ATE308977T1 - Herstellung von mikropartikeln mit einem gewählten freisetzungsprofil - Google Patents
Herstellung von mikropartikeln mit einem gewählten freisetzungsprofilInfo
- Publication number
- ATE308977T1 ATE308977T1 AT99965212T AT99965212T ATE308977T1 AT E308977 T1 ATE308977 T1 AT E308977T1 AT 99965212 T AT99965212 T AT 99965212T AT 99965212 T AT99965212 T AT 99965212T AT E308977 T1 ATE308977 T1 AT E308977T1
- Authority
- AT
- Austria
- Prior art keywords
- microparticles
- release profile
- release
- production
- active agent
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
- Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US09/223,276 US6194006B1 (en) | 1998-12-30 | 1998-12-30 | Preparation of microparticles having a selected release profile |
PCT/US1999/029349 WO2000040221A1 (en) | 1998-12-30 | 1999-12-10 | Preparation of microparticles having a selected release profile |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE308977T1 true ATE308977T1 (de) | 2005-11-15 |
Family
ID=22835812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99965212T ATE308977T1 (de) | 1998-12-30 | 1999-12-10 | Herstellung von mikropartikeln mit einem gewählten freisetzungsprofil |
Country Status (10)
Country | Link |
---|---|
US (4) | US6194006B1 (de) |
EP (1) | EP1140029B1 (de) |
JP (1) | JP4694694B2 (de) |
AT (1) | ATE308977T1 (de) |
AU (1) | AU759214B2 (de) |
CA (1) | CA2352818C (de) |
DE (1) | DE69928283T2 (de) |
DK (1) | DK1140029T3 (de) |
ES (1) | ES2251850T3 (de) |
WO (1) | WO2000040221A1 (de) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
US6291013B1 (en) | 1999-05-03 | 2001-09-18 | Southern Biosystems, Inc. | Emulsion-based processes for making microparticles |
US6458387B1 (en) * | 1999-10-18 | 2002-10-01 | Epic Therapeutics, Inc. | Sustained release microspheres |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6331317B1 (en) * | 1999-11-12 | 2001-12-18 | Alkermes Controlled Therapeutics Ii Inc. | Apparatus and method for preparing microparticles |
WO2001069245A2 (en) * | 2000-03-14 | 2001-09-20 | Trustees Of Tufts College | Cross-reactive sensors |
WO2001068080A2 (en) | 2000-03-15 | 2001-09-20 | Wolfgang Sadee | Neutral antagonists and use thereof in treating drug abuse |
US6495164B1 (en) * | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
CA2419115C (en) * | 2000-08-15 | 2011-03-08 | Board Of Trustees Of The University Of Illinois | Microparticles, and method and apparatus for forming same |
US7785810B2 (en) * | 2000-09-09 | 2010-08-31 | The Research Foundation Of State University Of New York | Method and compositions for isolating metastatic cancer cells, and use in measuring metastatic potential of a cancer thereof |
US6824822B2 (en) * | 2001-08-31 | 2004-11-30 | Alkermes Controlled Therapeutics Inc. Ii | Residual solvent extraction method and microparticles produced thereby |
WO2002043580A2 (en) | 2000-10-27 | 2002-06-06 | Epic Therapeutics, Inc. | Production of microspheres |
ES2382636T3 (es) * | 2000-10-31 | 2012-06-12 | Surmodics Pharmaceuticals, Inc. | Método para producir composiciones para la administración mejorada de moléculas bioactivas |
ATE309788T1 (de) * | 2000-12-13 | 2005-12-15 | Merckle Gmbh | Mikropartikel mit verbessertem freisetzungsprofil und verfahren zu deren herstellung |
CA2432904C (en) † | 2000-12-21 | 2007-09-11 | Nektar Therapeutics | Induced phase transition method for the production of microparticles containing hydrophobic active agents |
