ATE320265T1 - Staphylococcus-antigene und impstoff - Google Patents
Staphylococcus-antigene und impstoffInfo
- Publication number
- ATE320265T1 ATE320265T1 AT00916405T AT00916405T ATE320265T1 AT E320265 T1 ATE320265 T1 AT E320265T1 AT 00916405 T AT00916405 T AT 00916405T AT 00916405 T AT00916405 T AT 00916405T AT E320265 T1 ATE320265 T1 AT E320265T1
- Authority
- AT
- Austria
- Prior art keywords
- antigen
- staphylococcus
- strains
- carry
- vaccine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/975—Kit
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Communicable Diseases (AREA)
- Cardiology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/272,359 US6936258B1 (en) | 1999-03-19 | 1999-03-19 | Staphylococcus antigen and vaccine |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE320265T1 true ATE320265T1 (de) | 2006-04-15 |
Family
ID=23039462
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00916405T ATE320265T1 (de) | 1999-03-19 | 2000-03-17 | Staphylococcus-antigene und impstoff |
Country Status (15)
Country | Link |
---|---|
US (2) | US6936258B1 (de) |
EP (1) | EP1162997B1 (de) |
JP (1) | JP4656728B2 (de) |
AT (1) | ATE320265T1 (de) |
AU (1) | AU773226B2 (de) |
BR (1) | BR0009157B1 (de) |
CA (1) | CA2366433C (de) |
CY (1) | CY1105500T1 (de) |
DE (1) | DE60026691T2 (de) |
DK (1) | DK1162997T3 (de) |
ES (1) | ES2261192T3 (de) |
MX (1) | MXPA01009476A (de) |
NZ (1) | NZ514455A (de) |
PT (1) | PT1162997E (de) |
WO (1) | WO2000056357A2 (de) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6294177B1 (en) | 1996-09-11 | 2001-09-25 | Nabi | Staphylococcus aureus antigen-containing whole cell vaccine |
US6936258B1 (en) * | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
AT410798B (de) * | 2001-01-26 | 2003-07-25 | Cistem Biotechnologies Gmbh | Verfahren zur identifizierung, isolierung und herstellung von antigenen gegen ein spezifisches pathogen |
CA2469714A1 (en) * | 2001-12-21 | 2003-07-24 | Biosynexus Incorporated | Multifunctional monoclonal antibodies directed to peptidoglycan of gram-positive bacteria |
US20060134141A1 (en) * | 2004-12-14 | 2006-06-22 | Nabi Biopharmaceuticals | Glycoconjugate vaccines containing peptidoglycan |
US20060153857A1 (en) * | 2005-01-10 | 2006-07-13 | Nabi Biopharmaceuticals | Method of treating staphylococcus aureus infection |
KR101302764B1 (ko) | 2005-06-13 | 2013-09-02 | 글락소스미스클라인 바이오로지칼즈 에스.에이. | 포도상구균 감염을 치료 및 예방하기 위한 팬톤-발렌타인류코시딘의 용도 |
WO2007008904A2 (en) * | 2005-07-08 | 2007-01-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Targeting poly-gamma-glutamic acid to treat staphylococcus epidermidis and related infections |
EP2368569A3 (de) | 2006-01-18 | 2012-05-02 | University Of Chicago | Zusammensetzungen und Verfahren im Zusammenhang mit Proteinen des Staphylococcus-Bakteriums |
MY148405A (en) | 2006-03-30 | 2013-04-30 | Glaxosmithkline Biolog Sa | Immunogenic composition |
MX2008015814A (es) | 2006-06-12 | 2009-01-12 | Nabi Biopharmaceuticals | Uso de alfa-toxina para tratar y prevenir infecciones por staphylococcus. |
EP2185190B1 (de) | 2007-08-31 | 2015-06-24 | University Of Chicago | Verfahren und zusammensetzungen zur immunisierung gegen durch staphylokokken vermittelte lungenerkrankungen und -leiden |
BRPI0920041A2 (pt) | 2008-10-06 | 2017-06-27 | Univ Chicago | composições e processos relacionados às proteínas eap, emp e/ou adsa bacterianas |
