DE602005017949D1 - Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln - Google Patents

Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln

Info

Publication number
DE602005017949D1
DE602005017949D1 DE602005017949T DE602005017949T DE602005017949D1 DE 602005017949 D1 DE602005017949 D1 DE 602005017949D1 DE 602005017949 T DE602005017949 T DE 602005017949T DE 602005017949 T DE602005017949 T DE 602005017949T DE 602005017949 D1 DE602005017949 D1 DE 602005017949D1
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DE
Germany
Prior art keywords
ultra
molecular polyethylene
uhmwpe
polyethylene articles
blend
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005017949T
Other languages
English (en)
Inventor
Niels A Abt
Werner Schneider-Storrer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zimmer GmbH
Original Assignee
Zimmer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36499465&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE602005017949(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Zimmer GmbH filed Critical Zimmer GmbH
Publication of DE602005017949D1 publication Critical patent/DE602005017949D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/28—Treatment by wave energy or particle radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A61K31/355—Tocopherols, e.g. vitamin E
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/505—Stabilizers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J7/00—Chemical treatment or coating of shaped articles made of macromolecular substances
    • C08J7/12—Chemical modification
    • C08J7/123—Treatment by wave energy or particle radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/04—Oxygen-containing compounds
    • C08K5/15—Heterocyclic compounds having oxygen in the ring
    • C08K5/151—Heterocyclic compounds having oxygen in the ring having one oxygen atom in the ring
    • C08K5/1545—Six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C08L23/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2323/00—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers
    • C08J2323/02—Characterised by the use of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Derivatives of such polymers not modified by chemical after treatment
    • C08J2323/04—Homopolymers or copolymers of ethene
    • C08J2323/06—Polyethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
    • C08K5/00—Use of organic ingredients
    • C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
    • C08K5/005—Stabilisers against oxidation, heat, light, ozone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2205/00—Polymer mixtures characterised by other features
    • C08L2205/02—Polymer mixtures characterised by other features containing two or more polymers of the same C08L -group
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2207/00—Properties characterising the ingredient of the composition
    • C08L2207/06—Properties of polyethylene
    • C08L2207/068—Ultra high molecular weight polyethylene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L23/00—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers
    • C08L23/02—Compositions of homopolymers or copolymers of unsaturated aliphatic hydrocarbons having only one carbon-to-carbon double bond; Compositions of derivatives of such polymers not modified by chemical after-treatment
    • C08L23/04—Homopolymers or copolymers of ethene
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2312/00—Crosslinking
    • C08L2312/06—Crosslinking by radiation
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2314/00—Polymer mixtures characterised by way of preparation
    • C08L2314/02—Ziegler natta catalyst
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/26—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension
    • Y10T428/269—Web or sheet containing structurally defined element or component, the element or component having a specified physical dimension including synthetic resin or polymer layer or component

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Materials For Medical Uses (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Manufacture Of Macromolecular Shaped Articles (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE602005017949T 2005-08-18 2005-08-18 Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln Active DE602005017949D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/EP2005/008967 WO2007019874A1 (en) 2005-08-18 2005-08-18 Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles

Publications (1)

Publication Number Publication Date
DE602005017949D1 true DE602005017949D1 (de) 2010-01-07

Family

ID=36499465

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005017949T Active DE602005017949D1 (de) 2005-08-18 2005-08-18 Ultrahochmolekulare polyethylen-artikel und verfahren zur herstellung von ultrahochmolekularen polyethylen-artikeln

Country Status (9)

Country Link
US (6) US7846376B2 (de)
EP (6) EP2792373B1 (de)
JP (1) JP5314423B2 (de)
AT (1) ATE449618T1 (de)
AU (1) AU2005335669B2 (de)
CA (1) CA2619502C (de)
DE (1) DE602005017949D1 (de)
ES (4) ES2334045T3 (de)
WO (1) WO2007019874A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004064618A2 (en) 2003-01-16 2004-08-05 Massachusetts General Hospital Methods for making oxidation resistant polymeric material
EP2792373B1 (de) 2005-08-18 2017-03-01 Zimmer GmbH Polyethylenartikel mit ultrahohem Molekulargewicht und Verfahren zur Herstellung von Polyethylenartikeln
US7923020B2 (en) * 2006-09-29 2011-04-12 Depuy Products, Inc. Composite for implantation in the body of an animal and method for making the same
CA2674955C (en) 2007-01-25 2015-05-26 The General Hospital Corporation Methods for making oxidation-resistant cross-linked polymeric materials
AU2008222967B2 (en) * 2007-03-02 2012-12-13 Cambridge Polymer Group, Inc. Cross-linking of antioxidant-containing polymers
JP2010521566A (ja) * 2007-03-20 2010-06-24 スミス アンド ネフュー オーソペディックス アーゲー 高度に架橋した耐酸化性超高分子量ポリエチレン
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2013200780B2 (en) * 2007-04-10 2015-01-22 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
AU2014274546B2 (en) * 2007-04-10 2016-06-02 Zimmer, Inc. An antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
ATE544476T1 (de) 2007-04-10 2012-02-15 Zimmer Inc Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
US8641959B2 (en) 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
WO2009032909A2 (en) 2007-09-04 2009-03-12 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
CA2712559C (en) * 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
RU2495054C2 (ru) 2008-05-13 2013-10-10 Смит Энд Нефью Ортопедикс Аг Устойчивый к окислению высокосшитый сверхвысокомолекулярный полиэтилен
WO2009158318A1 (en) 2008-06-27 2009-12-30 Zimmer, Inc. Acl accommodating tibial design
GB0812890D0 (en) * 2008-07-11 2008-08-20 Smith & Nephew Orthopaedics Ag Compositions and methods of making compositions
US8133436B2 (en) 2008-08-05 2012-03-13 Howmedica Osteonics Corp. Polyethylene cross-linked with an anthocyanin
CN102307945B (zh) 2008-11-20 2015-07-01 捷迈有限责任公司 聚乙烯材料
WO2010096053A1 (en) 2009-02-19 2010-08-26 Smith & Nephew Orthopaedics Ag Medical implant producing wear particles with benign body response
US8933145B2 (en) 2009-02-20 2015-01-13 The General Hospital Corporation High temperature melting
CN102405252B (zh) * 2009-03-31 2014-07-02 捷迈有限公司 超高分子量聚乙烯的表面改性
ES2617186T3 (es) 2009-05-04 2017-06-15 Smith & Nephew, Inc Efectos sinérgicos de mezclar múltiples aditivos en UHMWPE
US20120070600A1 (en) * 2009-05-20 2012-03-22 Muratoglu Orhun K Metods of preventing oxidation
US8968411B2 (en) * 2009-12-17 2015-03-03 Zimmer, Inc. Modular elbow prosthesis
GB0922339D0 (en) 2009-12-21 2010-02-03 Mcminn Derek J W Acetabular cup prothesis and introducer thereof
