ATE345780T1 - Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung - Google Patents

Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung

Info

Publication number
ATE345780T1
ATE345780T1 AT02746004T AT02746004T ATE345780T1 AT E345780 T1 ATE345780 T1 AT E345780T1 AT 02746004 T AT02746004 T AT 02746004T AT 02746004 T AT02746004 T AT 02746004T AT E345780 T1 ATE345780 T1 AT E345780T1
Authority
AT
Austria
Prior art keywords
production
active ingredient
polymer micelle
encapsulating polymer
composition
Prior art date
Application number
AT02746004T
Other languages
English (en)
Inventor
Yasuaki Ogawa
Shoko Nagasaki
Yoshihiko Nogata
Katsuhiko Sagawa
Chieko Tsuchiya
Original Assignee
Nanocarrier Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2001213652A external-priority patent/JP3615721B2/ja
Priority claimed from JP2001213617A external-priority patent/JP4063510B2/ja
Application filed by Nanocarrier Co Ltd filed Critical Nanocarrier Co Ltd
Application granted granted Critical
Publication of ATE345780T1 publication Critical patent/ATE345780T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/243—Platinum; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
    • A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT02746004T 2001-07-13 2002-07-12 Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung ATE345780T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001213652A JP3615721B2 (ja) 2001-07-13 2001-07-13 薬物含有高分子ミセルの製造方法
JP2001213617A JP4063510B2 (ja) 2001-07-13 2001-07-13 薬物含有高分子ミセルの凍結乾燥用組成物およびその凍結乾燥製剤

Publications (1)

Publication Number Publication Date
ATE345780T1 true ATE345780T1 (de) 2006-12-15

Family

ID=26618693

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02746004T ATE345780T1 (de) 2001-07-13 2002-07-12 Lyophilisierende zusammensetzung von wirkstoff- verkapselnder polymer-mizelle und verfahren zu ihrer herstellung

Country Status (8)

Country Link
US (3) US20040253315A1 (de)
EP (1) EP1415648B1 (de)
KR (1) KR100776557B1 (de)
CN (1) CN1268321C (de)
AT (1) ATE345780T1 (de)
CA (1) CA2453441C (de)
DE (1) DE60216287T2 (de)
WO (1) WO2003005992A1 (de)

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US20050152979A1 (en) * 2003-09-05 2005-07-14 Cell Therapeutics, Inc. Hydrophobic drug compositions containing reconstitution enhancer
JPWO2006057429A1 (ja) * 2004-11-24 2008-06-05 ナノキャリア株式会社 ブロックコポリマーのモーフォロジーの変化方法
EP1859812B1 (de) * 2005-02-10 2014-01-01 The University of Tokyo Polykationisch aufladbares polymer und seine verwendung als träger von nukleinsäure
US7612139B2 (en) 2005-05-20 2009-11-03 E.I. Du Pont De Nemours And Company Core/shell fluoropolymer dispersions with low fluorosurfactant content
KR100917809B1 (ko) * 2006-05-22 2009-09-18 에스케이케미칼주식회사 우수한 저장안정성을 갖는 도세탁셀 함유 주사제 조성물
TWI392507B (zh) * 2006-10-20 2013-04-11 Solvay Pharm Bv 包埋的膠束奈米顆粒
US9801818B2 (en) * 2007-12-31 2017-10-31 Samyang Biopharmaceuticals Corporation Method for stabilizing amphiphilic block copolymer micelle composition containing poorly water-soluble drug
US20090232762A1 (en) * 2008-03-11 2009-09-17 May Pang Xiong Compositions for delivery of therapeutic agents
US8697098B2 (en) 2011-02-25 2014-04-15 South Dakota State University Polymer conjugated protein micelles
DK2287230T3 (da) * 2008-05-23 2012-12-10 Nanocarrier Co Ltd Docetaxel polymer derivative, method for producing same and use of same
US20150359777A1 (en) * 2008-12-26 2015-12-17 Samyang Biopharmaceuticals Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
AU2009331027B2 (en) * 2008-12-26 2012-12-13 Samyang Holdings Corporation Preparation method of polymeric micellar nanoparticles composition containing a poorly water-soluble drug
US20100310660A1 (en) * 2009-06-08 2010-12-09 Taipei Medical University Dry powder microparticles for pulmonary delivery
EP2474306B1 (de) * 2009-08-31 2016-11-09 NanoCarrier Co., Ltd. Partikelzusammensetzung und medizinische vorrichtung damit
JP4653242B1 (ja) 2010-02-12 2011-03-16 ナノキャリア株式会社 粒子状医薬組成物
KR20130087517A (ko) 2010-06-25 2013-08-06 백시바디 에이에스 동종이합체 단백질 구조물
JP2014518842A (ja) 2011-02-25 2014-08-07 サウス ダコタ ステート ユニバーシティー ポリマーコンジュゲートタンパク質ミセル
KR101038563B1 (ko) * 2011-04-12 2011-06-02 주식회사 세종전력기술단 분배전반용 캐비넷
CN102526756A (zh) * 2012-02-15 2012-07-04 中国科学院长春应用化学研究所 阿霉素复合物、胶束及胶束的制备方法
US10765753B2 (en) 2014-12-30 2020-09-08 Samyang Biopharmaceuticals Corporation Polymer nanoparticle freeze-dried product, and preparation method therefor
KR102072419B1 (ko) 2018-04-19 2020-02-03 중앙대학교 산학협력단 항암제 봉입 마이셀 제제 조성물
MX2022005996A (es) * 2019-11-18 2022-10-27 Onconano Medicine Inc Composiciones sensibles al ph, formulaciones, y métodos de imagenología de un tumor.

