ATE328573T1 - Behandlung und zusammensetzungen zur erzielung eines hautalterungsschutzes durch corneum protease aktivatoren - Google Patents
Behandlung und zusammensetzungen zur erzielung eines hautalterungsschutzes durch corneum protease aktivatorenInfo
- Publication number
- ATE328573T1 ATE328573T1 AT00948721T AT00948721T ATE328573T1 AT E328573 T1 ATE328573 T1 AT E328573T1 AT 00948721 T AT00948721 T AT 00948721T AT 00948721 T AT00948721 T AT 00948721T AT E328573 T1 ATE328573 T1 AT E328573T1
- Authority
- AT
- Austria
- Prior art keywords
- compositions
- treatment
- skin aging
- aging protection
- corneum protease
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/042—Gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/463—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfuric acid derivatives, e.g. sodium lauryl sulfate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9706—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/30—Characterized by the absence of a particular group of ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/51—Chelating agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Gerontology & Geriatric Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Emergency Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/357,288 US6495126B1 (en) | 1999-07-20 | 1999-07-20 | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE328573T1 true ATE328573T1 (de) | 2006-06-15 |
Family
ID=23405006
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00948721T ATE328573T1 (de) | 1999-07-20 | 2000-07-17 | Behandlung und zusammensetzungen zur erzielung eines hautalterungsschutzes durch corneum protease aktivatoren |
Country Status (24)
| Country | Link |
|---|---|
| US (11) | US6495126B1 (de) |
| EP (1) | EP1200063B1 (de) |
| KR (1) | KR100768413B1 (de) |
| CN (1) | CN1213730C (de) |
| AR (1) | AR024813A1 (de) |
| AT (1) | ATE328573T1 (de) |
| AU (1) | AU772445B2 (de) |
| BR (1) | BR0012567B1 (de) |
| CA (1) | CA2379682C (de) |
| CZ (1) | CZ300239B6 (de) |
| DE (1) | DE60028573T2 (de) |
| EA (2) | EA005099B1 (de) |
| ES (1) | ES2265351T3 (de) |
| HK (1) | HK1043942B (de) |
| MX (1) | MXPA02000754A (de) |
| MY (1) | MY128963A (de) |
| NO (1) | NO20020299L (de) |
| NZ (1) | NZ516940A (de) |
| PE (1) | PE20010279A1 (de) |
| PL (1) | PL352986A1 (de) |
| TW (1) | TWI261522B (de) |
| UA (1) | UA72533C2 (de) |
| UY (1) | UY26255A1 (de) |
| WO (1) | WO2001005369A1 (de) |
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|---|---|---|---|---|
| US5874463A (en) * | 1994-10-24 | 1999-02-23 | Ancira; Margaret | Hydroxy-kojic acid skin peel |
| US6495126B1 (en) * | 1999-07-20 | 2002-12-17 | Mary Kay Inc. | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
| EP1166765A3 (de) * | 2000-06-20 | 2002-05-02 | Laboratoires Serobiologiques | Verfahren zum Schutz der menschlichen Haut |
| ITPN20010004A1 (it) * | 2001-01-24 | 2002-07-24 | Giovanna Zuddas | Prodotto cancella - rughe |
| US20030093297A1 (en) * | 2001-11-08 | 2003-05-15 | Schilling Kurt Matthew | Method for providing feedback as to product efficacy |
| US20030161853A1 (en) * | 2002-01-17 | 2003-08-28 | L'oreal | Methylglycinediacetic acid and deribatives thereof useful as exfoliating agents |
| US8420699B1 (en) | 2002-06-19 | 2013-04-16 | Irvine L. Dubow | Composition and methods of treatment using deionized and ozonated solution |
| US7897642B1 (en) * | 2002-06-19 | 2011-03-01 | Dr. Irvine Dubow | Compositions and methods for dry eye syndrome |
