ATE353921T1 - Chimäre polypeptide, verfahren zur herstellung und verwendung dafür - Google Patents
Chimäre polypeptide, verfahren zur herstellung und verwendung dafürInfo
- Publication number
- ATE353921T1 ATE353921T1 AT00948017T AT00948017T ATE353921T1 AT E353921 T1 ATE353921 T1 AT E353921T1 AT 00948017 T AT00948017 T AT 00948017T AT 00948017 T AT00948017 T AT 00948017T AT E353921 T1 ATE353921 T1 AT E353921T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- chimeric polypeptides
- chimeric
- polypeptides
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/624—Disulfide-stabilized antibody (dsFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
- C12N2710/22022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/22011—Polyomaviridae, e.g. polyoma, SV40, JC
- C12N2710/22023—Virus like particles [VLP]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP99115022A EP1074563A1 (de) | 1999-08-02 | 1999-08-02 | Erhöhte Bildung von Chimären Polypeptiden durch Ausbildung von Dimeren mittels elektrostatischen wechselwirkungen und Disulfidbindungen sowie Verfahren zur Herstellung und Anwendungen |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE353921T1 true ATE353921T1 (de) | 2007-03-15 |
Family
ID=8238697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00948017T ATE353921T1 (de) | 1999-08-02 | 2000-07-31 | Chimäre polypeptide, verfahren zur herstellung und verwendung dafür |
Country Status (17)
Country | Link |
---|---|
US (1) | US6437095B1 (de) |
EP (2) | EP1074563A1 (de) |
JP (1) | JP4011914B2 (de) |
KR (1) | KR100484084B1 (de) |
CN (1) | CN1184235C (de) |
AR (1) | AR021448A1 (de) |
AT (1) | ATE353921T1 (de) |
AU (1) | AU768645B2 (de) |
BR (1) | BR0012926A (de) |
CA (1) | CA2380569C (de) |
DE (1) | DE60033405T2 (de) |
DK (1) | DK1206495T3 (de) |
ES (1) | ES2280231T3 (de) |
MX (1) | MXPA02001139A (de) |
TR (1) | TR200200252T2 (de) |
WO (1) | WO2001009193A1 (de) |
ZA (1) | ZA200109746B (de) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7192596B2 (en) * | 1996-08-23 | 2007-03-20 | The Health Protection Agency Ipsen Limited | Recombinant toxin fragments |
US20030157091A1 (en) * | 2002-02-14 | 2003-08-21 | Dyax Corporation | Multi-functional proteins |
US7335361B2 (en) * | 2003-06-09 | 2008-02-26 | Animal Technology Institute Taiwan | Fusion antigen used as vaccine |
US7550557B2 (en) | 2003-08-29 | 2009-06-23 | Louisiana Tech University Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
US7348399B2 (en) * | 2003-08-29 | 2008-03-25 | Louisiana Tech University Foundation, Inc. | Nanofabricated polypeptide multilayer films, coatings, and microcapsules |
US7544770B2 (en) * | 2003-08-29 | 2009-06-09 | Louisiana Tech Foundation, Inc. | Multilayer films, coatings, and microcapsules comprising polypeptides |
AU2004325199B2 (en) * | 2004-11-22 | 2011-09-08 | Louisiana Tech University Foundation | Method for designing polypeptides for the nanofabrication of thin films, coatings and microcapsules by electrostatic layer-by-layer self assembly. |
BRPI0519047A2 (pt) * | 2004-12-17 | 2008-12-23 | Koninkl Philips Electronics Nv | mÉtodo para a produÇço de um agente de contraste marcador ou agente terapÊutico marcador, agentes de contraste marcadores e uso de agentes de contraste marcadores ou de agentes terapÊuticos marcadores |
RU2015153109A (ru) | 2009-09-16 | 2019-01-15 | Дженентек, Инк. | Содержащие суперспираль и/или привязку белковые комплексы и их применения |
TW201138821A (en) | 2010-03-26 | 2011-11-16 | Roche Glycart Ag | Bispecific antibodies |
EP2659269B1 (de) | 2010-12-23 | 2016-10-26 | Roche Diagniostics GmbH | Erkennung von posttranslational modifiziertem polypeptid durch ein bivalentes bindungsmolekül |
