DE69935318D1 - Immununterdrückung durch blockierung des t-zellencostimulierungssignales 2 (b7/cd28 interaktion) - Google Patents
Immununterdrückung durch blockierung des t-zellencostimulierungssignales 2 (b7/cd28 interaktion)Info
- Publication number
- DE69935318D1 DE69935318D1 DE69935318T DE69935318T DE69935318D1 DE 69935318 D1 DE69935318 D1 DE 69935318D1 DE 69935318 T DE69935318 T DE 69935318T DE 69935318 T DE69935318 T DE 69935318T DE 69935318 D1 DE69935318 D1 DE 69935318D1
- Authority
- DE
- Germany
- Prior art keywords
- recipient
- cells
- interaction
- ctla
- stimulation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 title abstract 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 title abstract 3
- 230000003993 interaction Effects 0.000 title abstract 3
- 230000000903 blocking effect Effects 0.000 title abstract 2
- 230000020385 T cell costimulation Effects 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 6
- 210000004027 cell Anatomy 0.000 abstract 5
- 108010021064 CTLA-4 Antigen Proteins 0.000 abstract 3
- 229940045513 CTLA4 antagonist Drugs 0.000 abstract 3
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 abstract 3
- 210000000056 organ Anatomy 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 2
- 102000043131 MHC class II family Human genes 0.000 abstract 1
- 108091054438 MHC class II family Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/001—Preparations to induce tolerance to non-self, e.g. prior to transplantation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70521—CD28, CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70532—B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Environmental Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Transplantation (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Devices Affording Protection Of Roads Or Walls For Sound Insulation (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9809280.2A GB9809280D0 (en) | 1998-04-30 | 1998-04-30 | Immunosupression |
GB9809280 | 1998-04-30 | ||
PCT/GB1999/001350 WO1999057266A2 (en) | 1998-04-30 | 1999-04-30 | Immunosuppression by blocking t cell co-stimulation signal 2 (b7/cd28 interaction) |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69935318D1 true DE69935318D1 (de) | 2007-04-12 |
DE69935318T2 DE69935318T2 (de) | 2007-11-15 |
Family
ID=10831274
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69935318T Expired - Lifetime DE69935318T2 (de) | 1998-04-30 | 1999-04-30 | Immununterdrückung durch blockierung des t-zellencostimulierungssignales 2 (b7/cd28 interaktion) |
Country Status (11)
Country | Link |
---|---|
US (3) | US7432344B1 (de) |
EP (2) | EP1854884A3 (de) |
JP (2) | JP2002513568A (de) |
AT (1) | ATE355373T1 (de) |
AU (1) | AU772239B2 (de) |
CA (1) | CA2326671C (de) |
DE (1) | DE69935318T2 (de) |
ES (1) | ES2284251T3 (de) |
GB (1) | GB9809280D0 (de) |
NZ (2) | NZ527297A (de) |
WO (1) | WO1999057266A2 (de) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
US7030228B1 (en) | 1999-11-15 | 2006-04-18 | Miltenyi Biotec Gmbh | Antigen-binding fragments specific for dendritic cells, compositions and methods of use thereof antigens recognized thereby and cells obtained thereby |
