ATE268353T1 - Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat - Google Patents
Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantatInfo
- Publication number
- ATE268353T1 ATE268353T1 AT00909859T AT00909859T ATE268353T1 AT E268353 T1 ATE268353 T1 AT E268353T1 AT 00909859 T AT00909859 T AT 00909859T AT 00909859 T AT00909859 T AT 00909859T AT E268353 T1 ATE268353 T1 AT E268353T1
- Authority
- AT
- Austria
- Prior art keywords
- antioxidant
- produced therefrom
- implant produced
- uhmwpe doped
- producing uhmwpe
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/20—Compounding polymers with additives, e.g. colouring
- C08J3/205—Compounding polymers with additives, e.g. colouring in the presence of a continuous liquid phase
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/15—Heterocyclic compounds having oxygen in the ring
- C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
- C08K5/1545—Six-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
- C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
- C08J2323/04—Homopolymers or copolymers of ethene
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Materials For Medical Uses (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9900519A SE9900519D0 (sv) | 1999-02-17 | 1999-02-17 | A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof |
PCT/SE2000/000314 WO2000049079A1 (en) | 1999-02-17 | 2000-02-17 | A method for the preparation of uhmwpe doped with an antioxidant and an implant made thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE268353T1 true ATE268353T1 (de) | 2004-06-15 |
Family
ID=20414490
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00909859T ATE268353T1 (de) | 1999-02-17 | 2000-02-17 | Verfahren zur herstellung von mit antioxidant gedoptem uhmwpe und daraus hergestelltes implantat |
Country Status (7)
Country | Link |
---|---|
US (1) | US6448315B1 (de) |
EP (1) | EP1161489B1 (de) |
AT (1) | ATE268353T1 (de) |
AU (1) | AU3203800A (de) |
DE (1) | DE60011243T2 (de) |
SE (1) | SE9900519D0 (de) |
WO (1) | WO2000049079A1 (de) |
Families Citing this family (87)
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WO2001080778A1 (en) | 2000-04-27 | 2001-11-01 | The Orthopaedic Hospital | Oxidation-resistant and wear-resistant polyethylenes for human joint replacements and methods for making them |
WO2002026464A1 (en) * | 2000-09-29 | 2002-04-04 | Depuy Orthopaedics, Inc. | Supercritical fluid treatment of irradiated polyethylene |
WO2003000751A1 (en) * | 2001-05-10 | 2003-01-03 | Bittner George D | Endocrine disruptive chemical free additives and method |
US7160492B2 (en) * | 2001-12-12 | 2007-01-09 | Depuy Products, Inc. | Orthopaedic device for implantation in the body of an animal and method for making the same |
US7819925B2 (en) * | 2002-01-28 | 2010-10-26 | Depuy Products, Inc. | Composite prosthetic bearing having a crosslinked articulating surface and method for making the same |
AU2003245420A1 (en) * | 2002-06-21 | 2004-01-06 | Massachusetts General Hospital | Metal back or mesh crosslinking |
US7431874B2 (en) | 2003-01-16 | 2008-10-07 | Massachusetts General Hospital | Methods for making oxidation resistant polymeric material |