CN103384831B (zh) | 2010-12-23 | 2016-02-10 | 霍夫曼-拉罗奇有限公司 | 通过二价结合剂来检测多肽二聚体 |
CN103384681B (zh) | 2010-12-23 | 2018-05-18 | 霍夫曼-拉罗奇有限公司 | 结合剂 |
SG191153A1 (en) | 2010-12-23 | 2013-07-31 | Hoffmann La Roche | Polypeptide-polynucleotide-complex and its use in targeted effector moiety delivery |
WO2012107932A1 (en) * | 2011-02-11 | 2012-08-16 | Transgene Biotek Ltd. | B cell clonal immunotoxin and use thereof |
AR086924A1 (es) | 2011-06-15 | 2014-01-29 | Hoffmann La Roche | Anticuerpos anti-receptor de epo humano y los metodos para su utilizacion |
KR20140127854A (ko) | 2012-02-10 | 2014-11-04 | 제넨테크, 인크. | 단일-쇄 항체 및 다른 이종다량체 |
RU2015100656A (ru) | 2012-06-27 | 2016-08-20 | Ф. Хоффманн-Ля Рош Аг | Способ получения конъюгатов fc-фрагмента антитела, включающих по меньшей мере одну связывающую группировку, которая специфически связывается с мишенью, и их применения |
WO2014001324A1 (en) | 2012-06-27 | 2014-01-03 | Hoffmann-La Roche Ag | Method for selection and production of tailor-made highly selective and multi-specific targeting entities containing at least two different binding entities and uses thereof |
BR112014029888A2 (pt) | 2012-06-27 | 2020-05-12 | Hoffmann La Roche | Métodos de produção de um anticorpo, de determinação de uma combinação de sítios de ligação e de tratamento de um indivíduo com câncer, formulação farmacêutica, anticorpo e uso de um anticorpo |
EP3647322B1 (de) | 2014-03-20 | 2021-10-20 | Bristol-Myers Squibb Company | Stabilisierte fibronectinbasierte gerüstmoleküle |
EA037006B1 (ru) | 2014-06-06 | 2021-01-26 | Бристол-Майерс Сквибб Компани | Антитела к индуцируемому глюкокортикоидами рецептору фактора некроза опухолей (gitr) и их применения |
RS60631B1 (sr) | 2014-11-21 | 2020-09-30 | Bristol Myers Squibb Co | Antitela protiv cd73 i njihova upotreba |
EP3224277B1 (de) | 2014-11-25 | 2020-08-26 | Bristol-Myers Squibb Company | Neuartige pd-l1-bindende polypeptide zur bildgebung |
EP3227332B1 (de) | 2014-12-03 | 2019-11-06 | F.Hoffmann-La Roche Ag | Multispezifische antikörper |
PT3233912T (pt) | 2014-12-19 | 2021-08-09 | Regenesance B V | Antocorpos que se ligam a c6 humano e utilizações destes |
WO2016127052A1 (en) | 2015-02-05 | 2016-08-11 | Bristol-Myers Squibb Company | Cxcl11 and smica as predictive biomarkers for efficacy of anti-ctla4 immunotherapy |
CA2987410A1 (en) | 2015-05-29 | 2016-12-08 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
EP3733698A1 (de) | 2015-09-23 | 2020-11-04 | Bristol-Myers Squibb Company | Glypican-3-bindende fibronektin-basierte gerüstmoleküle |
AU2016356780A1 (en) | 2015-11-19 | 2018-06-28 | Bristol-Myers Squibb Company | Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof |
EA201891983A8 (ru) | 2016-03-04 | 2020-05-28 | Бристол-Майерс Сквибб Компани | Комбинированная терапия антителами к cd73 |
CN109562195A (zh) | 2016-06-01 | 2019-04-02 | 百时美施贵宝公司 | 用pd-l1结合多肽进行pet成像 |
JP7027401B2 (ja) | 2016-07-14 | 2022-03-01 | ブリストル-マイヤーズ スクイブ カンパニー | Tim3に対する抗体およびその使用 |
WO2018083538A1 (en) | 2016-11-07 | 2018-05-11 | Neuracle Scienc3 Co., Ltd. | Anti-family with sequence similarity 19, member a5 antibodies and method of use thereof |
AR110755A1 (es) * | 2017-01-20 | 2019-05-02 | Genzyme Corp | Anticuerpos dirigidos a hueso |
EP3583124A1 (de) | 2017-02-17 | 2019-12-25 | Bristol-Myers Squibb Company | Antikörper gegen alpha-synuklein und verwendungen davon |
JP7358361B2 (ja) | 2018-01-12 | 2023-10-10 | ブリストル-マイヤーズ スクイブ カンパニー | Tim3に対する抗体およびその使用 |
TW202003565A (zh) | 2018-03-23 | 2020-01-16 | 美商必治妥美雅史谷比公司 | 抗mica及/或micb抗體及其用途 |
US11155618B2 (en) | 2018-04-02 | 2021-10-26 | Bristol-Myers Squibb Company | Anti-TREM-1 antibodies and uses thereof |
