ATE337008T1 - Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen salzen - Google Patents

Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen salzen

Info

Publication number
ATE337008T1
ATE337008T1 AT04001441T AT04001441T ATE337008T1 AT E337008 T1 ATE337008 T1 AT E337008T1 AT 04001441 T AT04001441 T AT 04001441T AT 04001441 T AT04001441 T AT 04001441T AT E337008 T1 ATE337008 T1 AT E337008T1
Authority
AT
Austria
Prior art keywords
carbamoylbenzofuran
cyanoindol
piperazine
butyl
acceptable salts
Prior art date
Application number
AT04001441T
Other languages
English (en)
Inventor
Gerd Bartoszyk
Christoph Seyfried
Amsterdam Christoph Van
Henning Boettcher
Ewen Sedman
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8238153&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ATE337008(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE337008T1 publication Critical patent/ATE337008T1/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT04001441T 1999-05-27 2000-05-16 Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen salzen ATE337008T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP99109295 1999-05-27

Publications (1)

Publication Number Publication Date
ATE337008T1 true ATE337008T1 (de) 2006-09-15

Family

ID=8238153

Family Applications (3)

Application Number Title Priority Date Filing Date
AT06017231T ATE438399T1 (de) 1999-05-27 2000-05-16 Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen salzen
AT04001441T ATE337008T1 (de) 1999-05-27 2000-05-16 Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und deren physiologisch akzeptablen salzen
AT00935031T ATE263564T1 (de) 1999-05-27 2000-05-16 Verwendung von 1-(4-(5-cyanoindol-3yl)butyl)-4-(2-carbamoylben ofuran-5-yl)piperazin und dessen physiologisch akzeptablen salzen zur behandlung von bipolaren krankheiten und manie

Family Applications Before (1)

Application Number Title Priority Date Filing Date
AT06017231T ATE438399T1 (de) 1999-05-27 2000-05-16 Verwendung von 1- 4-(5-cyanoindol-3-yl)butyl -4- (2-carbamoylbenzofuran-5-yl)piperazin und dessem physiologisch akzeptablen salzen

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT00935031T ATE263564T1 (de) 1999-05-27 2000-05-16 Verwendung von 1-(4-(5-cyanoindol-3yl)butyl)-4-(2-carbamoylben ofuran-5-yl)piperazin und dessen physiologisch akzeptablen salzen zur behandlung von bipolaren krankheiten und manie

Country Status (31)

Country Link
US (4) US6900212B1 (de)
EP (3) EP1410800B1 (de)
JP (2) JP4884588B2 (de)
KR (1) KR100683367B1 (de)
CN (3) CN1198618C (de)
AR (1) AR024112A1 (de)
AT (3) ATE438399T1 (de)
AU (1) AU771778B2 (de)
BR (1) BR0010948A (de)
CA (3) CA2372668C (de)
CY (2) CY1105750T1 (de)
CZ (1) CZ295623B6 (de)
DE (3) DE60009697T2 (de)
DK (3) DK1410800T3 (de)
ES (3) ES2271707T3 (de)
HK (1) HK1048444B (de)
HU (1) HU229059B1 (de)
IL (2) IL146707A0 (de)
MX (1) MXPA01012172A (de)
MY (1) MY135627A (de)
NO (2) NO322120B1 (de)
PL (3) PL200490B1 (de)
PT (3) PT1185272E (de)
RU (1) RU2237477C2 (de)
SI (2) SI1410800T1 (de)
SK (1) SK287851B6 (de)
TR (1) TR200103361T2 (de)
TW (1) TW518218B (de)
UA (1) UA74337C2 (de)
WO (1) WO2000072832A2 (de)
ZA (1) ZA200110485B (de)

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TW518218B (en) * 1999-05-27 2003-01-21 Merck Patent Gmbh Pharmaceutical compositions comprising 1-[4-(5-cyanoindol-3-yl)butyl]-4-(2-carbamoylbenzofuran-5-yl)piperazine or its physiologically acceptable salts for use in the treatment of sub-type anxiety disorders
UA76130C2 (en) * 2000-11-20 2006-07-17 Merck Patent Gmbh Use of compounds combining properties of selective inhibitors of serotonin re-uptake and agonists of 5-ht1a receptor for treatment of irritable bowel syndrome
DE10112151A1 (de) * 2001-03-14 2002-09-19 Merck Patent Gmbh Substituierte Benzofuran-2-carbonsäureamide
UA76758C2 (uk) 2001-06-19 2006-09-15 Мерк Патент Гмбх Поліморфні форми гідрохлориду 1-'4-(5-ціаноіндол-3-іл)бутил-4-(2-карбамоїлбензофуран-5-іл)піперазину
DE10217006A1 (de) * 2002-04-16 2003-11-06 Merck Patent Gmbh Substituierte Indole
DE10305739A1 (de) 2003-02-11 2004-08-19 Merck Patent Gmbh Benzofuranderivate
US20040192730A1 (en) * 2003-03-13 2004-09-30 Dynogen Pharmaceuticals, Inc. Methods of using compounds with combined 5-HT1A and SSRI activities as-needed to treat sexual dysfunction
US7893261B2 (en) 2004-03-26 2011-02-22 Baylor University Serotonin reuptake inhibitors
AU2007266890B2 (en) 2006-05-30 2011-02-17 Astrazeneca Ab 1, 3, 4 -oxadiazole derivatives as DGAT1 inhibitors
CA2707660A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Carbamoyl compounds as dgat1 inhibitors 190
MX2011014018A (es) 2009-06-19 2012-02-22 Astrazeneca Ab Pirazincarboxamidas como inhibidores de dgati.
KR101783632B1 (ko) 2009-11-06 2017-10-10 에스케이바이오팜 주식회사 주의력 결핍/과잉행동 장애(ａｄｈｄ)의 치료 방법
EP2496227B1 (de) 2009-11-06 2019-05-22 SK Biopharmaceuticals Co., Ltd. Verfahren zur behandlung des fibromyalgie-syndroms
US9610274B2 (en) 2010-06-30 2017-04-04 Sk Biopharmaceuticals Co., Ltd. Methods for treating bipolar disorder
US8623913B2 (en) 2010-06-30 2014-01-07 Sk Biopharmaceuticals Co., Ltd. Methods for treating restless legs syndrome
TWI577377B (zh) * 2010-09-16 2017-04-11 Ｖｉｉｖ醫療保健公司 醫藥組合物
EP2688884A1 (de) 2011-03-20 2014-01-29 Cadila Healthcare Limited Amorphe form von vilazodon-hydrochlorid und verfahren zu ihrer herstellung
CN102949364A (zh) * 2011-08-30 2013-03-06 天津药物研究院 一种含有效成分盐酸维拉佐酮的缓释片
EP2861586A4 (de) 2012-06-13 2015-11-11 Apotex Inc Formen von vilazodon und verfahren zur herstellung davon
CN102860993A (zh) * 2012-10-16 2013-01-09 北京诚创思达医药科技有限公司 一种盐酸维拉唑酮快速释放片剂及其制备方法
WO2014064715A2 (en) 2012-10-22 2014-05-01 Cadila Healthcare Limited Amorphous form of vilazodone hydrochloride and process for preparing thereof
CN102977083A (zh) * 2012-12-17 2013-03-20 南京海纳医药科技有限公司 1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰-苯并呋喃-5-基)-哌嗪盐酸盐的新晶型xⅶ及其制备方法
EP3598971B1 (de) 2013-01-22 2024-03-20 Vistagen Therapeutics, Inc. Dosierungsformen und therapeutische verwendungen von l-4-chlorkynurenin
EP2824104A1 (de) 2013-07-12 2015-01-14 Sandoz AG Verfahren zur Herstellung von Form III von Vilazodonhydrochlorid
EP3297619B1 (de) * 2015-05-22 2022-07-06 Vistagen Therapeutics, Inc. Therapeutische verwendung von l-4-chlorokynurenin

