ATE274507T1 - Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren - Google Patents

Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren

Info

Publication number
ATE274507T1
ATE274507T1 AT01994723T AT01994723T ATE274507T1 AT E274507 T1 ATE274507 T1 AT E274507T1 AT 01994723 T AT01994723 T AT 01994723T AT 01994723 T AT01994723 T AT 01994723T AT E274507 T1 ATE274507 T1 AT E274507T1
Authority
AT
Austria
Prior art keywords
benzofuran
inhibitors
selective cox
benzothiophene derivatives
benzothiophene
Prior art date
Application number
AT01994723T
Other languages
German (de)
English (en)
Inventor
Laren Kevin Lee Mc
David Bernard Smith
Jahari Laurant Tracy
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of ATE274507T1 publication Critical patent/ATE274507T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT01994723T 2000-12-05 2001-11-26 Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren ATE274507T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25128300P 2000-12-05 2000-12-05
PCT/EP2001/013716 WO2002046178A2 (en) 2000-12-05 2001-11-26 Benzofuran and benzothiophene derivatives as selective cox-2 inhibitors

Publications (1)

Publication Number Publication Date
ATE274507T1 true ATE274507T1 (de) 2004-09-15

Family

ID=22951260

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01994723T ATE274507T1 (de) 2000-12-05 2001-11-26 Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren

Country Status (16)

Country Link
US (1) US6433005B1 (enExample)
EP (1) EP1347963B1 (enExample)
JP (1) JP4212892B2 (enExample)
KR (1) KR20030070054A (enExample)
CN (1) CN1273460C (enExample)
AR (1) AR035719A1 (enExample)
AT (1) ATE274507T1 (enExample)
AU (2) AU2002224890B2 (enExample)
BR (1) BR0115963A (enExample)
CA (1) CA2437048A1 (enExample)
DE (1) DE60105195T2 (enExample)
ES (1) ES2225641T3 (enExample)
MX (1) MXPA03004398A (enExample)
PT (1) PT1347963E (enExample)
WO (1) WO2002046178A2 (enExample)
ZA (1) ZA200303641B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999051587A1 (en) * 1998-04-01 1999-10-14 Ono Pharmaceutical Co., Ltd. Fused thiophene derivatives and drugs containing the same as the active ingredient
JP2001261674A (ja) * 2000-03-22 2001-09-26 Mitsui Chemicals Inc ベンゾチオフェン誘導体およびそれを有効成分として含有する核内レセプター作動薬
AU5878001A (en) * 2000-05-18 2001-11-26 Daiichi Pharmaceutical Co., Ltd. Novel benzothiophene derivatives
AU2001268051A1 (en) * 2000-06-28 2002-01-08 Eli Lilly And Company Spla2 inhibitors
US7071220B2 (en) * 2000-09-18 2006-07-04 Toa Eiyo Ltd. N-substituted benzothiophenesulfonamide derivatives
WO2005033112A2 (en) * 2003-10-02 2005-04-14 Cephalon, Inc. Substituted indole derivatives
ATE555091T1 (de) 2006-02-03 2012-05-15 Bionomics Ltd Substituierte benzofurane, benzothiophene, benzoselenophene und indole und ihre verwendung als tubulinpolymerisationsinhibitoren
WO2008055808A1 (en) 2006-11-09 2008-05-15 F. Hoffmann-La Roche Ag Indole and benzofuran 2-carboxamide derivatives
AU2011202542A1 (en) 2010-07-14 2012-02-02 Indian Institute Of Science Benzothiophene carboxamide compounds, composition and applications thereof
CN103819371B (zh) * 2012-11-16 2016-05-04 中国科学院大连化学物理研究所 一种对甲砜基苯甲醛的合成方法
CN103058988B (zh) * 2012-12-31 2015-09-02 中国人民大学 苯并噻吩及其衍生物及其制备方法与应用
CN110903225B (zh) * 2019-12-11 2021-11-09 苏州开元民生科技股份有限公司 一种对甲砜基苯甲醛的合成方法
CN114456136B (zh) * 2022-01-27 2024-06-07 广西中医药大学 双靶点非甾体抗炎化合物及其制备方法与用途
KR102542698B1 (ko) * 2022-04-05 2023-06-14 주식회사 베노바이오 신규한 벤조사이오펜 유도체 및 bet 억제제로서의 용도