| US20040126449A1 (en) * | 2002-12-30 | 2004-07-01 | Gopa Majmudar | Topical composition and methods for treatment of aged or environmentally damaged skin |
| FR2857266B1 (fr) * | 2003-07-07 | 2007-09-21 | Jean Noel Thorel | Composition a usage dermatologique et/ou cosmetique, comprenant a titre de principe actif au moins un antioxydant lipophile |
| US20060198800A1 (en) * | 2003-08-14 | 2006-09-07 | Natalie Dilallo | Skin care compositions including hexapeptide complexes and methods of their manufacture |
| US20050063932A1 (en) * | 2003-08-14 | 2005-03-24 | Natalie Dilallo | Skin care compositions including hexapeptide complexes and methods of their manufacture |
| WO2005023968A1 (ja) * | 2003-09-05 | 2005-03-17 | Shiseido Co., Ltd. | 温度感覚調整用香料組成物、感覚調整用物品並びに感覚調整方法及び香料マップ |
| KR100552245B1 (ko) * | 2003-10-24 | 2006-02-14 | 주식회사 코리아나화장품 | 예덕나무 추출물을 함유하는 주름 개선 화장료 조성물 |
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| US20050148906A1 (en) * | 2003-12-24 | 2005-07-07 | Gregory Skover | Apparatus for treatment of the skin having a signaling marker |
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| US20050220832A1 (en) * | 2004-03-25 | 2005-10-06 | Richard Walton | Gels containing metallic soaps and coupling agents |
| US20090257968A1 (en) * | 2004-03-25 | 2009-10-15 | Richard Walton | Gels containing anionic surfactants and coupling agents |
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| DE102005026069A1 (de) * | 2005-06-07 | 2006-12-14 | Goldschmidt Gmbh | Topische kosmetische Formulierungen zur Regulierung und Verbesserung des Feuchtigkeitsgehalts der Haut |
| US20070031357A1 (en) * | 2005-08-02 | 2007-02-08 | Anton Mentlik | High PH compositions |
| TWI367109B (en) | 2006-01-19 | 2012-07-01 | Mary Kay Inc | Compositions comprising kakadu plum extract or acai berry extract |
| JP5075345B2 (ja) * | 2006-03-23 | 2012-11-21 | 花王株式会社 | 毛髪洗浄剤組成物 |
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| KR101527829B1 (ko) | 2007-04-19 | 2015-06-12 | 마리 케이 인코포레이티드 | 마그놀리아 추출물 함유 조성물 |
| EP2164960A2 (de) | 2007-05-25 | 2010-03-24 | North Carolina State University | Plattform zur zuführung von virusnanopartikeln an zielzellen |
| US8133516B2 (en) * | 2008-10-31 | 2012-03-13 | Lauer Scott D | Therapeutic ultrasound gel |
| ES2322122B1 (es) * | 2009-02-10 | 2010-07-16 | Laboratorios Starga S.L. | Composicion cosmetica para el cuidado y reparacion de telangiectasias. |
| US8257720B2 (en) * | 2009-04-20 | 2012-09-04 | Conopco, Inc. | Stabilized cationic ammonium compounds and compositions comprising the same |
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| US20110277796A1 (en) * | 2010-05-13 | 2011-11-17 | Russel Walters | Method of cleansing skin having an impaired barrier |
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| GB201106161D0 (en) | 2011-04-12 | 2011-05-25 | Zephyros Inc | Improvements in or relating to vehicle subframe reinforcement |
| WO2013096645A1 (en) | 2011-12-20 | 2013-06-27 | The Procter & Gamble Company | Human skin sample methods and models for validating hypotheses for mechanisms driving skin pigmentation |
| JP5945142B2 (ja) * | 2012-03-27 | 2016-07-05 | 株式会社 資生堂 | しわ改善効果について化粧料を評価する方法 |
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| KR102246477B1 (ko) | 2014-04-30 | 2021-04-30 | 킴벌리-클라크 월드와이드, 인크. | 피부 노화의 징후를 감소시키는 방법 |
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| ES3038642T3 (en) | 2015-12-31 | 2025-10-14 | Colgate Palmolive Co | Personal care composition comprising taurine, arginine, glycine |