AT412969B (de) * | 2003-05-19 | 2005-09-26 | Klaus Dr Lederer | Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe) |
US7214764B2 (en) | 2003-06-30 | 2007-05-08 | Depuy Products, Inc. | Free radical quench process for irradiated ultrahigh molecular weight polyethylene |
EP1720485B8 (de) * | 2004-02-03 | 2016-10-12 | The General Hospital Corporation | Hochkristallines vernetztes oxidationsresistentes polyethylen |
EP1750614B1 (de) | 2004-05-11 | 2017-09-27 | The General Hospital Corporation | Verfahren zur herstellung von oxidationsbeständigem polymermaterial |
US7344672B2 (en) | 2004-10-07 | 2008-03-18 | Biomet Manufacturing Corp. | Solid state deformation processing of crosslinked high molecular weight polymeric materials |
US7335697B2 (en) * | 2004-12-23 | 2008-02-26 | Depuy Products, Inc. | Polymer composition comprising cross-linked polyethylene and methods for making the same |
AU2006247099A1 (en) * | 2005-05-18 | 2006-11-23 | The General Hospital Corporation Dba Massachusetts General Hospital | Hydrogels and hydrogel particles |
AU2006259555B2 (en) * | 2005-06-14 | 2011-03-03 | Omni Life Science, Inc. | Crosslinked polyethylene article |
US20090062909A1 (en) * | 2005-07-15 | 2009-03-05 | Micell Technologies, Inc. | Stent with polymer coating containing amorphous rapamycin |
EP1909973B1 (de) | 2005-07-15 | 2018-08-22 | Micell Technologies, Inc. | Polymer-überzüge mit einem arzneipulver mit kontrollierter morphologie |
DE602005017949D1 (de) * | 2005-08-18 | 2010-01-07 | Zimmer Gmbh | Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln |
AU2012203503B2 (en) * | 2005-08-18 | 2014-01-30 | Zimmer Gmbh | Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles |
EP2441780A1 (de) * | 2005-08-22 | 2012-04-18 | The General Hospital Corporation d/b/a Massachusetts General Hospital | Hochkristallines Polyethylen |
ATE529464T1 (de) * | 2005-08-22 | 2011-11-15 | Gen Hospital Corp Dba Massachusetts General Hospital | Oxidationsbeständiges homogenisiertes polymermaterial |
US8343230B2 (en) * | 2005-09-22 | 2013-01-01 | Depuy Products, Inc. | Orthopaedic bearing material |
US20070077268A1 (en) * | 2005-09-30 | 2007-04-05 | Depuy Products, Inc. | Hydrophobic carrier modified implants for beneficial agent delivery |
WO2007106582A2 (en) * | 2006-03-15 | 2007-09-20 | Promethean Lifesciences, Inc. | Preparation and storage of stable, biologically active materials |
US8425614B2 (en) * | 2006-03-20 | 2013-04-23 | Biomet Manufacturing Corp. | Modular center pegged glenoid |
US7812098B2 (en) | 2006-03-31 | 2010-10-12 | Depuy Products, Inc. | Bearing material of medical implant having reduced wear rate and method for reducing wear rate |
CA2996768C (en) | 2006-04-26 | 2020-12-08 | Micell Technologies, Inc. | Coatings containing multiple drugs |
ES2350708T3 (es) * | 2006-08-25 | 2011-01-26 | Depuy Products, Inc. | Material de soporte de implante médico. |
WO2008042909A2 (en) | 2006-10-02 | 2008-04-10 | Micell Technologies Inc. | Surgical sutures having increased strength |
US9539593B2 (en) | 2006-10-23 | 2017-01-10 | Micell Technologies, Inc. | Holder for electrically charging a substrate during coating |
CN101711137B (zh) | 2007-01-08 | 2014-10-22 | 米歇尔技术公司 | 具有可生物降解层的支架 |