US8101190B2 (en) * | 2009-03-03 | 2012-01-24 | Ingen Biosciences | Method for diagnosing staphylococcal infections |
SI3281947T1 (sl) | 2009-04-03 | 2020-07-31 | The University Of Chicago | Sestave in metode v zvezi z variantami proteina A (SPA) |
ES2729934T3 (es) | 2009-06-22 | 2019-11-07 | Wyeth Llc | Composiciones y procedimientos para preparar composiciones inmunogénicas de conjugado de polisacárido capsular de serotipo 8 de Staphylococcus aureus |
AR078601A1 (es) | 2009-06-22 | 2011-11-23 | Wyeth Llc | Composiciones inmunogenicas de antigenos de staphylococcus aureus |
GB0913681D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
GB0913680D0 (en) | 2009-08-05 | 2009-09-16 | Glaxosmithkline Biolog Sa | Immunogenic composition |
US10266585B2 (en) | 2009-08-28 | 2019-04-23 | The Board Of Regents Of The Univerity Of Texas System | Methods of treating brain injury |
MX338753B (es) | 2009-09-30 | 2016-04-29 | Novartis Ag | Conjugacion de polisacaridos capsulares de tipo 5 y de tipo 8 de staphylococcus aureus. |
ES2626416T3 (es) | 2009-10-30 | 2017-07-25 | Glaxosmithkline Biologicals Sa | Purificación de sacáridos capsulares de Staphilococcus aureus de tipo 5 y de tipo 8 |
EP2555794A4 (de) | 2010-04-05 | 2014-01-15 | Univ Chicago | Zusammensetzungen und verfahren im zusammenhang mit protein-a-(spa)-antikörpern als immunreaktionsverstärker |
US8821894B2 (en) | 2010-07-02 | 2014-09-02 | The University Of Chicago | Compositions and methods related to protein A (SpA) variants |
US9095540B2 (en) | 2010-09-09 | 2015-08-04 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens |
WO2012051498A2 (en) | 2010-10-15 | 2012-04-19 | The Board Of Regents Of The University Of Texas System | Antibodies that bind amyloid oligomers |
MX350170B (es) | 2010-12-22 | 2017-08-28 | Wyeth Llc | Composición inmunogénica estable de antígenos de staphylococcus aureus. |
US8945588B2 (en) | 2011-05-06 | 2015-02-03 | The University Of Chicago | Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides |
EP2729178A1 (de) | 2011-07-08 | 2014-05-14 | Novartis AG | Tyrosinverbindungsverfahren |
CN103906535B (zh) | 2011-08-15 | 2017-07-14 | 芝加哥大学 | 与葡萄球菌蛋白a的抗体相关的组合物和方法 |
JP6170932B2 (ja) | 2011-11-07 | 2017-07-26 | ノバルティス アーゲー | spr0096抗原およびspr2021抗原を含むキャリア分子 |
EP2814803A4 (de) | 2011-12-14 | 2015-11-11 | Indicator Systems International Inc | Trisubstituierte methylalkohole und polymerisierbare derivate daraus |
WO2013162751A1 (en) | 2012-04-26 | 2013-10-31 | University Of Chicago | Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease |
EP3805395A1 (de) | 2012-04-26 | 2021-04-14 | University Of Chicago | Staphylokokken-coagulase-antigene und verfahren zu deren verwendung |
DK3421051T3 (da) | 2012-08-16 | 2020-06-22 | Pfizer | Fremgangsmåder til glycokonjugering og sammensætninger |
CA2943263C (en) | 2012-12-20 | 2018-12-04 | Pfizer Inc. | Glycoconjugation process |
WO2014116721A1 (en) | 2013-01-22 | 2014-07-31 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Geminiviral vector for expression of rituximab |
GB201310008D0 (en) | 2013-06-05 | 2013-07-17 | Glaxosmithkline Biolog Sa | Immunogenic composition for use in therapy |
CN105593238B (zh) | 2013-07-11 | 2020-09-08 | 诺华股份有限公司 | 使用微生物转谷氨酰胺酶进行赖氨酸特异性化学酶法蛋白质修饰 |
