ATE309693T1 - Zusammensetzungen enthaltend heparin mit niedrigem molekülargewicht - Google Patents

Zusammensetzungen enthaltend heparin mit niedrigem molekülargewicht

Info

Publication number
ATE309693T1
ATE309693T1 AT99500184T AT99500184T ATE309693T1 AT E309693 T1 ATE309693 T1 AT E309693T1 AT 99500184 T AT99500184 T AT 99500184T AT 99500184 T AT99500184 T AT 99500184T AT E309693 T1 ATE309693 T1 AT E309693T1
Authority
AT
Austria
Prior art keywords
molecular weight
low molecular
compositions containing
containing low
weight heparin
Prior art date
Application number
AT99500184T
Other languages
English (en)
Inventor
Jean Mardiguian
Original Assignee
Rovi Lab Farmaceut Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rovi Lab Farmaceut Sa filed Critical Rovi Lab Farmaceut Sa
Application granted granted Critical
Publication of ATE309693T1 publication Critical patent/ATE309693T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
AT99500184T 1999-07-23 1999-10-13 Zusammensetzungen enthaltend heparin mit niedrigem molekülargewicht ATE309693T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009901671A ES2161615B1 (es) 1999-07-23 1999-07-23 Composiciones de heparinas de muy bajo peso molecular.

Publications (1)

Publication Number Publication Date
ATE309693T1 true ATE309693T1 (de) 2005-07-15

Family

ID=8309360

Family Applications (1)

Application Number Title Priority Date Filing Date
AT99500184T ATE309693T1 (de) 1999-07-23 1999-10-13 Zusammensetzungen enthaltend heparin mit niedrigem molekülargewicht

Country Status (8)

Country Link
US (1) US6384021B1 (de)
EP (1) EP1070503B8 (de)
AT (1) ATE309693T1 (de)
BR (1) BR9905820A (de)
DE (1) DE69925821T2 (de)
DK (1) DK1070503T3 (de)
ES (2) ES2161615B1 (de)
PT (1) PT1070503E (de)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP1518120A4 (de) * 2002-03-11 2008-08-13 Momenta Pharmaceuticals Inc Analyse sulfatierter polysaccharide
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
KR101104107B1 (ko) 2002-10-10 2012-01-12 아방티 파르마 소시에테 아노님 헤파린으로부터 유도된 다당류의 혼합물, 이의 제조방법 및이를 함유하는 약제학적 조성물
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
GB0327723D0 (en) * 2003-09-15 2003-12-31 Vectura Ltd Pharmaceutical compositions
EP1574516A1 (de) * 2004-03-05 2005-09-14 Sanofi-Aventis Antithrombotische Verbindungen
US20060183712A1 (en) * 2005-02-17 2006-08-17 The Texas A&M University System Affinity purified heparin/heparan sulfate for controlling the biological activity of the FGF receptor
US9139876B1 (en) 2007-05-03 2015-09-22 Momenta Pharmacueticals, Inc. Method of analyzing a preparation of a low molecular weight heparin
ES2340902B1 (es) * 2008-07-01 2011-05-03 Laboratorios Farmaceuticos Rovi, S.A. Composicion farmaceutica con glicosaminoglicanos y su uso en tratamiento de ulceras cronicas.
CN101711771B (zh) * 2008-10-07 2015-12-09 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制法和药物组合物
ES2817779T3 (es) * 2010-01-19 2021-04-08 Momenta Pharmaceuticals Inc Evaluación de preparaciones de heparina
CN102399379B (zh) * 2010-09-09 2016-08-31 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制备方法和药物组合物
WO2012072799A1 (en) * 2010-12-02 2012-06-07 Aventis Pharma S.A. New methods for the in vitro measurement of the biological activity of an ultra low molecular weight heparin sample
US9068957B2 (en) 2011-02-21 2015-06-30 Momenta Pharmaceuticals, Inc. Evaluating heparin preparations
CN102816255B (zh) * 2011-06-10 2015-11-25 王芃 一种超低分子肝素钠的制备方法
ES2445494B1 (es) 2012-08-02 2015-03-06 Rovi Lab Farmaceut Sa Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
US20160331775A1 (en) * 2015-05-14 2016-11-17 The Regents Of The University Of Michigan E-selectin inhibition works in combination with low-molecular weight heparin to decrease venous thrombosis and bleeding risk
AU2020263142A1 (en) 2019-04-26 2021-10-28 Laboratorios Farmacéuticos Rovi, S.A. Method for obtaining low-molecular-weight heparins by means of tangential flow filtration
ES2847281A1 (es) * 2020-01-31 2021-08-02 Farm Rovi Lab Sa Heparinas de bajo y muy bajo peso molecular para el tratamiento de trombosis venosa profunda
ES2792298B2 (es) * 2020-04-27 2022-04-20 Farm Rovi Lab Sa Procedimiento para la obtencion de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo
CN113384758B (zh) * 2021-06-18 2022-10-04 海思盖德(苏州)生物医学科技有限公司 抗凝血涂层组合物及其制备方法与应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2548672A1 (fr) * 1983-07-04 1985-01-11 Pharmuka Lab Oligosaccharides sulfates et leur utilisation comme medicaments
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
GB8826448D0 (en) * 1988-11-11 1988-12-14 Thrombosis Res Inst Improvements in/relating to organic compounds
JP3522775B2 (ja) * 1992-07-03 2004-04-26 生化学工業株式会社 ヘパリン不飽和４糖およびその製造法
US6001820A (en) * 1995-03-31 1999-12-14 Hamilton Civic Hospitals Research Development Inc. Compositions and methods for inhibiting thrombogenesis
AU754936B2 (en) * 1996-11-27 2002-11-28 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising a compound having anti-Xa activity and a platelet aggregation antagonist compound
IT1290814B1 (it) * 1997-03-24 1998-12-11 Istituto Scient Di Chimica E B Glicosaminoglicani aventi elevata attivita' antitrombotica
CA2293595A1 (en) * 1997-06-06 1998-12-10 Hamilton Civic Hospitals Research Development, Inc. Modified low molecular weight heparin that inhibits clot associated coagulation factors

Also Published As

Publication number Publication date
PT1070503E (pt) 2005-10-31
ES2161615B1 (es) 2003-03-16
DE69925821T2 (de) 2006-05-18
US6384021B1 (en) 2002-05-07
ES2161615A1 (es) 2001-12-01
DK1070503T3 (da) 2005-12-05
EP1070503A1 (de) 2001-01-24
EP1070503B8 (de) 2005-09-14
EP1070503B1 (de) 2005-06-15
DE69925821D1 (de) 2005-07-21
BR9905820A (pt) 2001-03-13
ES2244165T3 (es) 2005-12-01

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