US20020114843A1 (en) * | 2000-12-27 | 2002-08-22 | Ramstack J. Michael | Preparation of microparticles having improved flowability |
WO2002058671A1 (en) * | 2001-01-26 | 2002-08-01 | Debio Recherche Pharmaceutique S.A. | Burst free pharmaceutical microparticules |
US6949251B2 (en) * | 2001-03-02 | 2005-09-27 | Stryker Corporation | Porous β-tricalcium phosphate granules for regeneration of bone tissue |
US20080026068A1 (en) * | 2001-08-16 | 2008-01-31 | Baxter Healthcare S.A. | Pulmonary delivery of spherical insulin microparticles |
DE60226613D1 (de) * | 2001-08-16 | 2008-06-26 | Baxter Int | Darreichungsformen welche mikropartikel und treibgas enthalten |
AU2003262048A1 (en) * | 2002-09-11 | 2004-04-30 | Tanabe Seiyaku Co., Ltd. | Process for the production of microspheres and unit therefor |
US7736391B2 (en) | 2003-02-06 | 2010-06-15 | Tonaba Healthscience Ii, Llc | Cosmetic and reconstructive prostheses with a microencapsulated biologically compatible rupture indicator for sustained release and methods of detecting compromise of a prosthesis |
EP1454630B1 (de) * | 2003-03-04 | 2010-10-20 | The Technology Development Company Ltd. | Injizierbare Insulinzubereitung mit Langzeitwirkung und Verfahren zur dessen Herstellung und Verwendung |
US20070207211A1 (en) * | 2003-04-10 | 2007-09-06 | Pr Pharmaceuticals, Inc. | Emulsion-based microparticles and methods for the production thereof |
WO2005003180A2 (en) * | 2003-04-10 | 2005-01-13 | Pr Pharmaceuticals | A method for the production of emulsion-based micro particles |
US20040224030A1 (en) * | 2003-05-06 | 2004-11-11 | Shastri Venkatram R. | Microsphere delivery systems |
CN102935069A (zh) * | 2003-07-15 | 2013-02-20 | Pr药品有限公司 | 控释组合物的制备方法 |
US20050142205A1 (en) * | 2003-07-18 | 2005-06-30 | Julia Rashba-Step | Methods for encapsulating small spherical particles prepared by controlled phase separation |
US20070092452A1 (en) * | 2003-07-18 | 2007-04-26 | Julia Rashba-Step | Methods for fabrication, uses, compositions of inhalable spherical particles |
EP1646445A4 (de) * | 2003-07-18 | 2007-09-19 | Baxter Int | Verfahren zur herstellung, verwendungen und zusammensetzungen von durch kontrollierte phasentrennung hergestellten kleinen kugelförmigen teilchen |
JP2007508240A (ja) * | 2003-07-22 | 2007-04-05 | バクスター・インターナショナル・インコーポレイテッド | 低分子量有機分子の小球状粒子ならびにその調製方法および使用方法 |
EP2444069B1 (de) * | 2003-07-23 | 2019-06-05 | Evonik Corporation | Zusammensetzung mit kontrollierter Freisetzung |
WO2005021026A2 (en) * | 2003-08-29 | 2005-03-10 | Amylin Pharmaceuticals, Inc. | Methods for treating or ameliorating ghrelin-associated diseases and disorders |
US7309500B2 (en) * | 2003-12-04 | 2007-12-18 | The Board Of Trustees Of The University Of Illinois | Microparticles |
RU2385878C2 (ru) * | 2004-02-11 | 2010-04-10 | Амилин Фармасьютикалз, Инк. | Пептид, обладающий свойствами амилина (варианты), и его применение (варианты) |
US7399744B2 (en) * | 2004-03-04 | 2008-07-15 | Amylin Pharmaceuticals, Inc. | Methods for affecting body composition |
PT1734971E (pt) | 2004-04-15 | 2012-02-02 | Amylin Pharmaceuticals Inc | Dispositivo de libertação sustentada baseado em polímero |
US7456254B2 (en) * | 2004-04-15 | 2008-11-25 | Alkermes, Inc. | Polymer-based sustained release device |
US20060110423A1 (en) * | 2004-04-15 | 2006-05-25 | Wright Steven G | Polymer-based sustained release device |
