 2007-11-01 |
GB9809280D0 (en) | 1998-07-01 |
DE69935318T2 (de) | 2007-11-15 |
US7432344B1 (en) | 2008-10-07 |
CA2326671A1 (en) | 1999-11-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1073737 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |