DK1131308T3 - Piperazin- og piperidinderivater - Google Patents
Piperazin- og piperidinderivaterInfo
- Publication number
- DK1131308T3 DK1131308T3 DK99955980T DK99955980T DK1131308T3 DK 1131308 T3 DK1131308 T3 DK 1131308T3 DK 99955980 T DK99955980 T DK 99955980T DK 99955980 T DK99955980 T DK 99955980T DK 1131308 T3 DK1131308 T3 DK 1131308T3
- Authority
- DK
- Denmark
- Prior art keywords
- piperazine
- piperidine derivatives
- piperidine
- derivatives
- Prior art date
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 2
- 150000003053 piperidines Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/26—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
- C07D277/62—Benzothiazoles
- C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98203871 | 1998-11-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1131308T3 true DK1131308T3 (da) | 2004-06-28 |
Family
ID=8234340
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99955980T DK1131308T3 (da) | 1998-11-13 | 1999-11-10 | Piperazin- og piperidinderivater |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6780864B1 (da) |
| EP (1) | EP1131308B1 (da) |
| JP (1) | JP3638874B2 (da) |
| KR (1) | KR100619465B1 (da) |
| CN (1) | CN1225462C (da) |
| AR (1) | AR021256A1 (da) |
| AT (1) | ATE267183T1 (da) |
| AU (1) | AU756470B2 (da) |
| BR (1) | BR9915293B1 (da) |
| CA (1) | CA2350137C (da) |
| CZ (1) | CZ299774B6 (da) |
| DE (1) | DE69917478T2 (da) |
| DK (1) | DK1131308T3 (da) |
| DZ (1) | DZ2934A1 (da) |
| ES (1) | ES2217833T3 (da) |
| HK (1) | HK1039489A1 (da) |
| HU (1) | HUP0104922A3 (da) |
| IL (2) | IL143028A0 (da) |
| MX (1) | MXPA01004854A (da) |
| NO (1) | NO318888B1 (da) |
| NZ (1) | NZ511584A (da) |
| PL (1) | PL193685B1 (da) |
| RU (1) | RU2225406C2 (da) |
| SI (1) | SI1131308T1 (da) |
| SK (1) | SK285648B6 (da) |
| TW (1) | TWI252230B (da) |
| UA (1) | UA71590C2 (da) |
| WO (1) | WO2000029397A1 (da) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA73981C2 (en) | 2000-03-10 | 2005-10-17 | Merck Patent Gmbh | (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit |
| CN1174979C (zh) * | 2000-05-12 | 2004-11-10 | 索尔瓦药物有限公司 | 哌嗪和哌啶化合物 |
| WO2001085168A1 (en) * | 2000-05-12 | 2001-11-15 | Solvay Pharmaceuticals B.V. | Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders |
| CA2428519A1 (en) * | 2000-11-14 | 2002-05-23 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Novel uses of combined selective dopamine d2 receptor antagonists and 5-ht1a receptor agonists |
| AR034206A1 (es) * | 2001-02-16 | 2004-02-04 | Solvay Pharm Bv | Un procedimiento para la preparacion de mesilatos de derivados de piperazina y dichos mesilatos |
| US6800648B2 (en) | 2001-04-26 | 2004-10-05 | Wyeth | Antipsychotic aminomethyl derivatives of 7,8-dihydro-3H-1,6,9-trioxa-3-AZA-cyclopenta[a]naphthalen-2-one |
| US6743796B2 (en) | 2001-05-07 | 2004-06-01 | Wyeth | Piperazinyl-isatins |
| CN1292749C (zh) | 2001-07-26 | 2007-01-03 | 默克专利股份有限公司 | 2－[5－(4－氟苯基)－3－吡啶基甲氨基甲基]苯并二氢吡喃及其生理学上可接受的盐的新用途 |
| EP1336406A1 (en) * | 2002-02-14 | 2003-08-20 | Solvay Pharmaceuticals B.V. | Partial dopamine-D2 receptor agonist plus serotonin and/or noradrenaline inhibitory activity |
| AU2003244160A1 (en) * | 2002-06-25 | 2004-01-06 | Sumitomo Pharmaceuticals Co., Ltd. | Novel benzoxazolinone derivative |
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| EP1595542A1 (en) * | 2004-03-26 | 2005-11-16 | Solvay Pharmaceuticals B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
| US7596407B2 (en) | 2004-03-26 | 2009-09-29 | Solvay Pharmaceuticals, B.V. | Transdermal iontophoretic delivery of piperazinyl-2(3H)-benzoxazolone compounds |
| CA2567909A1 (en) * | 2004-05-27 | 2005-12-15 | Ucb, S.A. | Benzoxazolone derivatives, processes for preparing them and their uses |
| US7405216B2 (en) | 2004-08-18 | 2008-07-29 | Solvay Pharmaceuticals, B.V. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| US7423040B2 (en) | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US7964604B2 (en) | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US7750013B2 (en) | 2005-08-22 | 2010-07-06 | Solvay Pharmaceuticals, B.V. | N-oxides as prodrugs of piperazine and piperidine derivatives |
| RU2394821C2 (ru) * | 2005-08-22 | 2010-07-20 | Солвей Фармасьютикал Б.В. | N-оксиды как пролекарства производных пиперазина и пиперидина |
| AR058022A1 (es) * | 2005-08-22 | 2008-01-23 | Solvay Pharm Bv | Derivados de benzooxazoles, composiciones farmaceuticas y su uso para el tratamiento de desordenes del sistema nervioso. |
| US8106056B2 (en) | 2006-06-16 | 2012-01-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising bifeprunox and a dopamine agonist |
| US7786126B2 (en) | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| UY32934A (es) * | 2009-10-12 | 2011-05-31 | Abbott Healthcare Products Bv | Monohidrato de pardoprunox |
| US11103499B2 (en) | 2016-08-26 | 2021-08-31 | EXCIVA (UG) (haftungsbeschränkt) | Compositions and methods thereof |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2567884B1 (fr) | 1984-07-19 | 1987-03-06 | Roussel Uclaf | Nouveaux derives de l'indole, leur preparation, leur application comme medicaments et les compositions les renfermant |
| DE3571436D1 (en) * | 1984-12-21 | 1989-08-17 | Duphar Int Res | New pharmaceutical compositions having anti-psychotic properties |
| ATE81975T1 (de) * | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| DK148392D0 (da) * | 1992-12-09 | 1992-12-09 | Lundbeck & Co As H | Heterocykliske forbindelser |
| ZA954689B (en) | 1994-06-08 | 1996-01-29 | Lundbeck & Co As H | 4-Aryl-1-(indanmethyl dihydrobenzofuranmethyl or dihydrobenzothiophenemethyl) piperidines tetrahydropyridines or piperazines |
| MX9700693A (es) | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
| CA2250347C (en) * | 1996-03-29 | 2006-02-21 | Duphar International Research B.V. | Piperazine and piperidine compounds with high affinity for dopamine-d2 and serotonin-5ht1a receptors |
| EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
-
1999
- 1999-10-11 UA UA2001064076A patent/UA71590C2/uk unknown
- 1999-11-10 SI SI9930574T patent/SI1131308T1/xx unknown
- 1999-11-10 IL IL14302899A patent/IL143028A0/xx active IP Right Grant
- 1999-11-10 MX MXPA01004854A patent/MXPA01004854A/es not_active IP Right Cessation
- 1999-11-10 BR BRPI9915293-2A patent/BR9915293B1/pt not_active IP Right Cessation
- 1999-11-10 DZ DZ990234A patent/DZ2934A1/xx active
- 1999-11-10 RU RU2001116117/04A patent/RU2225406C2/ru not_active IP Right Cessation
- 1999-11-10 WO PCT/EP1999/008702 patent/WO2000029397A1/en active IP Right Grant
- 1999-11-10 ES ES99955980T patent/ES2217833T3/es not_active Expired - Lifetime
- 1999-11-10 SK SK649-2001A patent/SK285648B6/sk not_active IP Right Cessation
- 1999-11-10 US US09/831,149 patent/US6780864B1/en not_active Expired - Fee Related
- 1999-11-10 DE DE69917478T patent/DE69917478T2/de not_active Expired - Lifetime
- 1999-11-10 AT AT99955980T patent/ATE267183T1/de active
- 1999-11-10 PL PL99347635A patent/PL193685B1/pl not_active IP Right Cessation
- 1999-11-10 CZ CZ20011657A patent/CZ299774B6/cs not_active IP Right Cessation
- 1999-11-10 JP JP2000582384A patent/JP3638874B2/ja not_active Expired - Fee Related
- 1999-11-10 CA CA002350137A patent/CA2350137C/en not_active Expired - Fee Related
- 1999-11-10 CN CNB998130710A patent/CN1225462C/zh not_active Expired - Fee Related
- 1999-11-10 DK DK99955980T patent/DK1131308T3/da active
- 1999-11-10 EP EP99955980A patent/EP1131308B1/en not_active Expired - Lifetime
- 1999-11-10 AU AU12709/00A patent/AU756470B2/en not_active Ceased
- 1999-11-10 NZ NZ511584A patent/NZ511584A/xx not_active IP Right Cessation
- 1999-11-10 HU HU0104922A patent/HUP0104922A3/hu unknown
- 1999-11-10 KR KR1020017005978A patent/KR100619465B1/ko not_active IP Right Cessation
- 1999-11-12 AR ARP990105763A patent/AR021256A1/es active IP Right Grant
-
2000
- 2000-01-05 TW TW089100097A patent/TWI252230B/zh not_active IP Right Cessation
-
2001
- 2001-05-08 IL IL143028A patent/IL143028A/en not_active IP Right Cessation
- 2001-05-11 NO NO20012339A patent/NO318888B1/no not_active IP Right Cessation
-
2002
- 2002-02-05 HK HK02100871A patent/HK1039489A1/xx not_active IP Right Cessation
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