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CA2694866A1 (en) 2000-12-07
SI1410800T1 (sl) 2007-02-28
CA2372668A1 (en) 2000-12-07
EP1736158A2 (de) 2006-12-27
AR024112A1 (es) 2002-09-04
UA74337C2 (uk) 2005-12-15
US20100063062A1 (en) 2010-03-11
SK287851B6 (sk) 2012-01-04
NO20015746D0 (no) 2001-11-26
SK16462001A3 (sk) 2002-02-05
US7642261B2 (en) 2010-01-05
NO324230B1 (no) 2007-09-10
PT1410800E (pt) 2007-01-31
TW518218B (en) 2003-01-21
EP1410800A1 (de) 2004-04-21
ES2271707T3 (es) 2007-04-16
US7371756B2 (en) 2008-05-13
DE60042710D1 (de) 2009-09-17
DE60009697T2 (de) 2005-04-14
CN1198618C (zh) 2005-04-27
DE60009697D1 (de) 2004-05-13
EP1736158B1 (de) 2009-08-05
PT1185272E (pt) 2004-08-31
CN1679577A (zh) 2005-10-12
NO20061562L (no) 2001-11-26
JP4884588B2 (ja) 2012-02-29
IL146707A (en) 2007-06-03
DK1185272T3 (da) 2004-08-09
US20080119484A1 (en) 2008-05-22
CY1105750T1 (el) 2010-12-22
ATE438399T1 (de) 2009-08-15
CA2615271C (en) 2011-02-15
JP2011148799A (ja) 2011-08-04
HU229059B1 (en) 2013-07-29
JP2003500441A (ja) 2003-01-07
DE60030338T2 (de) 2007-08-16
AU5066300A (en) 2000-12-18
TR200103361T2 (tr) 2002-05-21
DE60030338D1 (de) 2006-10-05
CZ295623B6 (cs) 2005-09-14
WO2000072832A2 (en) 2000-12-07
PL352373A1 (en) 2003-08-25
NO322120B1 (no) 2006-08-14
ZA200110485B (en) 2003-06-30
HK1048444B (zh) 2005-12-09
DK1736158T3 (da) 2009-11-02
CZ20014226A3 (cs) 2002-03-13
MY135627A (en) 2008-05-30
AU771778B2 (en) 2004-04-01
PL199650B1 (pl) 2008-10-31
HUP0201275A3 (en) 2004-04-28
SI1185272T1 (en) 2004-12-31
RU2237477C2 (ru) 2004-10-10
BR0010948A (pt) 2002-04-23
DK1410800T3 (da) 2006-12-27
CN101869565A (zh) 2010-10-27
CA2372668C (en) 2009-11-03
EP1410800B1 (de) 2006-08-23
HUP0201275A2 (en) 2002-08-28
NO20015746L (no) 2001-11-26
PT1736158E (pt) 2009-11-11
IL146707A0 (en) 2002-07-25
HK1048444A1 (en) 2003-04-04
KR100683367B1 (ko) 2007-02-15
US20050113386A1 (en) 2005-05-26
US6900212B1 (en) 2005-05-31
KR20020008847A (ko) 2002-01-31
ATE263564T1 (de) 2004-04-15
CA2615271A1 (en) 2000-12-07
MXPA01012172A (es) 2002-07-22
CY1109472T1 (el) 2012-05-23
EP1736158A3 (de) 2007-01-03
EP1185272A2 (de) 2002-03-13
ES2219342T3 (es) 2004-12-01
ES2330774T3 (es) 2009-12-15
WO2000072832A3 (en) 2001-12-20
EP1185272B1 (de) 2004-04-07
PL200490B1 (pl) 2009-01-30
PL199516B1 (pl) 2008-09-30
CN1361692A (zh) 2002-07-31

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