US20050260272A1 (en) * | 2004-05-05 | 2005-11-24 | Alkermes Controlled Therapeutics, Inc. | Method of forming microparticles that include a bisphosphonate and a polymer |
US8333995B2 (en) | 2004-05-12 | 2012-12-18 | Baxter International, Inc. | Protein microspheres having injectable properties at high concentrations |
DK2072040T3 (da) | 2004-05-12 | 2013-07-29 | Baxter Healthcare Sa | Terapeutisk anvendelse af nukleinsyremikrokugler |
US8728525B2 (en) * | 2004-05-12 | 2014-05-20 | Baxter International Inc. | Protein microspheres retaining pharmacokinetic and pharmacodynamic properties |
CN103432079A (zh) * | 2004-05-12 | 2013-12-11 | 巴克斯特国际公司 | 含有寡核苷酸的微球体及其在制备用于治疗1型糖尿病的药物中的应用 |
US20060073208A1 (en) * | 2004-10-01 | 2006-04-06 | Allergan, Inc. | Cosmetic neurotoxin compositions and methods |
EP1814590B2 (de) | 2004-11-01 | 2013-12-11 | Amylin Pharmaceuticals, Inc. | Behandlung von fettsucht und verbundenen erkrankungen |
US7748343B2 (en) | 2004-11-22 | 2010-07-06 | The Board Of Trustees Of The University Of Illinois | Electrohydrodynamic spraying system |
NZ555533A (en) | 2004-12-13 | 2010-03-26 | Amylin Pharmaceuticals Inc | Pancreatic polypeptide family motifs, polypeptides and methods comprising the same |
EP1679065A1 (de) * | 2005-01-07 | 2006-07-12 | OctoPlus Sciences B.V. | Zubereitung mit kontrollierter Freisetzung von Interferon auf PEGT/PBT-Block-Copolymer-Basis |
WO2006078841A1 (en) * | 2005-01-21 | 2006-07-27 | President And Fellows Of Harvard College | Systems and methods for forming fluidic droplets encapsulated in particles such as colloidal particles |
CA2597649A1 (en) | 2005-02-11 | 2006-08-17 | Amylin Pharmaceuticals, Inc. | Gip analog and hybrid polypeptides with selectable properties |
JP5114381B2 (ja) | 2005-03-31 | 2013-01-09 | アミリン・ファーマシューティカルズ,インコーポレイテッド | 精神疾患および障害治療用アミリンおよびアミリンアゴニスト |
US20060260777A1 (en) * | 2005-04-27 | 2006-11-23 | Julia Rashba-Step | Surface-modified microparticles and methods of forming and using the same |
US8852638B2 (en) | 2005-09-30 | 2014-10-07 | Durect Corporation | Sustained release small molecule drug formulation |
US20070244377A1 (en) * | 2006-03-14 | 2007-10-18 | Cozad Jenny L | Pulse oximeter sleeve |
US20070281031A1 (en) * | 2006-06-01 | 2007-12-06 | Guohan Yang | Microparticles and methods for production thereof |
MX2009001226A (es) | 2006-08-04 | 2009-03-20 | Baxter Int | Composicion basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nuevo inicio. |
US20080248122A1 (en) * | 2006-10-06 | 2008-10-09 | Baxter International Inc. | Microencapsules Containing Surface-Modified Microparticles And Methods Of Forming And Using The Same |
EP2120985B1 (de) | 2007-02-05 | 2012-06-27 | Amylin Pharmaceuticals, Inc. | FN-38 Peptide zur Verwendung bei der Behandlung Psychotischer- und Angsterkrankungen |
JP2010522196A (ja) * | 2007-03-22 | 2010-07-01 | アルカームズ,インコーポレイテッド | コアセルベーション工程 |
CN101801415B (zh) * | 2007-05-25 | 2015-09-23 | Rb医药品有限公司 | 利培酮化合物的持续递送制剂 |
US8137661B2 (en) * | 2007-07-25 | 2012-03-20 | Biolex Therapeutics, Inc. | Controlled release interferon drug products and treatment of HCV infections using same |
JP2011500686A (ja) * | 2007-10-18 | 2011-01-06 | アイコ バイオテクノロジー | オピオイドと中性アンタゴニストを用いる組合せ鎮痛剤 |
US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
US8613951B2 (en) | 2008-06-16 | 2013-12-24 | Bind Therapeutics, Inc. | Therapeutic polymeric nanoparticles with mTor inhibitors and methods of making and using same |