PE20212335A1 (es) | 2014-01-21 | 2021-12-16 | Pfizer | Composiciones inmunogenicas que comprenden antigenos sacaridos capsulares conjugados y usos de los mismos |
US11160855B2 (en) | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP3957321A3 (de) | 2014-01-21 | 2022-07-13 | Pfizer Inc. | Kapsulare polysaccharide aus streptococcus pneumoniae und konjugate davon |
MX371453B (es) | 2014-01-21 | 2020-01-29 | Pfizer | Polisacaridos capsulares de streptococcus pneumoniae y conjugados de los mismos. |
CA2939416A1 (en) | 2014-02-14 | 2015-08-20 | Pfizer Inc. | Immunogenic glycoprotein conjugates |
WO2016091904A1 (en) | 2014-12-10 | 2016-06-16 | Glaxosmithkline Biologicals Sa | Method of treatment |
IL252915B2 (en) | 2015-01-15 | 2024-04-01 | Pfizer | Immunogenic preparations for use in pneumococcal vaccines |
MX368897B (es) | 2015-05-04 | 2019-10-21 | Pfizer | Conjugados proteina-polisacarido de estreptococo grupo b, metodos para producir conjugados, composiciones inmunogenas que comprenden conjugados y sus usos. |
RU2721128C2 (ru) | 2015-07-21 | 2020-05-18 | Пфайзер Инк. | Иммуногенные композиции, содержащие конъюгированные антигены капсульного сахарида, наборы, содержащие эти композиции, и их применения |
JP6884145B2 (ja) | 2015-11-20 | 2021-06-09 | ファイザー・インク | 肺炎連鎖球菌ワクチンにおいて用いるための免疫原性組成物 |
US11246924B2 (en) | 2016-04-01 | 2022-02-15 | Duke University | Alpha-helical peptide nanofibers as a self-adjuvanting vaccine platform |
US10751402B2 (en) | 2016-11-09 | 2020-08-25 | Pfizer Inc. | Immunogenic compositions and uses thereof |
KR102459629B1 (ko) | 2017-01-20 | 2022-10-28 | 화이자 인코포레이티드 | 폐렴구균 백신에 사용하기 위한 면역원성 조성물 |
WO2019183500A1 (en) | 2018-03-23 | 2019-09-26 | Hung Chiung Yu | Coccidioides antigens and methods of their use |
WO2020121159A1 (en) | 2018-12-12 | 2020-06-18 | Pfizer Inc. | Immunogenic multiple hetero-antigen polysaccharide-protein conjugates and uses thereof |
EP3952906A1 (de) | 2019-04-10 | 2022-02-16 | Pfizer Inc. | Immunogene zusammensetzungen mit konjugierten kapselförmigen saccharidantigenen, kits damit und verwendungen davon |
CA3192786A1 (en) | 2020-08-26 | 2022-03-03 | Pfizer Inc. | Group b streptococcus polysaccharide-protein conjugates, methods for producing conjugates, immunogenic compositions comprising conjugates, and uses thereof |
CN116744965A (zh) | 2020-11-04 | 2023-09-12 | 辉瑞大药厂 | 用于肺炎球菌疫苗的免疫原性组合物 |
WO2022234416A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
CA3218544A1 (en) | 2021-05-03 | 2022-11-10 | Pfizer Inc. | Vaccination against bacterial and betacoronavirus infections |
WO2024084397A1 (en) | 2022-10-19 | 2024-04-25 | Pfizer Inc. | Vaccination against pneumoccocal and covid-19 infections |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2619122B1 (fr) | 1987-08-03 | 1990-03-09 | Pasteur Institut | Procede d'obtention de polyosides capsulaires de staphylocoques, polyosides obtenus, applications de ces polyosides et souches pour la mise en oeuvre du procede |
US7279162B1 (en) * | 1990-10-22 | 2007-10-09 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Isolated broadly reactive opsonic immunoglobulin for treating a pathogenic coagulase-negative staphylococcus infection |
FR2682388B1 (fr) * | 1991-10-10 | 1995-06-09 | Pasteur Merieux Serums Vacc | Procede de preparation d'un oligoside par depolymerisation d'un polyoside issu d'un agent pathogene, oligoside ainsi obtenu et son utilisation notamment comme agent vaccinal. |