US8399535B2 (en) 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
US20120109301A1 (en) 2010-11-03 2012-05-03 Zimmer, Inc. Modified Polymeric Materials And Methods Of Modifying Polymeric Materials
US20140024736A1 (en) 2010-11-03 2014-01-23 Zimmer, Inc. Polymer articles having chemically bonded agents and methods of making the same
DK2649122T3 (en) 2010-12-10 2016-12-19 Dsm Ip Assets Bv Hppe element and method of producing a hppe element
US8747479B2 (en) 2011-04-26 2014-06-10 Michael A. McShane Tibial component
ITVR20110196A1 (it) * 2011-10-21 2013-04-22 Luigi Costa Metodo per la realizzazione di un dispositivo medicale, quale una protesi, in polietilene
CN102604188B (zh) * 2012-03-02 2014-02-05 中国科学院宁波材料技术与工程研究所 一种抗氧化交联聚合物及其制备方法
US8936647B2 (en) 2012-06-22 2015-01-20 Zimmer, Inc. Elbow prosthesis
US10201374B2 (en) 2012-06-22 2019-02-12 Zimmer, Inc. Assembly tool for a prosthesis
JP6004225B2 (ja) * 2012-09-04 2016-10-05 帝人ナカシマメディカル株式会社 成形品の製造方法
WO2014058003A1 (ja) * 2012-10-11 2014-04-17 国立大学法人京都工芸繊維大学 成形品の製造方法
US10577440B2 (en) 2013-03-13 2020-03-03 Chevron Phillips Chemical Company Lp Radically coupled resins and methods of making and using same
US10654948B2 (en) 2013-03-13 2020-05-19 Chevron Phillips Chemical Company Lp Radically coupled resins and methods of making and using same
WO2015050851A1 (en) 2013-10-01 2015-04-09 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
CA2927056A1 (en) 2013-10-17 2015-04-23 The General Hospital Corporation Peroxide cross-linking and high temperature melting
AU2015229947A1 (en) 2014-03-12 2016-10-27 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
US9757243B2 (en) 2014-07-08 2017-09-12 Zimmer, Inc. Intercondylar component and fin attachment features for use in knee arthroplasty
AU2015358476B2 (en) 2014-12-03 2019-08-15 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
WO2016145025A1 (en) 2015-03-12 2016-09-15 Zimmer, Inc. Tibial implant for use in knee arthroplasty
CZ2015267A3 (cs) * 2015-04-21 2016-11-09 Ústav makromolekulární chemie AV ČR, v. v. i. Směs pro stabilizaci polyethylenu, polyethylen a způsob jeho přípravy, polyethylenové implantáty
US10323225B2 (en) 2015-10-20 2019-06-18 Locus Solutions Apparatus, systems and methods for growing microorganisms
EP3373990A1 (de) * 2015-11-12 2018-09-19 The General Hospital Corporation Verfahren zur herstellung eines therapeutischen polymermaterials
DE102016116597A1 (de) 2016-09-06 2018-03-08 Aesculap Ag Verfahren zur Herstellung eines vernetzten Formkörpers aus UHMWPE
WO2019046243A2 (en) 2017-08-29 2019-03-07 The General Hospital Corporation UV-INITIATED REACTIONS IN POLYMERIC MATERIALS
CN110194889B (zh) * 2018-02-27 2022-11-15 嘉丰工业科技（惠州）有限公司 一种制备抗微生物附着的改性热塑性塑料及产品的方法及用于制备改性热塑性塑料的组合物
US11970600B2 (en) 2021-03-31 2024-04-30 The General Hospital Corporation Di-cumyl peroxide crosslinking of UHMWPE