JP2012501965A (ja) | 2008-06-16 | 2012-01-26 | バインド バイオサイエンシズ インコーポレイテッド | 薬剤を装填したポリマーナノ粒子及びその製造方法と使用方法 |
WO2010005725A2 (en) | 2008-06-16 | 2010-01-14 | Bind Biosciences, Inc. | Therapeutic polymeric nanoparticles comprising vinca alkaloids and methods of making and using same |
US8323685B2 (en) | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US20100047292A1 (en) * | 2008-08-20 | 2010-02-25 | Baxter International Inc. | Methods of processing microparticles and compositions produced thereby |
US8367427B2 (en) * | 2008-08-20 | 2013-02-05 | Baxter International Inc. | Methods of processing compositions containing microparticles |
US8323615B2 (en) * | 2008-08-20 | 2012-12-04 | Baxter International Inc. | Methods of processing multi-phasic dispersions |
WO2010075072A2 (en) | 2008-12-15 | 2010-07-01 | Bind Biosciences | Long circulating nanoparticles for sustained release of therapeutic agents |
JP2012515790A (ja) * | 2009-01-23 | 2012-07-12 | サーモディクス ファーマシューティカルズ, インコーポレイテッド | 微粒子製造のための連続二重エマルジョン工程 |
WO2011031996A2 (en) | 2009-09-10 | 2011-03-17 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Engineered microparticles for macromolecule delivery |
US8641900B2 (en) * | 2009-11-05 | 2014-02-04 | Taiwan Biotech Co., Ltd | Method and device for continuously preparing microspheres, and collection unit thereof |
JP5965844B2 (ja) | 2009-12-15 | 2016-08-10 | バインド セラピューティックス インコーポレイテッド | 高いガラス転移温度または高分子量のコポリマーを有する治療用ポリマーナノ粒子組成物 |
USRE49251E1 (en) | 2010-01-04 | 2022-10-18 | Mapi Pharma Ltd. | Depot systems comprising glatiramer or pharmacologically acceptable salt thereof |
WO2011143226A1 (en) | 2010-05-11 | 2011-11-17 | Howmedica Osteonics Corp. | Organophosphorous, multivalent metal compounds, & polymer adhesive interpenetrating network compositions & methods |
US9272044B2 (en) | 2010-06-08 | 2016-03-01 | Indivior Uk Limited | Injectable flowable composition buprenorphine |
GB2481017B (en) | 2010-06-08 | 2015-01-07 | Rb Pharmaceuticals Ltd | Microparticle buprenorphine suspension |
WO2012050925A2 (en) | 2010-09-28 | 2012-04-19 | Amylin Pharmaceuticals, Inc. | Highly soluble leptins |
CN103370083B (zh) | 2010-09-28 | 2016-11-16 | 艾米琳制药有限责任公司 | 具有增强的作用持续时间的工程化多肽 |
US8765189B2 (en) | 2011-05-13 | 2014-07-01 | Howmedica Osteonic Corp. | Organophosphorous and multivalent metal compound compositions and methods |
KR101481859B1 (ko) * | 2011-05-20 | 2015-01-14 | 에스케이케미칼주식회사 | 초기 약물 방출이 감소된 고분자 미립자의 제조방법 및 그 방법에 의해 제조된 고분자 미립자 |
WO2013009545A1 (en) | 2011-07-08 | 2013-01-17 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
WO2013009539A1 (en) | 2011-07-08 | 2013-01-17 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action and reduced immunogenicity |
US9481777B2 (en) | 2012-03-30 | 2016-11-01 | The Procter & Gamble Company | Method of dewatering in a continuous high internal phase emulsion foam forming process |
EP2934562A1 (de) | 2012-08-14 | 2015-10-28 | Wockhardt Limited | Mikropartikuläre pharmazeutische zusammensetzungen aus polypeptiden |
EP2931300A1 (de) | 2012-08-14 | 2015-10-21 | Wockhardt Limited | Mikropartikuläre pharmazeutische zusammensetzungen aus polypeptiden |
RU2015121799A (ru) * | 2012-11-09 | 2017-01-10 | Эвоник Корпорейшн | Способы сушки для регулировки свойств микрочастиц |
EP3010962B2 (de) | 2013-06-20 | 2023-02-08 | Pharmathen S.A. | Herstellung von polylactid-polyglycolid-mikropartikeln mit sigmoidalem freisetzungsprofil |