US20030086932A1 (en) * | 2000-04-12 | 2003-05-08 | Jeffrey A. Bluestone | Surface-bound antigen binding portions of antibodies that bind to CTLA-4 and CD28 and uses therefor |
ATE271066T1 (de) * | 2000-05-26 | 2004-07-15 | Bristol Myers Squibb Co | Lösliche mutante ctla4 moleküle und deren verwendung |
US7094874B2 (en) | 2000-05-26 | 2006-08-22 | Bristol-Myers Squibb Co. | Soluble CTLA4 mutant molecules |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
CN1268394C (zh) * | 2001-01-17 | 2006-08-09 | 特鲁比昂药品公司 | 结合域-免疫球蛋白融合蛋白 |
ITRM20010408A1 (it) | 2001-07-10 | 2003-01-10 | Univ Napoli Federico Ii | Mini-anticorpo umano citotossico per cellule tumorali che esprimono il recettore erbb2. |
US7601351B1 (en) | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
WO2004003144A2 (en) | 2002-07-01 | 2004-01-08 | Human Genome Sciences, Inc. | Antibodies that specifically bind to reg iv |
WO2005009134A1 (en) | 2003-07-21 | 2005-02-03 | Lifecell Corporation | ACELLULAR TISSUE MATRICES MADE FROM GALACTOSE α-1,3-GALACTOSE-DEFICIENT TISSUE |
CA2559720A1 (en) | 2004-03-17 | 2005-09-29 | Revivicor, Inc. | Tissue products derived from animals lacking any expression of functional alpha 1,3 galactosyltransferase |
KR20070072608A (ko) | 2004-10-22 | 2007-07-04 | 레비비코르 인코포레이션 | 유전자 변형된 면역계를 가지는 유제류 |
RS54088B1 (en) | 2005-07-25 | 2015-10-30 | Emergent Products Development Seattle Llc | B-CELL REDUCTION BY USING CD37-SPECIFIC AND CD20-SPECIFIC BINDING MOLECULES |
EP3138403A1 (de) | 2005-08-09 | 2017-03-08 | Revivicor, Inc. | Ctla4-ig exprimierende transgene huftiere und verwendungen davon |
KR101571027B1 (ko) | 2006-06-12 | 2015-11-23 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | 효과기 기능을 갖는 단일쇄 다가 결합 단백질 |
NZ588671A (en) | 2008-04-11 | 2012-11-30 | Emergent Product Dev Seattle | Cd37 immunotherapeutic and combination with bifunctional chemotherapeutic thereof |
EP2348827B1 (de) | 2008-10-27 | 2015-07-01 | Revivicor, Inc. | Immunsupprimierte huftiere |
KR20180036810A (ko) | 2009-08-14 | 2018-04-09 | 레비비코르 인코포레이션 | 당뇨병 치료를 위한 복수 형질전환 돼지 |
US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
CN102822198B (zh) | 2010-03-12 | 2016-08-31 | 艾伯维生物医疗股份有限公司 | Ctla4蛋白和其用途 |
CN103492576A (zh) | 2011-02-14 | 2014-01-01 | 雷维维科公司 | 用于血管化异种移植物及其衍生物的异种移植的遗传修饰的猪 |
US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
US9944689B2 (en) * | 2013-03-07 | 2018-04-17 | The General Hospital Corporation | Human CTLA4 mutants and use thereof |
BR112016009178B1 (pt) | 2013-11-04 | 2020-12-15 | Lifecell Corporation | Método de preparação de um produto de tecido e uso de um produto de tecido |
WO2017036255A1 (en) * | 2015-09-01 | 2017-03-09 | Tse-Wen Chang | Molecular constructs for preventing the formation of blood clot and/or treating thrombosis |
CA2999138C (en) | 2015-09-21 | 2024-05-21 | Aptevo Research And Development Llc | Cd3 binding polypeptides |
CN111214646B (zh) * | 2019-12-30 | 2023-08-01 | 中山大学·深圳 | Pd-l1/ctla-4在制备免疫抑制剂中的应用 |
WO2022109316A1 (en) | 2020-11-20 | 2022-05-27 | Revivicor, Inc. | Multi-transgenic pigs with growth hormone receptor knockout for xenotransplantation |