Family Cites Families (130)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010A (en) * 1858-04-20 Bit-holder
JPS5284258A (en) 1976-01-01 1977-07-13 Toyo Contact Lens Co Ltd Silicone having hydrophilized surface and contact lens consisted of said silicone
CS221405B1 (cs) 1981-12-23 1983-04-29 Ludmila Adamirova Způsob zdravotně nezávadné stabilizace polyolefinů proti degradaci ionizujícím zářením
CS221403B1 (cs) 1981-12-23 1983-04-29 Bretislav Dolezel Způsob zdravotně nezávadné stabilizace polyolefinů proti termooxidační a fotooxidační degradaci
JPH02504333A (ja) 1986-01-14 1990-12-06 レイケム・コーポレイション 導電性ポリマー組成物
US5308549A (en) 1991-11-12 1994-05-03 Hoffmann-La Roche Inc. Stabilizers for thermo plastic materials
US5282861A (en) 1992-03-11 1994-02-01 Ultramet Open cell tantalum structures for cancellous bone implants and cell and tissue receptors
US5414049A (en) * 1993-06-01 1995-05-09 Howmedica Inc. Non-oxidizing polymeric medical implant
US5559167A (en) 1993-07-22 1996-09-24 General Electric Company Gamma irradiated thermoplastics and articles
WO1995006148A1 (en) * 1993-08-20 1995-03-02 Smith & Nephew Richards, Inc. Self-reinforced ultra-high molecular weight polyethylene composites
TW317568B (de) 1994-04-13 1997-10-11 Ciba Sc Holding Ag
US20050125074A1 (en) * 1995-01-20 2005-06-09 Ronald Salovey Crosslinking of polyethylene for low wear using radiation and thermal treatments
CA2166450C (en) * 1995-01-20 2008-03-25 Ronald Salovey Chemically crosslinked ultrahigh molecular weight polyethylene for artificial human joints
US5879398A (en) 1995-02-14 1999-03-09 Zimmer, Inc. Acetabular cup
US5577368A (en) * 1995-04-03 1996-11-26 Johnson & Johnson Professional, Inc. Method for improving wear resistance of polymeric bioimplantable components
US6087559A (en) * 1995-06-07 2000-07-11 Pioneer Hi-Bred International, Inc. Plant cells and plants transformed with Streptococcus mutans genes encoding wild-type or mutant glucosyltransferase B enzymes
DE69623308T2 (de) 1995-10-18 2002-12-19 Chisso Corp Olefin(co)polymerzusammensetzung, verfahren zu dessen herstellung, katalysator for olefin(co)polymerisation und verfahren zu dessen herstellung
US6437048B1 (en) * 1995-12-01 2002-08-20 Chisso Corporation Molded resin articles
US5827104A (en) * 1996-01-11 1998-10-27 Patent Category Corporation Constructional toy pieces
US8865788B2 (en) * 1996-02-13 2014-10-21 The General Hospital Corporation Radiation and melt treated ultra high molecular weight polyethylene prosthetic devices
EP1563857A3 (de) 1996-02-13 2008-06-04 Massachusetts Institute Of Technology Bestrahlte und Schmeltz behandelte ultrahoch molekulare Polyethylen Prothesen
US8563623B2 (en) * 1996-02-13 2013-10-22 The General Hospital Corporation Radiation melt treated ultra high molecular weight polyethylene prosthetic devices
US20020156536A1 (en) 1996-02-13 2002-10-24 Harris William H. Polyethylene hip joint prosthesis with extended range of motion
US5879400A (en) * 1996-02-13 1999-03-09 Massachusetts Institute Of Technology Melt-irradiated ultra high molecular weight polyethylene prosthetic devices
US5753182A (en) * 1996-02-14 1998-05-19 Biomet, Inc. Method for reducing the number of free radicals present in ultrahigh molecular weight polyethylene orthopedic components
US5721334A (en) * 1996-02-16 1998-02-24 Newyork Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery Process for producing ultra-high molecular weight low modulus polyethylene shaped articles via controlled pressure and temperature and compositions and articles produced therefrom
US6087553A (en) * 1996-02-26 2000-07-11 Implex Corporation Implantable metallic open-celled lattice/polyethylene composite material and devices
EP1795212A3 (de) 1996-07-09 2007-09-05 Orthopaedic Hospital Vernetzung von Polyethylen für geringen Verschleiss mit Hilfe von Strahlen- und Wärmebehandlung
US6228900B1 (en) * 1996-07-09 2001-05-08 The Orthopaedic Hospital And University Of Southern California Crosslinking of polyethylene for low wear using radiation and thermal treatments
GB9617671D0 (en) * 1996-08-23 1996-10-02 Microbiological Res Authority Recombinant toxin fragments
US5827904A (en) * 1996-09-27 1998-10-27 Hahn; David Medical implant composition