US11426494B2 (en) | 2007-01-08 | 2022-08-30 | MT Acquisition Holdings LLC | Stents having biodegradable layers |
CA2674955C (en) * | 2007-01-25 | 2015-05-26 | The General Hospital Corporation | Methods for making oxidation-resistant cross-linked polymeric materials |
DE102007006086B4 (de) | 2007-02-07 | 2009-12-03 | Kisielinski, Kajetan Stefan, Dr. med. | Vorrichtung und Verfahren zum Erfassen des Verschleißes eines Implantatwerkstoffes und ein entsprechend hergestelltes Implantat |
JP2010529213A (ja) * | 2007-03-02 | 2010-08-26 | ザ・ジェネラル・ホスピタル・コーポレイション | 酸化防止剤含有ポリマーの架橋 |
EP2125907B1 (de) * | 2007-03-20 | 2012-11-21 | Smith & Nephew Orthopaedics AG | Oxidationsbeständiges hochvernetztes uhmwpe |
US8664290B2 (en) | 2007-04-10 | 2014-03-04 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
US20080319137A1 (en) * | 2007-04-10 | 2008-12-25 | Zimmer, Inc. | Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
AU2014274546B2 (en) * | 2007-04-10 | 2016-06-02 | Zimmer, Inc. | An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications |
AU2008256684B2 (en) | 2007-05-25 | 2012-06-14 | Micell Technologies, Inc. | Polymer films for medical device coating |
US8641959B2 (en) | 2007-07-27 | 2014-02-04 | Biomet Manufacturing, Llc | Antioxidant doping of crosslinked polymers to form non-eluting bearing components |
US8546460B2 (en) * | 2007-09-04 | 2013-10-01 | Smith & Nephew, Inc. | Ultra high molecular weight polyethylene for bearing surfaces |
WO2009048456A1 (en) * | 2007-10-12 | 2009-04-16 | Peak Plastic & Metal Products (International) Limited | Wafer container with staggered wall structure |
EP2249887B1 (de) | 2008-01-30 | 2017-06-21 | Zimmer, Inc. | Orthopädischer bestandteil geringer steifheit |
EA020655B1 (ru) | 2008-04-17 | 2014-12-30 | Миселл Текнолоджиз, Инк. | Стенты, имеющие биорассасывающиеся слои |
CA2723929A1 (en) * | 2008-05-13 | 2009-11-19 | Smith & Nephew Orthopaedics Ag | Oxidation resistant highly-crosslinked uhmwpe |
JP5311457B2 (ja) * | 2008-06-20 | 2013-10-09 | ナカシマメディカル株式会社 | 人工関節用摺動部材の成形方法及びこの方法によって成形された人工関節用摺動部材 |
DE102008047009B4 (de) | 2008-07-11 | 2020-08-06 | Mathys Ag Bettlach | Gelenkpfanne mit physiologischer Lastübertragung |
CN102159257B (zh) | 2008-07-17 | 2015-11-25 | 米歇尔技术公司 | 药物递送医疗设备 |
US20100022678A1 (en) * | 2008-07-24 | 2010-01-28 | Zimmer, Inc. | Reduction of free radicals in crosslinked polyethylene by infrared heating |
US8133436B2 (en) * | 2008-08-05 | 2012-03-13 | Howmedica Osteonics Corp. | Polyethylene cross-linked with an anthocyanin |
DE102008053793A1 (de) | 2008-10-21 | 2010-04-22 | Aesculap Ag | Antioxidativ wirksames, synthetisches Polymermaterial |
WO2010057644A1 (en) * | 2008-11-20 | 2010-05-27 | Zimmer Gmbh | Polyethylene materials |
US8834913B2 (en) | 2008-12-26 | 2014-09-16 | Battelle Memorial Institute | Medical implants and methods of making medical implants |
US8933145B2 (en) | 2009-02-20 | 2015-01-13 | The General Hospital Corporation | High temperature melting |
WO2010117752A1 (en) * | 2009-03-31 | 2010-10-14 | Zimmer, Inc. | Surface modification of ultrahigh molecular weight polyethylene |
US9981072B2 (en) | 2009-04-01 | 2018-05-29 | Micell Technologies, Inc. | Coated stents |
WO2010121187A2 (en) | 2009-04-17 | 2010-10-21 | Micell Techologies, Inc. | Stents having controlled elution |
DE102009023651B4 (de) | 2009-05-26 | 2021-07-01 | Aesculap Ag | Verfahren zur Herstellung eines mit einem Stabilisator dotierten Polyethylens und Verwendung eines nach diesem Verfahren hergestellten Polyethylens |
EP2453834A4 (de) | 2009-07-16 | 2014-04-16 | Micell Technologies Inc | Medizinische wirkstofffreisetzungsvorrichtung |
GB0922339D0 (en) | 2009-12-21 | 2010-02-03 | Mcminn Derek J W | Acetabular cup prothesis and introducer thereof |
EP2531140B1 (de) | 2010-02-02 | 2017-11-01 | Micell Technologies, Inc. | Stent und stenteinsatzsystem mit verbesserter einsetzbarkeit |
US8795762B2 (en) | 2010-03-26 | 2014-08-05 | Battelle Memorial Institute | System and method for enhanced electrostatic deposition and surface coatings |
US10232092B2 (en) | 2010-04-22 | 2019-03-19 | Micell Technologies, Inc. | Stents and other devices having extracellular matrix coating |
US8399535B2 (en) | 2010-06-10 | 2013-03-19 | Zimmer, Inc. | Polymer [[s]] compositions including an antioxidant |
CA2805631C (en) | 2010-07-16 | 2018-07-31 | Micell Technologies, Inc. | Drug delivery medical device |
US8858979B1 (en) | 2011-01-28 | 2014-10-14 | Clemson University | Service induced byproducts for localized drug delivery in orthopaedic implants |
US10464100B2 (en) | 2011-05-31 | 2019-11-05 | Micell Technologies, Inc. | System and process for formation of a time-released, drug-eluting transferable coating |
US20130018476A1 (en) | 2011-07-13 | 2013-01-17 | Biomet Manufacturing Corp. | Shoulder prosthesis |
US8506638B2 (en) | 2011-07-13 | 2013-08-13 | Biomets Manufacturing, LLC | Shoulder prosthesis |
US10117972B2 (en) | 2011-07-15 | 2018-11-06 | Micell Technologies, Inc. | Drug delivery medical device |
US10188772B2 (en) | 2011-10-18 | 2019-01-29 | Micell Technologies, Inc. | Drug delivery medical device |
US9889224B2 (en) * | 2012-08-06 | 2018-02-13 | The General Hospital Corporation | Spatial control of additives by high temperature |
KR20150143476A (ko) | 2013-03-12 | 2015-12-23 | 미셀 테크놀로지즈, 인코포레이티드 | 생흡수성 생체의학적 임플란트 |
JP2016519965A (ja) | 2013-05-15 | 2016-07-11 | マイセル・テクノロジーズ,インコーポレイテッド | 生体吸収性バイオメディカルインプラント |
US9586370B2 (en) | 2013-08-15 | 2017-03-07 | Biomet Manufacturing, Llc | Method for making ultra high molecular weight polyethylene |
WO2015050851A1 (en) | 2013-10-01 | 2015-04-09 | Zimmer, Inc. | Polymer compositions comprising one or more protected antioxidants |
WO2015057943A2 (en) * | 2013-10-17 | 2015-04-23 | The General Hospital Corporation | Peroxide cross-linking and high temperature melting |
EP3116941A1 (de) | 2014-03-12 | 2017-01-18 | Zimmer, Inc. | Schmelzstabilisiertes polyethylen mit ultrahohem molekulargewicht und verfahren zu seiner herstellung |
US9707314B2 (en) * | 2014-03-26 | 2017-07-18 | DePuy Synthes Products, Inc. | Acrylic bone cement having a delayed release polymerization inhibitor such as an anti-oxidant for increased working time |
AU2015358476B2 (en) | 2014-12-03 | 2019-08-15 | Zimmer, Inc. | Antioxidant-infused ultra high molecular weight polyethylene |
