ATE324894T1 - Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen - Google Patents
Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionenInfo
- Publication number
- ATE324894T1 ATE324894T1 AT00904529T AT00904529T ATE324894T1 AT E324894 T1 ATE324894 T1 AT E324894T1 AT 00904529 T AT00904529 T AT 00904529T AT 00904529 T AT00904529 T AT 00904529T AT E324894 T1 ATE324894 T1 AT E324894T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- d4fc
- hiv
- didesoxy
- fluorocytidine
- Prior art date
Links
- 208000031886 HIV Infections Diseases 0.000 title 1
- 108020004705 Codon Proteins 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000035772 mutation Effects 0.000 abstract 2
- 238000009118 salvage therapy Methods 0.000 abstract 2
- 206010059866 Drug resistance Diseases 0.000 abstract 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- 239000002259 anti human immunodeficiency virus agent Substances 0.000 abstract 1
- 229940124411 anti-hiv antiviral agent Drugs 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11677399P | 1999-01-22 | 1999-01-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE324894T1 true ATE324894T1 (de) | 2006-06-15 |
Family
ID=22369127
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00904529T ATE324894T1 (de) | 1999-01-22 | 2000-01-21 | Beta-d-2', 3' -didehydro-2', 3' -didesoxy-5- fluorocytidin für die verwendung in der behandlung von hiv infektionen |
Country Status (21)
| Country | Link |
|---|---|
| EP (1) | EP1143976B9 (de) |
| JP (1) | JP2002535278A (de) |
| KR (1) | KR100745408B1 (de) |
| CN (2) | CN101219148A (de) |
| AT (1) | ATE324894T1 (de) |
| AU (1) | AU781281B2 (de) |
| BR (1) | BR0007627A (de) |
| CA (1) | CA2360039C (de) |
| DE (1) | DE60027691T2 (de) |
| DK (1) | DK1143976T3 (de) |
| ES (1) | ES2263449T3 (de) |
| HK (1) | HK1040064B (de) |
| IL (1) | IL144382A (de) |
| MX (1) | MXPA01007359A (de) |
| NO (1) | NO323586B1 (de) |
| NZ (1) | NZ528156A (de) |
| PL (1) | PL198237B1 (de) |
| PT (1) | PT1143976E (de) |
| RU (1) | RU2254133C2 (de) |
| WO (1) | WO2000043014A2 (de) |
| ZA (1) | ZA200105971B (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60303131T2 (de) * | 2002-06-27 | 2006-07-20 | Medivir Ab | Synergistische wechselwirkung von abacavir und alovudin |
| CA2548144A1 (en) * | 2003-12-09 | 2005-06-23 | Pharmasset, Inc. | Dosing methods for .beta.-d-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine antiviral therapy |
| WO2005097618A2 (en) | 2004-04-01 | 2005-10-20 | Achillion Pharmaceuticals, Inc. | Low dose therapy for treating viral infections |
| EP1802315A2 (de) * | 2004-10-19 | 2007-07-04 | Achillion Pharmaceuticals, Inc. | Kombinationstherapie zur behandlung von virusinfektionen |
| US8091224B2 (en) * | 2008-10-06 | 2012-01-10 | GE Intelligent Platforms Embedded Systems, Inc. | Method for coupling a battery within an embedded system |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU707246A1 (ru) * | 1978-09-29 | 1980-12-23 | Институт Биоорганической Химии Ан Белорусской Сср | Способ получени хлоргидрата 2"2 -ангидро-1- - -арабинофуранозил - 5-фторцитозина |
| NL8901258A (nl) * | 1989-05-19 | 1990-12-17 | Stichting Rega V Z W | 5-halogeno-2',3'-dideoxycytidinederivaten in geneesmiddelen voor het behandelen van retrovirus-infecties. |
| RU2092177C1 (ru) * | 1994-08-19 | 1997-10-10 | Научно-производственное объединение "Всероссийский научно-исследовательский институт лекарственных и ароматических растений" | Средство, обладающее действием против инфекционных агентов |