US6017975A (en) 1996-10-02 2000-01-25 Saum; Kenneth Ashley Process for medical implant of cross-linked ultrahigh molecular weight polyethylene having improved balance of wear properties and oxidation resistance
AU4986497A (en) 1996-10-15 1998-05-11 Orthopaedic Hospital, The Wear resistant surface-gradient cross-linked polyethylene
US6231804B1 (en) * 1997-04-02 2001-05-15 Chisso Corporation Modified olefin (co)polymer composition, process for preparing the same, and modified olefin (co)polymer composition molding
JP4315261B2 (ja) 1998-02-25 2009-08-19 ナカシマメディカル株式会社 人工関節用摺動部材および製造方法
US6692679B1 (en) * 1998-06-10 2004-02-17 Depuy Orthopaedics, Inc. Cross-linked molded plastic bearings
JP2002519417A (ja) 1998-07-06 2002-07-02 イーストマン ケミカル カンパニー ビタミンｅの製造方法
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
EP0995449A1 (de) 1998-10-21 2000-04-26 Sulzer Orthopädie AG UHMW-Polyethylen für Implantate
SE9900519D0 (sv) 1999-02-17 1999-02-17 Lars Lidgren A method for the preparation of UHMWPE doped with an antioxidant and an implant made thereof
ATE291446T1 (de) * 1999-05-27 2005-04-15 Monsanto Co Biomaterialien, modifiziert mit superoxid- dismutase imitatoren
US6627141B2 (en) * 1999-06-08 2003-09-30 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6245276B1 (en) * 1999-06-08 2001-06-12 Depuy Orthopaedics, Inc. Method for molding a cross-linked preform
US6432349B1 (en) 1999-06-29 2002-08-13 Zimmer, Inc. Process of making an articulating bearing surface
US6184265B1 (en) * 1999-07-29 2001-02-06 Depuy Orthopaedics, Inc. Low temperature pressure stabilization of implant component
US6620198B2 (en) * 1999-10-07 2003-09-16 Exactech, Inc. Composite bearing inserts for total knee joints
US6664317B2 (en) * 2000-02-18 2003-12-16 Ciba Specialty Chemicals Corporation Stabilized gamma irradiated polyolefins
US6391390B1 (en) 2000-03-22 2002-05-21 Basf Corporation Curable coating composition with improved durability
DK1276436T3 (da) 2000-04-27 2009-04-06 Orthopaedic Hospital Oxidationsbestandige og slidbestandige polyethylener til humane lederstatninger og fremgangsmåder til fremstilling af dem
US6503439B1 (en) * 2000-06-15 2003-01-07 Albert H. Burstein Process for forming shaped articles of ultra high molecular weight polyethylene suitable for use as a prosthetic device or a component thereof
US6558794B1 (en) * 2000-06-26 2003-05-06 Technology Assessment & Transfer, Inc. Ceramic particulate reinforced orthopedic implants
US6818172B2 (en) * 2000-09-29 2004-11-16 Depuy Products, Inc. Oriented, cross-linked UHMWPE molding for orthopaedic applications
US7205339B2 (en) * 2000-12-12 2007-04-17 Massachusetts General Hospital Selective controlled manipulation of polymers
US6547828B2 (en) * 2001-02-23 2003-04-15 Smith & Nephew, Inc. Cross-linked ultra-high molecular weight polyethylene for medical implant use
US20020156436A1 (en) * 2001-04-18 2002-10-24 Jeffrey Kerchner Treatment assembly and method of treatment
US8524884B2 (en) 2001-10-30 2013-09-03 Colorado State University Research Foundation Outer layer material having entanglement of hydrophobic polymer hostblended with a maleated hydrophobic polymer co-host, and hydrophilic polymer guest
WO2003049930A1 (en) 2001-12-12 2003-06-19 Depuy Products, Inc. Orthopaedic device and method for making same
CA2471771C (en) * 2002-01-04 2012-01-03 Massachusetts General Hospital A high modulus crosslinked polyethylene with reduced residual free radical concentration prepared below the melt
US7595074B2 (en) 2002-04-05 2009-09-29 University Of Massachusetts Lowell Polymeric antioxidants
WO2003089501A1 (en) * 2002-04-19 2003-10-30 Gammatron (Pty) Ltd Method of increasing the hydrostatic stress strength of a polymer
AU2003245420A1 (en) * 2002-06-21 2004-01-06 Massachusetts General Hospital Metal back or mesh crosslinking
WO2004009690A2 (en) * 2002-07-18 2004-01-29 Exxonmobil Chemical Patents Inc. Ultraviolet radiation stabilized polyolefins
US8337968B2 (en) 2002-09-11 2012-12-25 Boston Scientific Scimed, Inc. Radiation sterilized medical devices comprising radiation sensitive polymers
US6976999B2 (en) 2002-11-19 2005-12-20 Zimmer Technology, Inc. Prosthetic device and method of making the same