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| WO2019232096A1 (en) * | 2018-05-29 | 2019-12-05 | Rr Health, Llc | Compositions for topical treatment |
| CN113784642A (zh) * | 2019-04-19 | 2021-12-10 | 株式会社资生堂 | 用于皮肤抗老化的方法以及装置 |
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| CN1221336A (zh) * | 1996-05-02 | 1999-06-30 | 普罗克特和甘保尔公司 | 包含分散的表面活性剂复合物的局部用组合物 |
| EP0926954A1 (de) * | 1996-09-06 | 1999-07-07 | Minnesota Mining And Manufacturing Company | Antimikrobielle zusammensetzungen |
| US5804168A (en) * | 1997-01-29 | 1998-09-08 | Murad; Howard | Pharmaceutical compositions and methods for protecting and treating sun damaged skin |
| US5902591A (en) * | 1997-04-03 | 1999-05-11 | La Prairie Sa | Stable topical cosmetic/pharmaceutical emulsion compositions containing ascorbic acid |
| EP0884045A1 (de) * | 1997-06-06 | 1998-12-16 | Pfizer Products Inc. | Selbstbräunende Dihydroxyaceton Formulierungen mit verbesserter Stabilität und eine erhöte Abgabe erzeugend |
| AR017859A1 (es) * | 1997-12-15 | 2001-10-24 | Unilever Nv | Una composicion cosmetica para aclarar la piel, de aplicacion topica sobre la piel humana y un metodo cosmetico para aclarar la piel que comprende la aplicacion topica sobre la misma de dicha composicion |
| WO1999049878A1 (en) | 1998-03-31 | 1999-10-07 | Mary Kay Inc. | Skin lightening composition containing magnesium ascorbyl phosphate and uninontan-u34tm (extract formulation of cucumber extract and lemon extract) |
| US5945093A (en) * | 1998-04-22 | 1999-08-31 | Amway Corporation | Conditioning shampoo |
| US6184247B1 (en) * | 1999-05-21 | 2001-02-06 | Amway Corporation | Method of increasing cell renewal rate |
| US6495126B1 (en) * | 1999-07-20 | 2002-12-17 | Mary Kay Inc. | Treatment and composition for achieving skin anti-aging benefits by corneum protease activation |
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| US20020022040A1 (en) * | 2000-07-10 | 2002-02-21 | The Proctor & Gamble Company | Methods of enhancing delivery of oil-soluble skin care actives |
| US7226583B2 (en) * | 2002-08-12 | 2007-06-05 | Hair Systems, Inc. | Composition containing leukocyte extract for the whitening or lightening of skin |
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| US7429391B2 (en) * | 2004-01-30 | 2008-09-30 | Access Business Group International Llc | Holistic composition and method for reducing skin pigmentation |
| CA2629711A1 (en) * | 2005-11-14 | 2007-05-24 | Tanning Research Laboratories, Inc. | High sunscreen efficiency water-in-oil emulsion |
-
1999
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2000
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- 2000-07-17 PL PL00352986A patent/PL352986A1/xx unknown
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- 2000-07-17 CN CNB008112312A patent/CN1213730C/zh not_active Expired - Lifetime
- 2000-07-17 KR KR1020027000791A patent/KR100768413B1/ko not_active Expired - Lifetime
- 2000-07-17 AU AU62183/00A patent/AU772445B2/en not_active Expired
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- 2000-07-17 EA EA200200185A patent/EA005099B1/ru not_active IP Right Cessation
- 2000-07-17 DE DE60028573T patent/DE60028573T2/de not_active Expired - Lifetime
- 2000-07-17 EP EP00948721A patent/EP1200063B1/de not_active Expired - Lifetime
- 2000-07-17 AT AT00948721T patent/ATE328573T1/de not_active IP Right Cessation
- 2000-07-17 WO PCT/US2000/019477 patent/WO2001005369A1/en not_active Ceased
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