CA3232376A1 (en) | 2021-09-20 | 2023-03-23 | Maria KOKKINAKI | Multitransgenic pigs comprising ten genetic modifications for xenotransplantation |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0784482A2 (de) | 1994-06-07 | 1997-07-23 | The Regents Of The University Of Minnesota | Methode zur inhibition der antigen spezifischen t-zellen immunantwort |
JPH11508126A (ja) * | 1995-05-23 | 1999-07-21 | モルフォシス ゲゼルシャフト ファー プロテインオプティマイルング エムベーハー | 多量体タンパク質 |
DK0892643T4 (da) * | 1996-03-20 | 2009-12-14 | Bristol Myers Squibb Co | Fremgangsmåder til inhibering af et immunrespons ved blokering af GP39/CD40- og CTLA4/CD28/B7-banerne og præparater til anvendelse derved |
US6165476A (en) * | 1997-07-10 | 2000-12-26 | Beth Israel Deaconess Medical Center | Fusion proteins with an immunoglobulin hinge region linker |
GB9809280D0 (en) * | 1998-04-30 | 1998-07-01 | Rpms Technology Ltd | Immunosupression |
-
1998
- 1998-04-30 GB GBGB9809280.2A patent/GB9809280D0/en not_active Ceased
-
1999
- 1999-04-30 EP EP06077284A patent/EP1854884A3/de not_active Withdrawn
- 1999-04-30 AT AT99919418T patent/ATE355373T1/de not_active IP Right Cessation
- 1999-04-30 CA CA2326671A patent/CA2326671C/en not_active Expired - Lifetime
- 1999-04-30 DE DE69935318T patent/DE69935318T2/de not_active Expired - Lifetime
- 1999-04-30 WO PCT/GB1999/001350 patent/WO1999057266A2/en active IP Right Grant
- 1999-04-30 US US09/674,462 patent/US7432344B1/en not_active Expired - Fee Related
- 1999-04-30 JP JP2000547221A patent/JP2002513568A/ja active Pending
- 1999-04-30 NZ NZ527297A patent/NZ527297A/xx active IP Right Revival
- 1999-04-30 NZ NZ507706A patent/NZ507706A/en not_active IP Right Cessation
- 1999-04-30 ES ES99919418T patent/ES2284251T3/es not_active Expired - Lifetime
- 1999-04-30 EP EP99919418A patent/EP1073737B1/de not_active Expired - Lifetime
- 1999-04-30 AU AU37213/99A patent/AU772239B2/en not_active Expired
-
2008
- 2008-09-04 US US12/231,608 patent/US8097598B2/en not_active Expired - Fee Related
-
2011
- 2011-04-22 JP JP2011096600A patent/JP5706225B2/ja not_active Expired - Lifetime
- 2011-12-12 US US13/316,791 patent/US9090708B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
AU3721399A (en) | 1999-11-23 |
AU772239B2 (en) | 2004-04-22 |
EP1854884A3 (de) | 2009-07-29 |
US20100146648A1 (en) | 2010-06-10 |
CA2326671C (en) | 2015-12-15 |
JP2011144205A (ja) | 2011-07-28 |
EP1073737B1 (de) | 2007-02-28 |
GB9809280D0 (en) | 1998-07-01 |
US9090708B2 (en) | 2015-07-28 |
ES2284251T3 (es) | 2007-11-01 |
JP2002513568A (ja) | 2002-05-14 |
CA2326671A1 (en) | 1999-11-11 |
NZ527297A (en) | 2004-12-24 |
EP1854884A2 (de) | 2007-11-14 |
US7432344B1 (en) | 2008-10-07 |
JP5706225B2 (ja) | 2015-04-22 |
NZ507706A (en) | 2004-01-30 |
WO1999057266A3 (en) | 2000-04-20 |
WO1999057266A2 (en) | 1999-11-11 |
DE69935318T2 (de) | 2007-11-15 |
ATE355373T1 (de) | 2006-03-15 |
EP1073737A2 (de) | 2001-02-07 |
US8097598B2 (en) | 2012-01-17 |
US20130078266A1 (en) | 2013-03-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8339 | Ceased/non-payment of the annual fee | ||
8370 | Indication related to discontinuation of the patent is to be deleted | ||
8364 | No opposition during term of opposition |