WO2004064618A2 (en) * 2003-01-16 2004-08-05 Massachusetts General Hospital Methods for making oxidation resistant polymeric material
US6933026B2 (en) * 2003-02-06 2005-08-23 Aradgim Corporation Method to reduce damage caused by irradiation of halogenated polymers
DE602004028638D1 (de) * 2003-05-02 2010-09-23 Surmodics Inc System zur kontrollierten Freisetzung eines bioaktiven Wirkstoffs im hinteren Bereich des Auges
US6853772B2 (en) 2003-05-13 2005-02-08 3M Innovative Properties Company Fiber grating writing interferometer with continuous wavelength tuning and chirp capability
AT412969B (de) 2003-05-19 2005-09-26 Klaus Dr Lederer Vernetztes, ultra-hochmolekulares polyethylen (uhmw-pe)
US7214764B2 (en) * 2003-06-30 2007-05-08 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
US20040265165A1 (en) * 2003-06-30 2004-12-30 Depuy Products, Inc. Free radical quench process for irradiated ultrahigh molecular weight polyethylene
JP2005054145A (ja) 2003-08-07 2005-03-03 Mitsubishi Gas Chem Co Inc ガスバリア性（メタ）アクリレート樹脂硬化物および塗料、接着剤、フィルム
US7205051B2 (en) * 2003-09-30 2007-04-17 Depuy Products, Inc. Medical implant or medical implant part
CA2554777C (en) 2004-02-03 2012-10-09 Orhun K. Muratoglu Highly crystalline cross-linked oxidation-resistant polyethylene
WO2005110276A1 (en) * 2004-05-11 2005-11-24 The General Hospital Corporation Dba Massachusetts General Hospital Methods for making oxidation resistant polymeric material
US7384430B2 (en) * 2004-06-30 2008-06-10 Depuy Products, Inc. Low crystalline polymeric material for orthopaedic implants and an associated method
US7344672B2 (en) 2004-10-07 2008-03-18 Biomet Manufacturing Corp. Solid state deformation processing of crosslinked high molecular weight polymeric materials
GB0422666D0 (en) 2004-10-12 2004-11-10 Benoist Girard Sas Prosthetic acetabular cups
US7235592B2 (en) * 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US7335697B2 (en) * 2004-12-23 2008-02-26 Depuy Products, Inc. Polymer composition comprising cross-linked polyethylene and methods for making the same
US7435372B2 (en) * 2005-03-31 2008-10-14 Zimmer, Inc. Liquid bath annealing of polymers for orthopaedic implants
WO2006125082A2 (en) * 2005-05-18 2006-11-23 The General Hospital Corporation Dba Massachusetts General Hospital Hydrogels and hydrogel particles
US8034029B2 (en) 2005-05-25 2011-10-11 Palyon Medical (Bvi) Limited Multi-reservoir implantable pump with patient controlled actuation
AU2012203503B2 (en) 2005-08-18 2014-01-30 Zimmer Gmbh Ultra high molecular weight polyethylene articles and methods of forming ultra high molecular weight polyethylene articles
EP2792373B1 (de) * 2005-08-18 2017-03-01 Zimmer GmbH Polyethylenartikel mit ultrahohem Molekulargewicht und Verfahren zur Herstellung von Polyethylenartikeln
WO2007024684A2 (en) 2005-08-22 2007-03-01 The General Hospital Corporation Dba Massachusetts General Hospital Highly crystalline polyethylene
CA2619869A1 (en) * 2005-08-22 2007-03-01 The General Hospital Corporation Dba Massachusetts General Hospital Highly cross-linked and wear-resistant polyethylene prepared below the melt
US8461225B2 (en) * 2005-08-22 2013-06-11 The General Hospital Corporation Oxidation resistant homogenized polymeric material
US20070077268A1 (en) * 2005-09-30 2007-04-05 Depuy Products, Inc. Hydrophobic carrier modified implants for beneficial agent delivery
US20070149660A1 (en) * 2005-10-27 2007-06-28 Vijayendra Kumar Stabilized polyolefin compositions
US7705176B2 (en) 2005-10-27 2010-04-27 Polnox Corporation Macromolecular antioxidants based on sterically hindered phenols and phosphites
US7615075B2 (en) 2005-11-04 2009-11-10 Rush University Medical Center Plastic implant impregnated with a degradation protector
WO2007056561A2 (en) 2005-11-09 2007-05-18 Liquidia Technologies, Inc. Medical device, materials, and methods
US7635725B2 (en) * 2006-02-21 2009-12-22 The Brigham And Women's Hospital, Inc. Crosslinked polymers
US20070232762A1 (en) * 2006-03-31 2007-10-04 Depuy Products, Inc. Bearing material of medical implant having reduced wear rate and method for reducing wear rate
US20070239283A1 (en) 2006-04-11 2007-10-11 Berger Richard A Acetabular cup conversion ring