RU2658004C2 (ru) | 2013-06-20 | 2018-06-19 | Фарматен С.А. | Получение полилактидно-полигликолидных микрочастиц, характеризующихся сигмоидальным профилем высвобождения |
GB201404139D0 (en) | 2014-03-10 | 2014-04-23 | Rb Pharmaceuticals Ltd | Sustained release buprenorphine solution formulations |
WO2015150942A2 (en) | 2014-03-29 | 2015-10-08 | The WOCKHARDT LIMITED | Improved process for preparing microparticles |
US9439864B2 (en) * | 2014-07-07 | 2016-09-13 | Antriabio, Inc. | Solvent extraction from biodegradable microparticles |
CA3015557C (en) | 2014-11-07 | 2019-07-16 | Indivior Uk Limited | The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders |
JP6915540B2 (ja) * | 2015-09-07 | 2021-08-04 | ニプロ株式会社 | リスペリドンを含有するマイクロカプセル、その製造方法および放出制御方法 |
PT3377041T (pt) | 2015-11-16 | 2023-12-15 | Maria Pereira Da Cruz Alves Garcia | Método para morcelação e/ou direcionamento de princípios farmaceuticamente ativos ao tecido sinovial |
WO2017192407A1 (en) | 2016-05-02 | 2017-11-09 | Roman Bielski | Microcapsules for controlled delivery of an active pharmaceutical ingredient |
US11167003B2 (en) | 2017-03-26 | 2021-11-09 | Mapi Pharma Ltd. | Methods for suppressing or alleviating primary or secondary progressive multiple sclerosis (PPMS or SPMS) using sustained release glatiramer depot systems |
US10646484B2 (en) | 2017-06-16 | 2020-05-12 | Indivior Uk Limited | Methods to treat opioid use disorder |
AR115378A1 (es) * | 2018-05-11 | 2021-01-13 | Syngenta Participations Ag | Composición química estabilizada |
EP4125823A1 (de) | 2020-03-30 | 2023-02-08 | Biological E Limited | Risperidon-mikrokugeln, verfahren zu ihrer herstellung und verwendungen davon |
TW202313047A (zh) | 2021-09-21 | 2023-04-01 | 西班牙商禾霏藥品實驗室有限公司 | 抗精神病可注射儲積型組合物 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE634668A (de) | 1962-07-11 | |||
BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
JPS523342B2 (de) | 1972-01-26 | 1977-01-27 | ||
GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
JPS523653A (en) | 1975-06-27 | 1977-01-12 | Fuji Photo Film Co Ltd | Process for producing fine polymer particles |
US4384975A (en) | 1980-06-13 | 1983-05-24 | Sandoz, Inc. | Process for preparation of microspheres |
US4389330A (en) * | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
US4530840A (en) | 1982-07-29 | 1985-07-23 | The Stolle Research And Development Corporation | Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents |
IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
AU2810189A (en) | 1987-10-30 | 1989-05-23 | Stolle Research & Development Corporation | Low residual solvent microspheres and microencapsulation process |
IL92344A0 (en) | 1989-01-04 | 1990-07-26 | Gist Brocades Nv | Microencapsulation of bioactive substances in biocompatible polymers,microcapsules obtained and pharmaceutical preparation comprising said microcapsules |
AU5741590A (en) | 1989-05-04 | 1990-11-29 | Southern Research Institute | Improved encapsulation process and products therefrom |
FR2658432B1 (fr) * | 1990-02-22 | 1994-07-01 | Medgenix Group Sa | Microspheres pour la liberation controlee des substances hydrosolubles et procede de preparation. |
US5478564A (en) * | 1990-02-22 | 1995-12-26 | Teva Pharmaceutical Industries, Ltd. | Preparation of microparticles for controlled release of water-soluble substances |
IT1243390B (it) | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