WO2020003210A1 (en) | 2018-06-29 | 2020-01-02 | Kangwon National University University-Industry Cooperation Foundation | Anti-l1cam antibodies and uses thereof |
CA3127236A1 (en) | 2019-01-22 | 2020-07-30 | Bristol-Myers Squibb Company | Antibodies against il-7r alpha subunit and uses thereof |
US20220214340A1 (en) * | 2019-04-28 | 2022-07-07 | Leide Biosciences Co., Ltd. | Zipper structure that helps the formation of protein dimer and application thereof |
EP3999543A1 (de) | 2019-07-15 | 2022-05-25 | Bristol-Myers Squibb Company | Anti-trem-1-antikörper und verwendungen davon |
WO2021011681A1 (en) | 2019-07-15 | 2021-01-21 | Bristol-Myers Squibb Company | Antibodies against human trem-1 and uses thereof |
CN112694527B (zh) * | 2020-12-25 | 2022-09-09 | 山东睿鹰制药集团有限公司 | 一种重组人干扰素-κ包涵体的纯化和复性方法 |
EP4314068A1 (de) | 2021-04-02 | 2024-02-07 | The Regents Of The University Of California | Antikörper gegen gespaltenes cdcp1 und verwendungen davon |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK132892D0 (da) * | 1992-10-30 | 1992-10-30 | Novo Nordisk As | Proteiner |
US5747654A (en) * | 1993-06-14 | 1998-05-05 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant disulfide-stabilized polypeptide fragments having binding specificity |
DE69830901T2 (de) * | 1997-05-02 | 2006-05-24 | Genentech Inc., San Francisco | ein verfahren zur herstellung multispezifischer antikörper die heteromultimere und gemeinsame komponenten besitzen |
-
1999
- 1999-08-02 EP EP99115022A patent/EP1074563A1/de not_active Withdrawn
-
2000
- 2000-07-24 AR ARP000103808A patent/AR021448A1/es active IP Right Grant
- 2000-07-26 US US09/625,570 patent/US6437095B1/en not_active Expired - Lifetime
- 2000-07-31 EP EP00948017A patent/EP1206495B1/de not_active Expired - Lifetime
- 2000-07-31 AU AU61610/00A patent/AU768645B2/en not_active Ceased
- 2000-07-31 ES ES00948017T patent/ES2280231T3/es not_active Expired - Lifetime
- 2000-07-31 KR KR10-2002-7001377A patent/KR100484084B1/ko not_active IP Right Cessation
- 2000-07-31 CA CA002380569A patent/CA2380569C/en not_active Expired - Fee Related
- 2000-07-31 MX MXPA02001139A patent/MXPA02001139A/es active IP Right Grant
- 2000-07-31 TR TR2002/00252T patent/TR200200252T2/xx unknown
- 2000-07-31 BR BR0012926-7A patent/BR0012926A/pt not_active IP Right Cessation
- 2000-07-31 JP JP2001513999A patent/JP4011914B2/ja not_active Expired - Lifetime
- 2000-07-31 AT AT00948017T patent/ATE353921T1/de active
- 2000-07-31 CN CNB008095159A patent/CN1184235C/zh not_active Expired - Fee Related
- 2000-07-31 DK DK00948017T patent/DK1206495T3/da active
- 2000-07-31 DE DE60033405T patent/DE60033405T2/de not_active Expired - Lifetime
- 2000-07-31 WO PCT/EP2000/007378 patent/WO2001009193A1/en active IP Right Grant
-
2001
- 2001-11-27 ZA ZA200109746A patent/ZA200109746B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2003506028A (ja) | 2003-02-18 |
KR100484084B1 (ko) | 2005-04-20 |
DE60033405T2 (de) | 2007-10-31 |
EP1206495A1 (de) | 2002-05-22 |
DK1206495T3 (da) | 2007-06-11 |
BR0012926A (pt) | 2002-04-30 |
CN1358198A (zh) | 2002-07-10 |
TR200200252T2 (tr) | 2002-05-21 |
AR021448A1 (es) | 2002-07-17 |
MXPA02001139A (es) | 2002-08-20 |
CA2380569A1 (en) | 2001-02-08 |
JP4011914B2 (ja) | 2007-11-21 |
AU6161000A (en) | 2001-02-19 |
US6437095B1 (en) | 2002-08-20 |
ZA200109746B (en) | 2003-03-12 |
CN1184235C (zh) | 2005-01-12 |
CA2380569C (en) | 2008-01-22 |
KR20020026558A (ko) | 2002-04-10 |
EP1206495B1 (de) | 2007-02-14 |
DE60033405D1 (de) | 2007-03-29 |
AU768645B2 (en) | 2003-12-18 |
WO2001009193A1 (en) | 2001-02-08 |
ES2280231T3 (es) | 2007-09-16 |
EP1074563A1 (de) | 2001-02-07 |
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