CZ2015267A3 (cs) | 2015-04-21 | 2016-11-09 | Ústav makromolekulární chemie AV ČR, v. v. i. | Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty |
WO2017181164A1 (en) | 2016-04-15 | 2017-10-19 | The General Hospital Corporation | Systems and methods of radioprotection of allografts |
US11667762B2 (en) | 2017-08-29 | 2023-06-06 | The General Hospital Corporation | UV-initiated reactions in polymeric materials |
CN110448723B (zh) * | 2019-07-12 | 2022-04-05 | 四川大学 | 协同抗氧型高交联超高分子量聚乙烯人工关节材料及其制备方法 |
AU2021200854A1 (en) | 2020-03-03 | 2021-09-16 | Howmedica Osteonics Corp. | Glenoid implant with additively manufactured fixation posts |
US11970600B2 (en) | 2021-03-31 | 2024-04-30 | The General Hospital Corporation | Di-cumyl peroxide crosslinking of UHMWPE |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CS221404B1 (cs) * | 1981-12-23 | 1983-04-29 | Bretislav Dolezel | Způsob stabilizace polyolefinů pro dosažení zvýšené odolnosti proti biologické degradaci v organismu |
US4439420A (en) | 1982-11-16 | 1984-03-27 | Ethicon, Inc. | Absorbable hemostatic composition |
GB8724897D0 (en) | 1987-10-23 | 1987-11-25 | Downes S | Material |
SE464912B (sv) | 1989-10-25 | 1991-07-01 | Bioapatite Ab | Implantationsmaterial foer aaterstaellning av benvaevnad samt saett foer dess tillverkning |
US5236456A (en) | 1989-11-09 | 1993-08-17 | Osteotech, Inc. | Osteogenic composition and implant containing same |
DE4306593A1 (de) * | 1993-03-03 | 1994-09-08 | Hoechst Ag | Stabilisierte Formmasse aus Polyethylen, ein Verfahren zur Herstellung und Verwendung |
DE4433201A1 (de) | 1994-09-17 | 1996-03-21 | Merck Patent Gmbh | Verfahren zur Herstellung von wirkstoffhaltigen Knochenzementen |
US5844027A (en) | 1996-05-03 | 1998-12-01 | Ciba Specialty Chemicals Corporation | Stabilizer composition for thermoplastic materials |
US5827904A (en) | 1996-09-27 | 1998-10-27 | Hahn; David | Medical implant composition |
IT1289935B1 (it) * | 1997-02-20 | 1998-10-19 | Great Lakes Chemical Italia | Forma solida di uno stabilizzante per polimeri organici |
SE9802528D0 (sv) | 1998-07-13 | 1998-07-13 | Gs Dev Ab | Bone tissue restoring composition |
WO2000007639A1 (en) | 1998-08-07 | 2000-02-17 | Tissue Engineering, Inc. | Bone precursor compositions |
EP0995449A1 (de) * | 1998-10-21 | 2000-04-26 | Sulzer Orthopädie AG | UHMW-Polyethylen für Implantate |
-
1999
- 1999-02-17 SE SE9900519A patent/SE9900519D0/xx unknown
-
2000
- 2000-02-17 DE DE60011243T patent/DE60011243T2/de not_active Expired - Lifetime
- 2000-02-17 AT AT00909859T patent/ATE268353T1/de not_active IP Right Cessation
- 2000-02-17 WO PCT/SE2000/000314 patent/WO2000049079A1/en active IP Right Grant
- 2000-02-17 US US09/890,077 patent/US6448315B1/en not_active Expired - Lifetime
- 2000-02-17 EP EP00909859A patent/EP1161489B1/de not_active Expired - Lifetime
- 2000-02-17 AU AU32038/00A patent/AU3203800A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US6448315B1 (en) | 2002-09-10 |
EP1161489A1 (de) | 2001-12-12 |
SE9900519D0 (sv) | 1999-02-17 |
AU3203800A (en) | 2000-09-04 |
DE60011243T2 (de) | 2005-06-23 |
DE60011243D1 (de) | 2004-07-08 |
EP1161489B1 (de) | 2004-06-02 |
WO2000049079A1 (en) | 2000-08-24 |
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