ATE354644T1 - Katalytischer antikörper gegen aldolase - Google Patents

Katalytischer antikörper gegen aldolase

Info

Publication number
ATE354644T1
ATE354644T1 AT96943772T AT96943772T ATE354644T1 AT E354644 T1 ATE354644 T1 AT E354644T1 AT 96943772 T AT96943772 T AT 96943772T AT 96943772 T AT96943772 T AT 96943772T AT E354644 T1 ATE354644 T1 AT E354644T1
Authority
AT
Austria
Prior art keywords
antibody against
catalytic
catalytic antibody
antibody
antibodies
Prior art date
Application number
AT96943772T
Other languages
English (en)
Inventor
Carlos F Barbas Iii
Richard A Lerner
Juergen Wagner
Original Assignee
Scripps Research Inst
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Inst filed Critical Scripps Research Inst
Application granted granted Critical
Publication of ATE354644T1 publication Critical patent/ATE354644T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/901—Antibodies with enzymatic activity; e.g. abzymes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT96943772T 1995-12-15 1996-12-16 Katalytischer antikörper gegen aldolase ATE354644T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/573,415 US5733757A (en) 1995-12-15 1995-12-15 Aldolase catalytic antibody

Publications (1)

Publication Number Publication Date
ATE354644T1 true ATE354644T1 (de) 2007-03-15

Family

ID=24291910

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96943772T ATE354644T1 (de) 1995-12-15 1996-12-16 Katalytischer antikörper gegen aldolase

Country Status (12)

Country Link
US (3) US5733757A (de)
EP (1) EP0870014B9 (de)
JP (1) JP3996642B2 (de)
AT (1) ATE354644T1 (de)
AU (1) AU729055B2 (de)
CA (1) CA2239167C (de)
DE (1) DE69636923T2 (de)
DK (1) DK0870014T3 (de)
ES (1) ES2283009T3 (de)
PT (1) PT870014E (de)
SI (1) SI0870014T1 (de)
WO (1) WO1997021803A1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002508188A (ja) * 1997-12-18 2002-03-19 ザ スクリップス リサーチ インスティテュート 触媒性抗体によるアルドール縮合
US6326176B1 (en) * 1997-12-18 2001-12-04 The Scripps Research Institute Aldol condensations by catalytic antibodies
US6440710B1 (en) 1998-12-10 2002-08-27 The Scripps Research Institute Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds
US6294374B1 (en) * 1999-10-08 2001-09-25 The Scripps Research Institute Use of catalytic antibodies for synthesizing epothilone
JP2006506323A (ja) * 2002-04-12 2006-02-23 レイヴェン バイオテクノロジーズ， インコーポレイテッド インテグリンα−ｖ−β−６に結合する抗体およびその使用方法
AU2006235781B2 (en) * 2004-04-27 2008-04-03 Teddy Yeung Man Lo LED illuminated glow stick
EP1853294A4 (de) * 2005-03-03 2010-01-27 Covx Technologies Ireland Ltd Antiangiogene verbindungen
MY146985A (en) 2006-11-10 2012-10-15 Covx Technologies Ireland Ltd Anti-angiogenic compounds
US20090098130A1 (en) * 2007-01-05 2009-04-16 Bradshaw Curt W Glucagon-like protein-1 receptor (glp-1r) agonist compounds
CA2697032C (en) 2007-08-22 2021-09-14 The Regents Of The University Of California Activatable binding polypeptides and methods of identification and use thereof
US8637435B2 (en) * 2007-11-16 2014-01-28 Merck Sharp & Dohme Corp. Eukaryotic cell display systems
US8340951B2 (en) * 2007-12-13 2012-12-25 University Of Washington Synthetic enzymes derived from computational design
CA2715212A1 (en) * 2008-03-03 2009-09-11 Glycofi, Inc. Surface display of recombinant proteins in lower eukaryotes
US8293714B2 (en) 2008-05-05 2012-10-23 Covx Technology Ireland, Ltd. Anti-angiogenic compounds
US8067339B2 (en) * 2008-07-09 2011-11-29 Merck Sharp & Dohme Corp. Surface display of whole antibodies in eukaryotes
CN102482347B (zh) 2009-01-12 2017-04-26 希托马克斯医疗有限责任公司 修饰抗体组合物及其制备和使用方法
US8399219B2 (en) 2009-02-23 2013-03-19 Cytomx Therapeutics, Inc. Protease activatable interferon alpha proprotein
CN102333872B (zh) 2009-02-25 2014-07-09 默沙东公司 在糖工程化的酵母巴斯德毕赤酵母中对半乳糖同化途径的代谢工程化
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
US8715963B2 (en) 2010-02-24 2014-05-06 Merck Sharp & Dohme Corp. Method for increasing N-glycosylation site occupancy on therapeutic glycoproteins produced in Pichia pastoris
WO2012007896A1 (en) 2010-07-12 2012-01-19 Covx Technologies Ireland, Ltd. Multifunctional antibody conjugates
US20120100166A1 (en) 2010-07-15 2012-04-26 Zyngenia, Inc. Ang-2 Binding Complexes and Uses Thereof
US9688735B2 (en) 2010-08-20 2017-06-27 Wyeth Llc Designer osteogenic proteins
MX2013001977A (es) 2010-08-20 2013-04-03 Wyeth Llc Proteinas osteogenicas de diseño.
RU2013118441A (ru) 2010-11-05 2014-12-10 КовЭкс Текнолоджиз Айэлэнд Лимитед Антидиабетические соединения
CN106432506A (zh) 2011-05-24 2017-02-22 泽恩格尼亚股份有限公司 多价和单价多特异性复合物及其用途
RU2014124989A (ru) 2011-12-20 2016-02-10 Пфайзер Инк. Улучшенные способы получения пептидных конъюгатов и линкеров
MX2014007626A (es) 2011-12-22 2014-09-16 Pfizer Compuestos anti-diabetes.
WO2013113127A1 (en) 2012-02-03 2013-08-08 The Governors Of The University Of Alberta Method of quantifying peptide-derivative libraries using phage display
EP3424530A1 (de) 2013-03-15 2019-01-09 Zyngenia, Inc. Multivalente und monovalente multispezifische komplexe und deren verwendungen
CN113329769A (zh) * 2018-10-11 2021-08-31 斯克里普斯研究学院 具有反应性精氨酸的抗体化合物及相关的抗体药物缀合物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5571681A (en) * 1994-03-10 1996-11-05 The Scripps Research Institute Chemical event selection by suicide substrate conjugates

Also Published As

Publication number Publication date
DK0870014T3 (da) 2007-06-11
US6368839B1 (en) 2002-04-09
PT870014E (pt) 2007-05-31
EP0870014B9 (de) 2007-10-10
DE69636923D1 (de) 2007-04-05
EP0870014A4 (de) 2002-03-13
CA2239167A1 (en) 1997-06-19
DE69636923T2 (de) 2007-11-08
JP3996642B2 (ja) 2007-10-24
WO1997021803A1 (en) 1997-06-19
AU1292397A (en) 1997-07-03
EP0870014B1 (de) 2007-02-21
AU729055B2 (en) 2001-01-25
SI0870014T1 (sl) 2007-08-31
EP0870014A1 (de) 1998-10-14
US5733757A (en) 1998-03-31
CA2239167C (en) 2009-09-22
US5985626A (en) 1999-11-16
ES2283009T3 (es) 2007-10-16
JPH11510063A (ja) 1999-09-07

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