DE60143799D1 - Genetisch hergestellte mhc moleküle - Google Patents
Genetisch hergestellte mhc moleküleInfo
- Publication number
- DE60143799D1 DE60143799D1 DE60143799T DE60143799T DE60143799D1 DE 60143799 D1 DE60143799 D1 DE 60143799D1 DE 60143799 T DE60143799 T DE 60143799T DE 60143799 T DE60143799 T DE 60143799T DE 60143799 D1 DE60143799 D1 DE 60143799D1
- Authority
- DE
- Germany
- Prior art keywords
- component
- cells
- polypeptide
- class
- zeta
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70539—MHC-molecules, e.g. HLA-molecules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Transplantation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IL13651100A IL136511A0 (en) | 2000-06-01 | 2000-06-01 | Genetically engineered mhc molecules |
PCT/IL2001/000506 WO2001091698A2 (en) | 2000-06-01 | 2001-05-31 | Genetically-engineered mhc molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60143799D1 true DE60143799D1 (de) | 2011-02-17 |
Family
ID=11074209
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60143799T Expired - Lifetime DE60143799D1 (de) | 2000-06-01 | 2001-05-31 | Genetisch hergestellte mhc moleküle |
Country Status (7)
Country | Link |
---|---|
US (1) | US7319143B2 (de) |
EP (1) | EP1301202B1 (de) |
AT (1) | ATE494004T1 (de) |
AU (1) | AU7443901A (de) |
DE (1) | DE60143799D1 (de) |
IL (2) | IL136511A0 (de) |
WO (1) | WO2001091698A2 (de) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1507550A1 (de) * | 2002-05-30 | 2005-02-23 | Sloan Kettering Institute For Cancer Research | Suizid-tetramere mit mhc klasse i und ihre verwendungen |
WO2003106616A2 (en) * | 2002-06-12 | 2003-12-24 | Gavish-Galilee Bio Applications Ltd | MEMBRANE-ANCHORED β2 MICROGLOBULIN COVALENTLY LINKED TO MHC CLASS I PEPTIDE EPITOPES |
WO2006077152A2 (en) * | 2005-01-21 | 2006-07-27 | Utku Nalan | Hla fusion molecules and uses thereof |
BR122021026169B1 (pt) | 2010-12-09 | 2023-12-12 | The Trustees Of The University Of Pennsylvania | Uso de uma célula |
WO2012127464A2 (en) | 2011-03-23 | 2012-09-27 | Gavish-Galilee Bio Applications Ltd | Constitutively activated t cells for use in adoptive cell therapy |
RU2708032C2 (ru) | 2013-02-20 | 2019-12-03 | Новартис Аг | ЛЕЧЕНИЕ РАКА С ИСПОЛЬЗОВАНИЕМ ХИМЕРНОГО АНТИГЕНСПЕЦИФИЧЕСКОГО РЕЦЕПТОРА НА ОСНОВЕ ГУМАНИЗИРОВАННОГО АНТИТЕЛА ПРОТИВ EGFRvIII |
WO2014130635A1 (en) | 2013-02-20 | 2014-08-28 | Novartis Ag | Effective targeting of primary human leukemia using anti-cd123 chimeric antigen receptor engineered t cells |
EP2970426B1 (de) | 2013-03-15 | 2019-08-28 | Michael C. Milone | Anzielung zytotoxischer zellen mit chimären rezeptoren für eine adoptive immuntherapie |
UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
CA3225453A1 (en) | 2013-12-19 | 2015-06-25 | Novartis Ag | Human mesothelin chimeric antigen receptors and uses thereof |
EP3087101B1 (de) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulierbarer chimärer antigenrezeptor |
WO2015112626A1 (en) | 2014-01-21 | 2015-07-30 | June Carl H | Enhanced antigen presenting ability of car t cells by co-introduction of costimulatory molecules |
HUE054588T2 (hu) | 2014-04-07 | 2021-09-28 | Novartis Ag | Rák kezelése CD19 elleni, kiméra antigénreceptor alkalmazásával |
AR101829A1 (es) | 2014-07-21 | 2017-01-18 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno cll-1 |
CA2955154C (en) | 2014-07-21 | 2023-10-31 | Novartis Ag | Treatment of cancer using a cd33 chimeric antigen receptor |
MY181834A (en) | 2014-07-21 | 2021-01-08 | Novartis Ag | Treatment of cancer using humanized anti-bcma chimeric antigen receptor |
US11542488B2 (en) | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
PL3183268T3 (pl) | 2014-08-19 | 2020-09-07 | Novartis Ag | Chimeryczny receptor antygenowy (CAR) anty-CD123 do zastosowania w leczeniu nowotworu złośliwego |
WO2016044605A1 (en) | 2014-09-17 | 2016-03-24 | Beatty, Gregory | Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy |
KR20170068504A (ko) | 2014-10-08 | 2017-06-19 | 노파르티스 아게 | 키메라 항원 수용체 요법에 대한 치료 반응성을 예측하는 바이오마커 및 그의 용도 |
IL253149B2 (en) | 2014-12-29 | 2023-11-01 | Novartis Ag | Methods for preparing cells expressing a chimeric receptor antigen |
WO2016115482A1 (en) | 2015-01-16 | 2016-07-21 | Novartis Pharma Ag | Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor |
WO2016126608A1 (en) | 2015-02-02 | 2016-08-11 | Novartis Ag | Car-expressing cells against multiple tumor antigens and uses thereof |
EP4056588A1 (de) | 2015-04-08 | 2022-09-14 | Novartis AG | Cd20-therapien, cd22-therapien und kombinationstherapien mit einer zelle zur expression des chimären antigen-rezeptors (car) cd19 |
CA2982996A1 (en) | 2015-04-17 | 2016-10-20 | David Maxwell Barrett | Methods for improving the efficacy and expansion of chimeric antigen receptor-expressing cells |
AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
WO2017027392A1 (en) | 2015-08-07 | 2017-02-16 | Novartis Ag | Treatment of cancer using chimeric cd3 receptor proteins |
CN108780084B (zh) | 2015-09-03 | 2022-07-22 | 诺华股份有限公司 | 预测细胞因子释放综合征的生物标志物 |
JP7082055B2 (ja) | 2015-12-22 | 2022-06-07 | ノバルティス アーゲー | 抗癌治療における組み合わせ使用のためのメソテリンキメラ抗原受容体(car)およびpd-l1阻害剤に対する抗体 |
WO2017165683A1 (en) | 2016-03-23 | 2017-09-28 | Novartis Ag | Cell secreted minibodies and uses thereof |
CN117866991A (zh) | 2016-10-07 | 2024-04-12 | 诺华股份有限公司 | 用于治疗癌症的嵌合抗原受体 |
RU2019133280A (ru) | 2017-03-22 | 2021-04-22 | Новартис Аг | Композиции и способы для иммуноонкологии |
US20190201443A1 (en) * | 2017-09-06 | 2019-07-04 | California Institute Of Technology | Signaling and antigen-presenting bifunctional receptors (sabr) |
KR20200086278A (ko) | 2017-10-18 | 2020-07-16 | 노파르티스 아게 | 선택적 단백질 분해를 위한 조성물 및 방법 |
EP3784696A1 (de) * | 2018-04-23 | 2021-03-03 | Baylor College Of Medicine | Chimärer akzessorischer hla-rezeptor |
KR20210005923A (ko) * | 2018-04-27 | 2021-01-15 | 크리스퍼 테라퓨틱스 아게 | 세포독성 t 세포 고갈의 방법 및 조성물 |
AU2019284911A1 (en) | 2018-06-13 | 2020-12-17 | Novartis Ag | BCMA chimeric antigen receptors and uses thereof |
WO2020097188A1 (en) * | 2018-11-06 | 2020-05-14 | Sangamo Therapeutics, Inc. | Identification of molecules for inhibition of nk-mediated cell killing |
CN114945382A (zh) | 2019-11-26 | 2022-08-26 | 诺华股份有限公司 | Cd19和cd22嵌合抗原受体及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69123241T2 (de) * | 1990-12-14 | 1997-04-17 | Cell Genesys Inc | Chimärische ketten zur transduktion von rezeptorverbundenen signalwegen |
WO1997008328A1 (en) * | 1995-08-30 | 1997-03-06 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Selective elimination of t cells that recognize specific preselected targets |
DE19545351C1 (de) * | 1995-12-05 | 1997-07-31 | Univ Ludwigs Albert | Eukaryotische Zellen mit Hybridrezeptor und dadurch steuerbarem Genkonstrukt, Verfahren zu deren Herstellung und Verwendung dieser Zellen in der Gentherapie |
-
2000
- 2000-06-01 IL IL13651100A patent/IL136511A0/xx unknown
-
2001
- 2001-05-31 DE DE60143799T patent/DE60143799D1/de not_active Expired - Lifetime
- 2001-05-31 WO PCT/IL2001/000506 patent/WO2001091698A2/en active Application Filing
- 2001-05-31 US US10/297,060 patent/US7319143B2/en not_active Expired - Fee Related
- 2001-05-31 EP EP01940953A patent/EP1301202B1/de not_active Expired - Lifetime
- 2001-05-31 AT AT01940953T patent/ATE494004T1/de not_active IP Right Cessation
- 2001-05-31 AU AU74439/01A patent/AU7443901A/en not_active Abandoned
-
2002
- 2002-11-26 IL IL153091A patent/IL153091A/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
WO2001091698A2 (en) | 2001-12-06 |
WO2001091698A3 (en) | 2002-04-11 |
US20040137562A1 (en) | 2004-07-15 |
US7319143B2 (en) | 2008-01-15 |
AU7443901A (en) | 2001-12-11 |
IL136511A0 (en) | 2001-06-14 |
EP1301202A4 (de) | 2005-01-05 |
EP1301202B1 (de) | 2011-01-05 |
IL153091A (en) | 2011-01-31 |
ATE494004T1 (de) | 2011-01-15 |
EP1301202A2 (de) | 2003-04-16 |
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