CA2653200A1 (en) * 2006-05-25 2007-12-06 The General Hospital Corporation Anti-cross-linking agents and methods for inhibiting cross-linking of injectable hydrogel formulations
ITMI20061375A1 (it) * 2006-07-14 2008-01-15 Fabio Conteduca Maeriale protesico sintetico a ridotta ossidabilita' e relativo processo di preparazione
JP4902455B2 (ja) 2006-08-01 2012-03-21 東レ東燃機能膜合同会社 ポリオレフィン多層微多孔膜、その製造方法、電池用セパレータ及び電池
DK1891987T3 (da) * 2006-08-25 2010-12-13 Depuy Products Inc Bæremateriale for medicinsk implantat
EP2460636A1 (de) 2006-10-30 2012-06-06 Smith & Nephew Orthopaedics AG Verfahren mit Vernetzung von Polyethylen oder Verwendung von vernetztem Polyethylen
US7966043B2 (en) * 2006-12-09 2011-06-21 Cisco Technology, Inc. Method for creating multiple-input-multiple-output channel with beamforming using signals transmitted from single transmit antenna
CA2674955C (en) 2007-01-25 2015-05-26 The General Hospital Corporation Methods for making oxidation-resistant cross-linked polymeric materials
WO2008101116A1 (en) 2007-02-14 2008-08-21 Brigham And Women's Hospital, Inc. Crosslinked polymers and methods of making the same
AU2008222967B2 (en) * 2007-03-02 2012-12-13 Cambridge Polymer Group, Inc. Cross-linking of antioxidant-containing polymers
JP2010521566A (ja) 2007-03-20 2010-06-24 スミス アンド ネフュー オーソペディックス アーゲー 高度に架橋した耐酸化性超高分子量ポリエチレン
ATE544476T1 (de) 2007-04-10 2012-02-15 Zimmer Inc Antioxidans-stabilisiertes vernetztes ultrahochmolekulares polyethylen für anwendungen in medizinprodukten
US8664290B2 (en) 2007-04-10 2014-03-04 Zimmer, Inc. Antioxidant stabilized crosslinked ultra-high molecular weight polyethylene for medical device applications
US8641959B2 (en) * 2007-07-27 2014-02-04 Biomet Manufacturing, Llc Antioxidant doping of crosslinked polymers to form non-eluting bearing components
WO2009032909A2 (en) 2007-09-04 2009-03-12 Smith & Nephew Orthopaedics Ag Ultra high molecular weight polyethylene for bearing surfaces
US20100292374A1 (en) 2007-10-05 2010-11-18 Anuj Bellare Crosslinked polymers and methods of making the same
EP2207848B1 (de) 2007-11-06 2011-10-19 DSM IP Assets B.V. Verfahren zur herstellung von polyethylen mit ultrahohem molekulargewicht
CA2712559C (en) * 2008-01-30 2015-03-31 Zimmer, Inc. Orthopedic component of low stiffness
US7806064B2 (en) * 2008-03-12 2010-10-05 Wellman John G Friction reducing pollution control system for marine vehicles
RU2495054C2 (ru) 2008-05-13 2013-10-10 Смит Энд Нефью Ортопедикс Аг Устойчивый к окислению высокосшитый сверхвысокомолекулярный полиэтилен
GB0812890D0 (en) 2008-07-11 2008-08-20 Smith & Nephew Orthopaedics Ag Compositions and methods of making compositions
CN102307945B (zh) * 2008-11-20 2015-07-01 捷迈有限责任公司 聚乙烯材料
ES2617186T3 (es) 2009-05-04 2017-06-15 Smith & Nephew, Inc Efectos sinérgicos de mezclar múltiples aditivos en UHMWPE
US20120070600A1 (en) 2009-05-20 2012-03-22 Muratoglu Orhun K Metods of preventing oxidation
US8399535B2 (en) * 2010-06-10 2013-03-19 Zimmer, Inc. Polymer [[s]] compositions including an antioxidant
US20140024736A1 (en) 2010-11-03 2014-01-23 Zimmer, Inc. Polymer articles having chemically bonded agents and methods of making the same
WO2012078514A1 (en) 2010-12-06 2012-06-14 Zimmer, Inc. Crosslinked polymers including one or more antioxidants, methods for making same and methods for selecting antioxidants
JP5735443B2 (ja) 2012-03-06 2015-06-17 ジンマー ゲーエムベーハー 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法
WO2013170005A1 (en) 2012-05-11 2013-11-14 The General Hospital Corporation Antioxidant-stabilized joint implants
US9765271B2 (en) 2012-06-27 2017-09-19 James J. Myrick Nanoparticles, compositions, manufacture and applications
WO2015050851A1 (en) 2013-10-01 2015-04-09 Zimmer, Inc. Polymer compositions comprising one or more protected antioxidants
AU2015229947A1 (en) 2014-03-12 2016-10-27 Zimmer, Inc. Melt-stabilized ultra high molecular weight polyethylene and method of making the same
AU2015358476B2 (en) 2014-12-03 2019-08-15 Zimmer, Inc. Antioxidant-infused ultra high molecular weight polyethylene
JP5969637B2 (ja) 2015-01-30 2016-08-17 ジンマー ゲーエムベーハー 超高分子量ポリエチレン物品および超高分子量ポリエチレン物品を形成する方法
CN107667137A (zh) 2015-03-25 2018-02-06 捷迈有限公司 熔融稳定的超高分子量聚乙烯

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