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CA1264162A (en) * 1984-03-15 1990-01-02 Manfred Breuninger Glycerol ether phosphatides
FR2618258B1 (fr) * 1987-07-17 1990-01-05 Suisse Electronique Microtech Detecteur de particules ionisantes.
JP2517760B2 (ja) * 1989-05-11 1996-07-24 新技術事業団 水溶性高分子化医薬製剤
JP2780116B2 (ja) * 1989-07-31 1998-07-30 日水製薬株式会社 リポソーム分散液安定化剤
AU654824B2 (en) * 1990-06-29 1994-11-24 Chiron Corporation Vaccine compositions containing liposomes
DE69329792T2 (de) * 1992-10-08 2001-05-31 Supratek Pharma, Inc. Zusammensetzung von in mizellen eingeschlossenen antineoplastischen wirkstoffen
US5552156A (en) * 1992-10-23 1996-09-03 Ohio State University Liposomal and micellular stabilization of camptothecin drugs
US5543158A (en) * 1993-07-23 1996-08-06 Massachusetts Institute Of Technology Biodegradable injectable nanoparticles
JPH07249723A (ja) * 1994-03-11 1995-09-26 Fujitsu Miyagi Electron:Kk 半導体装置の実装構造及び半導体装置の実装方法及びリードフレーム
US6143276A (en) * 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
JPH11335267A (ja) * 1998-05-27 1999-12-07 Nano Career Kk 水難溶性薬物を含有するポリマーミセル系
EP1582204B1 (de) * 1999-03-03 2013-09-25 Eli Lilly & Company Echinocandin pharmazeutische Zusammensetzungen enthaltend Mizellen bildende Tenside
JP2003504389A (ja) * 1999-07-16 2003-02-04 アルザ・コーポレーション 凍結／融解ダメージに耐性を有するリポソーム組成物
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JP4659937B2 (ja) * 1999-11-19 2011-03-30 ナノキャリア株式会社 コア−シェル構造のポリイオンコンプレックスミセル

Also Published As

Publication number Publication date
CN1268321C (zh) 2006-08-09
KR20040018432A (ko) 2004-03-03
EP1415648A4 (de) 2006-01-18
US20140141072A1 (en) 2014-05-22
US20040253315A1 (en) 2004-12-16
CA2453441A1 (en) 2003-01-23
DE60216287D1 (de) 2007-01-04
EP1415648A1 (de) 2004-05-06
US20120141556A1 (en) 2012-06-07
KR100776557B1 (ko) 2007-11-16
WO2003005992A1 (fr) 2003-01-23
EP1415648B1 (de) 2006-11-22
DE60216287T2 (de) 2007-05-31
CN1543340A (zh) 2004-11-03
CA2453441C (en) 2011-10-18

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