EP0648127B1 (de) | 1991-11-22 | 2003-04-16 | Univax Biologics Incorporated | Mit staphylococcus epidermidis assoziierte oberflächenantigene des typs i |
US6294177B1 (en) * | 1996-09-11 | 2001-09-25 | Nabi | Staphylococcus aureus antigen-containing whole cell vaccine |
US5770208A (en) | 1996-09-11 | 1998-06-23 | Nabi | Staphylococcus aureus B-linked hexosamine antigen |
AU5804198A (en) | 1996-12-20 | 1998-07-17 | Research Foundation Of The City University Of New York | A novel pathogenic coccoid organism, (staphylococcus leei), with trophism for gastric mucin |
US5965374A (en) * | 1997-10-16 | 1999-10-12 | Biowhittaker Technologies, Inc. | Glucan-specific assay |
US7030101B2 (en) * | 1998-09-14 | 2006-04-18 | Nabi Biopharmaceuticals | Compositions of β-glucans and specific antibodies |
PT1121135E (pt) * | 1998-09-14 | 2009-03-05 | Nabi Biopharmaceuticals | Composições de b-glucanos e de imunoglobulinas específicas |
US6936258B1 (en) * | 1999-03-19 | 2005-08-30 | Nabi Biopharmaceuticals | Staphylococcus antigen and vaccine |
US20030113350A1 (en) * | 2001-09-19 | 2003-06-19 | Fattom Ali I. | Glycoconjugate vaccines for use in immune-compromised populations |
-
1999
- 1999-03-19 US US09/272,359 patent/US6936258B1/en not_active Expired - Fee Related
-
2000
- 2000-03-17 ES ES00916405T patent/ES2261192T3/es not_active Expired - Lifetime
- 2000-03-17 AU AU37513/00A patent/AU773226B2/en not_active Ceased
- 2000-03-17 CA CA2366433A patent/CA2366433C/en not_active Expired - Fee Related
- 2000-03-17 JP JP2000606261A patent/JP4656728B2/ja not_active Expired - Fee Related
- 2000-03-17 PT PT00916405T patent/PT1162997E/pt unknown
- 2000-03-17 NZ NZ514455A patent/NZ514455A/en not_active IP Right Cessation
- 2000-03-17 DE DE60026691T patent/DE60026691T2/de not_active Expired - Lifetime
- 2000-03-17 MX MXPA01009476A patent/MXPA01009476A/es active IP Right Grant
- 2000-03-17 EP EP00916405A patent/EP1162997B1/de not_active Expired - Lifetime
- 2000-03-17 AT AT00916405T patent/ATE320265T1/de active
- 2000-03-17 WO PCT/US2000/006922 patent/WO2000056357A2/en active IP Right Grant
- 2000-03-17 DK DK00916405T patent/DK1162997T3/da active
- 2000-03-17 BR BRPI0009157-0B1A patent/BR0009157B1/pt not_active IP Right Cessation
-
2004
- 2004-12-20 US US11/014,997 patent/US7531633B2/en not_active Expired - Fee Related
-
2006
- 2006-05-12 CY CY20061100620T patent/CY1105500T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2261192T3 (es) | 2006-11-16 |
JP4656728B2 (ja) | 2011-03-23 |
MXPA01009476A (es) | 2003-08-19 |
DE60026691D1 (de) | 2006-05-11 |
JP2002539272A (ja) | 2002-11-19 |
BR0009157B1 (pt) | 2013-12-24 |
AU3751300A (en) | 2000-10-09 |
WO2000056357A3 (en) | 2001-02-01 |
US7531633B2 (en) | 2009-05-12 |
PT1162997E (pt) | 2006-07-31 |
US20050118190A1 (en) | 2005-06-02 |
EP1162997B1 (de) | 2006-03-15 |
NZ514455A (en) | 2003-11-28 |
AU773226B2 (en) | 2004-05-20 |
BR0009157A (pt) | 2002-04-16 |
DE60026691T2 (de) | 2006-09-07 |
US6936258B1 (en) | 2005-08-30 |
CA2366433C (en) | 2012-01-03 |
EP1162997A2 (de) | 2001-12-19 |
CY1105500T1 (el) | 2010-04-28 |
DK1162997T3 (da) | 2006-07-17 |
WO2000056357A2 (en) | 2000-09-28 |
CA2366433A1 (en) | 2000-09-28 |
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