HU222501B1 (hu) | 1991-06-28 | 2003-07-28 | Endorecherche Inc. | MPA-t vagy MGA-t tartalmazó nyújtott hatóanyag-felszabadulású gyógyászati készítmény és eljárás előállítására |
US6013853A (en) * | 1992-02-14 | 2000-01-11 | The University Of Texas System | Continuous release polymeric implant carrier |
DK0669128T3 (da) | 1992-11-17 | 2000-06-19 | Yoshitomi Pharmaceutical | Sustained-release mikrosfære indeholdende antipsykotikum og fremgangsmåde til at fremstille samme |
JPH09505308A (ja) | 1993-11-19 | 1997-05-27 | アルカーミズ・コントロールド・セラピューティクス・インコーポレイテッド・トゥー | 生物学的活性剤を含有する生分解性微粒子の製造 |
ES2236700T3 (es) | 1993-11-19 | 2005-07-16 | Janssen Pharmaceutica N.V. | 1,2-benzazoles microencapsulados. |
US5650173A (en) * | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
US5904935A (en) | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
US5851538A (en) * | 1995-12-29 | 1998-12-22 | Advanced Polymer Systems, Inc. | Retinoid formulations in porous microspheres for reduced irritation and enhanced stability |
US5792477A (en) * | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
US5945126A (en) | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
GB9718986D0 (en) | 1997-09-09 | 1997-11-12 | Danbiosyst Uk | Controlled release microsphere delivery system |
US6194006B1 (en) * | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
US6306425B1 (en) * | 1999-04-09 | 2001-10-23 | Southern Research Institute | Injectable naltrexone microsphere compositions and their use in reducing consumption of heroin and alcohol |
US6264987B1 (en) * | 2000-05-19 | 2001-07-24 | Alkermes Controlled Therapeutics Inc. Ii | Method for preparing microparticles having a selected polymer molecular weight |
-
1998
- 1998-12-30 US US09/223,276 patent/US6194006B1/en not_active Expired - Lifetime
-
1999
- 1999-12-10 AU AU31178/00A patent/AU759214B2/en not_active Expired
- 1999-12-10 JP JP2000591978A patent/JP4694694B2/ja not_active Expired - Lifetime
- 1999-12-10 DE DE69928283T patent/DE69928283T2/de not_active Expired - Lifetime
- 1999-12-10 WO PCT/US1999/029349 patent/WO2000040221A1/en active IP Right Grant
- 1999-12-10 AT AT99965212T patent/ATE308977T1/de active
- 1999-12-10 EP EP99965212A patent/EP1140029B1/de not_active Expired - Lifetime
- 1999-12-10 CA CA002352818A patent/CA2352818C/en not_active Expired - Lifetime
- 1999-12-10 ES ES99965212T patent/ES2251850T3/es not_active Expired - Lifetime
- 1999-12-10 DK DK99965212T patent/DK1140029T3/da active
-
2000
- 2000-11-28 US US09/722,335 patent/US6379703B1/en not_active Expired - Lifetime
-
2002
- 2002-01-31 US US10/059,115 patent/US6596316B2/en not_active Expired - Lifetime
-
2003
- 2003-05-12 US US10/435,586 patent/US20030203039A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CA2352818C (en) | 2009-04-14 |
EP1140029A1 (de) | 2001-10-10 |
AU3117800A (en) | 2000-07-24 |
US6596316B2 (en) | 2003-07-22 |
US6379703B1 (en) | 2002-04-30 |
CA2352818A1 (en) | 2000-07-13 |
US20030203039A1 (en) | 2003-10-30 |
EP1140029B1 (de) | 2005-11-09 |
WO2000040221A1 (en) | 2000-07-13 |
DE69928283D1 (de) | 2005-12-15 |
US6194006B1 (en) | 2001-02-27 |
JP4694694B2 (ja) | 2011-06-08 |
DK1140029T3 (da) | 2006-02-13 |
AU759214B2 (en) | 2003-04-10 |
ES2251850T3 (es) | 2006-05-01 |
US20030003156A1 (en) | 2003-01-02 |
JP2002534372A (ja) | 2002-10-15 |
DE69928283T2 (de) | 2006-08-10 |
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