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3331854A (en) * 1964-12-14 1967-07-18 American Cyanamid Co Novel furan and thiophene compounds
US4663347A (en) 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4745127A (en) * 1983-10-31 1988-05-17 Merck Frosst Canada, Inc. Benzyl esters of benzofuran-2-carboxylic acids useful as inhibitors of leukotriene biosynthesis
US4822803A (en) 1983-10-31 1989-04-18 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid hydrazides useful as inhibitors of leukotriene biosynthesis
US4933351A (en) 1983-10-31 1990-06-12 Merck Frosst Canada, Inc. Benzofuran 2-carbox amides useful as inhibitors of leukoriene biosynthesis
DE3342624A1 (de) 1983-11-25 1984-03-29 Heinfried Dr. 4019 Monheim Grote Benzaronderivate, verfahren zu ihrer herstellung und diese derivate enthaltende arzneimittel
US4621091A (en) 1984-10-09 1986-11-04 Merck & Co., Inc. 3-hydroxybenzo[b]thiophene-2-sulfide derivatives compositions, and method of use therefor
US5208253A (en) * 1992-02-24 1993-05-04 Warner-Lambert Company 3-alkyloxy-, aryloxy-, or arylalkyloxy-benzo(b) thiophene-2-carboxamides as inhibitors of cell adhesion
WO1995002406A2 (en) 1993-07-15 1995-01-26 Warner-Lambert Company Use of benzothiophenes and benzofurans for the treatment of inflammatory bowel disease and inflammation assay method
US5426113A (en) 1994-04-08 1995-06-20 Warner-Lambert Company Method of preventing ulcer formation caused by nonsteroidal antiinflammatory drugs employing tetrazol-benzothiophene carboxamide compounds
US5521213A (en) * 1994-08-29 1996-05-28 Merck Frosst Canada, Inc. Diaryl bicyclic heterocycles as inhibitors of cyclooxygenase-2
CN1211921A (zh) * 1996-02-22 1999-03-24 伊莱利利公司 苯并噻吩、含有它们的制剂及其制备方法
US5731342A (en) 1996-02-22 1998-03-24 Eli Lilly And Company Benzothiophenes, formulations containing same, and methods

Also Published As

Publication number Publication date
US20020107280A1 (en) 2002-08-08
EP1347963B1 (en) 2004-08-25
WO2002046178A2 (en) 2002-06-13
CN1479736A (zh) 2004-03-03
EP1347963A2 (en) 2003-10-01
US6433005B1 (en) 2002-08-13
AR035719A1 (es) 2004-07-07
AU2489002A (en) 2002-06-18
DE60105195D1 (de) 2004-09-30
BR0115963A (pt) 2003-10-28
ZA200303641B (en) 2004-08-12
CA2437048A1 (en) 2002-06-13
CN1273460C (zh) 2006-09-06
JP4212892B2 (ja) 2009-01-21
JP2004517088A (ja) 2004-06-10
PT1347963E (pt) 2004-12-31
WO2002046178A3 (en) 2002-10-10
ES2225641T3 (es) 2005-03-16
KR20030070054A (ko) 2003-08-27
DE60105195T2 (de) 2005-09-08
MXPA03004398A (es) 2003-09-05
AU2002224890B2 (en) 2007-03-22

Similar Documents

Publication Publication Date Title
ATE437862T1 (de) Pyrimidin-5-onderivate als ldl-pla2 inhibitoren
DE69919887D1 (de) Pyrazolopyridin derivative als selektive cox-2 inhibitoren
ATE323072T1 (de) Pyrimidin-derivate als selective inhibitoren von cox-2
ATE256127T1 (de) Betacarbolinderivate als phosphodiesterase- inhibitoren
AR028567A1 (es) Nuevos derivados de fenil-propargileter
ATE330954T1 (de) Quinazolin-derivate als vegf-hemmer
DE69906311D1 (de) Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren
DE60136571D1 (de) Guanidinobenzamide als mc4-r agonisten
AR028596A1 (es) Nuevos derivados de fenilglicina
ATE278690T1 (de) Substituierte pyprolopyridinonderivate als phosphodiesterase-inhibitoren
FR2818646B1 (fr) Nouveaux derives c-glycoside et utilisation
ATE274507T1 (de) Benzofuran- und benzothiophen-derivative als selektive cox-2 inhibitoren
DE60203529D1 (de) Indolderivate als cox-ii-inhibitoren
ATE428420T1 (de) Substituierte 8-arylchinoline als phosphodiesterase-4-hemmer
DE50114491D1 (de) Substituierte C-Cyclohexylmethylamin-Derivative
NO20025474D0 (no) Benzofuranderivater
ATE370944T1 (de) Chromenon- und chromanonderivate als integrinhemmer
NO20022985D0 (no) Substituerte aminometyl-fenyl-cykloheksanderivater
DE60005980D1 (de) Benzopyran und benzothiopyran, verwendbar als selektive retinoid-agonisten
DK1322592T4 (da) Substituerede 1-aminobutan-3-ol-derivater
NO20025475L (no) Nye benzotiofenderivater
DE60118941D1 (de) Pyrrolidin-2-carbonsäure-hydrazid-derivate als metalloprotease-inhibitoren
ATE273973T1 (de) Benzofuranderivate
ATE361274T1 (de) Substituierte 5-amino-1-penten-3-ol-derivate
DK1347963T3 (da) Benzofuran- og benzothiophenderivater som selektive COX-2-inhibitorer

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1347963

Country of ref document: EP

REN Ceased due to non-payment of the annual fee