| FR2729390A1 (fr) * | 1995-01-18 | 1996-07-19 | Rhone Poulenc Rorer Sa | Nouveaux inhibiteurs de farnesyl transferase, leur preparation et les compositions pharmaceutiques qui les contiennent |
| US5703058A (en) * | 1995-01-27 | 1997-12-30 | Emory University | Compositions containing 5-fluoro-2',3'-didehydro-2',3'-dideoxycytidine or a mono-, di-, or triphosphate thereof and a second antiviral agent |
| US5869461A (en) * | 1995-03-16 | 1999-02-09 | Yale University | Reducing toxicity of L-nucleosides with D-nucleosides |
| BR9911457A (pt) * | 1998-06-24 | 2001-12-11 | Univ Emory | Uso de 3'-azida-2', 3'-dideoxiuridina em combinaçãocom drogas anti-hiv adicionais para a manufaturade um medicamento para o tratamento de hiv |
-
2000
- 2000-01-21 DK DK00904529T patent/DK1143976T3/da active
- 2000-01-21 AU AU26270/00A patent/AU781281B2/en not_active Ceased
- 2000-01-21 ES ES00904529T patent/ES2263449T3/es not_active Expired - Lifetime
- 2000-01-21 HK HK02101840.8A patent/HK1040064B/en not_active IP Right Cessation
- 2000-01-21 RU RU2001123432/15A patent/RU2254133C2/ru not_active IP Right Cessation
- 2000-01-21 NZ NZ528156A patent/NZ528156A/en not_active IP Right Cessation
- 2000-01-21 BR BR0007627-9A patent/BR0007627A/pt not_active Application Discontinuation
- 2000-01-21 CN CNA2007101666768A patent/CN101219148A/zh active Pending
- 2000-01-21 IL IL144382A patent/IL144382A/en not_active IP Right Cessation
- 2000-01-21 KR KR1020017009139A patent/KR100745408B1/ko not_active Expired - Fee Related
- 2000-01-21 CA CA002360039A patent/CA2360039C/en not_active Expired - Fee Related
- 2000-01-21 PL PL349576A patent/PL198237B1/pl not_active IP Right Cessation
- 2000-01-21 DE DE60027691T patent/DE60027691T2/de not_active Expired - Lifetime
- 2000-01-21 MX MXPA01007359A patent/MXPA01007359A/es not_active Application Discontinuation
- 2000-01-21 EP EP00904529A patent/EP1143976B9/de not_active Expired - Lifetime
- 2000-01-21 CN CN00802998A patent/CN1337880A/zh active Pending
- 2000-01-21 WO PCT/US2000/001738 patent/WO2000043014A2/en not_active Ceased
- 2000-01-21 JP JP2000594468A patent/JP2002535278A/ja active Pending
- 2000-01-21 PT PT00904529T patent/PT1143976E/pt unknown
- 2000-01-21 AT AT00904529T patent/ATE324894T1/de not_active IP Right Cessation
-
2001
- 2001-07-19 ZA ZA200105971A patent/ZA200105971B/en unknown
- 2001-07-20 NO NO20013599A patent/NO323586B1/no not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| KR100745408B1 (ko) | 2007-08-02 |
| CA2360039C (en) | 2009-11-24 |
| DE60027691D1 (de) | 2006-06-08 |
| WO2000043014A2 (en) | 2000-07-27 |
| NO20013599D0 (no) | 2001-07-20 |
| MXPA01007359A (es) | 2003-09-22 |
| PL198237B1 (pl) | 2008-06-30 |
| JP2002535278A (ja) | 2002-10-22 |
| CN101219148A (zh) | 2008-07-16 |
| AU2627000A (en) | 2000-08-07 |
| KR20020068260A (ko) | 2002-08-27 |
| NO323586B1 (no) | 2007-06-11 |
| EP1143976B1 (de) | 2006-05-03 |
| IL144382A0 (en) | 2002-05-23 |
| BR0007627A (pt) | 2002-04-09 |
| PT1143976E (pt) | 2006-09-29 |
| ZA200105971B (en) | 2002-10-21 |
| EP1143976B9 (de) | 2007-02-14 |
| WO2000043014A3 (en) | 2000-11-30 |
| CA2360039A1 (en) | 2000-07-27 |
| AU781281B2 (en) | 2005-05-12 |
| NZ528156A (en) | 2005-03-24 |
| WO2000043014A8 (en) | 2001-01-18 |
| IL144382A (en) | 2007-02-11 |
| ES2263449T3 (es) | 2006-12-16 |
| HK1040064A1 (en) | 2002-05-24 |
| CN1337880A (zh) | 2002-02-27 |
| NO20013599L (no) | 2001-09-20 |
| HK1040064B (en) | 2006-07-21 |
| DK1143976T3 (da) | 2006-09-04 |
| RU2254133C2 (ru) | 2005-06-20 |
| DE60027691T2 (de) | 2007-04-12 |
| EP1143976A2 (de) | 2001-10-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1143976 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |